LOCUS       NM_001366845           10396 bp    mRNA    linear   PRI 16-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 106 (ZNF106), transcript variant
            5, mRNA.
ACCESSION   NM_001366845 XM_005254591
VERSION     NM_001366845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10396)
  AUTHORS   van den Berg,F.F., Issa,Y., Vreijling,J.P., Lerch,M.M., Weiss,F.U.,
            Besselink,M.G., Baas,F., Boermeester,M.A. and van Santvoort,H.C.
  CONSRTM   Dutch Pancreatitis Study Group
  TITLE     Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as
            Novel Genetic Risk Factors for (Early) Multiple-organ Failure in
            Acute Pancreatitis
  JOURNAL   Ann Surg 275 (6), e781-e788 (2022)
   PUBMED   33427755
  REMARK    GeneRIF: Whole-exome Sequencing Identifies SLC52A1 and ZNF106
            Variants as Novel Genetic Risk Factors for (Early) Multiple-organ
            Failure in Acute Pancreatitis.
REFERENCE   2  (bases 1 to 10396)
  AUTHORS   Contreras-Martos,S., Piai,A., Kosol,S., Varadi,M., Bekesi,A.,
            Lebrun,P., Volkov,A.N., Gevaert,K., Pierattelli,R., Felli,I.C. and
            Tompa,P.
  TITLE     Linking functions: an additional role for an intrinsically
            disordered linker domain in the transcriptional coactivator CBP
  JOURNAL   Sci Rep 7 (1), 4676 (2017)
   PUBMED   28680062
  REMARK    GeneRIF: Study identified ZFP106 as a novel substrate for
            CBP-mediated acetylation, and showed that the fully disordered
            isolated ID3 in CREBBP transiently interacts with an IDR of ZFP106
            in a fashion that both IDR regions are maintained.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10396)
  AUTHORS   Grasberger,H., Ye,H., Mashima,H. and Bell,G.I.
  TITLE     Dual promoter structure of ZFP106: regulation by myogenin and
            nuclear respiratory factor-1
  JOURNAL   Gene 344, 143-159 (2005)
   PUBMED   15656981
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018362.8 and AC012651.8.
            
            On Apr 21, 2020 this sequence version replaced NM_001366845.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.7812.1,
                                           SRR14038193.2738685.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000564754.7/ ENSP00000456845.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC018362.8         28081-28242         c
            163-248             AC018362.8         9337-9422           c
            249-310             AC018362.8         3154-3215           c
            311-511             AC012651.8         137286-137486       c
            512-2695            AC012651.8         130099-132282       c
            2696-3329           AC012651.8         128400-129033       c
            3330-3399           AC012651.8         126917-126986       c
            3400-3554           AC012651.8         125155-125309       c
            3555-3615           AC012651.8         124530-124590       c
            3616-3957           AC012651.8         122401-122742       c
            3958-4738           AC012651.8         119361-120141       c
            4739-4794           AC012651.8         118940-118995       c
