LOCUS       NM_001282359            5630 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 107 (ZNF107), transcript variant
            3, mRNA.
ACCESSION   NM_001282359 XM_005250400
VERSION     NM_001282359.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5630)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5630)
  AUTHORS   Li,X.A., Kokame,K., Okubo,K., Shimokado,K., Tsukamoto,Y.,
            Miyata,T., Kato,H. and Yutani,C.
  TITLE     Cloning and characterization of a novel human gene encoding a zinc
            finger protein with 25 fingers
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 405-412 (1999)
   PUBMED   10673043
REFERENCE   3  (bases 1 to 5630)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA723595.1 and AC091799.5.
            
            On Aug 13, 2020 this sequence version replaced NM_001282359.1.
            
            Summary: This gene encodes a protein containing multiple C2H2-type
            zinc finger regions. Proteins containing zinc fingers may act as
            transcriptional regulators, but may also have other cellular
            functions. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (3) lacks three alternate exons
            and initiates translation at an alternate upstream start codon,
            compared to variant 1. The encoded isoform (b) has a longer
            N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.30200.1,
                                           SRR18074969.90361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620827.6/ ENSP00000483720.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               DA723595.1         51-536
            487-5630            AC091799.5         1738-6881
FEATURES             Location/Qualifiers
     source          1..5630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..5630
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="zinc finger protein 107"
                     /db_xref="GeneID:51427"
                     /db_xref="HGNC:HGNC:12887"
                     /db_xref="MIM:603989"
     exon            1..153
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2709
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="isoform b is encoded by transcript variant 3; zinc
                     finger protein (ZFD25); zinc finger protein 588; C2H2 type
                     zinc-finger protein"
                     /codon_start=1
                     /product="zinc finger protein 107 isoform b"
                     /protein_id="NP_001269288.1"
                     /db_xref="CCDS:CCDS75605.1"
                     /db_xref="GeneID:51427"
                     /db_xref="HGNC:HGNC:12887"
                     /db_xref="MIM:603989"
                     /translation="MEPLTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFLG
                     IAVSKPYLITCLEQKKEPWNIKRHEMVAKPPVMSFHFAQDLWPEQNIKDSFQKVTLRR
                     YGKCEYENLQLRKGCKHVDECTGHKGGHNTVNQCLTATPSKIFQCNKYVKVFDKFSNS
                     NRYKRRHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFSTLTK
                     HKRIHTGEKPYKCEECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQASHLTIHK
                     IIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHKRI
                     HAGEKPYKCKECGRAFNISSNLNKQEKIHTGGKLNKCEECDKAFNRSLKLTAHKKILM
                     EEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKCKECGKAFNQSSNLTEHKKIHTAE
                     KSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTGEKP
                     YKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRFSTLTKHKRIHTGEKPYK
                     CEECGKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCE
                     EHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFSNITNHKIIYTGEKPHKCEEC
                     GKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGK
                     AFNLSSTLTAHKKIHTGEKPYKCEECGKAFNQSSNLTTHKKIHTSEKPYKCEECGKSF
                     NQFSSLNIHKIIHTGEKPYKCGDYGRAFNLSSNLTTHKKIHTGEKPYKCEYGKT"
     exon            154..280
