LOCUS       NM_016265               5075 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 12 (ZNF12), transcript variant 1,
            mRNA.
ACCESSION   NM_016265
VERSION     NM_016265.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5075)
  AUTHORS   Lagou,V., Magi,R., Hottenga,J.J., Grallert,H., Perry,J.R.B.,
            Bouatia-Naji,N., Marullo,L., Rybin,D., Jansen,R., Min,J.L.,
            Dimas,A.S., Ulrich,A., Zudina,L., Gadin,J.R., Jiang,L., Faggian,A.,
            Bonnefond,A., Fadista,J., Stathopoulou,M.G., Isaacs,A.,
            Willems,S.M., Navarro,P., Tanaka,T., Jackson,A.U., Montasser,M.E.,
            O'Connell,J.R., Bielak,L.F., Webster,R.J., Saxena,R.,
            Stafford,J.M., Pourcain,B.S., Timpson,N.J., Salo,P., Shin,S.Y.,
            Amin,N., Smith,A.V., Li,G., Verweij,N., Goel,A., Ford,I.,
            Johnson,P.C.D., Johnson,T., Kapur,K., Thorleifsson,G.,
            Strawbridge,R.J., Rasmussen-Torvik,L.J., Esko,T., Mihailov,E.,
            Fall,T., Fraser,R.M., Mahajan,A., Kanoni,S., Giedraitis,V.,
            Kleber,M.E., Silbernagel,G., Meyer,J., Muller-Nurasyid,M.,
            Ganna,A., Sarin,A.P., Yengo,L., Shungin,D., Luan,J., Horikoshi,M.,
            An,P., Sanna,S., Boettcher,Y., Rayner,N.W., Nolte,I.M., Zemunik,T.,
            Iperen,E.V., Kovacs,P., Hastie,N.D., Wild,S.H., McLachlan,S.,
            Campbell,S., Polasek,O., Carlson,O., Egan,J., Kiess,W.,
            Willemsen,G., Kuusisto,J., Laakso,M., Dimitriou,M., Hicks,A.A.,
            Rauramaa,R., Bandinelli,S., Thorand,B., Liu,Y., Miljkovic,I.,
            Lind,L., Doney,A., Perola,M., Hingorani,A., Kivimaki,M., Kumari,M.,
            Bennett,A.J., Groves,C.J., Herder,C., Koistinen,H.A., Kinnunen,L.,
            Faire,U., Bakker,S.J.L., Uusitupa,M., Palmer,C.N.A., Jukema,J.W.,
            Sattar,N., Pouta,A., Snieder,H., Boerwinkle,E., Pankow,J.S.,
            Magnusson,P.K., Krus,U., Scapoli,C., de Geus,E.J.C.N., Bluher,M.,
            Wolffenbuttel,B.H.R., Province,M.A., Abecasis,G.R., Meigs,J.B.,
            Hovingh,G.K., Lindstrom,J., Wilson,J.F., Wright,A.F.,
            Dedoussis,G.V., Bornstein,S.R., Schwarz,P.E.H., Tonjes,A.,
            Winkelmann,B.R., Boehm,B.O., Marz,W., Metspalu,A., Price,J.F.,
            Deloukas,P., Korner,A., Lakka,T.A., Keinanen-Kiukaanniemi,S.M.,
            Saaristo,T.E., Bergman,R.N., Tuomilehto,J., Wareham,N.J.,
            Langenberg,C., Mannisto,S., Franks,P.W., Hayward,C., Vitart,V.,
            Kaprio,J., Visvikis-Siest,S., Balkau,B., Altshuler,D., Rudan,I.,
            Stumvoll,M., Campbell,H., van Duijn,C.M., Gieger,C., Illig,T.,
            Ferrucci,L., Pedersen,N.L., Pramstaller,P.P., Boehnke,M.,
            Frayling,T.M., Shuldiner,A.R., Peyser,P.A., Kardia,S.L.R.,
            Palmer,L.J., Penninx,B.W., Meneton,P., Harris,T.B., Navis,G.,
            Harst,P.V., Smith,G.D., Forouhi,N.G., Loos,R.J.F., Salomaa,V.,
            Soranzo,N., Boomsma,D.I., Groop,L., Tuomi,T., Hofman,A.,
            Munroe,P.B., Gudnason,V., Siscovick,D.S., Watkins,H., Lecoeur,C.,
            Vollenweider,P., Franco-Cereceda,A., Eriksson,P., Jarvelin,M.R.,
            Stefansson,K., Hamsten,A., Nicholson,G., Karpe,F.,
            Dermitzakis,E.T., Lindgren,C.M., McCarthy,M.I., Froguel,P.,
            Kaakinen,M.A., Lyssenko,V., Watanabe,R.M., Ingelsson,E.,
            Florez,J.C., Dupuis,J., Barroso,I., Morris,A.P. and Prokopenko,I.
