LOCUS       NM_015394               4406 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 10 (ZNF10), mRNA.
ACCESSION   NM_015394
VERSION     NM_015394.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4406)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4406)
  AUTHORS   Lorenz,P., Steinbeck,F., Krause,L. and Thiesen,H.J.
  TITLE     The KRAB Domain of ZNF10 Guides the Identification of Specific
            Amino Acids That Transform the Ancestral KRAB-A-Related Domain
            Present in Human PRDM9 into a Canonical Modern KRAB-A Domain
  JOURNAL   Int J Mol Sci 23 (3), 1072 (2022)
   PUBMED   35162997
  REMARK    GeneRIF: The KRAB Domain of ZNF10 Guides the Identification of
            Specific Amino Acids That Transform the Ancestral KRAB-A-Related
            Domain Present in Human PRDM9 into a Canonical Modern KRAB-A
            Domain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4406)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4406)
  AUTHORS   Nishitsuji,H., Sawada,L., Sugiyama,R. and Takaku,H.
  TITLE     ZNF10 inhibits HIV-1 LTR activity through interaction with
            NF-kappaB and Sp1 binding motifs
  JOURNAL   FEBS Lett 589 (15), 2019-2025 (2015)
   PUBMED   26096782
  REMARK    GeneRIF: results indicate that ZNF10 could be involved in a potent
            intrinsic antiretroviral defense
REFERENCE   5  (bases 1 to 4406)
  AUTHORS   Born,N., Thiesen,H.J. and Lorenz,P.
  TITLE     The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is
            responsible for its weaker transcriptional repressor activity
            compared to human ZNF10/Kox1
  JOURNAL   PLoS One 9 (2), e87609 (2014)
   PUBMED   24498343
  REMARK    GeneRIF: Data indicate that Xenopus laevis XFIN-AB displayed
            reduced potency in repression compared to human ZNF10 KRAB-AB.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4406)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   7  (bases 1 to 4406)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
REFERENCE   8  (bases 1 to 4406)
  AUTHORS   Rousseau-Merck,M.F., Hillion,J., Jonveaux,P., Couillin,P.,
            Seite,P., Thiesen,H.J. and Berger,R.
  TITLE     Chromosomal localization of 9 KOX zinc finger genes: physical
            linkages suggest clustering of KOX genes on chromosomes 12, 16, and
            19
  JOURNAL   Hum Genet 92 (6), 583-587 (1993)
   PUBMED   8262519
REFERENCE   9  (bases 1 to 4406)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   10 (bases 1 to 4406)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026786.5, BC024182.2,
            AL110188.1, BE895826.1 and AI972895.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015394.4.
            
            Summary: The protein encoded by this gene contains a C2H2 zinc
            finger, and has been shown to function as a transcriptional
            repressor. The Kruppel-associated box (KRAB) domain of this protein
            is found to be responsible for its transcriptional repression
            activity. RING finger containing protein TIF1 was reported to
            interact with the KRAB domain, and may serve as a mediator for the
            repression activity of this protein. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024182.2, SRR1660805.254984.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248211.11/ ENSP00000248211.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC026786.5         72249-72249         c
            2-1062              BC024182.2         2-1062
            1063-1932           AL110188.1         779-1648
            1933-2216           BC024182.2         1933-2216
            2217-2403           BE895826.1         371-557
            2404-4400           BC024182.2         2404-4400
            4401-4405           AI972895.1         5-9                 c
            4406-4406           BC024182.2         4406-4406
FEATURES             Location/Qualifiers
     source          1..4406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..4406