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /inference="alignment:Splign:2.1.0"
     exon            281..376
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /inference="alignment:Splign:2.1.0"
     exon            377..5630
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5056..5061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="hexamer: AATAAA"
     polyA_site      5079
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="major polyA site"
     regulatory      5111..5116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="hexamer: ATTAAA"
     polyA_site      5136
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="major polyA site"
     regulatory      5614..5619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
                     /note="hexamer: AATAAA"
     polyA_site      5630
                     /gene="ZNF107"
                     /gene_synonym="smap-7; Y8; ZFD25; ZNF588"
ORIGIN      
        1 gcctttgtct ctggctgcag ccggagctcc tgctctcctc ctcactgctc agtgtcctct
       61 gctcctagag gcccagcctc tgtgtccctg tgacctgcag atattgggag atccacagct
      121 aagacgccgg gactccctgg aaacctagaa atggaaccac tgacatttaa agatgtcgcc
      181 atagaattct ctctggagga gtggcaatgc ctggatactg cacagcggga tttatatagg
      241 aatgtgttgt tagagaacta cagaaacctg gtctttttgg gtattgctgt ctctaagcca
      301 tatctgatca cctgtctgga gcaaaaaaaa gagccctgga atataaaaag acatgagatg
      361 gtagccaaac ccccagtaat gtcttttcat tttgcccaag acctttggcc agagcagaac
      421 ataaaagatt ctttccagaa agtgacactg agaagatacg gaaaatgtga atatgagaat
      481 ttacagttaa gaaaaggctg taaacatgtg gatgagtgta cggggcacaa aggaggtcat
      541 aatacagtta accaatgttt gacagctacc ccaagcaaaa tattccagtg taataaatat
      601 gtgaaagtct ttgataaatt ttcaaattca aatagatata agagaagaca tacaggaaac
      661 aaacacttca aatgtaaaga atgtagcaaa tcattttgcg tgctttcaca actaactcag
      721 catagaagaa ttcatactag agtgaattcc tacaaatgtg aagaatgtgg aaaagccttt
      781 aactggttct caactcttac taaacataag agaattcata ctggagaaaa gccctacaaa
      841 tgtgaagaat gtggcaaagc ctttaaccag tcctcacaac ttactaggca taagataatt
      901 catactgaag agaaacccaa caaatgtgaa gaatgtggca aggcctttaa acaggcctca
      961 caccttacta tacataaaat aattcatact ggagaaaaac cttacaaata tgaagaatgt
     1021 ggcaaagtct ttagccagtc ctcacacctt actacacaaa agatacttca cactggagag
     1081 aacctctaca agtgtaaaga atgtggaaaa gcttttaacc tattctcaaa tcttactaac
     1141 cataagagaa ttcatgctgg ggagaaaccc tacaaatgta aagaatgtgg cagagctttt
     1201 aacatatcct caaaccttaa taaacaggag aaaattcata ctggagggaa actcaacaaa
     1261 tgtgaagaat gtgacaaagc ttttaaccga tccttaaaac ttactgcaca taagaaaatt
     1321 ctaatggaag agaaacccta caaatgtgaa gaatgtggca aagtctttaa ccagttctca
     1381 actcttacta gacataagat aattcatact ggagagaaac cctacaaatg taaagaatgt
     1441 ggcaaagctt ttaaccaatc ttcaaacctt actgaacata agaaaattca tactgcagag
     1501 aaatcctata aatgtgaaga atgtggcaaa gcttttaacc aacactcaaa cctaattaac
     1561 cataggaaaa tttattctgg agagaaacca tacaaatgtg aagaatgtgg aaaagctttt
     1621 aatcgatcct caacccttac tagacataag aaaattcata ctggagagaa accctacaaa
     1681 tgtgaagaat gtgacagagc ttttagccag tcttcaaacc ttactgaaca taagaaaatt
     1741 catactggag agaaacccta taaatgtgag gaatgtggca aagcttttaa ccgattctca
     1801 acccttacta aacataagag aattcatact ggagaaaaac cctataaatg tgaagaatgt
     1861 ggaaaagcct ttaatcaatc ctatcaactt actagacata agatagttca tactaaagag
     1921 aaactcaaca aatgtgaaga atttggcaag gcctttaaac agtcctcaca ccgtactata
     1981 cataaaatta ttcatactgg agagaaaccc tacaaatgtg aagaacatgg caaagttttt
     2041 aaccagtcct caaaccttac tacacaaaag ataattcata ctggagagaa cctctacaaa
     2101 tttgaagaac atggaaaagc ttttaaccta ttctcaaaca ttactaacca taagataatt
     2161 tatactggag agaaacccca caaatgtgaa gaatgtggaa aagcttataa ccgattctca
     2221 aacctaacta tacataagag aattcatacg ggagagaaac cttaccaatg tgcagaatgt
     2281 ggcaaagcct ttaactgctc ctcaaccctt aatagacata agataattca tactggagag
     2341 aaaccttaca aatgtaaaga atgtggcaaa gcttttaacc tatcctcaac ccttactgca
     2401 cataagaaaa ttcatactgg agagaaaccc tataaatgtg aagaatgtgg caaagctttt
