LOCUS       NM_001136046            2600 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger MYND-type containing 15 (ZMYND15),
            transcript variant 1, mRNA.
ACCESSION   NM_001136046
VERSION     NM_001136046.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2600)
  AUTHORS   Wen,Y., Wang,X., Zheng,R., Dai,S., Li,J., Yang,Y. and Shen,Y.
  TITLE     Sequencing of the ZMYND15 gene in a cohort of infertile Chinese men
            reveals novel mutations in patients with teratozoospermia
  JOURNAL   J Med Genet 60 (4), 380-390 (2023)
   PUBMED   35973810
  REMARK    GeneRIF: Sequencing of the ZMYND15 gene in a cohort of infertile
            Chinese men reveals novel mutations in patients with
            teratozoospermia.
REFERENCE   2  (bases 1 to 2600)
  AUTHORS   Kherraf,Z.E., Cazin,C., Lestrade,F., Muronova,J., Coutton,C.,
            Arnoult,C., Thierry-Mieg,N. and Ray,P.F.
  TITLE     From azoospermia to macrozoospermia, a phenotypic continuum due to
            mutations in the ZMYND15 gene
  JOURNAL   Asian J Androl 24 (3), 243-247 (2022)
   PUBMED   35017390
  REMARK    GeneRIF: From azoospermia to macrozoospermia, a phenotypic
            continuum due to mutations in the ZMYND15 gene.
REFERENCE   3  (bases 1 to 2600)
  AUTHORS   Hu,T.Y., Zhang,H., Meng,L.L., Yuan,S.M., Tu,C.F., Du,J., Lu,G.X.,
            Lin,G., Nie,H.C. and Tan,Y.Q.
  TITLE     Novel homozygous truncating variants in ZMYND15 causing severe
            oligozoospermia and their implications for male infertility
  JOURNAL   Hum Mutat 42 (1), 31-36 (2021)
   PUBMED   33169450
  REMARK    GeneRIF: Novel homozygous truncating variants in ZMYND15 causing
            severe oligozoospermia and their implications for male infertility.
REFERENCE   4  (bases 1 to 2600)
  AUTHORS   Hashemi,M.S., Mozdarani,H., Ghaedi,K. and Nasr-Esfahani,M.H.
  TITLE     Could analysis of testis-specific genes, as biomarkers in seminal
            plasma, predict presence of focal spermatogenesis in
            non-obstructive azoospermia?
  JOURNAL   Andrologia 52 (2), e13483 (2020)
   PUBMED   31793700
  REMARK    GeneRIF: Could analysis of testis-specific genes, as biomarkers in
            seminal plasma, predict presence of focal spermatogenesis in
            non-obstructive azoospermia?
REFERENCE   5  (bases 1 to 2600)
  AUTHORS   Ayhan,O., Balkan,M., Guven,A., Hazan,R., Atar,M., Tok,A. and
            Tolun,A.
  TITLE     Truncating mutations in TAF4B and ZMYND15 causing recessive
            azoospermia
  JOURNAL   J Med Genet 51 (4), 239-244 (2014)
   PUBMED   24431330
  REMARK    GeneRIF: Two candidate loci in each family and homozygous
            truncating mutations p.R611X in TAF4B in family 1 and p.K507Sfs*3
            in ZMYND15 in family 2, were identified.
REFERENCE   6  (bases 1 to 2600)
  AUTHORS   Yan,W., Si,Y., Slaymaker,S., Li,J., Zheng,H., Young,D.L.,
            Aslanian,A., Saunders,L., Verdin,E. and Charo,I.F.
  TITLE     Zmynd15 encodes a histone deacetylase-dependent transcriptional
            repressor essential for spermiogenesis and male fertility
  JOURNAL   J Biol Chem 285 (41), 31418-31426 (2010)
   PUBMED   20675388
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091153.10, DB453494.2 and
            AK302181.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2018 this sequence version replaced NM_001136046.2.
