LOCUS       NM_001281775            5281 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens zinc finger MYND-type containing 8 (ZMYND8),
            transcript variant 9, mRNA.
ACCESSION   NM_001281775 XM_005260357
VERSION     NM_001281775.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5281)
  AUTHORS   Tang,K., Yin,T., Deng,B., Wang,M., Ren,Z., Wang,S., Liu,X., Li,H.,
            Wang,J., Du,Y., Zhou,J., Chen,Y. and Wang,Y.
  TITLE     USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast
            cancer cell migration and invasion
  JOURNAL   J Biol Chem 300 (9), 107672 (2024)
   PUBMED   39128723
  REMARK    GeneRIF: USP7 deubiquitinates epigenetic reader ZMYND8 to promote
            breast cancer cell migration and invasion.
REFERENCE   2  (bases 1 to 5281)
  AUTHORS   Guha,D., Singh,V., Nandi,S., Ramos,E.I., Gadad,S.S. and Das,C.
  TITLE     ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in ATRA-Mediated
            Differentiation of Neuroblastoma Cells
  JOURNAL   Biochemistry 63 (12), 1534-1542 (2024)
   PUBMED   38804064
  REMARK    GeneRIF: ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in
            ATRA-Mediated Differentiation of Neuroblastoma Cells.
REFERENCE   3  (bases 1 to 5281)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5281)
  AUTHORS   Adhikary,S., Singh,V., Choudhari,R., Yang,B., Adhikari,S.,
            Ramos,E.I., Chaudhuri,S., Roy,S., Gadad,S.S. and Das,C.
  TITLE     ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal
            differentiation
  JOURNAL   Cell Death Dis 13 (9), 766 (2022)
   PUBMED   36064715
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5281)
  AUTHORS   Dias,K.R., Carlston,C.M., Blok,L.E.R., De Hayr,L., Nawaz,U.,
            Evans,C.A., Bayrak-Toydemir,P., Htun,S., Zhu,Y., Ma,A., Lynch,S.A.,
            Moorwood,C., Stals,K., Ellard,S., Bainbridge,M.N., Friedman,J.,
            Pappas,J.G., Rabin,R., Nowak,C.B., Douglas,J., Wilson,T.E., Guillen
            Sacoto,M.J., Mullegama,S.V., Palculict,T.B., Kirk,E.P.,
            Pinner,J.R., Edwards,M., Montanari,F., Graziano,C., Pippucci,T.,
            Dingmann,B., Glass,I., Mefford,H.C., Shimoji,T., Suzuki,T.,
            Yamakawa,K., Streff,H., Schaaf,C.P., Slavotinek,A.M., Voineagu,I.,
            Carey,J.C., Buckley,M.F., Schenck,A., Harvey,R.J. and Roscioli,T.
  TITLE     De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations
  JOURNAL   Genet Med 24 (9), 1952-1966 (2022)
   PUBMED   35916866
  REMARK    GeneRIF: De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations.
REFERENCE   6  (bases 1 to 5281)
  AUTHORS   Nelson,D., Yoshida,E.M., Paulson,M.S., Hengen,P.N., Ge,D.,
            Kanwar,B., McNally,J., Pang,P.S., Subramanian,G.M.,
            McHutchison,J.G., Urbanek,P., Lawitz,E. and Urban,T.J.
  TITLE     Genome-wide association study to characterize serum bilirubin
            elevations in patients with HCV treated with GS-9256, an HCV NS3
            serine protease inhibitor
  JOURNAL   Antivir Ther 19 (7), 679-686 (2014)
   PUBMED   24503447
REFERENCE   7  (bases 1 to 5281)
  AUTHORS   Miles,R.R., Crockett,D.K., Lim,M.S. and Elenitoba-Johnson,K.S.
  TITLE     Analysis of BCL6-interacting proteins by tandem mass spectrometry
  JOURNAL   Mol Cell Proteomics 4 (12), 1898-1909 (2005)
   PUBMED   16147992
REFERENCE   8  (bases 1 to 5281)
  AUTHORS   Westendorf,J.J. and Koka,S.
  TITLE     Identification of FHOD1-binding proteins and mechanisms of
            FHOD1-regulated actin dynamics
  JOURNAL   J Cell Biochem 92 (1), 29-41 (2004)
   PUBMED   15095401
REFERENCE   9  (bases 1 to 5281)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   10 (bases 1 to 5281)
  AUTHORS   Fossey,S.C., Kuroda,S., Price,J.A., Pendleton,J.K., Freedman,B.I.
            and Bowden,D.W.
