LOCUS       NM_015852               9084 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens zinc finger protein 117 (ZNF117), mRNA.
ACCESSION   NM_015852 NM_024498
VERSION     NM_015852.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9084)
  AUTHORS   Bellefroid,E.J., Ried,T., Riviere,M., Marine,J.C., Levan,G.,
            Szpirer,J., Szpirer,C., Ward,D.C. and Martial,J.A.
  TITLE     Localization of the human KRAB finger gene ZNF117 (HPF9) to
            chromosome 7q11.2
  JOURNAL   Genomics 14 (3), 780-781 (1992)
   PUBMED   1427907
REFERENCE   2  (bases 1 to 9084)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
REFERENCE   3  (bases 1 to 9084)
  AUTHORS   Kato,N., Shimotohno,K., VanLeeuwen,D. and Cohen,M.
  TITLE     Human proviral mRNAs down regulated in choriocarcinoma encode a
            zinc finger protein related to Kruppel
  JOURNAL   Mol Cell Biol 10 (8), 4401-4405 (1990)
   PUBMED   2115127
REFERENCE   4  (bases 1 to 9084)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073210.8.
            
            On Mar 1, 2023 this sequence version replaced NM_015852.4.
            
            Summary: This gene encodes a protein containing multiple C2H2-type
            zinc finger motifs. Readthrough transcription occurs between this
            gene and the upstream endogenous retrovirus group 3 member 1
            (ERV3-1) locus, and may result in additional transcript variants
            encoding the zinc finger protein. [provided by RefSeq, Jan 2017].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4347844.1, M55422.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282869.11/ ENSP00000282869.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1090              AC073210.8         53899-54988         c
            1091-1223           AC073210.8         45936-46068         c
            1224-1319           AC073210.8         45339-45434         c
            1320-9084           AC073210.8         35724-43488         c
FEATURES             Location/Qualifiers
     source          1..9084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..9084
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="zinc finger protein 117"
                     /db_xref="GeneID:51351"
                     /db_xref="HGNC:HGNC:12897"
                     /db_xref="MIM:194624"
     exon            1..1090
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1223
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1319
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             1286..2737
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="Krueppel-related zinc finger protein;
                     provirus-linked krueppel; zinc finger protein HPF9"
                     /codon_start=1
                     /product="zinc finger protein 117"
                     /protein_id="NP_056936.2"
                     /db_xref="GeneID:51351"
                     /db_xref="HGNC:HGNC:12897"
                     /db_xref="MIM:194624"
                     /translation="MKRHEMVAKHLVMFYYFAQHLWPEQNIRDSFQKVTLRRYRKCGY
                     ENLQLRKGCKSVVECKQHKGDYSGLNQCLKTTLSKIFQCNKYVEVFHKISNSNRHKMR
                     HTENKHFKCKECRKTFCMLSHLTQHKRIQTRVNFYKCEAYGRAFNWSSTLNKHKRIHT