            4795-4940           AC012651.8         117560-117705       c
            4941-5075           AC012651.8         115712-115846       c
            5076-5192           AC012651.8         108346-108462       c
            5193-5384           AC012651.8         105162-105353       c
            5385-5447           AC012651.8         104326-104388       c
            5448-5567           AC012651.8         102829-102948       c
            5568-5639           AC012651.8         102245-102316       c
            5640-5711           AC012651.8         101389-101460       c
            5712-5858           AC012651.8         98133-98279         c
            5859-10396          AC012651.8         93151-97688         c
FEATURES             Location/Qualifiers
     source          1..10396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..10396
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="zinc finger protein 106"
                     /db_xref="GeneID:64397"
                     /db_xref="HGNC:HGNC:12886"
                     /db_xref="MIM:603988"
     exon            1..162
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            163..248
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..5915
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="isoform 5 is encoded by transcript variant 5;
                     SH3-domain binding protein 3; zinc finger protein 474"
                     /codon_start=1
                     /product="zinc finger protein 106 isoform 5"
                     /protein_id="NP_001353774.1"
                     /db_xref="CCDS:CCDS91986.1"
                     /db_xref="GeneID:64397"
                     /db_xref="HGNC:HGNC:12886"
                     /db_xref="MIM:603988"
                     /translation="MVRERKCILCHIVYSSKKEMDEHMRSMLHHRELENLKGRDISHE
                     CRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRK
                     EQSRQDEPSNSNQEINSDDRRPQWRREDRIPYQDRESYSQPAWHHRGPPQRDWKWEKD
                     GFNNTRKNSFPHSLRNGGGPRGRSGWHKGVAGGSSTWFHNHSNSGGGWLSNSGAVDWN
                     HNGTGRNSSWLSEGTGGFSSWHMNNSNGNWKSSVRSTNNWNYSGPGDKFQPGRNRNSN
                     CQMEDMTMLWNKKSNKSNKYSHDRYNWQRQENDKLGTVATYRGPSEGFTSDKFPSEGL
                     LDFNFEQLESQTTKQADTATSKVSGKNGSAAREKPRRWTPYPSQKTLDLQSGLKDITG
                     NKSEMIEKPLFDFSLITTGIQEPQTDETRNSPTQKTQKEIHTGSLNHKASSDSAASFE
                     VVRQCPTAEKPEQEHTPNKMPSLKSPLLPCPATKSLSQKQDPKNISKNTKTNFFSPGE
                     HSNPSNKPTVEDNHGPYISKLRSSCPHVLKGNKSTFGSQKQSGDNLNDTLRKAKEVLQ
                     CHESLQNPLLSTSKSTRNYAKASRNVEESEKGSLKIEFQVHALEDESDGETSDTEKHG
                     TKIGTLGSATTELLSGSTRTADEKEEDDRILKTSRELSTSPCNPIVRQKESELQMTSA
                     ASPHPGLLLDLKTSLEDAQVDDSIKSHVSYETEGFESASLDAELQKSDISQPSGPLLP
                     ELSKLGFPASLQRDLTRHISLKSKTGVHLPEPNLNSARRIRNISGHRKSETEKESGLK
                     PTLRQILNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEALDLDGEP
                     DLSSLEGFQWEGVSISSSPGLARKRSLSESSVIMDRAPSVYSFFSEEGTGKENEPQQM
                     VSPSNSLRAGQSQKATMHLKQEVTPRAASLRTGERAENVATQRRHSAQLSSDHIIPLM
                     HLAKDLNSQERSIPPSENQNSQESNGEGNCLSSSASSALAISSLADAATDSSCTSGAE
                     QNDGQSIRKKRRATGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLNISLREEELSK
                     SLQCMDNNLLQARAALQTAYVEVQRLLMLKQQITMEMSALRTHRIQILQGLQETYEPS
                     EHPDQVPCSLTRERRNSRSQTSIDAALLPTPFFPLFLEPPSSHVSPSPTGASLQITTS
                     PTFQTHGSVPAPDSSVQIKQEPMSPEQDENVNAVPPSSACNVSKELLEANREISDSCP
                     VYPVITARLSLPESTESFHEPSQELKFSVEQRNTRNRENSPSSQSAGLSSINKEGEEP
                     TKGNSGSEACTSSFLRLSFASETPLEKEPHSPADQPEQQAESTLTSAETRGSKKKKKL
                     RKKKSLRAAHVPENSDTEQDVLTVKPVRKVKAGKLIKGGKVTTSTWEDSRTGREQESV
                     RDEPDSDSSLEVLEIPNPQLEVVAIDSSESGEEKPDSPSKKDIWNSTEQNPLETSRSG
                     CDEVSSTSEIGTRYKDGIPVSVAETQTVISSIKGSKNSSEISSEPGDDDEPTEGSFEG
                     HQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKNA
                     ALYTGSSDHTIRCYNVKSRECVEQLQLEDRVLCLHSRWRILYAGLANGTVVTFNIKNN
                     KRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTI
                     LCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKF
                     VRVYELQSHDRLQVYGGHKDMIMCMTIHKSMIYTGCYDGSIQAVRLNLMQNYRCWWHG
                     CSLIFGVVDHLKQHLLTDHTNPNFQTLKCRWKNCDAFFTARKGSKQDAAGHIERHAED
                     DSKIDS"
     exon            249..310
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            311..511
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            512..2695
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..3329
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3399
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3554
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3615
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3957
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4738
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4794
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            4795..4940
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            4941..5075
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5192
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5193..5384
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5385..5447
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5448..5567
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5568..5639
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5640..5711
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5712..5858
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5859..10396
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10374..10379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="hexamer: AATAAA"
     polyA_site      10396
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtgcgcc tgcgcgttgg cggcggctgt ggcggggccc ggcggggagc gggtccggag
       61 caggctcccg gacccaaaac tgaagggggc gtctgaggcg tcagggagct ccctcgcctg
      121 gctctcggcg gcctgatgga gtaagagggg ttggctgtga atctgtgacg ttgagtgctt
      181 cagatctggt cactatggta cgagaacgaa aatgcatatt atgccacatc gtgtacagct
      241 caaaaaagga gatggacgaa cacatgcgga gcatgttgca tcacagggaa cttgagaacc
      301 tcaagggcag ggacattagt catgagtgcc gagtgtgcgg ggtcacagaa gtgggtcttt