            
            Summary: This gene encodes a MYND-containing zinc-binding protein
            with a nuclear localization sequence. A similar gene in mice has
            been shown to act as a testis-specific transcriptional repressor by
            recruiting histone deacetylase enzymes to regulate spatiotemporal
            expression of many haploid genes. This protein may play an
            important role in spermatogenesis. Alternative splicing results in
            multiple transcript variants and protein isoforms. [provided by
            RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000433935.6/
                                                ENSP00000391742.1
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC091153.10        42020-42201         c
            183-191             DB453494.2         1-9
            192-2600            AK302181.1         1-2409
FEATURES             Location/Qualifiers
     source          1..2600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2600
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /note="zinc finger MYND-type containing 15"
                     /db_xref="GeneID:84225"
                     /db_xref="HGNC:HGNC:20997"
                     /db_xref="MIM:614312"
     exon            1..218
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            219..840
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..2477
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger MYND domain-containing protein 15"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 15
                     isoform 1"
                     /protein_id="NP_001129518.1"
                     /db_xref="CCDS:CCDS45584.1"
                     /db_xref="GeneID:84225"
                     /db_xref="HGNC:HGNC:20997"
                     /db_xref="MIM:614312"
                     /translation="MEFVSGYRDEFLDFTALLFGWFRKFVAERGAVGTSLEGRCRQLE
                     AQIRRLPQDPALWVLHVLPNHSVGISLGQGAEPGPGPGLGTAWLLGDNPPLHLRDLSP
                     YISFVSLEDGEEGEEEEEEDEEEEKREDGGAGSTEKVEPEEDRELAPTSRESPQETNP
                     PGESEEAAREAGGGKDGCREDRVENETRPQKRKGQRSEAAPLHVSCLLLVTDEHGTIL
                     GIDLLVDGAQGTASWGSGTKDLAPWAYALLCHSMACPMGSGDPRKPRQLTVGDARLHR
                     ELESLVPRLGVKLAKTPMRTWGPRPGFTFASLRARTCHVCHRHSFEAKLTPCPQCSAV
                     LYCGEACLRADWQRCPDDVSHRFWCPRLAAFMERAGELATLPFTYTAEVTSETFNKEA
                     FLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPV
                     PPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQ
                     SLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
                     SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTW
                     LRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADN
                     CMSWYCNAFIFHLVYKPAQGSGARPAPGPPPPSPTPSAPPAPTRRRRGEKKPGRGARR
                     RK"
     exon            841..1075
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1231
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1392
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1545
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1626
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1743
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1832
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1931
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2085
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2144
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2305
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2600