  CONSRTM   Meta-Analyses of Glucose and Insulin-related traits Consortium
            (MAGIC)
  TITLE     Sex-dimorphic genetic effects and novel loci for fasting glucose
            and insulin variability
  JOURNAL   Nat Commun 12 (1), 24 (2021)
   PUBMED   33402679
  REMARK    GeneRIF: Sex-dimorphic genetic effects and novel loci for fasting
            glucose and insulin variability.
            Erratum:[Nat Commun. 2021 Feb 8;12(1):995. doi:
            10.1038/s41467-021-21276-3.. PMID: 33558525]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5075)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 5075)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 5075)
  AUTHORS   Zhao,Y., Zhou,L., Liu,B., Deng,Y., Wang,Y., Wang,Y., Huang,W.,
            Yuan,W., Wang,Z., Zhu,C., Liu,M., Wu,X. and Li,Y.
  TITLE     ZNF325, a novel human zinc finger protein with a RBaK-like
            RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional
            activity
  JOURNAL   Biochem Biophys Res Commun 346 (4), 1191-1199 (2006)
   PUBMED   16806083
  REMARK    GeneRIF: A zinc finger protein with a RBaK-like RB-binding domain,
            inhibits AP-1- and SRE-mediated transcriptional activity
REFERENCE   6  (bases 1 to 5075)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
REFERENCE   7  (bases 1 to 5075)
  AUTHORS   Seite,P., Huebner,K., Rousseau-Merck,M.F., Berger,R. and
            Thiesen,H.J.
  TITLE     Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and
            ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33,
            respectively
  JOURNAL   Hum Genet 86 (6), 585-590 (1991)
   PUBMED   2026422
REFERENCE   8  (bases 1 to 5075)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073343.6, AI879099.1,
            AF505656.1, BC051892.1 and BX114779.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016265.3.
            
            Summary: This gene is a member of the krueppel C2H2-type
            zinc-finger protein family and encodes a protein with eight
            C2H2-type zinc fingers and a KRAB domain. This nuclear protein is
            involved in developmental control of gene expression. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC154414.1, DRR138524.1162568.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405858.6/ ENSP00000385939.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC073343.6         92176-92187         c
            13-377              AI879099.1         40-404
            378-399             AF505656.1         33-54
            400-906             BC051892.1         376-882
            907-1077            AF505656.1         562-732
            1078-3056           BC051892.1         940-2918
            3057-5041           AC073343.6         73707-75691         c
            5042-5075           BX114779.1         12-45               c
FEATURES             Location/Qualifiers
     source          1..5075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..5075
