LOCUS       NM_153608               2499 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 114 (ZNF114), transcript variant
            1, mRNA.
ACCESSION   NM_153608
VERSION     NM_153608.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2499)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2499)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2499)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008392.6, BG476217.1 and AK075062.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153608.3.
            
            Transcript Variant: This variant (1), as well as variants 3, 5, and
            6, encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014935.2, BG476217.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595607.6/ ENSP00000469998.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC008392.6         26518-26535
            19-291              BG476217.1         2-274
            292-1810            AK075062.1         1-1519
            1811-2499           AC008392.6         43357-44045
FEATURES             Location/Qualifiers
     source          1..2499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2499
                     /gene="ZNF114"
                     /note="zinc finger protein 114"
                     /db_xref="GeneID:163071"
                     /db_xref="HGNC:HGNC:12894"
                     /db_xref="MIM:603996"
     exon            1..139
                     /gene="ZNF114"
                     /inference="alignment:Splign:2.1.0"
     exon            140..344
                     /gene="ZNF114"
                     /inference="alignment:Splign:2.1.0"
     exon            345..446
                     /gene="ZNF114"
                     /inference="alignment:Splign:2.1.0"
     exon            447..524
                     /gene="ZNF114"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1769
                     /gene="ZNF114"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 114 (Y18)"
                     /codon_start=1
                     /product="zinc finger protein 114 isoform 1"
                     /protein_id="NP_705836.1"
                     /db_xref="CCDS:CCDS12713.1"
                     /db_xref="GeneID:163071"
                     /db_xref="HGNC:HGNC:12894"
                     /db_xref="MIM:603996"
                     /translation="MSQDSVTFADVAVNFTKEEWTLLDPAQRNLYRDVMLENSRNLAF
                     IDWATPCKTKDATPQPDILPKRTFPEANRVCLTSISSQHSTLREDWRCPKTEEPHRQG
                     VNNVKPPAVAPEKDESPVSICEDHEMRNHSKPTCRLVPSQGDSIRQCILTRDSSIFKY
                     NPVLNDSQKTHENNEDDGVLGWNIQWVPCGRKTELKSSTWTGSQNTVHHIRDEIDTGA
                     NRHQRNPFGKAFREDGSLRAHNTHGREKMYDFTQCENTSRNNSIHAMQMQLYTAETNK
                     KDCQTGATSANAPNSGSHKSHCTGEKTHKCPECGRAFFYQSFLMRHMKIHTGEKPYEC
                     GKCGKAFRYSLHLNKHLRKHVVQKKPYECEECGKVIRESSKYTHIRSHTGEKPYKCKT
                     CGKDFAKSSGLKKHLKTHKDEKPCE"
     exon            525..651
                     /gene="ZNF114"
                     /inference="alignment:Splign:2.1.0"
     exon            652..2499
                     /gene="ZNF114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF114"
                     /note="hexamer: AATAAA"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF114"
                     /note="hexamer: AAGAAA"
     polyA_site      2496