      361 ctgcatatgc aaagcacatt tctggccagt tgcacaaaga taacgttgat gcccaggaaa
      421 gagaagatga tggaaaagga gaggaagagg aagaagatta ttttgacaag gaactcattc
      481 agttaataaa acaaaggaaa gaacaaagtc gacaagatga accttccaat agcaaccaag
      541 aaataaactc tgatgacaga cgaccccaat ggagacgaga agaccgaatt ccttaccaag
      601 acagagagag ttacagtcag cctgcatggc atcatcgtgg acctccacag cgggattgga
      661 aatgggaaaa agatggcttt aataatacta ggaaaaacag ctttccacat tctttgagga
      721 atggtggtgg accaagagga cgttccgggt ggcataaggg tgttgcagga ggctcctcga
      781 cttggtttca caaccatagt aattctggag gtggttggct ttcaaatagt ggagcagtag
      841 attggaatca taatggtaca ggaaggaatt ccagttggct ttctgaagga acaggtggct
      901 tttccagttg gcatatgaac aacagtaacg gaaactggaa atccagtgta cgtagtacaa
      961 ataattggaa ttacagtggc cctggagaca aatttcaacc aggcagaaac agaaattcta
     1021 actgtcaaat ggaagacatg actatgctat ggaacaagaa atctaataag tcaaacaaat
     1081 acagtcacga cagatataat tggcagcggc aagaaaatga caaacttggt acagttgcca
     1141 catatagagg tccttctgaa ggatttacaa gtgataaatt tccttcagaa ggcttactcg
     1201 acttcaattt tgagcagctg gaaagccaaa ccactaaaca agcagacact gctacttcca
     1261 aagttagtgg aaagaatggc agtgcggcaa gggaaaagcc tcgtcgctgg acgccttacc
     1321 cttctcagaa gactctggat ttacagtcgg gattgaaaga catcactggt aacaagtcag
     1381 aaatgataga gaaacctctc tttgatttta gcttgataac tacaggaata caggagcccc
     1441 aaactgatga aacacgtaat tccccaacac agaaaacaca aaaagaaata catactggat
     1501 ctcttaatca caaggcctct tctgattccg ctgcttcctt cgaggtggtg agacagtgcc
     1561 ccactgcaga aaaacctgaa caagagcata caccaaataa aatgccatca ttgaaatccc
     1621 cactccttcc atgtccagcc actaaatcat tgtctcaaaa gcaagatcca aagaatatct
     1681 caaaaaacac caaaacaaat tttttttccc ctggagaaca ctcaaatccc tcgaacaagc
     1741 ccactgtgga agataaccat ggtccttaca tatccaaact gcgtagttca tgtcctcatg
     1801 ttttaaaagg gaataaaagt acatttggct ctcaaaagca atctggtgat aatttaaatg
     1861 atactttacg aaaggccaaa gaggtgctac agtgtcatga gtcattgcaa aatccacttc
     1921 ttagcacttc taaaagtacc aggaactatg caaaagcaag tagaaatgta gaagaatctg
     1981 aaaaagggtc tttgaaaatt gagtttcaag tgcacgcact agaagatgaa agtgatggag
     2041 agacatctga cacggaaaag catggaacaa aaattggaac cctaggttct gcaactacag
     2101 aattgttatc tggcagcact cgaactgctg atgagaaaga ggaggatgac cgcatcctga
     2161 agacttctag agagctatcc acttccccat gtaatcccat agttcgccag aaagaatctg
     2221 aattacaaat gacatctgca gccagtccac accctggctt attgctagac ttgaaaacct
     2281 ctctagaaga tgcacaggtt gatgactcta ttaaatctca tgtatcttat gaaacagaag
     2341 gctttgagag tgctagcttg gatgcagagc ttcaaaaaag tgacatcagt cagccctcgg
     2401 gccctctcct gcctgaacta agtaagcttg gctttcctgc ctcacttcag agggatctaa
     2461 cccggcacat tagtttgaag agcaaaactg gagtacacct tcctgagcca aacctcaata
     2521 gtgcccgccg cattcgcaat attagcggtc accgaaagag tgagacagag aaggagtctg
     2581 ggctcaagcc aaccctacgg cagattctaa atgcatctcg gagaaatgtc aactgggaac
     2641 aggtcattca gcaagtaacc aagaaaaagc aagagctggg caaaggctta cccaggtttg
     2701 gcatagaaat ggtacccctt gttcaaaatg aacaagaagc cttagatttg gatggggaac
     2761 ctgatctgtc cagtctagaa ggattccagt gggaaggtgt ttccatttcc tcgtcccctg
     2821 gcttggcaag aaagcgaagc ctttctgaga gcagcgtgat catggacaga gctccttctg
