LOCUS       NM_001008727            6987 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 121 (ZNF121), transcript variant
            2, mRNA.
ACCESSION   NM_001008727
VERSION     NM_001008727.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6987)
  AUTHORS   Liu,W., Ma,W., Yuan,Y., Zhang,Y. and Sun,S.
  TITLE     Circular RNA hsa_circRNA_103809 promotes lung cancer progression
            via facilitating ZNF121-dependent MYC expression by sequestering
            miR-4302
  JOURNAL   Biochem Biophys Res Commun 500 (4), 846-851 (2018)
   PUBMED   29698681
  REMARK    GeneRIF: Circular RNA hsa_circRNA_103809 promotes lung cancer
            progression via facilitating ZNF121-dependent MYC expression by
            sequestering miR-4302.
REFERENCE   3  (bases 1 to 6987)
  AUTHORS   Luo,A., Zhang,X., Fu,L., Zhu,Z. and Dong,J.T.
  TITLE     Zinc finger factor ZNF121 is a MYC-interacting protein functionally
            affecting MYC and cell proliferation in epithelial cells
  JOURNAL   J Genet Genomics 43 (12), 677-685 (2016)
   PUBMED   27988300
  REMARK    GeneRIF: ZNF121 as a MYC-interacting protein with functional
            effects on MYC and cell proliferation
REFERENCE   4  (bases 1 to 6987)
  AUTHORS   Ohira,M., Morohashi,A., Inuzuka,H., Shishikura,T., Kawamoto,T.,
            Kageyama,H., Nakamura,Y., Isogai,E., Takayasu,H., Sakiyama,S.,
            Suzuki,Y., Sugano,S., Goto,T., Sato,S. and Nakagawara,A.
  TITLE     Expression profiling and characterization of 4200 genes cloned from
            primary neuroblastomas: identification of 305 genes differentially
            expressed between favorable and unfavorable subsets
  JOURNAL   Oncogene 22 (35), 5525-5536 (2003)
   PUBMED   12934113
REFERENCE   5  (bases 1 to 6987)
  AUTHORS   Chen,H., Kalaitsidaki,M., Warren,A.C., Avramopoulos,D. and
            Antonarakis,S.E.
  TITLE     A novel zinc finger cDNA with a polymorphic pentanucleotide repeat
            (ATTTT)n maps on human chromosome 19p
  JOURNAL   Genomics 15 (3), 621-625 (1993)
   PUBMED   8468057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU253046.1, AC008759.9 and AC008567.5.
            
            On May 20, 2020 this sequence version replaced NM_001008727.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an exon in the 5' coding region resulting in use of an
            alternate start codon compared to variant 1. Variants 1 and 2
            encode the same protein sequence.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.15012.1,
                                           SRR14038197.1734033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320451.7/ ENSP00000326967.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AU253046.1         30-235
            207-1093            AC008759.9         18962-19848         c
            1094-6987           AC008567.5         147811-153704       c
FEATURES             Location/Qualifiers
     source          1..6987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6987
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /note="zinc finger protein 121"
                     /db_xref="GeneID:7675"
                     /db_xref="HGNC:HGNC:12904"
                     /db_xref="MIM:194628"
     exon            1..44
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /inference="alignment:Splign:2.1.0"
     exon            45..125
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /inference="alignment:Splign:2.1.0"
