LOCUS       NM_001297568            2776 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 124 (ZNF124), transcript variant
            4, mRNA.
ACCESSION   NM_001297568 XM_005273256
VERSION     NM_001297568.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2776)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2776)
  AUTHORS   de Sa Machado Araujo,G., da Silva Francisco Junior,R., Dos Santos
            Ferreira,C., Mozer Rodrigues,P.T., Terra Machado,D., Louvain de
            Souza,T., Teixeira de Souza,J., Figueiredo Osorio da Silva,C.,
            Alves da Silva,A.F., Andrade,C.C.F., da Silva,A.T., Ramos,V.,
            Garcia,A.B., Machado,F.B. and Medina-Acosta,E.
  TITLE     Maternal 5mCpG Imprints at the PARD6G-AS1 and GCSAML Differentially
            Methylated Regions Are Decoupled From Parent-of-Origin Expression
            Effects in Multiple Human Tissues
  JOURNAL   Front Genet 9, 36 (2018)
   PUBMED   29545821
  REMARK    GeneRIF: RNA-Seq evidence for lung tissue-specific monoallelic
            expression of ZNF124, located 363 kb upstream of the GCSAML somatic
            (secondary), imprinted differentially methylated region (iDMR). The
            ZNF124 locus has no overlapping hemimethylated CGIs in normal
            tissues, including lung tissue The GCSAML iDMR might regulate the
            lung tissue-specific, monoallelic expression of ZNF124. In the
            placenta, ZNF124 is biallelically expressed.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2776)
  AUTHORS   Poot,M., Kroes,H.Y., V D Wijst,S.E., Eleveld,M.J., Rooms,L.,
            Nievelstein,R.A., Olde Weghuis,D., Vreuls,R.C., Hageman,G., Kooy,F.
            and Hochstenbach,R.
  TITLE     Dandy-Walker complex in a boy with a 5 Mb deletion of region 1q44
            due to a paternal t(1;20)(q44;q13.33)
  JOURNAL   Am J Med Genet A 143A (10), 1038-1044 (2007)
   PUBMED   17431901
REFERENCE   5  (bases 1 to 2776)
  AUTHORS   Miyake,N., Katoh,O., Hirata,S., Kimura,S., Watanabe,H. and Yajin,K.
  TITLE     Expression of the Kruppel-type zinc finger gene, ZK7, in head and
            neck squamous cell carcinoma and normal mucosa
  JOURNAL   Cancer Lett 185 (1), 111-118 (2002)
   PUBMED   12142086
REFERENCE   6  (bases 1 to 2776)
  AUTHORS   Kuramoto,K., Uesaka,T., Kimura,A., Kobayashi,M., Watanabe,H. and
            Katoh,O.
  TITLE     ZK7, a novel zinc finger gene, is induced by vascular endothelial
            growth factor and inhibits apoptotic death in hematopoietic cells
  JOURNAL   Cancer Res 60 (2), 425-430 (2000)
   PUBMED   10667597
REFERENCE   7  (bases 1 to 2776)
  AUTHORS   Saleh,M., Selleri,L. and Evans,G.A.
  TITLE     A novel zinc finger gene on human chromosome 1qter that is
            alternatively spliced in human tissues and cell lines
  JOURNAL   Am J Hum Genet 52 (1), 192-203 (1993)
   PUBMED   7916577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390728.37, DA911997.1,
            AK054647.1, BC096351.2 and BU607971.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_001297568.1.
            
            Summary: This gene encodes a protein with an amino-terminal KRAB-A
            box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at
            its carboxy terminus. The encoded protein may function as a
            transcription factor. Expression of this gene is increased after
            vascular endothelial growth factor (VEGF) stimulation in human
            leukemia cell lines and results in inhibition of apoptotic cell
            death induced by irradiation or exposure to etoposide. Alternative
            splicing results in multiple transcript variants encoding distinct
            proteins. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (4) is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099661.3, SRR5189661.120297.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543802.3/ ENSP00000440365.2
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL390728.37        62129-62131         c
            4-45                DA911997.1         1-42
            46-53               AK054647.1         42-49
            54-1345             BC096351.2         1-1292
            1346-1864           AK054647.1         1156-1674
            1865-2484           AL390728.37        45392-46011         c
            2485-2776           BU607971.1         17-308
FEATURES             Location/Qualifiers
     source          1..2776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..2776
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /note="zinc finger protein 124"
                     /db_xref="GeneID:7678"
                     /db_xref="HGNC:HGNC:12907"
                     /db_xref="MIM:194631"
     exon            1..173
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1199
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /note="isoform 4 is encoded by transcript variant 4; zinc
                     finger protein HZF-16"