     2881 tgtatagctt cttcagtgag gaaggtacag gcaaagaaaa tgagccccag cagatggttt
     2941 cacctagtaa ctcattgagg gctggacaga gccagaaagc aaccatgcac ctcaaacaag
     3001 aagtgacacc tcgggctgcc tccctccgaa caggtgaaag ggctgaaaat gttgctaccc
     3061 aaaggcgaca tagtgcacaa ttatcctctg accatataat acctttgatg catttggcaa
     3121 aagacttgaa cagccaggag aggtctatac caccgtcaga gaatcagaat tcccaggaga
     3181 gtaatggaga gggaaactgt ctgtcatcaa gcgcatcctc agcccttgcg atctccagtt
     3241 tagcggatgc agccacagat agtagctgta cctctggtgc tgaacaaaat gatggccaaa
     3301 gtattagaaa gaaacgaaga gccactggag atggatcttc tcctgaactc ccaagtcttg
     3361 agagaaaaaa taaaagaagg aaaattaaag gaaaaaaaga acgttctcag gttgaccagc
     3421 tgctgaatat ttctttaagg gaggaagaac ttagtaagtc attgcagtgc atggataaca
     3481 atcttctgca agcccgtgca gcccttcaga cagcttatgt ggaagttcag aggctactta
     3541 tgctcaagca gcagataact atggagatga gtgcactgag gacccataga atacagattc
     3601 tacagggatt acaagaaaca tatgaacctt ctgagcaccc agaccaggtt ccctgtagcc
     3661 tcacacgaga acgaaggaac agtagatctc aaacatccat tgatgccgca ctgctgccca
     3721 ctcccttttt cccacttttt ctggagcctc catcttccca tgtgtctcca tcacccaccg
     3781 gagcctctct tcaaataacc acgtctccta ctttccaaac ccatggcagt gtccctgctc
     3841 cagactcatc agttcagatt aaacaagagc ccatgtctcc tgaacaagat gagaatgtga
     3901 atgctgtgcc accaagctct gcctgcaatg tgtccaagga attactggaa gctaatagag
     3961 agatcagtga cagttgtcca gtttatccag tcatcactgc tagattgtcc ttaccagagt
     4021 caacagaaag tttccatgag cctagccaag aactgaagtt ttctgtggag caaagaaata
     4081 ccagaaacag agaaaactct ccctcttccc aatcagctgg tctttctagc ataaataaag
     4141 aaggggaaga gccaaccaaa ggcaatagtg ggtctgaagc ctgtaccagt tcttttctaa
     4201 gattgtcttt tgcttcagaa acccctttgg agaaggaacc ccactctcca gctgaccagc
     4261 ctgaacaaca ggcagaatcc actttgacat cagctgagac taggggaagc aagaaaaaga
     4321 agaaactccg gaagaagaaa agtctacggg ctgcccatgt tcctgagaat agtgacactg
     4381 aacaggatgt tttgactgtt aaacctgtaa ggaaagtaaa agctggaaag ttaattaaag
     4441 gggggaaagt aacaacctcc acttgggaag acagcaggac tggtcgggag caggagagtg
     4501 tcagagatga gccagatagt gactcgtctc tggaagtcct agaaattcct aatcctcagt
     4561 tagaagtagt agccattgat tcttcagaat caggagaaga gaaaccagac agcccatcta
     4621 aaaaggatat ttggaactct acagagcaaa acccactaga aacgtctcgt tctgggtgtg
     4681 atgaagttag ctctaccagt gaaattggca ctcgctataa agatggcatc cctgtaagtg
     4741 tggcagaaac tcagactgtg atctcctcca taaaaggatc aaagaattct tcagaaatat
     4801 cttcagagcc aggagatgat gatgaaccca cagaaggaag ctttgaggga caccaagctg
     4861 ccgtaaatgc aattcagata tttgggaact tgctatatac ctgttcagca gataaaactg
     4921 ttcgggttta taatctggtg agtcggaaat gtattggtgt ctttgagggt catacctcca
     4981 aagttaactg cctcctggtt actcagacct ccgggaagaa tgctgccctt tacaccgggt
     5041 ccagtgacca taccatccgc tgctataatg ttaagagccg agagtgtgtg gagcagttac
     5101 agctggaaga ccgggtcctc tgcctccaca gtagatggcg aatcctctat gcgggactgg
     5161 caaatggcac tgtggtcacc ttcaacataa agaacaacaa acgacttgag atctttgaat
     5221 gccatggccc tcgggcagtc agctgtcttg ctacagctca ggaaggtgcc cgaaaactgc
     5281 tggtcgtggg gtcttatgac tgcacaatta gtgtacgcga tgcccggaat ggactgctcc
     5341 tcagaactct ggagggccat agcaaaacca ttctttgcat gaaggtggtg aatgatctcg