     exon            126..206
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1376
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /note="zinc finger protein 121 (clone ZHC32); zinc finger
                     protein 20"
                     /codon_start=1
                     /product="zinc finger protein 121"
                     /protein_id="NP_001008727.1"
                     /db_xref="CCDS:CCDS32902.1"
                     /db_xref="GeneID:7675"
                     /db_xref="HGNC:HGNC:12904"
                     /db_xref="MIM:194628"
                     /translation="MAEIHNGGELCDFMENGEIFSEHSCLNAHMGTENTGDTYDCDEY
                     GENFPMLHNSAPAGETLSVLNQCRKAFSLPPNVHQRTWIGDKSFEYSDCEEAFVDQSH
                     LQANRITHNGETLYEQKQCGRAFTYSTSHAVSVKMHTVEKPYECKECGKFFRYSSYLN
                     SHMRTHTGEKPYECKECGKCFTVSSHLVEHVRIHTGEKPYQCKECGRAFAGRSGLTKH
                     VRIHTGEKPYECNECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCLKNHFR
                     IHTGIKPYKCKECGKAFTVSSSLHNHVKIHTGEKPYECKDCGKAFATSSQLIEHIRTH
                     TGEKPYICKECGKTFRASSHLQKHVRIHTGEKPYICNECGKAYNRFYLLTKHLKTH"
     exon            207..6987
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6966..6971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /note="hexamer: AATAAA"
     polyA_site      6987
                     /gene="ZNF121"
                     /gene_synonym="D19S204; ZHC32; ZNF20"
                     /note="major polyA site"
ORIGIN      
        1 agtgccattt cgcctttatc gtggtggagt ccaccctggc tgtggaccta ttcaaactca
       61 gtctgtctct tgactggagg aggagaagga aaagttgagc acattgccaa ccggagttcc
      121 ccaagaatgg caagttaaaa ccaaagtgtc agcacctcaa caacattttt ttttggctta
      181 acaaaacatc aaacggcata caaatggcag aaatccacaa tggaggggaa ctctgtgact
      241 ttatggaaaa tggagaaatc ttcagtgaac actcatgcct taatgcacac atgggaactg
      301 aaaatacagg ggacacttat gactgtgatg agtatggaga aaactttccc atgttacaca
      361 acagtgcccc tgctggagag acactttctg tgttgaatca gtgcagaaaa gccttcagcc
      421 tgccaccaaa tgttcaccag agaacgtgga taggagacaa atcctttgaa tacagtgact
      481 gtgaggaagc ctttgttgat cagtcacatc ttcaggcaaa taggataact cacaatggag
      541 aaacactcta tgaacagaag caatgtggga gagcttttac ttactccaca agccatgctg
      601 tgtctgttaa aatgcatact gtagaaaaac cctacgaatg taaggaatgt ggaaaattct
      661 ttagatattc ttcatatctt aatagtcaca tgcgaaccca tactggggag aaaccctatg
      721 aatgtaagga atgtgggaaa tgcttcactg tttcttcaca cctagttgaa catgtaagaa
      781 ttcatactgg agagaaacct tatcaatgta aggaatgtgg aagagccttc gctgggcgct
      841 caggccttac taaacatgta cgaatacaca ctggagagaa gccctatgaa tgtaacgaat
      901 gtgggaaagc ctacaatagg ttttatctac taactgaaca ttttaaaact cacacagagg
      961 agaagccctt tgaatgtaag gtatgtggaa aatccttcag aagctcttca tgccttaaga
     1021 atcactttag aattcacact ggaataaaac cctataaatg taaggagtgt gggaaagcat
     1081 tcactgtttc ctcaagctta cataatcatg taaaaatcca tactggagag aagccctatg
     1141 aatgtaagga ctgtgggaaa gcctttgcta catcttcaca actcattgaa catataagaa
     1201 ctcacactgg agagaaaccg tatatatgta aggaatgtgg gaaaaccttc cgtgcttctt
     1261 cacatctaca gaaacatgtt agaattcaca ctggagagaa accctatata tgtaacgaat
     1321 gtgggaaagc ctacaataga ttttatttac ttactaaaca tttaaaaaca cactgaagaa
     1381 aaactctgaa tgtaaggaat gtggaaatct tttaggaatt tctcatacca taattaccac
     1441 atttgaattc acactgaaga gaaattttat tggtacaaag aatgtgagga ggccttcagt
     1501 tatccccatt cacttcgaag acatgaaaga actcatactc tatgtgtccc ctataaattt
