LOCUS       NM_173531               5691 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 100 (ZNF100), transcript variant
            1, mRNA.
ACCESSION   NM_173531
VERSION     NM_173531.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5691)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5691)
  AUTHORS   Glubb,D.M., Johnatty,S.E., Quinn,M.C.J., O'Mara,T.A., Tyrer,J.P.,
            Gao,B., Fasching,P.A., Beckmann,M.W., Lambrechts,D., Vergote,I.,
            Velez Edwards,D.R., Beeghly-Fadiel,A., Benitez,J., Garcia,M.J.,
            Goodman,M.T., Thompson,P.J., Dork,T., Durst,M., Modungo,F.,
            Moysich,K., Heitz,F., du Bois,A., Pfisterer,J., Hillemanns,P.,
            Karlan,B.Y., Lester,J., Goode,E.L., Cunningham,J.M., Winham,S.J.,
            Larson,M.C., McCauley,B.M., Kjaer,S.K., Jensen,A.,
            Schildkraut,J.M., Berchuck,A., Cramer,D.W., Terry,K.L.,
            Salvesen,H.B., Bjorge,L., Webb,P.M., Grant,P., Pejovic,T.,
            Moffitt,M., Hogdall,C.K., Hogdall,E., Paul,J., Glasspool,R.,
            Bernardini,M., Tone,A., Huntsman,D., Woo,M., Group,A., deFazio,A.,
            Kennedy,C.J., Pharoah,P.D.P., MacGregor,S. and Chenevix-Trench,G.
  CONSRTM   AGO Study Group
  TITLE     Analyses of germline variants associated with ovarian cancer
            survival identify functional candidates at the 1q22 and 19p12
            outcome loci
  JOURNAL   Oncotarget 8 (39), 64670-64684 (2017)
   PUBMED   29029385
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5691)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA241750.1, AK126551.1, AC092364.3 and CN302052.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_173531.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035579.2, SRR1660805.245414.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358296.11/ ENSP00000351042.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DA241750.1         50-107
            59-777              AK126551.1         58-776
            778-3812            AC092364.3         86083-89117         c
            3813-4421           CN302052.1         7-615
            4422-5691           AC092364.3         84204-85473         c
FEATURES             Location/Qualifiers
     source          1..5691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..5691
                     /gene="ZNF100"
                     /note="zinc finger protein 100"
                     /db_xref="GeneID:163227"
                     /db_xref="HGNC:HGNC:12880"
                     /db_xref="MIM:603982"
     exon            1..153
                     /gene="ZNF100"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1779
                     /gene="ZNF100"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 100 (Y1)"
                     /codon_start=1
                     /product="zinc finger protein 100 isoform 1"
                     /protein_id="NP_775802.2"
                     /db_xref="CCDS:CCDS42538.1"
                     /db_xref="GeneID:163227"
                     /db_xref="HGNC:HGNC:12880"
                     /db_xref="MIM:603982"