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="zinc finger protein 10"
                     /db_xref="GeneID:7556"
                     /db_xref="HGNC:HGNC:12879"
                     /db_xref="MIM:194538"
     exon            1..128
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..220
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1909
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="zinc finger protein 10 (KOX 1); zinc finger protein
                     KOX1"
                     /codon_start=1
                     /product="zinc finger protein 10"
                     /protein_id="NP_056209.2"
                     /db_xref="CCDS:CCDS9283.1"
                     /db_xref="GeneID:7556"
                     /db_xref="HGNC:HGNC:12879"
                     /db_xref="MIM:194538"
                     /translation="MDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVML
                     ENYKNLVSLGYQLTKPDVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSVSSRSI
                     FKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQ
                     ERVSESGKYGGNCLLPAQLVLREYFHKRDSHTKSLKHDLVLNGHQDSCASNSNECGQT
                     FCQNIHLIQFARTHTGDKSYKCPDNDNSLTHGSSLGISKGIHREKPYECKECGKFFSW
                     RSNLTRHQLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFS
                     HLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHL
                     ILHQRTHVRVRPYECNECGKSYSQRSHLVVHHRIHTGLKPFECKDCGKCFSRSSHLYS
                     HQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQ
                     RIHVGEETYKCNQCGIIFSQNSPFIVHQIAHTGEQFLTCNQCGTALVNTSNLIGYQTN
                     HIRENAY"
     exon            221..347
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..443
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..4406
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4210..4215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="hexamer: AATAAA"
     polyA_site      4233
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="major polyA site"
     regulatory      4273..4278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="hexamer: ATTAAA"
     polyA_site      4310
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
     regulatory      4376..4381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="hexamer: AATAAA"
     polyA_site      4406
                     /gene="ZNF10"
                     /gene_synonym="KOX1"
                     /note="major polyA site"
ORIGIN      
        1 agactcacct ctgacgccgc tcttcgcgct ccgctggtga atggagtcgc gttctctgtt
       61 ttgctgttgc tgctgccttt gtgacgggat cgctttctcc catcgaacct tctagttgct
      121 tattgcagct ttgtctcctc agcactctgc tgtcactcaa ggaagtatca tcaagaacaa
      181 ggagggcatg gatgctaagt cactaactgc ctggtcccgg acactggtga ccttcaagga
      241 tgtatttgtg gacttcacca gggaggagtg gaagctgctg gacactgctc agcagatcgt
      301 gtacagaaat gtgatgctgg agaactataa gaacctggtt tccttgggtt atcagcttac
      361 taagccagat gtgatcctcc ggttggagaa gggagaagag ccctggctgg tggagagaga
      421 aattcaccaa gagacccatc ctgattcaga gactgcattt gaaatcaaat catcagtttc
      481 cagcaggagc atttttaaag ataagcaatc ctgtgacatt aaaatggaag gaatggcaag
      541 gaatgatctc tggtatttgt cattagaaga agtctggaaa tgtagagacc agttagacaa
      601 gtatcaggaa aacccagaga gacatttgag gcaagtggca ttcacccaaa agaaagtact
      661 tactcaggag agagtctctg aaagtggtaa atatggggga aactgtcttc ttcctgctca
      721 gctagtactg agagagtatt tccataaacg tgactcacat actaaaagtt taaaacatga
      781 tttagttctt aatggtcatc aggacagttg tgcaagtaac agtaatgaat gtggtcaaac
      841 tttctgtcaa aacattcacc ttattcagtt tgcaagaact cacacaggtg ataaatccta
      901 caaatgccct gataatgaca actctcttac tcatggttca tctcttggta tatcaaaggg
      961 catacataga gagaaaccct atgaatgtaa ggaatgtgga aaattcttca gctggcgctc
     1021 taatcttact aggcatcagc ttattcatac tggagaaaaa ccctatgagt gtaaagaatg
     1081 tggaaagtct ttcagccgga gttctcacct cattggacat caaaagaccc atactggtga
     1141 ggaaccctat gaatgtaaag aatgtggaaa atccttcagc tggttctctc accttgttac