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /note="zinc finger protein 12"
                     /db_xref="GeneID:7559"
                     /db_xref="HGNC:HGNC:12902"
                     /db_xref="MIM:194536"
     exon            1..516
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /inference="alignment:Splign:2.1.0"
     exon            517..581
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..2660
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 325; gonadotropin inducible transcription
                     repressor 3; zinc finger protein 11; zinc finger protein
                     KOX3; gonadotropin-inducible ovary transcription repressor
                     3"
                     /codon_start=1
                     /product="zinc finger protein 12 isoform a"
                     /protein_id="NP_057349.2"
                     /db_xref="CCDS:CCDS47538.1"
                     /db_xref="GeneID:7559"
                     /db_xref="HGNC:HGNC:12902"
                     /db_xref="MIM:194536"
                     /translation="MNKSLGPVSFKDVAVDFTQEEWQQLDPEQKITYRDVMLENYSNL
                     VSVGYHIIKPDVISKLEQGEEPWIVEGEFLLQSYPDEVWQTDDLIERIQEEENKPSRQ
                     TVFIETLIEERGNVPGKTFDVETNPVPSRKIAYKNSLCDSCEKCLTSVSEYISSDGSY
                     ARMKADECSGCGKSLLHIKLEKTHPGDQAYEFNQNGEPYTLNEESLYQKIRILEKPFE
                     YIECQKAFQKDTVFVNHMEEKPYKWNGSEIAFLQMSDLTVHQTSHMEMKPYECSECGK
                     SFCKKSKFIIHQRTHTGEKPYECNQCGKSFCQKGTLTVHQRTHTGEKPYECNECGKNF
                     YQKLHLIQHQRTHSGEKPYECSYCGKSFCQKTHLTQHQRTHSGERPYVCHDCGKTFSQ
                     KSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHLRTHTGEKPYECNECGKFFSRLS
                     YLTVHYRTHSGEKPYECNECGKTFYLNSALMRHQRVHTGEKPYECNECGKLFSQLSYL
                     TIHHRTHSGVKPYECSECGKTFYQNSALCRHRRIHKGEKPYECYICGKFFSQMSYLTI
                     HHRIHSGEKPYECSECGKTFCQNSALNRHQRTHTGEKAYECYECGKCFSQMSYLTIHH
                     RIHSGEKPFECNECGKAFSRMSYLTVHYRTHSGEKPYECTECGKKFYHKSAFNSHQRI
                     HRRGNMNVIDVGRLL"
     exon            582..708
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /inference="alignment:Splign:2.1.0"
     exon            709..804
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /inference="alignment:Splign:2.1.0"
     exon            805..5075
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5052..5057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /note="hexamer: AGTAAA"
     polyA_site      5075
                     /gene="ZNF12"
                     /gene_synonym="GIOT-3; HZF11; KOX3; ZNF325"
                     /note="major polyA site"
ORIGIN      
        1 agtgccctcg cttcctgtgc gtccccaggt caccgctcgc cctagttccc aggctttggc
       61 ctccggtggg cgagaatcgc ggagcctgcg gggctgggcg ccgaagagcc gggccggcac
      121 ccaagcgggc gcggggctgt gcgggccagg cggaggctca agcggggatc cccgagcacg
      181 acccccggag ccgacggcgc tggggcccaa ggggccggcc gggcggtgac gacggcggag
      241 gcgaaggggc ggcgggaccc gggcccggcc cgtgtgcgtc ctcgacggcc cggccccggc