                     /translation="MDDPRYGMCPLKGASGCPGAERSLLVQSYFEKGPLTFRDVAIEF
                     SLEEWQCLDSAQQGLYRKVMLENYRNLVFLAGIALTKPDLITCLEQGKEPWNIKRHEM
                     VAKPPVICSHFPQDLWAEQDIKDSFQEAILKKYGKYGHDNLQLQKGCKSVDECKVHKE
                     HDNKLNQCLITTQSNIFQCDPSAKVFHTFSNSNRHKIRHTRKKPFKCKKCEKSFCMLL
                     HLTQHKRFHITENSYQCKDCGKAFNWFSTLTTHRRIHTGEKPYKCEECGKAFNRSSHL
                     TTHKIIHTGEKPYRCEECGKAFNRSSHLTTHKRIHTGVKPYKCTECGKAFNRSSHLTT
                     HRIIHTGEKPYKCEECGKAFNQSSTLTTHKITHAGEKPYKCEECGKAFYRFSYLTKHK
                     TSHTGEKFYKCEECGKGFNWSSALTKHKRIHTGEKPYKCEECGKAFNESSNLTTHKMI
                     HTGEKPYKCDECGKAFNRSSQLTAHKMIHTGEKPYKCEECGKAFNRSSTLTKHKITHT
                     GEKSYKWEECGKDFNQSLSLIKQNNSYWRETLQM"
     exon            154..246
                     /gene="ZNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            247..373
                     /gene="ZNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            374..472
                     /gene="ZNF100"
                     /inference="alignment:Splign:2.1.0"
     exon            473..5691
                     /gene="ZNF100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3964..3969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF100"
                     /note="hexamer: AATAAA"
     polyA_site      3993
                     /gene="ZNF100"
                     /note="major polyA site"
     regulatory      4395..4400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF100"
                     /note="hexamer: TATAAA"
     polyA_site      4421
                     /gene="ZNF100"
                     /note="major polyA site"
     regulatory      4819..4824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF100"
                     /note="hexamer: AATAAA"
     polyA_site      4847
                     /gene="ZNF100"
     regulatory      5667..5672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF100"
                     /note="hexamer: AATATA"
     polyA_site      5691
                     /gene="ZNF100"
ORIGIN      
        1 gtctttgtct ctcgctgtag ccggagctcc aggttttgct ctcacttctc tgtgtcttct
       61 gctcctaggg gcctagcctg tgtggccctc tgacctgcag atattgggag atccacagct
      121 aagacgccag gaccccctag aagcctagaa atggatgacc cgaggtatgg aatgtgtcct
      181 ctcaagggag caagtggatg ccctggggct gagaggagtc ttctggtgca gtcttatttt
      241 gaaaaggggc cattgacgtt tagggatgtg gccatagaat tctctctgga ggagtggcaa
      301 tgcctggaca gtgctcagca gggtttgtat aggaaagtga tgttagagaa ctacagaaac
      361 ctggtcttct tggcaggtat tgctctcact aagccagacc tgatcacctg tctggagcaa
      421 ggaaaagagc cctggaatat aaagagacat gagatggtag ccaaaccccc agttatatgt
      481 tctcattttc cccaagacct ttgggcagag caggacatta aagattcttt tcaagaagcg
      541 attctgaaaa aatatggaaa atatggacat gacaatttac agttacaaaa aggctgtaaa
      601 agtgtggatg agtgtaaagt gcacaaagaa catgataaca aattaaacca gtgtttgata
      661 actacccaga gcaacatatt tcaatgtgat ccatctgcaa aagtctttca tacattttca
      721 aattcaaaca gacataagat aagacatact agaaagaaac ctttcaaatg taaaaaatgt