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /note="hexamer: AATAAA"
     polyA_site      2600
                     /gene="ZMYND15"
                     /gene_synonym="SPGF14"
                     /note="major polyA site"
ORIGIN      
        1 agccgcgctg catgagcctc ccgggcggcc cggtggagag agtcgccgcc agccccggcc
       61 gcgcgcacct gcggggcagc cacccgcgga cgcaccgagc ccggggggcg tggccgcccg
      121 ctgagccggc gagggctcgg gcagccctga cgtcacaacc gcacccgcgc accctccacc
      181 gcgaggtatt taccttcgaa aagtggtggc ggctgcagtc tgggccgggg ccctgtgccg
      241 ctgaagacat ggagtttgtg tctggatacc gggatgagtt ccttgatttc actgcccttc
      301 tcttcggctg gttccgaaag tttgtggcag agcgtggagc tgtagggact agccttgagg
      361 gccgctgccg gcagctggag gcccagatca gaaggctacc ccaggaccct gccctttggg
      421 tgctccatgt cctgcccaac catagtgtgg gcatcagcct ggggcaaggg gcagaaccag
      481 gtcctggacc aggcctgggg actgcctggc tcctgggaga caaccctcca ctccacctgc
      541 gagacctgag cccctacatc agctttgtca gcctagagga tggggaggaa ggggaggagg
      601 aagaggagga agatgaagaa gaagagaaga gagaggacgg gggtgcaggc agcacagaga
      661 aggtggaacc agaggaggac cgggagctag cccctaccag cagggagtcc ccccaggaaa
      721 caaaccctcc aggagagtca gaggaggctg cccgggaggc aggaggtggc aaggatggct
      781 gccgagagga cagggtggag aacgaaacaa gaccccagaa gaggaaggga cagaggagtg
      841 aggctgcccc cctgcacgtt tcctgtctct tacttgtgac ggatgagcat ggcaccatct
      901 tgggcattga tctgctagtg gatggagccc agggaaccgc aagctggggc tcagggacca
      961 aggacctggc tccttgggcc tatgctctcc tctgtcacag catggcctgt cccatgggct
     1021 ctggggatcc ccgaaagccc cgacagctta ctgtgggaga tgcccggctg catcgagagc
     1081 tggagagctt ggtcccaagg ctaggtgtga agttagccaa aaccccaatg cggacatggg
     1141 gtccccggcc aggcttcacc tttgcttccc ttcgtgctcg aacctgccat gtgtgtcaca
     1201 ggcacagctt tgaagcgaag ctgacacctt gcccccagtg tagtgctgtc ttgtattgtg
     1261 gagaggcttg tctccgggct gactggcagc ggtgcccaga tgatgtgagt caccgatttt
     1321 ggtgcccaag gcttgcagcc ttcatggagc gggcaggaga actggcaacc ctgcctttta
     1381 cctacaccgc agaggtgacc agtgaaacct tcaacaaaga ggccttcctg gcctctcggg
     1441 gcctcactcg tggctattgg acccagctca gcatgctgat tccaggcccg ggcttctcca
     1501 gacacccccg aggcaacacg ccatccctca gccttcttcg cggtggagac ccctaccagc
     1561 ttctccaggg agacgggact gccctgatgc ctcctgtgcc cccacatcca ccccggggtg
     1621 tttttggctc atggcaggat tactacacat ggcggggcct cagcttggac tcccccatag
     1681 ccgtgcttct cacctacccg ctgaccgtgt actacgtcat cacccacctg gtgccccagt
     1741 ccttccctga gctcaacatc caaaacaaac agtcactgaa gatccacgtg gtggaggccg
     1801 ggaaggagtt tgaccttgtc atggtgtttt gggagctttt ggtcctgctc ccccatgtgg
     1861 ccctggagct gcagtttgta ggtgatggcc tgccccccga aagcgacgag cagcatttta
     1921 ccctgcagag ggacagcctg gaggtgtctg tccggcctgg ttccggcata tcagcacggc
     1981 ccagctctgg cactaaggag aaagggggcc gcagggacct gcagatcaag gtgtcagcaa
     2041 ggccctacca cctgttccag gggcccaagc ctgacctggt tattggattt aactccgggt
     2101 ttgctctcaa ggatacgtgg ctgaggtctc tgccccggtt acagtccctc cgagtgccag
     2161 ccttcttcac cgagagcagc gagtacagct gtgtgatgga cggccagacc atggcggtgg
     2221 ccactggagg gggcaccagc cctccccagc ccaacccctt ccgctccccc tttcgcctca
     2281 gagcggccga caactgcatg tcctggtact gcaatgcctt catcttccac ctggtttaca
     2341 agcctgctca agggagcggg gcccgcccgg cgcccgggcc cccaccccca tccccaactc
     2401 cctctgctcc tcctgccccc acccgaaggc gccgaggaga aaagaaacct gggcgggggg
     2461 cccgccggcg gaaatgaatg ctgataccct agtagtcccc agctcccaaa cactgaaagg
     2521 aaaacgtgaa aacactcaag gcctaggggg aggacaggtt ggtaaaacat gaaaaggtaa
     2581 ataaaattac ttgtttgaaa
//