      301 tccgcaggac ggtgagcccc agggagacgg atctgggctc cgggagggac gccccgcctg
      361 gatttgtccc gtaggcccgg cccgggcccc tctggagcag aacggccttg gtgaggtgga
      421 caggaaggga cctcgcgagc agacgcgcgc ccgcgacagc aatcccgccc cggcctgtcg
      481 ggagcggtgg ggcagaggct gcggagcccc aggaggatct gcctccgctt tcacagtcct
      541 ccagattttt ccaagagcag cagaaaatga ataaatccct ggggccagtg tcattcaagg
      601 acgtggctgt ggacttcacc caggaggaat ggcagcagct ggatcctgag cagaagataa
      661 cttacaggga tgtgatgctg gagaactaca gcaatctagt ttctgtgggg tatcacatta
      721 tcaaaccgga tgttatcagc aagttggagc aaggagaaga gccatggata gtagaaggag
      781 aattcctact tcagagctat ccagatgaag tctggcaaac tgatgaccta atagagagaa
      841 tccaggaaga ggaaaataaa ccttcaaggc aaactgtgtt cattgagacc ctgattgaag
      901 agagaggtaa tgttcctggt aaaacttttg atgtagaaac gaaccctgtt ccttcaagaa
      961 aaatagccta taaaaatagc ctctgtgact catgtgaaaa gtgtttaacg tctgtttcag
     1021 aatatattag tagtgatgga agctatgcaa gaatgaaagc tgatgaatgt agtggatgtg
     1081 ggaaatcact cctccatatt aagcttgaga aaactcatcc aggagatcaa gcttatgaat
     1141 ttaatcaaaa tggggaacct tatactctaa atgaagaaag tctttatcag aaaattcgta
     1201 ttttggagaa accttttgaa tatattgaat gccagaaagc cttccaaaag gacactgttt
     1261 ttgttaatca catggaagaa aagccctata agtggaatgg atctgaaata gcctttctcc
     1321 agatgtcgga cctcactgta catcagacat ctcatatgga aatgaagccc tatgaatgca
     1381 gtgaatgtgg gaaatccttc tgtaaaaagt caaaatttat tatacatcag aggactcaca
     1441 caggagagaa accttacgaa tgtaatcagt gtgggaaatc cttctgccag aagggaaccc
     1501 ttactgtgca tcagagaaca cacacagggg agaagcccta tgaatgtaat gaatgtggga
     1561 agaactttta ccagaagtta cacctcattc agcatcagag aactcactca ggagagaagc
     1621 cctatgaatg tagttattgt ggaaaatcct tttgccagaa gacacacctc acacaacatc
     1681 agagaacaca ttcaggagag agaccttatg tttgtcatga ctgtgggaaa accttctcgc
     1741 agaagtcagc acttaatgac catcagaaaa ttcacacagg tgtgaaactc tacaagtgta
     1801 gtgaatgtgg gaaatgcttc tgccgcaagt ctactctcac gacccacctg aggacccaca
     1861 caggagagaa accgtatgaa tgtaatgagt gtggaaaatt cttctctcgg ttgtcatatc
     1921 tcactgtaca ttatagaact cattcaggag agaaacccta tgaatgtaat gaatgtggaa
     1981 aaaccttcta cctgaattca gccctcatga gacatcagag agtgcacaca ggagagaaac
     2041 cttacgaatg taatgaatgt ggaaagttat tctcccagtt gtcatacctc actatccatc
     2101 atagaactca ttcaggagta aaaccctatg aatgtagtga atgtgggaaa accttctacc
     2161 agaactcagc cctttgtaga catcggagaa tacacaaagg agagaagccc tatgaatgct
     2221 atatatgtgg aaaattcttc tctcagatgt catacctcac tatacatcat agaattcatt
     2281 caggagagaa gccctatgaa tgtagtgaat gtgggaaaac cttctgccag aattcagccc
     2341 ttaatcgaca tcagagaaca cacacaggag agaaagccta cgaatgttat gaatgtggga
     2401 agtgcttctc tcagatgtcc tatctcacta tacatcatcg aattcattca ggagagaaac
     2461 cctttgaatg taatgagtgt ggaaaagcct tctctcggat gtcatacctc actgtacatt
     2521 atagaactca ttcaggagag aaaccctatg agtgtactga atgtggaaaa aaattctacc
     2581 acaaatcagc attcaacagc catcagagaa ttcataggag aggcaatatg aatgtaatag
     2641 atgtgggaag gcttctctga agtcagacct cattttatat cagagaaccc tttcagtata