  TITLE     Identification and characterization of PRKCBP1, a candidate
            RACK-like protein
  JOURNAL   Mamm Genome 11 (10), 919-925 (2000)
   PUBMED   11003709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC362133.1, DQ368673.1,
            AL022342.7, DR422399.1, BC146802.1 and AI275390.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001281775.2.
            
            Summary: The protein encoded by this gene is a receptor for
            activated C-kinase (RACK) protein. The encoded protein has been
            shown to bind in vitro to activated protein kinase C beta I. In
            addition, this protein is a cutaneous T-cell lymphoma-associated
            antigen. Finally, the protein contains a bromodomain and two zinc
            fingers, and is thought to be a transcriptional regulator. Multiple
            transcript variants encoding several different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (9) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (i) is longer, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225857.1, DQ368673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471951.7/ ENSP00000420095.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DC362133.1         346-374
            30-3217             DQ368673.1         1-3188
            3218-3218           AL022342.7         99092-99092         c
            3219-3734           DQ368673.1         3190-3705
            3735-4221           DR422399.1         206-692
            4222-5038           BC146802.1         2811-3627
            5039-5281           AI275390.1         1-243               c
FEATURES             Location/Qualifiers
     source          1..5281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..5281
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /note="zinc finger MYND-type containing 8"
                     /db_xref="GeneID:23613"
                     /db_xref="HGNC:HGNC:9397"
                     /db_xref="MIM:615713"
     exon            1..43
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..3734
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /note="isoform i is encoded by transcript variant 9; CTCL
                     tumor antigen se14-3; RACK like clone 7; protein kinase
                     C-binding protein 1; predicted protein of HQ2893; zinc
                     finger MYND domain-containing protein 8; cutaneous T-cell
                     lymphoma-associated antigen se14-3; transcription
                     coregulator ZMYND8; MYND-type zinc finger-containing
                     chromatin reader ZMYND8"
                     /codon_start=1
                     /product="MYND-type zinc finger-containing chromatin
                     reader ZMYND8 isoform i"
                     /protein_id="NP_001268704.1"
                     /db_xref="CCDS:CCDS63306.1"
                     /db_xref="GeneID:23613"
                     /db_xref="HGNC:HGNC:9397"
                     /db_xref="MIM:615713"
                     /translation="MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPS
                     PPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVP
                     QDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIE
                     TQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTL
                     EKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCP
                     ECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRA
                     WVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPN
                     SQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
                     RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLS
                     GSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLI
                     SPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYIS
                     DDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGA
                     VKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED
                     HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATAT
                     TSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQK
                     MQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSP
                     LVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNT
                     TGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQ
                     LELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATA
                     PQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGS
                     RETPSSILLGSNQGSVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDE
                     KRGSTRSDHNTSTSTKSLLPKESRLDTFWD"
     exon            44..114
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            115..263
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            264..482
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            483..596
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            597..689
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            690..777
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            778..833
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            834..911
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1027
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1509
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1650
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1803
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2313
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2694
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2885
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2966
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3045
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3285
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3446
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3513
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3597
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..5281
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5124..5129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /note="hexamer: ATTAAA"
     polyA_site      5146
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /note="major polyA site"
     regulatory      5259..5264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /note="hexamer: ATTAAA"
     polyA_site      5281
                     /gene="ZMYND8"
                     /gene_synonym="PRKCBP1; PRO2893; RACK7"
                     /note="major polyA site"
ORIGIN      
        1 ataagtattg acattacaca gtgttaacaa tgcatccaca gagcttggct gaagaggaaa
       61 taaaaacaga acaggaggtg gtagagggca tggatatctc tactcgctcc aaagatcctg
      121 gctctgcaga gagaacagcc cagaaaagaa agttccccag ccctccacat tcttccaatg
      181 gccactcgcc gcaggacaca tcaacaagcc ccattaaaaa gaaaaagaaa cctggcttac
      241 tgaacagtaa caataaggag cagtcagaac taagacatgg tccgttttac tatatgaagc
      301 agccactcac cacagaccct gttgatgttg taccgcagga tggacggaat gatttctact
      361 gctgggtttg tcaccgggaa ggccaagtcc tttgctgtga gctctgtccc cgggtttatc
      421 acgctaagtg tctgagactg acatcggaac cagaggggga ctggttttgt cctgaatgtg
      481 agaaaattac agtagcagaa tgcatcgaga cccagagtaa agccatgaca atgctcacca
      541 ttgaacagtt atcctacctg ctcaagtttg ccattcagaa aatgaaacag ccagggacag
      601 atgcattcca gaagcccgtt ccattggaac agcaccctga ctatgcggaa tacatcttcc
      661 atccaatgga cctttgtaca ttggaaaaga atgcgaaaaa gaaaatgtat ggctgcacag
      721 aagccttcct ggctgatgca aagtggattt tgcacaactg catcatttat aatgggggaa
      781 atcacaaatt gacgcaaata gcgaaagtag tcatcaaaat ctgtgaacat gagatgaatg
      841 aaatcgaagt atgtccagaa tgttatctag ctgcttgcca aaaacgagat aactggtttt
      901 gtgagccttg tagcaatcca catcctttgg tctgggccaa actgaagggg tttccattct
      961 ggcctgcaaa agctctaagg gataaagacg ggcaggtcga tgcccgattc tttggacaac
     1021 atgacagggc ctgggttcca ataaataatt gctacctcat gtctaaagaa attccttttt
     1081 ctgtgaaaaa gactaagagc atcttcaaca gtgccatgca agagatggag gtttacgtgg
     1141 agaacatccg caggaagttt ggggttttta attactctcc atttaggaca ccctacacac
     1201 ccaacagcca gtatcaaatg ctgctcgatc ccaccaaccc cagcgccggc actgccaaga
     1261 tagacaagca ggagaaggtc aagctcaact ttgacatgac ggcatccccc aagatcctga
     1321 tgagcaagcc tgtgctgagt gggggcacag gccgccggat ttccttgtcg gatatgccgc
     1381 gctcccccat gagcacaaac tcttctgtgc acacgggctc cgacgtggag caggatgctg
     1441 agaagaaggc cacgtcgagc cacttcagtg cgagcgagga gtccatggac ttcctggata
     1501 agagcacagc ttcaccagcc tccaccaaga cgggacaagc agggagttta tccggcagcc
     1561 caaagccctt ctctcctcaa ctgtcagctc ctatcacgac gaaaacggac aaaacctcca
     1621 ccaccggcag catcctgaat cttaacctgg atcgaagcaa agctgagatg gatttgaagg
     1681 agctgagcga gtcggtccag caacagtcca cccctgttcc tctcatctct cccaagcgcc
     1741 agattcgtag caggttccag ctgaatcttg acaagaccat agagagttgc aaagcacaat