                     GEKPYKCKECGKAFNQTSHLIRHKRIHTEEKPYKCEECGKAFNQSSTLTTHNIIHTGE
                     IPYKCEKCVRAFNQASKLTEHKLIHTGEKRYECEECGKAFNRSSKLTEHKYIHTGEKL
                     YKCEECGKAFNQSSTLTTHKRIHSGEKPYKCEECGKAFKQFSNLTDHKKIHTGEKPYK
                     CEECGKAFNQLSNLTRHKVIHTGEKPYKCGECGKAFNQSSALNTHKIIHTGENPHKCR
                     ESGKVFHLSSKLSTCKKIHTGEKLYKCEECGKAFNRSSTLIGHKRIHTGEKPYKCEEC
                     GKAFNQSSTLTTHKIIHTEEKQYKCDECGKAST"
     exon            1320..9084
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6268..6273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="hexamer: AATAAA"
     polyA_site      6289
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="major polyA site"
     regulatory      7626..7631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="hexamer: AATAAA"
     polyA_site      7650
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
     regulatory      7947..7952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="hexamer: AATAAA"
     polyA_site      7973
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
     regulatory      9061..9066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
                     /note="hexamer: AATAAA"
     polyA_site      9084
                     /gene="ZNF117"
                     /gene_synonym="H-plk; HPF9"
ORIGIN      
        1 gactaatggc cctaactaag tattaacccc tgccaagaaa agagctactt cctcttgaag
       61 taaatgaaga tagtgatgct ttctcttaaa ctttacttat aaaaagcatc aaagggggga
      121 atgaagcagg aaatataaaa ggaaaaacaa gtaaagggaa aacaagtcct ttcctgacca
      181 gtctgactca ctccaaagtc ctgctggagc tatgataatt atctgcaagg ccaggcaggg
      241 gctccgaagg agtgggctcc aggagcaggg atgagaaaaa caagttctcc ttatcagttt
      301 ccctgtttga aattctctcc ccataacatt attctttgtt ctgctctcac aactattttt
      361 gtaactattt ctgcaagtct gtaaagattt tgtaagttct tgtttttctt tctgtagcat
      421 ggcaaggtca caagacatgt ttaagtaagg taggctcatg ttgcaaatcc tgttgtaaaa
      481 cctgtcacgg tatgattaac tgcctttgtt ctgcttctgt aagactgctt tctcacctcg
      541 caggttttgc gccaaaaacc cgacttgccc ctgcctgatg catgtataaa agtcaagccc
      601 tgtctttgtt cagggctcag cctttggatg ttaatccgct gggccagtgg ccacctaaat
      661 aaaaccttcc tgttgcaccc agtgatctct ccggcctcct gattcccaca acatataagc
      721 attccttttt ctctgcaacc tagcccgcat ctgtcattga ctttttaaca ataggcattc
      781 tgactggatg agatggtatc tcactgtggt ttttctctgc atttttctaa taattaacaa
      841 cgtgaatttt gttttcatat gcttgtcagc cacatgtatg tcttcttttg aaaagtatct
      901 gttcatgttt ttgcttactt tttaattagg tttttggttt tctttttgtt gttgttgttg
      961 ttttctgaga tggagtcttg ctgtgtcacc aggatggagt gcagtggcat gatctcgact
     1021 cactgcaacc tccacctccc aggttcagat gattcttctg cttcagtctc ctgagtagct
     1081 gggatcacag ggaccattga catttatgga tgtggccata gaattctctt tggaggagtg
     1141 gcaatgcctg gacactgcac agcagaattt atataggcat gtgatgtgag agaactacag
     1201 aaacctggtt ttcttgggtg aaggtattgc tgtctctaag ccagacctga ttacctgtct
     1261 ggagcaagga aaagagccct ggaatatgaa gagacatgag atggtagcta aacatttagt
     1321 tatgttttat tattttgccc aacacctttg gccagagcag aacataagag attctttcca
     1381 gaaagtgacc ctaagaagat atagaaaatg tggatatgag aatttacagt taagaaaagg