     5401 tgttcagtgg ctccagtgat cagtcagtcc atgctcacaa cattcacact ggtgagctcg
     5461 tgcggatcta taaaggtcac aatcatgcag tgactgtggt gaatatccta ggaaaagtga
     5521 tggtgactgc ttgcctggat aaatttgttc gtgtctatga attacagtct catgatcgat
     5581 tacaagttta tggaggacac aaagacatga ttatgtgtat gaccatccat aaaagcatga
     5641 tttacactgg ctgttatgat ggcagtattc aggccgtgag gcttaatctg atgcagaatt
     5701 accgctgttg gtggcatggt tgctctctga tatttggcgt tgtagatcat ttaaaacaac
     5761 acttgctgac cgaccacact aatcccaact tccagactct gaaatgtcgc tggaagaact
     5821 gcgatgcttt tttcactgct aggaaaggat ccaaacagga tgctgcagga catattgaac
     5881 gacatgctga agatgacagc aaaattgatt catgaagttt tttgcctccc acgttgggaa
     5941 gtcattagtt gaactatttt cacattggcc ccccacacag gccactctct tccctttctt
     6001 ggtgaagtaa ggaaggagaa agtggttact agccaggcat acccctagca taagtctggg
     6061 cagctctatg ggatgataaa ttacactttt aagttcttgc tggaggtttt aaatagattt
     6121 agacaaatgt taaggaacca tacttctctg ggacagcatg gcatatagtg atatatgcta
     6181 tttgcgttct ccagatgttt attgaagata cagatcctaa ttggttaccc agtttgaccc
     6241 taatcatatg tatattttat tgatttcagt ttgcaatttt taatttatgt tcttatgatg
     6301 gtttaaacct atagtcaggc ttttaagtac aagtttgttt aagtgccaga ctttgaggat
     6361 cagttttaat ttctccattt gtaatagctg ggtatttaaa ctggaagcaa atagttttct
     6421 ttcttaacaa ttatgtgcag tgtgtgtcac tgttttcttg ctttatagat agagctggct
     6481 ttaagtgcta aaggacacag tagatttttg acaaacagtg gctgctctgc tgactatctt
     6541 ttaggaattc aggaagcaaa tcacatagtg acaagtcctt acagacacca cttctagtaa
     6601 atctctgtaa atgtggatag aaagctcagt gtgaggcagt gcgtagacct aacgtctacc
     6661 tttacatctg ctgttgaacc tgggcactac ctgttacaga tcctgtcagg ctgttgaact
     6721 ggaggtgtac ctttatcttc ctttctagtg tctgaccctg caagcctaat gttggtttga
     6781 acccttttgg tttgttcagt tgccagcctc catctctccc actgtatggc cgtgcctaga
     6841 ccgatggcag ccatcgaata ttcctctggg ctcacggggt gttttccacc cccctgcagc
     6901 aactaagatg gtgggggaga gggggttaga ataaagcatc tgaatacagt tttcaggacc
     6961 tcaagcagac ttcctagaga cttgtttctg agacagttct ttgccttcac ttccctgcta
     7021 gctgggaaag aagagtggag cagagactct gcctggccac tgagaacagc caaattcaca
     7081 aaccctcagt ggggctttgt ttttggattt tctccggact catcagtaaa cctgtagaag
     7141 tgtcgctttc cagccttttg tttctggatc ctcaaaactc agaacgtggc cgggcgtggt
     7201 ggctcacgcc tgtaatccca gcactttggg aggctgaggc aggcagatca cctgaggcta
     7261 ggagttgcag accagcctgg ccaacatggc aaaaccccgt ctctactaaa aatacaaaaa
     7321 gccgggcgtg gtgggcgcct gtaatcccag ctgctcagga ggctgaggca ggagaatcgc
     7381 ttgaacccgg gaggcagaga ttgcagtaag ctgagatcgt gccactgcac tccagcctgg
     7441 tgacagagtg agactccgtc tcaaaaaaaa aaaaaaaaac tcagcttctt cagagagata
     7501 aaattggggg aggagcccag ggccacatac caagctttgg gacatggtgc ctcatgctct
     7561 ctgggattgc agaccatcca ggtctgtctt cgcccctgtt agtgcacata tatccactca
     7621 catgtcttcc ctcaggctat cgggcagggg gacttcacca gggggtttat ggataggctt
     7681 caagagggtc tgtgagcccc cagaaattgt gtgtgagact gagtatgtgt tcttttttcc
     7741 aggaaaggct ccagtggttc ttacttgatc caaaaaatgt caagaattaa tctaggaggc
     7801 cgggcctggt ggctcacacc tgtaatccca gctctttggg aggccgaggc gggtggatca
     7861 ctcaaggtca ggcatttgag accagcctgg ccaacatagt gaaaccccgt ctctattaaa