     1801 taggcataaa tgaaatctcg gaagatgtct atacggccgt agagcacagc gattcggagg
     1861 attctgagaa gtcagatagt agcgatagtg agtatatcag tgatgatgag cagaagtcta
     1921 agaacgagcc agaagacaca gaggacaaag aaggttgtca gatggacaaa gagccatctg
     1981 ctgttaaaaa aaagcccaag cctacaaacc cagtggagat taaagaggag ctgaaaagca
     2041 cgtcaccagc cagcgagaag gcagaccctg gagcagtcaa ggacaaggcc agccctgagc
     2101 ctgagaagga cttttccgaa aaggcaaaac cttcacctca ccccataaag gataaactga
     2161 agggaaaaga tgagacggat tccccaacag tccatttggg cctggactct gattcagaga
     2221 gcgaacttgt catagattta ggagaagacc attctgggcg ggagggtcga aaaaataaga
     2281 aggaacccaa agaaccatct cccaaacagg atgttgtagg taaaactcca ccatccacga
     2341 cggtgggcag ccattctccc ccggaaacac cggtgctcac ccgctcttcc gcccaaactt
     2401 ccgcggctgg cgccacagcc accaccagca cgtcctccac ggtcaccgtc acggccccgg
     2461 cccccgccgc cacaggaagc ccagtgaaaa agcagaggcc gcttttaccg aaggagactg
     2521 ccccggccgt gcagcgggtc gtgtggaact catcaagtaa gtttcaaacg tcctcccaaa
     2581 agtggcacat gcagaagatg cagcgtcagc agcagcagca gcagcagcaa aaccagcagc
     2641 agcagcctca gtcttcccag gggacgagat atcagaccag acaggctgtg aaagctgtcc
     2701 agcagaagga gatcacacag agcccatcca cgtccaccat caccctggtg accagcacac
     2761 agtcatcgcc cctggtcacc agctcggggt ccatgagcac ccttgtgtcc tcagtcaacg
     2821 ctgacctgcc catcgccact gcctcagctg atgtcgccgc tgatattgcc aagtacacta
     2881 gcaaaatgat ggatgcaata aaaggaacaa tgacagaaat atacaacgat ctttctaaaa
     2941 acactactgg aagcacaata gctgagattc gcaggctgag gatcgagata gagaagctcc
     3001 agtggctgca ccagcaagag ctctccgaaa tgaaacacaa cttagagctg accatggcgg
     3061 agatgcggca gagcctggag caggagcggg accggctcat cgccgaggtg aagaagcagc
     3121 tggagttgga gaagcagcag gcggtggatg agaccaagaa gaagcagtgg tgcgccaact
     3181 gcaagaagga ggccatcttt tactgctgtt ggaacaccag ctactgtgac tacccctgcc
     3241 agcaagccca ctggcctgag cacatgaagt cctgcaccca gtcagctact gctcctcagc
     3301 aggaagcgga tgctgaggtg aacacagaaa cactaaataa gtcctcccag gggagctcct
     3361 cgagcacaca atcagcacct tcagaaacgg ccagcgcctc caaagagaag gagacgtcag
     3421 ctgagaaaag caaggagagt ggctcgaccc ttgacctttc tggctccaga gagacgccct
     3481 cctccattct cttaggctcc aaccaaggct ctgttagcaa aaggtgtgac aagcaacctg
     3541 cctatgcccc aaccaccaca gaccaccagc cgcaccccaa ctaccccgcc cagaagtacc
     3601 attcccggag taataaatcc agttggagca gcagtgatga gaagagggga tcgacacgtt
     3661 ccgatcacaa caccagtacc agcacgaaga gcctcctccc gaaagagtct cggctggaca
     3721 ccttctggga ctagcagtga atcgggacac aaaccaccca ccccattggg agaaaaaccc
     3781 agacgccagg aaaagaagaa acaacaaagg caggagaaca gccactttca gacttgaaaa
     3841 tgacaaaacc ctcagttgag cctgagcccc cggcgcgggg gctgctacac tacaggacac
     3901 ccagcatcgg ctttgactgc agactgttca cccacacgag ccctgtgctt ttggtgtaaa
     3961 taatgtacaa tttgtggatg tcattgaatc tagaggactt tccccttttt atatttgtat
     4021 taactttaac ttattaaaaa aaaaaaaaga aaaagaaaaa cgatttaaaa aaaaaaaaaa
     4081 aagcaaccaa ccccaacaac aaaaaagaat gttttggtat tggagaaggg atggtcagtt
     4141 agcctgtctg tcacacgacg gaatggatac tgggcccggg gaccactttc atactcacgt
     4201 cctcatcctt ggatacccag gggagggcga accgttttcg ctcgtgtgtc tgtacgcagc
     4261 atgttgggat cgggagtttc ggcacagact atcccatcaa gccgttggct cctttcagct
     4321 actacgttac cacgttccta aaacgcaagc tctccggacc agacggacac agggagaagc
     4381 tagtttcttt catgtgattg aaatgatgac tctactccta aaagggaaaa aacaatatcc
     4441 ttgtttacag aagagaaaca aacaagcccc actcagctca gtcacaggag agaacacaga
     4501 aagtcttagg atcatgaact ctgaaaaaaa gagaaacctt atctttgctt tgtggttcct
     4561 ttaaacacac tcacacacac ttggtcagag atgctgtgct tcttggaagc aaggactcaa
     4621 aggcaaggtg cacgcagagg acgtttgagt ctgggatgaa gcatgtacgt attatttata
     4681 tgatggaatt tcacgttttt atgtaagcat gaaacacagg cagtatgaga gaaagcaagg
     4741 cccgtcatgc tgtccgtaca ctacgtatgc tgtagagcca ttttgtatgt tgtgtaaaac
     4801 aaaaagcatt gatgaaaaag caaaaggtga tgtatgtata tgagaaaatt aattgtacga
     4861 tatcattcca gtacgttttg ttgtacattt tagtcttgtt tactttctct tcattgttaa
     4921 gaggatgcga actgtacagt ttccagctag ttacccatat tagagaagaa ataagagagt
     4981 attagaagaa aacaggagag aaagaacatt tgtgaattgc agttgtcaaa aaaaaaaaat
     5041 agcctagctg gccttatttg tgaagcataa ttgcttttag catatggaag tattttttca
     5101 cattttcttt gtataaaatt tgtattaaac ttaaatatct ttttgatggt ggtgtttctt
     5161 tgtgactgag ccagtagact cacactatat gcttttttgg gtttgcccgt tccttccccc
     5221 acccccccag ttttttcaga tttctttacc tttttttaat taaactgttt tggaaaaatg
     5281 c
//
