LOCUS       NM_013380               3660 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 112 (ZNF112), transcript variant
            2, mRNA.
ACCESSION   NM_013380
VERSION     NM_013380.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   2  (bases 1 to 3660)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   3  (bases 1 to 3660)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138473.1, BC117223.1 and AA449338.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_013380.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 3. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 3. Variants 2, 4, and
            5 all encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.119692.1,
                                           SRR3476690.461392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354340.9/ ENSP00000346305.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC138473.1         69534-69565         c
            33-264              BC117223.1         1-232
            265-265             AC138473.1         49522-49522         c
            266-516             BC117223.1         234-484
            517-3231            AC138473.1         39870-42584         c
            3232-3660           AA449338.1         5-433               c
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..3660
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /note="zinc finger protein 112"
                     /db_xref="GeneID:7771"
                     /db_xref="HGNC:HGNC:12892"
                     /db_xref="MIM:603994"
     exon            1..55
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /inference="alignment:Splign:2.1.0"
     exon            56..182
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2782
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 228; zinc finger protein 112 (Y14); zinc
                     finger protein 112 homolog"
                     /codon_start=1
                     /product="zinc finger protein 112 isoform 2"
                     /protein_id="NP_037512.3"
                     /db_xref="CCDS:CCDS12637.1"
                     /db_xref="GeneID:7771"
                     /db_xref="HGNC:HGNC:12892"
                     /db_xref="MIM:603994"
                     /translation="MVTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLVAHQ
                     PFKPDLISQLEREEKLLMVETETPRDGCSGRKNQQKMESIQEVTVSYFSPKELSSRQT
                     WQQSAGGLIRCQDFLKVFQGKNSQLQEQGNSLGQVWAGIPVQISEDKNYIFTHIGNGS
                     NYIKSQGYPSWRAHHSWRKMYLKESHNYQCRCQQISMKNHFCKCDSVSWLSHHNDKLE
                     VHRKENYSCHDCGEDIMKVSLLNQESIQTEEKPYPCTGYRKAFSNDSSSEVHQQFHLE
                     GKPYTYSSCGKGCNYSSLLHIHQNIEREDDIENSHLKSYQRVHTEEKPCKCGEYGENF
                     NHCSPLNTYELIHTGEMSYRHNIYEKAFSHSLDLNSIFRVHTRDEPHEYEENENVFNQ
                     SSCLQVHQKIHTEEKLYTDIEYGKSFICSSNLDIQHRVHMEENSYNSEECGNGFSLAS
                     HFQDLQIVHTKEQPYKRYVCSNSFSHNLYLQGHPKIHIGEKPRKEHGNGFNWSSKLKD
                     HQRVHTGQKPYKCNICGKGFNHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQ
                     RVHTGEKPYKCEECGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRV
                     HTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCEECGKGFSKASTLLAHQRVHT
                     GEKPYQCDECGKSFSQRSYLQSHQSVHSGERPYICEVCGKGFSQRAYLQGHQRVHTRV
                     KPYKCEMCGKGFSQSSRLEAHRRVHTGGKPYKCEVCTKGFSESSRLQAHQRVHVEGRP
                     YKCEQCGKGFSGYSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYK
                     CDACGKGFRWSSGLLIHQRVHSSDKFYKSEDYGKDYPSSENLHRNEDSVLF"
     exon            183..278
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /inference="alignment:Splign:2.1.0"
     exon            279..3660
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3641..3646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="ZNF112"
                     /gene_synonym="ZFP112; ZNF228"
                     /note="major polyA site"
ORIGIN      
        1 agagccactt ccgccccagg tacgctaggc cgcggccttc gttcctccca gaaaggagat
       61 ggtgacattc aaggatgttg ctgtggtctt cactgaggag gagctggggc tgctggactc
      121 tgtccagagg aagctgtacc gagatgtgat gctggagaac ttcaggaacc tgctcttagt
      181 agcacatcag cccttcaagc cagacctaat atcccagctg gagagagaag aaaagctttt