      781 gaaaaatcat tttgcatgct tttacaccta actcaacata aaagatttca tattacagag
      841 aattcctacc aatgtaaaga ttgtggcaaa gccttcaact ggttctcaac ccttactaca
      901 cacaggagaa ttcatactgg agagaaaccc tacaaatgtg aagaatgtgg gaaagcattt
      961 aaccggtcct cacaccttac tacacataag ataattcata ctggagagaa accatacaga
     1021 tgtgaagaat gtgggaaagc ttttaaccgg tcttcacacc ttactacaca taaaagaatt
     1081 catactggag tgaaacccta caaatgtaca gaatgtggca aagcttttaa ccggtcctca
     1141 caccttacta cacacaggat aattcatact ggagagaaac cctacaaatg tgaagaatgt
     1201 ggcaaagcct ttaaccagtc ctcaaccctt actacacata agataactca tgctggagag
     1261 aaaccttaca aatgtgaaga atgtggcaaa gctttttacc gattctcata ccttactaaa
     1321 cataagacaa gtcatactgg agagaaattc tacaaatgtg aagaatgcgg caaaggcttt
     1381 aactggtcct cagccctcac taaacataag agaattcata ctggagagaa accctacaaa
     1441 tgtgaagaat gtggcaaagc ttttaatgag tcctcaaacc ttactaccca taagatgatt
     1501 catactggag agaaacccta caaatgtgac gaatgtggca aagcctttaa ccggtcctca
     1561 caactaactg cacataagat gattcatact ggagagaaac cctacaaatg tgaggaatgt
     1621 ggcaaagctt ttaaccgatc ctcaaccctt actaaacata agataactca tactggagag
     1681 aaatcttaca aatgggaaga atgtggtaaa gactttaacc agtccctaag ccttattaaa
     1741 caaaataact catactggag agaaacccta caaatgtgaa aaatgtggca aagcctttta
     1801 ccagtcctca actcttacta aacataaaaa aattcatact ggagggaact cctgtgactg
     1861 tgaagaatat ggcaaagcct ttaataaatt ctcaattcct aacagacata agataattca
     1921 tactagagag aaattctaca aaccagaaag atgtgacagt gctttgaaaa cacctcaaac
     1981 ttttcaaaac ataaatcata gtgttgagaa atcctagaaa tgtgaagaat gtgataaagt
     2041 tttaaatggt tgtcacactt gattgtaggt aaggtaagtt atactggaga aaacttctac
     2101 atgtgtgaac agtgtgacaa aacttttaac taatgctcac accttcacag gaaagcattt
     2161 atacttgaga aatattgtac aaatataaag actgtgaaaa agccattaat acatgctcac
     2221 atcttactca acatcagaga gttcatactc aataaaaaca taagtgcaac tactgtcaaa
     2281 atatctttaa gaaaatataa gcttttaaag tgaagagtat tttgaagaag aacattgtag
     2341 tagaattgta atatgtttac ttgtatcaca gatcttactg tacacgtttt gtattagagg
     2401 aaacctctga agcagttgct caaactttgt tcaatatcag ggaatttata ttgaaaaaaa
     2461 ctgtgcgaat gtaataaagt tggaaaaata ctttttcaaa aactacagct tagaaaacac
     2521 cagagagttc atactaaaac atatttttgc agatacagga aaaatttttt aaaaatttta
     2581 atcattaagt ctgtaaatat cagagaattt acagtagaaa tatgtaaggc actgatgctt
     2641 caggtatttt actaaatcag agtgctgagt atagaaaata atctaaaact aaaattggta
     2701 aaatatttgt atataacttt aaaagtagaa attttttgca gttattgcat tcaaagtatg
     2761 cttaactttt tgaaaaaatt agattttttg aaaagtgagt aataatgtaa ttcaactctt
     2821 aaattatttc ctgccttttc ttcactccta tttacatgtg aaagcatgtg atcaattgtt
     2881 gctgcatcag atatgagaga ttctttttta ttaggtgagc attatttata aactttgcta
     2941 tgaaaaagac attaaaatat gagatgtatg atgaaaatct aagtgaagag acttttatgg
     3001 ttaacttata atattaagca atgtgtgcgt taggcattca gagtaatatt ctgcattatg
     3061 agaaaactta atttcattta taagtaaatt aaaattagta tattttacta atacttttat
     3121 ataaaatgca gtatattttt taaatttcag attatatgtg atgttaatat attcaacctt
     3181 tttaacatgt taaatactat tgtgcattca gtgaagtgtt attatgccac agacattaac