                     /gene="ZNF114"
     polyA_site      2499
                     /gene="ZNF114"
                     /note="major polyA site"
ORIGIN      
        1 gctgactctc ttttccaact cagcccactt gcacccaagt gaataaacag cctttgttgc
       61 ttacacaaag cctgtttagg tggtcttcta tacggacacg cgtgacaccc aggagttcga
      121 gacgagtctg ggcagcatat actgagggga aaaaaaagcc ttctttcctt gggaaatgca
      181 ggaagccagc aagcggccgg agtctccgga gcccgcaagg aggcgcgttg gctgcgcaga
      241 gagcgcgctt cccagctgga gagcctagga acggtggcgc gggcggaggc gacagcgagg
      301 acccaaggct ggggtttcct gcttggatca ggagtgcctg gggatttgat ccccatcctg
      361 gtgcagctcc gagacgctcc tgggctgcgc gcgcttttgg gctgcgccac cgacagagac
      421 atctggaagc cggagctagt ggaagactct gcctcacctg cctccttgaa ggaaacacgg
      481 ggaagccagg actggccgtc acgttggtga caaatatgtc ccaggactcg gtgaccttcg
      541 cagacgtggc tgtgaacttc accaaagagg agtggaccct gctggaccca gctcagagga
      601 atctctacag agacgtgatg ctggaaaatt ctaggaactt ggcattcata gattgggcaa
      661 ctccatgtaa aaccaaagac gcaacccctc agccggatat tcttcctaaa agaacatttc
      721 ctgaagccaa cagagtgtgt ctcacgagca tcagttccca gcactccaca ttaagagaag
      781 actggagatg ccccaaaaca gaggaaccac acaggcaggg ggtgaataat gtgaagccac
      841 ctgcagttgc ccctgagaaa gatgaatctc ctgttagcat ttgtgaagat catgaaatga
      901 ggaaccactc taaacctacc tgcaggcttg tgccttcaca gggagattcc ataagacaat
      961 gtatcctaac acgtgactca agtattttca agtataatcc tgtcttaaac gatagtcaaa
     1021 aaacacatga aaacaacgaa gacgatggag tcttggggtg gaacattcag tgggttccgt
     1081 gtgggagaaa aacagagctg aaatcaagca catggactgg cagtcagaac actgtgcatc
     1141 atatacgtga tgaaattgat acgggggcca acaggcacca gcggaatcca tttggaaaag
     1201 ctttccgtga agacggatcc cttagggcac acaacactca tggtcgagag aaaatgtatg
     1261 attttactca gtgcgagaac acctccagaa ataactcaat tcacgccatg cagatgcagt
     1321 tgtataccgc agagacaaac aagaaggatt gtcaaactgg ggcaacctct gccaacgctc
     1381 caaattccgg ttcacacaag agtcattgca ctggagagaa aacccataaa tgccccgaat
     1441 gtgggagagc ctttttttat cagtcattcc ttatgagaca tatgaaaatt cacactggag
     1501 agaaaccgta tgaatgtggg aaatgtggga aagcctttag atattcctta caccttaata
     1561 aacatttaag aaagcatgtt gtgcagaaga agccctacga atgtgaagaa tgtgggaaag
     1621 tcattcggga gtcctcaaaa tatacacata taaggagcca cactggagag aaaccctata
     1681 aatgtaagac atgtggaaaa gactttgcaa agtcgtcagg acttaaaaaa catcttaaga
     1741 ctcacaaaga tgagaagccc tgtgaatgaa aggaaggtgg aaaatttttc attaattttc
     1801 tgactgtacc aaacatgtga ggaggacata ttggaaggga gctcaagggg ttagcatgag
     1861 tgagaacatc ttccctgaac tctcgtatct tacagaaatg tgaaaaaaaa ccctgtgaag
     1921 gtaaagtcta cagaaagcct ttcatcttca ttcatcttga gtagacattt gttctcaccc
     1981 tggagagaaa ctgcgaatct aaaaggaata tgacaaagcc ttcagcgtgg tctcaaattc
     2041 atggttcata caagaactca cactgcagag actccttacg gaaataaaaa atgtaggaaa
     2101 gacctgccgg ccgcggtggc tcatgcctgt aatcccagca ctttgggagg ccgaggcggg
     2161 cggatcacga ggtcaggaga tcaagaccat cctggctaac acggtgatac cccgtctcta
     2221 ctaaaaatac aaaaaaaatt agccaggcgt ggtggcaggt gcctgtagtc ccagctactt
     2281 gggaggctga ggtaggagaa tggtgtaaac ctgggaggtg gagcttgcag tgagccgaga
     2341 tggagccact gcactccagc ctgggggaaa gagcgagact ccgtctcaaa aaaaaaaaaa
     2401 agtaggaaag acctctttaa acacttacca ctcatgttgc atgtgaatcc acatcctgaa
     2461 gggaggctac aactggaata aaaataagaa agctttcaa
//