                     /codon_start=1
                     /product="zinc finger protein 124 isoform 4"
                     /protein_id="NP_001284497.1"
                     /db_xref="CCDS:CCDS73057.1"
                     /db_xref="GeneID:7678"
                     /db_xref="HGNC:HGNC:12907"
                     /db_xref="MIM:194631"
                     /translation="MSGHPGSWEMNSVAFEDVAVNFTQEEWALLDPSQKNLYRDVMQE
                     TFRNLASIGNKGEDQSIEDQYKNSSRNLRHIISHSGNNPYGCEECGKKPCTCKQCQKT
                     SLSVTRVHRDTVMHTGNGHYGCTICEKVFNIPSSFQIHQRNHTGEKPYECMECGKALG
                     FSRSLNRHKRIHTGEKRYECKQCGKAFSRSSHLRDHERTHTGEKPYECKHCGKAFRYS
                     NCLHYHERTHTGEKPYVCMECGKAFSCLSSLQGHIKAHAGEEPYPCKQCGKAFRYASS
                     LQKHEKTHIAQKPYVCNNCGKGFRCSSSLRDHERTHTGEKPYECQKCGKAFSRASTLW
                     KHKKTHTGEKPYKCKKM"
     exon            174..300
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /inference="alignment:Splign:2.1.0"
     exon            301..361
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /inference="alignment:Splign:2.1.0"
     exon            362..2776
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2753..2758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /note="hexamer: AATAAA"
     polyA_site      2776
                     /gene="ZNF124"
                     /gene_synonym="HZF-16; HZF16; ZK7"
                     /note="major polyA site"
ORIGIN      
        1 gcccggcctt tgtctctcgt gcccgcacgt gcgtgtctcg gtcagtagcc ctgcgcttct
       61 ccttcactct cggcggttca ggaggctctg ccgcagccgg ggccctcctg tgacctgcat
      121 gtactggggg attcgcaggg aggatgtcgg gacaccccgg aagctgggaa atgaactcgg
      181 ttgcctttga ggatgtggct gtgaacttca cccaggagga gtgggctttg ttggatcctt
      241 cccagaagaa tctctataga gacgtgatgc aggaaacctt caggaatctg gcttccatag
      301 gaaacaaagg ggaagaccag agcattgaag atcagtacaa aaattcttca agaaatctaa
      361 ggcacatcat atctcattct ggaaacaacc catatgggtg tgaggaatgc ggaaagaagc
      421 catgtacatg taaacaatgt cagaaaactt ccctttctgt cacaagggtt cacagagaca
      481 cagtaatgca cactggaaat ggacattatg gttgtacaat atgtgagaaa gtttttaata
      541 ttcccagttc atttcagata catcagagaa atcacactgg agagaaaccc tatgaatgta
      601 tggaatgtgg gaaagcctta ggtttttccc gttctcttaa tagacataaa aggattcaca
      661 ctggagaaaa acgctatgaa tgtaagcaat gtgggaaagc cttcagtcgt tccagtcacc
      721 ttcgtgacca tgaaagaact catactggag agaaacccta tgaatgtaag cactgtggga
      781 aagccttccg ttactccaat tgccttcatt accatgaaag aactcacact ggagagaaac
      841 cttatgtgtg catggaatgt ggcaaagctt tcagttgtct cagttccttg caaggacata
      901 taaaggctca tgctggtgaa gaaccctatc catgtaagca atgtgggaaa gccttcagat
      961 acgccagttc ccttcagaaa cacgagaaaa ctcatattgc acagaaaccc tatgtatgta
     1021 acaattgtgg taaaggcttc agatgttcca gttcccttcg tgaccatgaa aggactcata
     1081 ctggagagaa accctatgaa tgtcagaaat gtggcaaagc ctttagtcgt gctagtaccc
     1141 tttggaagca taaaaaaact catactggag aaaagcccta taaatgtaaa aaaatgtaaa
     1201 ggctttaatc actacagttt ttgtcaaaaa catgaacagt cacatacttg agagaaactg
     1261 tgaatgtaag gtgtaggaaa gtacttaatt ttcccagatt tcctcaaata catgaaacga
     1321 atcaaactgg agataaaccc tatgactata agcaataagg taaagcattc aatttttcca
     1381 tttctttttg aaaacttgaa aggactcact gaagaaaatc catatgaatg tttaaaatgt
     1441 ggtaaggcct gcagttgttc cagtggtatt tgatggtata acataactca ttctagagaa
     1501 aaactttatg aaggtatcga atgtgagaat gccttcattt atcctataac tcactcagag
     1561 acacatggta acacatactc cagattgacc ttataaataa aagaatgccc accagattga
     1621 aatcctagaa atacagaaaa ttctgaattt taacaattac tttaaaggtc atgtgaaaac
     1681 tcccactgga aataaatcct gtaaatgtaa atattatgga aaaccttatg gaaaataatt
     1741 atagtacaat tctcaagaaa attcactatg tgaatgagat gttttaggag ctataaataa
     1801 attgaatata ttggttgctc atttttgaag agagtctcta gaatatagat tttcacttct
     1861 tttgaaaaaa aaaaaattga ggtgagactt tttttttttt ttttgagatg gagtctcact
     1921 ttgtcgccca ggctggtgtg cagtggcaca atctcagttc actgtaagct ctgcctccca
     1981 ggttcacgcc attctcctgc ctcagcctcc tgagtagctg ggactacagg tgcctgccac
     2041 catgcccagc taattttttg tatttttagt agagatgggg tttcaccgtg ttagccagga
     2101 tggtctcaat ctcctgacct cgtgatccgc ccgcttcagc ctcccaaagt gctgggatta
     2161 caggcgtgag ccaccacgcc cagctgaggc aagacttctg taagtattct tcaagcagta
     2221 gtacaagagt taaatatgta ttcttctttt ttaagctggt aaataaattt cctttttcta
     2281 cccattttaa agtgtgttgg ttatatgggt aaattgaaat gtatttcttt tccttttttc
     2341 ttgcatagcc attttaaaaa atatttttta aatatttaaa gtataaaata tttttaaaat
     2401 tttttaaaaa ttttgtgggt tacacagtag atgtgtgaaa tgtatttgta ggtttaactt
     2461 ctgtgtagtt taattatttt gttattaatt ggccattgat aaatgagtct attttctttg
     2521 ctaatagagt tgctgtcaat ttgtaagtat gtaaagttta ttatagagta tattctcacg
     2581 tgaattatta ttttcatctg ttgttcttta cattgtcatt atttttggct atttgcatag
     2641 gtaacattgg tttaaggaga gagacctgtg atcgaacagt gtcttgtgtc taatctgaga
     2701 aagaaagcat ccagtcttat catcatgtat gatgttagct gagggttttt aaaataaatt
     2761 ccttaaagca ggttga
//