     1201 tcatcagaga actcatacag gagacaaact gtacacatgt aatcagtgtg ggaaatcttt
     1261 tgttcatagc tctaggctta ttagacacca gaggacacat actggagaga aaccctatga
     1321 atgtcctgaa tgtgggaaat ctttcagaca gagcacacat ctcattctgc atcagagaac
     1381 ccatgtgaga gtgaggccct atgaatgcaa tgaatgtgga aagtcttaca gccagagatc
     1441 tcaccttgtt gtgcatcata gaattcacac tggactaaaa ccttttgagt gtaaggattg
     1501 tggaaaatgt tttagtcgaa gctctcacct ttattcacat caaagaaccc acactggaga
     1561 gaaaccatat gagtgtcatg attgtggaaa atctttcagc cagagttctg cccttattgt
     1621 gcatcagagg atacacactg gagagaaacc atatgaatgc tgtcagtgtg ggaaagcctt
     1681 catccggaag aatgacctca ttaagcacca gagaattcat gttggagaag agacctataa
     1741 atgtaatcaa tgtggcatta tcttcagcca gaactctcca tttatagttc atcaaatagc
     1801 tcacactgga gagcagttct taacatgcaa tcaatgtggg acagcgcttg ttaatacctc
     1861 taaccttatt ggataccaga caaatcatat tagagaaaat gcttactaat aaatatggga
     1921 atttttcaca aagagcaatg actttatttt gcattggaga actcctggag ataagctgta
     1981 caaattgaat ctatgtggaa atgctttcag tcttgttact atcctattgc acattagaga
     2041 attggtcctg gaagggaaag aaaccacaga ttttatttca gtacacaaat ccatcagatt
     2101 ttcttctttt catgaattcc tacagaagta attggcctga gagcattctt gaccaagtct
     2161 taaatgctag aatctgagaa ggaattatta aataggtgag ttgttgagcg agaacccctt
     2221 catttgaaaa gaaatgagta tgctactata gggagagttg ttgctgagaa ttaagaaatg
     2281 atacagttaa tgcaacaaaa gatggaaaat aatatttcag tcaatatgtc attgttttct
     2341 tgactatgtc tctcttctgg gacatttagt agtgtttggt atgttttatg tgtctggtag
     2401 aaaccatatt ttggttaaca gcaagaaaaa tgcttataat gtagtacaat taaaaacaac
     2461 acatctccac taccagtgct aacccatttt taagtacatt tgcatgtggg caagaattga
     2521 aagtatacag ataattgaac agaattgatt tgttagataa ggagattttg actgagtttt
     2581 atagtctgtt taatgttgct gtaataatta ttttaagaaa cttttaaata ttgtaagagg
     2641 atatctagtt tctctattct accatcaaag aagcttttga gtaccacctg ttaatgagct
     2701 ttcctattct aaattgtttt gggtcacaga gttccacttt ttccactctt attagcactg
     2761 caaaagctcc tgagaattta aaaacacagt aattctctgg atgttaggac ctaggggaac
     2821 attgggcatt tgaacatatc agggagggtc cccattttag tgggaacaag tatttaaaca
     2881 atatttagag caagtgtcct catgtgataa acagagcaca gtccaaagat accctctttc
     2941 tcaaggtagt cttttatctt tataaagaaa gattagtgtt taagagcgta gacttgagct
     3001 agactaccca ggttgaaacc ccactagctg ggtgatcttg aacatgctgc ttagcttctc
     3061 tgtgccaaac ttactgatat cctcatctgt aaattagcga taataatagt acttacctgg
     3121 taggattatg gtgagtatta aatgagtaaa tggaaacagc ttagaatagt gcctgacata
     3181 tattatgttc tctgtagtta ctggctgtga ttattaataa tattgccgca ccctaatatc
     3241 tgttatttaa ttgaaatctg cttgtgtgct tataagaatt tactgagttc tcacttccct
     3301 tacagtcata catggttttt cccttttgcc taaatcagaa ctcaacagcc tgggaaaatc
     3361 actgacaaat agtggatata ggtttcattt ctgaggatca ataaacagct tgtaatgttg
     3421 tatacacatt tattctgttt gtacaaaggt tttccattct atggagagga tcccagtctt
     3481 cagattctct ggtaagttaa taacccacaa aagattcagg aagaggatct attttaattt
     3541 tctctttcat tctataaatc agtctgttgt atatagggac tgaccatgat tctccatttt
     3601 ctggcataaa tattagctgc tcaatgattg attgttgaat gatagatgaa gtattgctga
     3661 agccaaccag agatcttgat ctctctctga ggaaaaaacc tagaaatgat ggttagaatc
     3721 aggagacttg agaactacga ggaacatggc agcctctagc tcatacttgt cgttgtacaa
     3781 ttgagatcaa gtgaattggc cccggtctca cattttcagt gaagtcagac tcagaactag
     3841 gtcctgggtt tcatgtttcc tgctgctctt ctcactgtgt acacaccatg cccacataca
     3901 acatacctat cagaaatggt tttcattaag ggagtagaat agtcacttaa ctggggctct
     3961 taacattgct aataacctgt ggctcaattt cctcaactgt ataatgaggt tactactagt
     4021 atctacctca aagcgttgtc atgtggattg agatgatatg tatgaatcac ataaaagagt
     4081 gcctggcaca tagtaggtgc cattaataat attactattg ttaacacctt aagggtctaa
     4141 cttgtaatga agacagaaat atgtatgagg atgatcactg aaatatttat gacagtgcat
     4201 aatttgcaaa ataaaaaatg tacactagca taatatttgt ggcatatccg tgtaatggaa
     4261 gattatgcag gcattaaaat atgtacacaa aaagtttggt aaaggaaaaa tgctgtcatg
     4321 tgttacaaaa gcatgataaa taattgttaa tatggaataa gctcaaatat gtcaaaataa
     4381 atgtaaaaaa tgagtgttgc ccaaaa
//