     1441 ctgtaaaagt gtggttgagt gtaaacagca caaaggagat tatagtggac ttaaccaatg
     1501 tttgaaaact accttgagca aaatatttca atgtaataaa tatgtagaag ttttccataa
     1561 aatttcaaat tcaaatagac acaagatgag acatactgaa aataaacatt ttaaatgtaa
     1621 agaatgtcgc aaaacatttt gcatgctttc acacctaact caacataaaa gaatccaaac
     1681 tagagtgaat ttctacaaat gtgaagcata tggaagagcc tttaactggt cctcaaccct
     1741 taataaacat aagagaattc atactggaga aaaaccttac aaatgtaaag aatgtggcaa
     1801 agcctttaac cagacctcac accttattag acataagaga attcatactg aagagaaacc
     1861 ctacaaatgt gaagaatgtg gcaaagcctt taaccagtca tcgaccctta ctacacataa
     1921 tataattcat actggggaaa ttccctacaa atgtgagaaa tgtgttagag cttttaacca
     1981 agcctcaaag cttactgaac ataagttaat tcataccgga gagaaacgtt atgaatgtga
     2041 agaatgcggc aaagctttta accgatcctc aaaacttact gaacataagt acattcatac
     2101 tggagagaag ctgtacaaat gtgaagaatg tggtaaagcc tttaaccagt cctcaaccct
     2161 tactacacat aagagaattc atagtggaga gaagccctac aaatgtgaag aatgtggcaa
     2221 agcttttaaa caattttcaa atcttactga ccataaaaaa attcatactg gagagaaacc
     2281 ctacaaatgt gaggaatgtg gcaaagcttt taaccaactc tcaaacctta ctagacataa
     2341 ggtaattcat actggagaga aaccctacaa atgtggagaa tgtggcaaag cctttaacca
     2401 gtcctcagcc cttaatacac ataagataat ccatactgga gagaatcccc acaaatgtag
     2461 agaatctggc aaagttttcc acctatcctc aaaacttagt acatgtaaga aaattcatac
     2521 tggagagaaa ctctacaaat gtgaagaatg tggcaaagcc tttaaccgat cttcaaccct
     2581 tattggacat aagagaattc atactggaga gaaaccctac aaatgtgaag aatgtggcaa
     2641 agcttttaac caatcttcaa cacttactac acataagata attcatactg aagagaaaca
     2701 gtacaaatgt gatgaatgtg gcaaagcttc tacctgatcc tcaaaactca ttgaacacaa
     2761 gaaaattcat actggagaga aaccttacaa gtgtgaagaa tgtggcaaaa cttctaacca
     2821 tttctcaacc cttactaaac ataagatgat tcatactgga gagaagttac acaaatgtga
     2881 tgaatgtgac aaagctttta accaatcttc aaccctttct acacataaaa gaattcatac
     2941 tggagagaaa ccctacaaat gtgaagaatg tggcagagct tttaattgat catcaaacct
     3001 tattaaacat aagaaaattc atattggaga gaaaccctac aaatgtgaag aatgtggaaa
     3061 agcttttaac cagttctcaa ctcttactac acataaaata attcatactg gagagaaacc
     3121 atataaatgt gaagaatgtg gcaaagcttt caacctatac gtaaacctta ctacacataa
     3181 gaaaattcat actggagaga aaccctacaa gtgtgaagaa tgtggcaaag cttttagcca
     3241 agtgtcaact cttactatac ataaaagaat tcatactgga gagaaaccct acaagtgtga
     3301 agaatgtggc aaagctttta accaagtgtc aactcttact atacataaaa gaattcatac
     3361 tggagagaaa ccttacaaat gtgaggaatg tggcaaaact ttcagtcgat gctcaaaact
     3421 tactacacat aagaaaattc atacaggaga gaaaccttac aaatgtgaaa aatgtgctaa
     3481 agcttttagc cagtcttcaa ccctttctac atataagata attcacactg gagagaaatg
     3541 ctacaaatgt gaagaatgtg gcaaagtttt taaccgatct tcaaacctta cagaccataa
     3601 aaaaattcat acaggagaga aatcctacaa atgtgaagaa tgtgacaagg cctttaacct
     3661 gtcctcaacg cttactaaac ataaggtaat tcatactgga gagaaactgt acaaatgtaa
     3721 agaatgtggt aaagctttta aacagttctc acaccttgct atacataata taattcatac
     3781 tggagagaaa ctctacaaat gtgaagaatg tggcaaagct tttaacttat cctcaaacct
     3841 tactgcacat aagaaaaatc gtactggaga gaaaccctac aaatgtgaag aatgtggcaa
     3901 agctaaccta tcatcaaccc ttactccaca taagacaatt catatttgag agaaaccctg
     3961 caaatgtgaa gaatgtggca atgcttgtaa ctaaatctca aactttacta aacataagaa