     1561 taggaatgtt agggagccaa tggaatcttt ttttattatt ttattttatt ttattttatt
     1621 ttattttatt ttattttatt ttatttgaga cagagttttg ctgttgtcat cacacaggct
     1681 ggagtgcaat ggcatgatcc cagctcactg caacctttgt ctcctgggtt caggcgattc
     1741 tgcctcagcc ttcaagtagc ttggattaca ggtgccgtca accacaccca gctaattttt
     1801 gtatttttag tagagatggg gtttcaccat gttggccagg ctggtctcga gctcctgacc
     1861 tcaggtgatc cacccgcctt ggcctcccaa agtgctggga ttataggagt gagccactgc
     1921 tcctggcctt tttttttttt tttttttttt tttttttttt ttgtaagtcg ttgttaatac
     1981 acattctttt ctcaagggat tggattgtgg tcacaatcca acatttgaga actcaccatg
     2041 gggccataca atgtagaaaa cacagaaagc cctcattatt tccttaggcc tttctaagta
     2101 tataagatgt tgcaatggag aagagaaacc ctattgatac aagatacagg catgccctgt
     2161 agatattgtg agttttgttc cagactacca ctataaagtg aatatcacaa taacatgaat
     2221 catacaaatg ttttggtttc ccagtgcata taagttaggt ttacatcata tggtagtctc
     2281 ttgtgtgcag ttgtgttatg tctaagtaaa gtaccttagt ttaaaatact ttattgccaa
     2341 aaagtgctaa tgatcatgtg agactttggt gagttgtaat ctttttgctt gtggtaggtc
     2401 ttgcctcagt gttgatggct gttgatcagg gtggctgtgg cagtttctta aaataagaca
     2461 gcagtgaaga ttgctgcatt gattgactct tcattacatg aaaaacttct ctttagcatt
     2521 cgacgctgtt tgataacatt ttacgcatag tggaacttct tttagaattg gacttaatcc
     2581 tctcaaactt cgccactgct tgatcaacta agttgatgta atattctaag tctgttgtct
     2641 tttcaacaat gttcacagca tcttcaggag tagatttcat ttcaggaaac cactttcttt
     2701 gcttatctat acaaagcagc ctctcatctg ttcaagtttt ttcacgagat tgaaacaatt
     2761 ctgtcacatc ttcaggctcc acttctaatt ctagttctct tttttccatc acatccacag
     2821 ttactttttc cactgaagac ttgaacccct cagagtcacc tatgaaggtt ggaatcaact
     2881 tcttccaaac tctggttaat gttggttttt atttttttaa ttaaaaaaat tttttttaga
     2941 gacaaggtct cgctgtgttg ttcatgctgg agtacaagtg ggtattcacc agcacgatga
     3001 gagcacactg tagccttgaa ctcctggcct caagtgatcc tccttcctat gcctcctgag
     3061 tagccaagac tccaggcaca caccaccaca cctgccttaa tgttgatatt ttgacctcct
     3121 tccatgaatc ataaatgttg ttaatggcat ctagaatgga gaatcctttc tgcaaggtct
     3181 gcaacttaat ttatccagat ccctcagaag aagcattatt agtggcagct atagccttat
     3241 gaaatgtatt tcttaaataa taagacttga aagtcagaat tattccagaa tccatgggct
     3301 gcggttagca gacatgaaaa cgccaatctt gtttatacct ccataagagc tcttggttag
     3361 taggttcatt atcagtggta atattttgaa aggaatctct gaacagtatg ttttacagtg
     3421 ggcttaaaat attcagtaaa ccatgctgta aatagatgta aatagatacc acaggaagag
     3481 tagatgtagc ataattctta actggctctt ggatttttgg aatggtaatt gaatattagc
     3541 attcatttaa agtcaccaac tgcattgacc tctaacaaga aagccagccc aggctgggaa
     3601 aagtggctta cacctgtaat tccagtgctt tgggaggctg aggttggagg atcacttgag
     3661 gtcaagagtt caagaccagc cagcacaaca gagcgtgacg ctgtctctac aaagtaaaga
     3721 gtcagcccgt cctttgaatc tttgaagtca gatattagct tacctagagc tgtgaaagtc
     3781 ctaaatggca tctcctgaag taaggctgtt ttgtctctgt taaaactcta gtagagctac
     3841 ctctgccatt tatctagata ttctggaaat gcttgctgca gattccacat cagcaattgc
     3901 tacttcactt tgtactttta tgttatggaa atgacttgtt aaacctcacg aactgatctt
     3961 tgccagcttc cagcatttct tctgcagcta actcacctct cagccttcat agaattagag
     4021 ttagggcctt gctctggatt aggttttggc ttaagggaat gttgtggctg gtctgatctt
     4081 ctatccagac cactaaaact tattccgtgt tagtggtgag gctgttttcc tttcttatta
     4141 tgtgtgtgtt cactggagta gcacttttag tttccttcaa gaactttaca ttcacaactt
     4201 ggctaactgg cacaagaggc ctagattttg gcctatccca gttttttttt tttttttttt