     2701 gtgaatcaga aactcctgcc tgaagtcaaa caccttgtac atcagagagt tcacacaggt
     2761 tagtgtggac atccccttgt gtgttggact cataatctga agactcacag aatggaaacc
     2821 atgattataa caagaccaca tggtataaca atactagact atagacaagt aaaaatttat
     2881 aaatattaag aatgtatata catgtcacca tggattggaa ctgttttgca tatcagggaa
     2941 atcatagcca aggggaaatc tatcagtata aggaatgtgg aagacataat cctttggaaa
     3001 ctgttaatac taaaagatat gtttctgata caatagcaaa cttgaaaaaa aaaaaagaaa
     3061 tagaagattc ctgctgtgaa taaacatact tcttgtgtaa atagaaactg taaagtcatc
     3121 aggatagcta gttaagtcgg taaccttaaa ctcatgtaag cagttcccaa agaacatagg
     3181 acttatgttt ggggagaggg ttgtttttat tacagtacat tacaggaatt gtatgttcac
     3241 ttcgaatcat gtttgaaaaa acgttgtatc cttattttgt aattcatata gtaagagtat
     3301 tctaaacagc actacattaa tatcatttga taggtataaa gtatactttt tcttgcactc
     3361 ttctctagga tttaatgcat tgatcattct taatgaacaa tatcagctct aaaggaccaa
     3421 tgcttttata atgttttcaa ctgtatctga gtcagccaga gagataaata tccatgtata
     3481 aaatagatag aaaactttgc ttggtaattt aaaattaata atgccagttt tccaagagtg
     3541 agaaaatcat tgcactctat acagttttaa gatatactta aaatattccc atttgtatct
     3601 attttttttt ctactgtttt ttatttggac acttacataa cagtgcagag cacaatgctg
     3661 tgtaacatag gaattcactg tgttttcatt tgatgtcgta ctggttttaa accttgtgct
     3721 ctactccttc ctgttaatga attaagaaca cattctaaca agggtctgtg gcagacattg
     3781 ccgagtgact ttctaacata ggaattcact gtgttttcat ttgatgtcgt actggtttta
     3841 aaccttgtgc tctactcctt cctgttaatg aattaagaac acattctaac aagggtctgt
     3901 ggcagacatt gccgagtgac tttcttagtc actcccttac tctgctggcg gagtttggtt
     3961 atccatttat cctcaaaagg aagtgagata aatcctgatt agttttaacc agtgacactc
     4021 cccttctcgt tgccagcagt tgatttacag tggtcacagg gcccaattct agacataaaa
     4081 caaaggatat acctgacaga ctacttctgg aaaaggtttt ctcaaaggcc caaggattca
     4141 agcaaaggga agtggaatct tgtggtgaac agtaccttgt ctggatgtgg tgcctggtaa
     4201 ccatctttca gcaatggatt atagtttaat catggcctga gcagaaatac tgaaagaccc
     4261 tgagacctgg atgatgtctt tgagccacca aaccaagcag ccttgtagcc actcctcctt
     4321 tggactgttt cttttgtgag agactaaact tatttttaag ccagttgatt taggatgctc
     4381 tattactaat aactgaagac attctaattg gtacagactg aaacctttat aggagttatg
     4441 cagttcagaa gtggacttta ggtaagtcat ttattttaag ctgttgatat agagatttat
     4501 tttctgtaaa ttttgacgta aatagtttga gcattagaaa tcaacttgaa acaataaaat
     4561 gtatgcttcc ttgaactgtc atatcgttga cctgcaaaat tcacctttgg aacgtgacac
     4621 aatgttaggc atacctcctt ttttctaata catggaatac attttgttgg aggtaattta
     4681 tgtgattcat ataccactgc tacagtgtta gctgacaaca tatagtatga ggtaaggatc
     4741 taattctgtt tcctctcaca tgattacttg atagctaagc atctgattgg tttactgctt
     4801 taccactgag ctgaaatgcc gtgttttcca tttattaaaa tcacacatgg ctcctgtttt
     4861 tgtcactcag cactttttct ccatattctt caagacgatt gtgagtatgg tacgtaacag
     4921 gaattacatc tggtaagttg tatagttttg tgtaggaact ctatattcat agcatatttg
     4981 tggaaatgat acctatggag gtttctcaca ctggtgtgtc attatacatt aattgtacaa
     5041 tatgcatttt cagtaaaata tttgaaaact gtaaa
//