     4021 aattaatact ggaaacttta caaacctgaa agatgtgaca atgattttga caacaccttc
     4081 aaacttttct aaacataaaa taaatcatac tggtgagaaa tcttaaaaat atgaagaatg
     4141 gtacaaagcc tttaaatggt tgtcacactt gattgtaggt aagataattt atactggagg
     4201 aaactcccag aagtgtgaag aatgtggcaa aacttttaat ttttcacacc ttatagcaca
     4261 ggaaagcact tcagaaaaat tgtacaaata taaatgtgga aaagccatta atatctgctt
     4321 acatcttact caacattaga gagttagtgc ttaataaaag cattataaaa gcaattagtg
     4381 taaaatcaga aaatgaaagt tttttttttt tttttagatg gagtcttgct ctgtcaccca
     4441 ggctggagtg cagtggtgtg atcttggctc actgcaacct ctgcctccca ggttcaagca
     4501 attctcctgc cttagcctcc agagtagctg agactacagg cacacaccac cacatttggc
     4561 taattttttt atttttagta gagactggct atcaccatgt tggccaggct gatcttgaac
     4621 tcctgacctc aagtgatcca catgcctctg cctcccaaag tgctgggatt ataggtgtga
     4681 gtcactgtgc ctgacaaata taagccttta aagagaagaa ggttttcatt ttgaagacaa
     4741 acattaggta cataaagagg gttgtagtgt ctttatttgt atcacagatt ttattgtaca
     4801 cattatgtac taaaggaaaa tcctgaagca gtgctcaaac tttgatcaac atcagggagt
     4861 ttatattgga gaaaaactgc aaatgtaata tatttggaaa aacatttttc aaaaactact
     4921 gcttagaaaa caccagggga tttatactaa aatatatttt tgcagatgca gtaagtataa
     4981 aagaaattta atccaaaatt aagtgtgtgt aaatatcaga gaattcacag tagaaatatc
     5041 taaggcactg acattttaga cattgaacta atcagtgtgc tgagtacaga aaataatcca
     5101 aaattaaagt tggtagataa attatttata tataacttta aaagaggtag aaatattttt
     5161 agttataatt acatttaaag tatacttttt tctttgaaaa aattacaaaa tttttaaaaa
     5221 gtgaatgatg taattcaact caaattactt catgcttttc attctattgt attcacatgt
     5281 gaaagcatgt gatcaattgc tgcttcatca aagatatgag acattctttt ttgttaggtg
     5341 ggcaatattt tttacctttt ctatggaaga gtaaagacat tacaatgtag gatgcatgat
     5401 aaaaatctaa gtggagaggc tctttgtgtt taatttataa tattgaatga tgtatgaggg
     5461 aagtgttcag aggaatattc tgcattctag tgaaaatatc ttttatttta gttaaaatta
     5521 aattaaaatt agtagtatat cattttacta actgtacttt tatgtaataa aatgcagcac
     5581 atttaaaaaa ttttagatta ttgtgaactt aattttttaa ttaaactttt tttttaacat
     5641 gttaagacca attgtgcatt cagtgaagta ttatcatgcc actaacttca acctatccca
     5701 ccttactcaa gggtgttggt aaaagatagt aacaatgtac tatttaataa cagagtggac
     5761 taacatctct aataatttct cttgccagtg actttaaact aaagaactta attaaagaac
     5821 attgttccca taggttaaat ttttattctt tttcttattt aaacatattt ttcttaactt
     5881 ttgtgggtac atagtgtgtg tatatattta tgccatatat ggcatatttt gatacaggca
     5941 tatgaatagg tattaatcac atcagggcaa atgaaatatc catcaactcc agcatttatc
     6001 atttgtatta caaaccgatt ctacactttt agttacttta aaatgtacaa gtaaattgct
     6061 attgactata gggtcatttt catgggtata ataaaaatta tatacaagta taaataaaat
     6121 cctgagtctt aaaattctga gtcctgctta aacattttaa aaattttgtt atgtattttt
     6181 ctttgaacat gtctctctgc ctgcaaacat aacagaattt tagtattggt ttacatagag
     6241 ttaactatac ccatatatta ctctaaaaat aaatgttaag tgcaagaaag ttatggactg
     6301 tttttgtgtg agtgtgagtt tgtacctatt ttcaaaagaa aagagcaata ttggagcaaa
     6361 acaaatattt taataaagta atgtactaga caactgaaaa cttcaaaaat gctgaaagta
     6421 aatgtatact ctgctttgta ttgaattcat tactgccaaa tcttctgact tatgattcag
     6481 aatctctcca tgcaaattat gtttttactt gcctgttagt catgctagac ctataatttt