     7921 aatacaaaaa ttagctgggt gtggtggtat gtgcctgtag tctcagctac tcaggaggct
     7981 gagacaggag aatcacttga accctggagg tagaagttgc agtgagccaa gatcatacta
     8041 ctgcactcca gcctgggcga caagagtgaa actccacctc aaaaaaaaaa aaaaaagagt
     8101 taatctagga gataatgaat ggcctagtac tagataatat atggccccac aagctcttga
     8161 cttctgtcct tggggaaagc cattttgtta accacactag tgagatttac atgatgctta
     8221 atggagaaca gagaagatct tgttgcaaaa ggtgtattaa atatttgtgc tgtttctgta
     8281 tgagattgag aagcttttcc cacctctcac ccctatttcc tataaggata tccagagaag
     8341 ccaaactgtt ctgtgggttt gggaatggtc atttcccggg aaaatgcatc tggatcgatg
     8401 actaaacctg gcccttttct ctgggctgta gtgaagccgc attttcacgc tggctggcag
     8461 tgtgctgaga gcctcgaatg ctctgcggcg tagtgccctt ctgccctgcc tgacgatgta
     8521 tcgaaaagat gagagtgaag gagactttgt gcagcaggaa acgggtaggt gaggtgttgg
     8581 gcagttgtgg gaacttctga gagtattaca gagtggtaga atcggtaaga actctgattt
     8641 ggacttcgct ttggtggaac tgtgtgccta tacctgcctg tgtgtgtgca agtgtgcagg
     8701 ttcctttgta tgtatgtgta cgtgtgggaa cctgtgtttg tcatattttt cttcatttca
     8761 caaaggcttt ttttgaagca gtggcagtat gcctttgttt caagaacaca tgaaattctt
     8821 ttaacaccag attagtgtgt taccccaaat gaacggttct agccctctat taagaaataa
     8881 agggaccata agcattttgg ctgcttatgg ctgtgtgtta ctacttacaa gagtcttgaa
     8941 aattatacag aactttgcct tcttttttta atgtcttcca caatgttgtg actgattata
     9001 accctgtttc ccctcagaga agagctatgg ctcagggatc tgtgttgact ctggcattta
     9061 gtggctttgt gaaggaaaga aaccattaaa tgacctgaca aaaactgact catgtcttta
     9121 aagtagttga agccactttt agaatgttac tctcggttgc ttttgtctaa ttctaatggc
     9181 ttaaagccaa gaaaaccata gtataaatct ttttgtgtac ctatgctagt gtttaaatgg
     9241 cagttcgttg tgataaagta tcagtcactt caagttttct gtgaaagttt ttaattaggt
     9301 taaaaataat tttggcatac gtctctactc agtttataaa gcagttccac accatgcaaa
     9361 caaaactcta acagcaaagg ttatcttgac ctgatgttac ttgaatctga gagaaagtca
     9421 ttacttacta ctgcactcct gcttttgtgg gaaaaatttt cttcttcccc agaagagtta
     9481 acagttgagt gttcagctcc tgacttacct ttaatttaga ggcaatatta ttactgttta
     9541 agtgattatt tgcttaacac aggttttatt ttgtcttttt gctggtagat tatacaaggg
     9601 acaactttag tgatgaggca tgtggatgat ttggtgggag taggtatata cttagtggaa
     9661 tggtttattt tatggaagag aattcattgg aggtgagatt gaagtatatt gtgaagtggg
     9721 atttgaacag cacatatgct ctggtttgct caaataactg cagtttatgc ttacatctaa
     9781 attttgtttc tgttacctaa acgggagctt ctagaattac gaaggccata cctgccacat
     9841 ttataaaata atggttttat ccctgccccc aaatcatcag gttcctcggg tttaagagaa
     9901 gtggtctaat agacaggaat agaagttgtg gtggaggtga tttgggatag actaggtttc
     9961 cttatgcaag tggatatgag ctcctcatag aaaccagacc tactgtatta gacagtaacc
    10021 tctaacctca cctccaagcc caagtatatg gccctgctgg gttacctggt gactacattt
    10081 cccagattca ctctaaattc aaggtagtga cccaaataaa ttgggaaagg agggggtcaa
    10141 ggaggaaaag ctgttgaaaa tctttctcct atttaagaga aatatatgcc ctagagctgc
    10201 tccagcaccc ttggtttctg atttttttaa tattgaatat ggattagaag aatgaaatca
    10261 gatgacacct gactgcaaaa atgtttataa gcaaatagcc ttcttacatt ttggtataaa
    10321 gctgtgaact tcgtaacttt gtaaagcaag atataaagca aatacaagag gaaaataaag
    10381 tacttttact aattga
//