     2461 aaccaatcct caaaccttac tacacataag aaaattcata cttcagagaa accctacaaa
     2521 tgtgaagaat gtggcaaatc ctttaaccag ttctcatctc ttaatataca taagataatt
     2581 catactggag agaaacccta caaatgtgga gattatggca gagctttcaa cctatcctca
     2641 aatcttacta cacataagaa aattcatact ggagagaaac cctacaaatg tgagtatggc
     2701 aaaacttaat tgatcctaca agcttactac acataggaaa attcatactg gagagaaact
     2761 acaaatgtga agaatgtgtt aaagccttta acaagtcttc aactttttct gcacacacga
     2821 ggtattttat actggtgaga aaccttacaa tgtaaagaat gtggcacagc ttttaactaa
     2881 tcttcaaacc ttactgaaag ttgagaaaat tcgtactgga gagaatccta caaatgtgaa
     2941 aaatgtggca aatcctttaa ctgatcctca acttttacta aacataaggt aattcatact
     3001 ggagaaaagc catacaaatg agaagaatgt ggcaatgcct ttaatcagtc ctcacacctt
     3061 tctacacata agataattta tactggagag gaactctata gttgtgaaga atgtggcaaa
     3121 gcttttaacc aatcctcata ccttactata cagaaattca tactggagag aaagcctaca
     3181 attgtgaaga atgtggcaaa gcttttaacc ttccttaacc cttaactgta gataagaaaa
     3241 ttcatactgg aaagaaaccc tacaaatgtg aagtctgtgg caaagctttt aactgattct
     3301 caactcttac tacatgtaag agtatttata ctggaaagaa accctacaaa tgtaaaaaac
     3361 gtggcaatgc ctttaactgg tcctcacacc ttgctacata taagacagtt tatactttga
     3421 gagaaaccct gcaaatgtga ataatgtggc aatactttaa accaatcctc aaacctcact
     3481 aaacataaga taatactgaa aactttacaa acctgaatga tgtgacaata attttgacaa
     3541 cacctcgaac tttctaacat aaatcatact ggtgaaaaat cctagaaatg tgaaaaatat
     3601 cacaaagcct ttaaatggtt gtcacacttg attgtaggta agaatccata ctgaagaaaa
     3661 ctcctggaag tgtaaaaaat gtggcaacac ttttaataaa tgctcacccc ttattgcaca
     3721 ggaaagcatt tatacttcag aaagattgta caaatacaag gaatgtggaa aagccattat
     3781 tatctgctca gattttactc aacattagag agttagtacg taataaaagc attataaatg
     3841 caatttttgt caagagatct ttcagaaaat ataagccttt aaagtgaaga agaggagcca
     3901 gttgtgctgg ctcacatctg taatgccagc actttgggag gccaaggtgg gtggatcacc
     3961 tgagggcagg agtctgagac cagcctggcc aacatagcaa aaccccatct ctattaaaaa
     4021 ttttacaaaa attagctgcg tgtggtggca ggcccctgta atcccagcta attgggaggc
     4081 tgaagcagga gaattgctca aacctgggag gcgaagattg cagtgagctg aaatcacacc
     4141 actacactcc agccaaagca acaagagcaa aaacttcgtc tcaaaaacaa aacaaaaaaa
     4201 gagtattcat tgtgaggaca aacaatacaa atacgaagag ggttgtagta cctttacttg
     4261 tatcacagat acttttgtac ccattttgca ctagaggaaa accatgaagc agttgctcaa
     4321 atgttgttca acaccagaaa atttatattg gagaaaagca ctgtaaatgt aatgcatttg
     4381 tgaaaacatt ttttaaaaaa ctacagctta gaaaatacca gaggcctcat actaaaatat
     4441 atttttgcaa gtgaagtaaa tataaaaata atttaatcca aaattaagtc tatataaata
     4501 tcagagaatt cacagtagaa atatctaagg tactgacact tcagacattg ctgagtatag
     4561 aatcagaatg ctgagtatag aaaataattt aaaactaaag ttggtaggta aataatgtgt
     4621 atataacttt aaaagaagta gaattttttt gtagatgtat aattacattc aaattatatt
     4681 ttttcttgaa aaattagttt ttgaaaagca aatgatgtaa ttcaactcaa attcatgctc
     4741 ttcattccta ttgtattcac atgtgaaagc atgtgattaa tttttcatgc atcaaagata
     4801 tgagaaatca tttctgttag gtcggtatta tttatgacac tttctatgaa agaataagga
     4861 cattaaaatg taagatgcat gatgaaaacc tgagtgaaga ggctgtttgt gtttaactta
     4921 taatattgag tgatccatga agtaggtttt cagagcaata ttcttctgca ttatagtaag
     4981 agaaaaccat ttttaatctt agttaaaatt aaagtgaatt agtagtatat cattttacta
     5041 tttgtacttt tatgtaataa aatgcaatgt gtttaaaaat ttttggatta tgcgtgaact
     5101 tagtttttta attaaacttt ttttaacatg ttaaaactat tgtgcattca atgaagtgtt
     5161 ttcatgccac tgactttacc tatcccacat tactcaaggg tttaggtaaa agagggtaac
     5221 agtatactac ttgataacat aatgggctaa catctctaat aattattttt gctagtgact
     5281 ttaaactgct aataaagaat attgttccca taggttagat ttttattctt tttaaaattt
     5341 aaacttattt ctcttaattt ttgtggatac atagtatgtg tatatcttta tgccatgtat
     5401 ggcatatttt gatacaggca tataatttta tgtattaatc acatcagggc aaaagatgta
     5461 tccatcaact ccagcatttc tcctttgtat tacaaaccaa ttctgcactt ttagatactt
     5521 tagaatgtac agtcgttact acagggtcat tttatggtta taataaaaat tatatacaag
     5581 tataaataaa ccatgagaaa attctgagtt ctgaataaac atttaaaaaa
//