     6541 cttgtttctt accatttttt tcttttatac tttatgaggt attatgtgag ctgttcatgg
     6601 attataagaa tgatttttat aaaattcagt actgcacaca agataagttt tagatgtatt
     6661 tccaaaattg tgtattaatt atatttagtt agaacattcc atttgttctt ttaattggag
     6721 aatcctatat aagcctatat ttcttattct tttctcttgt tataattgac ataagtaaat
     6781 ttatttattt attgagccaa tttgttcagg taagaactag gaatgcttca taagtcatga
     6841 ggatgttttt atatatatat gtggcaaaca aatatgacag tgcttgctgt gtaacagatg
     6901 ttccataata acctgtaaac attcctgctg gagttagttt gtaacttcaa gtcagagatg
     6961 gaaaatacca atagtgaaga aataacattg attcttcatg tgcagataac attttttttc
     7021 catgctgcaa agctaaattt tgctgaattt aaaaagaaat tttggttctt ttatttccta
     7081 attaccttta gttttgtttg tcttattatg tgacttctgt gtattcatca cagcccttct
     7141 ccttcttttt ctatgtgatg gctacacttt gctcactgtt gtcttcatgc catgtcattt
     7201 tatacagtac tttgtaggtt ttgatgagaa agttggtatt tttaatgcac tcaaaaattg
     7261 ctttttattg gagagtactt atcaatataa ctttctgatc agttaattaa gataaaaggc
     7321 atacattgtc cacaggtgag aggattaaat cagttagcat tatttttttc tgtttgtaaa
     7381 aggaaaaact tattaaattt ttaaacggag ttattaaaca gagtttcact cttattgccc
     7441 aggctggagt gcaaatatat tgtggcaaat ataaaatttg ctagaaaata catcttagaa
     7501 attaagttat aagagagcaa atggtaagtg aagaatttta aatttaattt tctatgatat
     7561 agcataacat acatttccat gcagaatctt ttatttttaa atgtgaaatt taaaggttgc
     7621 aaaataataa aatgacttct gtggatttga tatttggaat gatatttctt ttttatattg
     7681 atattacaat tccgaggaat ttttcactca ttattttttt agtgggtgaa ggtgagtgta
     7741 cagttattgc tttttgtcac ctaactatag tcagcttctt ggtcattttc tctagaaaac
     7801 ttttgaagat tatggcagct ttttgattaa acattttctg ttatttttat gcaaattcat
     7861 ttattgtgtt cacagggtgg ccagtcatga gaccataagc aacagctgcc cttttagtgt
     7921 ctttcatgcc attaccatct gtaataaata aatgtgtact ttattctgca aaacatgatg
     7981 tttggaagta tatgttgtca aatgcttaat tctaggtaat taaggcttta cctcacatcg
     8041 ttaacatttt tgtggtcaga gtatgtgaca ttgtcaatgt ttttcaaaaa cacaactaca
     8101 ttattatgat ctgtagtcac tatgctgtac aaaaagatct cttaaactta ttcctcctat
     8161 taaactataa ttatgtattc tttgaccaac atcttccaaa accccccttt tttctaaata
     8221 ccttggtgtc tggtggtcac cactttactc tctactttaa tgggattaag tttcttagaa
     8281 tccctgtgta agtaaaatca tgaaaaataa tctttgtgtc tggctcatgt agacaaatat
     8341 gatgtcctcc aggttaattc atgtgattga aaataataga aatttctttt ttaaagacga
     8401 agagtattcc attgtgtata tgtaccacat tgtctttatt tactcataaa tgttgaactg
     8461 ttgattgtgt attttggtaa ttgtgaagag tgttgcaaac aacatagaag cataaatgtt
     8521 tcttcattct gatttcactt gttttggata tatacagtaa aattgctgta ttgtggttta
     8581 attttaaatt ttttgacaaa tttttgtttt tcatagtgac tctcctcatt cacattcaaa
     8641 ccaacagtgt gcaagcattc cttttcttca tactttgact aacactttct tttcttttta
     8701 gtaagagtaa ttctaacagg agtgagttga taatctcctg gtttttcttt ttgctttcct
     8761 gattatagtt gatattgagc attttttata tatcttgacc atttgtcttt tcttgaaaaa
     8821 tatttaagcc ttttgctcat ttttaatagt tatttgtctt ctgttgtata gtcatttaag
     8881 ttgtttatat gtttctgtta ttaacccttt gtcccacgta tgatttgcaa atattttctc
     8941 ccattttttt cagttgtctc attttgttga ttgtatcaga ttccatgaag cagcttttta
     9001 atttcaagta atctaacgta tctatttttc ttttgatttc cttggatttt gaggttaaat
     9061 aataaaagtc acagcctaga tcaa
//