     4261 tttgagacat ggtctccctt ttgcccaggc tggagtgtag tacagttata gcccattgca
     4321 gcctcaaact tacgggttcc agtgatcttc ctgtctcctg agtagctaaa gactgcaggt
     4381 gtgcaccacc atggccagct aatttttttt tttttttttt ttttttttta aagaggcagg
     4441 actttactgt ttacccggct gatcttgaac ttaaaacctc aagtgatgct cccctatctg
     4501 cctcccaaca ctctgggatt acaggtgtga gccactgcac ctggctctta tcttggcttt
     4561 tgacatgact ttctcactga ggttaatcat ttccagcttt tgatctaaag tgagaaattt
     4621 gcaactcctt ctttcacttg aacagttaga ggccattgtg gggtaatgaa ttggcctaat
     4681 ttcaatattg tccctcaggg aattaggagg cctgggaaga ggaggagaga ggggagagtg
     4741 gccagttggt ggagcagtga gaacatagca tttgttaagt ttgctgtctt cgaaggttgt
     4801 ggtttgtggt accccaaaac aattaaaata ggaacatcaa agatcacaga gcagccgggc
     4861 acggtggctc acacctgtaa tcccagcacc ttgagaggct gaggtgagtg aatcatgagg
     4921 tcaggagttc gagaccagcc tggccaccat ggtgaaaccc cgtctctact aaaaatacaa
     4981 aaaattagcc gggcatggtg gcaggcacct atagtcccag ctattcagga ggctgaggca
     5041 ggagaatcac ttgaatccag gaggtggagg ttagagtgag ctgagatcac accactgcac
     5101 tccagcccag gtgacagagt gagattcctt ctcaaaaaaa aaaaaaaaaa aaaatcacac
     5161 agcaccacag taagtataat aataaggaaa atgtttgaaa tattgtcaga attgtcagga
     5221 tgtgagagac aaagtaagca catgctgttg gaaaaaatgg tgttatagat ttattcgaca
     5281 tgacattgcc acaggacttc tacttgtgaa aaatatctgt aaagtgagat gaagcaaagt
     5341 gaagtaacat gaggtatgtc tgtagctgtt gctgtagtgg tttccaaatg gtggttttct
     5401 tttccttttt tttttttttc tttttggtct gcattggggt cttgctctgt tgcctagggt
     5461 gtggagtgcg gtggcatgat catgcctcac tatagccttg acctcctggg ctcaagcgat
     5521 cctcccacct gagtctcctg agtacctggg accacaggca catgctaacg cacccactta
     5581 atttttttat tcgtagagcc gaggtctcac tatgttgccc agactggtct caagctcttg
     5641 ggctcaagca gtcctcctgc ctcagcctcc caaagtgcca ggattacagg tgtgagccac
     5701 cacacccagt ccaaaaagtg attttctaat tccatagttt cttctacatt tcttaactgg
     5761 aattttgtaa ggaagagtta tccttattca tttatttacc catttacttg taggagcatg
     5821 tatcataaat tcttaatcta tggggtgtag ttagctactg taaatttgat gcacatattt
     5881 ttccagattc aataagtagg atccccatca agctatcttc tgaatcttta aaaatgtatt
     5941 ctccttattt catgggtata taattatttt ctgggcaaca gtttgttcat ggtacatttg
     6001 tctccagccc tagactcaga aaaatgtaat ttattttaat ggagaatact atttagaagc
     6061 tgcagtctct gtgtagggag gtgttcctag gtaatagtgc cctggctttt aggtcttctc
     6121 tatggaggat atggcaaaga catacaaaat tatatatacg tatccacaca ttaataactc
     6181 tatttctata ttaaaaacat gaccacaagc caacactttt aattccactg cagcactgct
     6241 gggttatttc ttgctttcca aattcccttg tctgtagcta tctttcatca cttgcaaaaa
     6301 tagcacgtgc tcaatcctag attaaaatat aagctactct cagaattgat aactcatacc
     6361 actcttttta aaaatcaact aaccagaatt cagtttttat tcacagttct tatctttagc
     6421 tcagggcgta atataaaagc actaggttta aaacttactt ggtcagcagc aatccacttc
     6481 taggtacatg tccaaaggaa ctgaagaaag catctcaatg tgtgaatgcc tacctgtgtt
     6541 cattgcagca ttattcagaa gagccaagag gtggaagcaa agtaaatgtc cattgacaga
     6601 tgaattggta aacaaaatgc attatataca tacaatgcaa tatcatttag ccttaaaaac
     6661 aaaattctgc catatgctac aacatggacg ttatgctaag tgaaataaac cagttccgaa
     6721 aggacaaata cacccatttc cacttatatg gggtatctaa cgtcaaactc agaagaacaa
     6781 agtactgcgg tatttgccac aagctggtgg aggagaaaat gagttgttca atgggtattg
     6841 agtgtcagcc acgcaagatg gaaaagcttt ttgagatttg ttgtataaaa atatgcctat
     6901 agttaacaat actcttcggt acacacaaag tatgtgaaag ggtaaatttt atgtgttttt
     6961 atcacaataa aaattgtaat aaaagaa
//