      241 gatggtggag acagaaaccc caagagatgg atgttcagga aggaagaatc aacaaaagat
      301 ggagagtatt caggaagtaa cagtaagcta cttttccccc aaagagcttt cctcccgtca
      361 gacctggcaa caaagtgcag gtgggttaat caggtgtcaa gatttcctga aagtttttca
      421 agggaagaat tctcagttgc aagaacaagg taattccctc ggccaggttt gggcaggaat
      481 accagttcag atttctgaag ataagaacta tatattcact catataggga atggctccaa
      541 ttatataaaa agtcaagggt atccatcttg gagggcacat cattcttgga ggaaaatgta
      601 tctgaaagag tcacataatt atcagtgtag atgtcagcaa atttccatga aaaatcattt
      661 ctgtaagtgt gacagtgtca gttggctctc acatcacaat gataaactgg aagtacacag
      721 aaaagaaaac tacagctgcc atgactgtgg agaagatatc atgaaggtat cattacttaa
      781 tcaggagtca attcaaacag aggagaagcc ctatccatgt actgggtata gaaaagcctt
      841 cagtaatgac tccagctctg aggttcatca gcagttccac ttggaaggga agccctatac
      901 atacagttca tgtggaaagg gctgtaatta tagttcactt cttcatattc atcaaaatat
      961 tgagagagaa gatgatattg agaattcaca tctgaaatcc tatcagagag tgcatacaga
     1021 ggagaaacca tgcaaatgtg gtgaatatgg tgagaacttc aatcactgtt cccctcttaa
     1081 cacttatgaa cttatccaca caggtgagat gtcctatagg cacaacattt atgagaaagc
     1141 cttcagtcat agcttagacc ttaatagtat ttttagggtc catactaggg atgaacccca
     1201 tgaatatgag gaaaatgaga atgtctttaa tcagagttca tgtcttcaag tccatcaaaa
     1261 aatccacact gaagagaaac tatacacaga tatagagtat ggaaagagtt tcatttgtag
     1321 ttcaaatctt gacattcagc atagggttca tatggaagag aattcatata attctgagga
     1381 gtgtggtaat ggcttcagtc tggcctcaca ttttcaggac cttcagatag tccacactaa
     1441 ggaacaacca tataaacgct atgtgtgtag taacagcttc agccataatt tatatcttca
     1501 aggtcatcca aaaattcaca ttggagagaa accacgtaag gagcatggga atggcttcaa
     1561 ctggagctca aaacttaaag atcatcagag agtccacact ggacagaagc catacaaatg
     1621 caatatatgc ggcaaaggtt tcaatcatag atcagttctg aatgttcatc agagagtcca
     1681 cacaggagag aaaccttata aatgcgagga atgtgataag ggattcagtc ggagttcata
     1741 tcttcaagcc catcagagag tccacactgg agaaaaacct tataaatgtg aggaatgtgg
     1801 gaaggggttc agtcgaaatt cataccttca aggccatcag agagttcaca ctggagaaaa
     1861 accatacaag tgtgaggagt gtgggaaggg cttcagtcgg agttcacacc ttcaaggcca
     1921 tcagagagtc cacactggag aaaaaccatt caaatgtgag gaatgtggga aggggttcag
     1981 ttggagcttt aatcttcaaa ttcatcagag ggttcacaca ggagaaaaac cctataaatg
     2041 tgaagaatgt ggtaaaggct tcagtaaggc ctcaacactt ttggcccatc agagggtcca
     2101 cacgggagag aagccatacc aatgtgatga gtgtggtaag agtttcagtc agagatcata
     2161 ccttcagagt catcagagtg tccattctgg agaaagacca tatatatgtg aggtatgtgg
     2221 aaagggcttc agtcagagag catatcttca aggtcatcag agagtccaca ctagagtgaa
     2281 accgtataaa tgtgagatgt gtgggaaggg ctttagtcag agttcgcgcc ttgaagcaca
     2341 tcggagggtt cacacaggag ggaaaccata caaatgtgag gtgtgtacaa agggtttcag
     2401 tgagagttca cgccttcaag cacaccaaag ggttcatgtg gaagggagac cctataaatg
     2461 tgaacagtgt ggtaagggtt tcagtgggta ttcaagtctt caagcccatc acagagtcca
     2521 cacaggagag aaaccataca aatgtgaggt atgtggaaag ggcttcagtc agagatcaaa
     2581 tcttcaggct caccagagag tccacacagg agagaaacca tacaaatgtg atgcatgtgg
     2641 taagggtttc cgttggagct caggtcttct cattcatcaa agagtccata gtagtgataa
     2701 attctataaa agcgaagact atggtaagga ctacccttca tcagagaatc tacacagaaa
     2761 tgaagattct gttttgtttt gaagtcctca aatgggagct gaaattttcc agtcactaga
     2821 gttctttcag tagaaaaaga atttttaaaa attaaaatgt aatgttgctg cccaacttca
     2881 acattcataa tggccaggag accacacaac agagacattt aatgagaggg gtttcacgag
     2941 ggattttgtt agaactttaa catcagtcat tgcacaggag ctaaggctta taaaatatga
     3001 gtatggtcag gaatttaata aaagtacagt gatgagcatg cctaaatcca tgttctctag
     3061 aatgtaagct tggtgaaaga agggactttg ttcattgcta gtctacaaaa ctaggacatt
     3121 tcataacgca atgtaggtgc tcagtacttt ttgctaaata actaaaagta tgtaaaggta
     3181 aaaggtttga aatttttaag cgcatttttt aaaacttaaa atgtatttgg aggagaaatc
     3241 ctgcaagtaa tcttaataaa atcatttcaa gtaaatattt gaaatgtaga acaataagca
     3301 ttatgatgat ctgaaataac attaatttga ttgtaaccct attggggtta gttcccaccc
     3361 tttgttccat cttgagcaga gatgtgctgc atttcttaac gtttggtctc tatacattat
     3421 accatctgct gaagtttagc tttgtgtgtg tgtatatgta cccatgtgtg cacttgaaat
     3481 atcagtacaa actgataaac aatgtttctg gttaatgttg caaaaatgga acactgtatt
     3541 ttacataatt gattttctac tcctgccctg tgaattaagg cagagtttta ctgtaatatt
     3601 tgcaagtatc caaaatggtt actgatgaca aatacttttt aataaatgtc aaaatcacaa
//