     3241 ctattccacc ttactcaagg gtgtacgtaa aacatggtaa cagtatacta tttggtaaca
     3301 taatggatta acatctctag taatctcttt tgctagtggc tttgactgca aataagttaa
     3361 agaatattat ttctgtaggt taaatttttg tttttatttt attttatttt tgagaggtag
     3421 tcttgctctg tcacccaggc tggagtgcag tggcacgatc tcggctcact gtaacctcca
     3481 cctcctgggt tcacgcaatt ctcctgcctc agcctcctaa gtagctggga ttacaggcac
     3541 ccaccaccat gcccagctaa tttttgtatt ttagtagaga cagggtttca taatgtaagt
     3601 caagctggtc tcgaactcct gaccttaaat gatttgcctg cctcggcttc ccaaagttct
     3661 gggattacag gcatgagcca ccgtgcccag ccaaatgttt attttattta aatttatttt
     3721 tcttaattat ttggggtaca taatatgagt atatattcat gcaatatatg gcatattttg
     3781 atacaagaat acagtatata ataatcacat cagggtaaat gaggtatcca tcacctctag
     3841 tatttatcct ttgtattaca agcaacccag ttttatactt ttagttattt taaaatgtaa
     3901 aattaaattg ttattgatta cagtgttatt tttatggtca taataaaagt tatgtagaag
     3961 tataataaaa tccctacatt tctgaggcct gaataagtat ttttaaagtt ttctaatatt
     4021 tattttttga gcatgtttcc tgtctgcctg caaacacatg cagacattta gttttgattt
     4081 acatatagtt aaatatatgt tagtctaaag ataaacctta agtgtaagaa aattatagag
     4141 tgagtttgtg tgtatgaatt tgtacctgtt ttccgaagaa aaaagcaata ctgaacaaaa
     4201 caaatcattt taacaagatg actactagaa aactaaaagc ctcaaaaatg ctaaaagaaa
     4261 atgtattctc tgctttgtat tgaatttatt actgtacatt ctgtggctta tagttctgaa
     4321 tctccccatg aaaattctgt ttatacttgc ctggtactca tgatagaccc ctaattattt
     4381 tgtatctttt ttcatataaa tattttacag attatgaagt attcattatg tgagctggtc
     4441 tgtgattata agaataattt ttacaaaatt tagtgcatac aaaattttta aatgtaattc
     4501 cacaattagt gtattaagtt acattttatt tagttagaac acttcatttt gtttttagtt
     4561 ggagaactct atagcccttt agttattttt cttttcactt tttatagttg acataagtaa
     4621 atttatttat tgagtcaatt tgttcaggta agtactaggg aagctttata agtcgtgagg
     4681 atgtttttat atttaaatgt agcaaacata catgacagtt cttgctgtgt aacagatgct
     4741 ccatagtaag ccataagtat tcctgctaaa gttagcttgt aacttcagtt cagagatgga
     4801 aaacatcagt ggtgaagaaa taaaattgat tcttcatgtg gagaggacat agtttccagg
     4861 ctgcaatgct gaatcttgct gaatttaaag agaagttctg catcttttat ttcttaatta
     4921 tcttcagatt tctctgtatt tattatgtgt atccccagct atgtatgcag cacagcccat
     4981 ctcctttttc tgtgttatgg cttcagtttt ctcactgttg tcttaatgcc atttcatttc
     5041 acatggtact ttgtaaattt tgacgagaaa gttggttgtt tttttttttt tttttttttt
     5101 tgagacagag tctcactctt gttgcccaag ctggagtgca gtggtgcaat gtgggctcac
     5161 tgcaacctct gccttccagg ttcaagcaat tatcctgcct cagcctccca agtagctggg
     5221 attacaggca cctgccacca catctggctg aatttttttt tttttaattt tttgtagaga
     5281 cgaagtttca ccatgttggc caggctggtt tcaaactcct gacctcatat gatccacctg
     5341 cctcagcctc ccaaagtgct tggattacag gcataagcca ctgcacccag ctgaaagttg
     5401 gtatttttta atgcactgaa taattgtttt taactggaga gtttggttat caatataact
     5461 ttcggattag ttaagataaa agcatacatt gtccacaggt gagaagatta aatcagaata
     5521 gttgttcttt gttaaaaaaa aaattagatt cttaaagtgt ggcaaacata aaatttgcaa
     5581 gaaaatgtag aaattaaatt tttaagagtt aatggtaagt gaacaatttt aaatttattt
     5641 tttattatgt aacatacttt tattaaaata tatacttata taataaaagt a
//
