LOCUS       NM_032257               1530 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger MYND-type containing 12 (ZMYND12),
            transcript variant 1, mRNA.
ACCESSION   NM_032257
VERSION     NM_032257.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Dacheux,D., Martinez,G., Broster Reix,C.E., Beurois,J., Lores,P.,
            Tounkara,M., Dupuy,J.W., Robinson,D.R., Loeuillet,C., Lambert,E.,
            Wehbe,Z., Escoffier,J., Amiri-Yekta,A., Daneshipour,A.,
            Hosseini,S.H., Zouari,R., Mustapha,S.F.B., Halouani,L., Jiang,X.,
            Shen,Y., Liu,C., Thierry-Mieg,N., Septier,A., Bidart,M., Satre,V.,
            Cazin,C., Kherraf,Z.E., Arnoult,C., Ray,P.F., Toure,A.,
            Bonhivers,M. and Coutton,C.
  TITLE     Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and
            is required for male fertility and flagellum function
  JOURNAL   Elife 12, 87698 (2023)
   PUBMED   37934199
  REMARK    GeneRIF: Novel axonemal protein ZMYND12 interacts with TTC29 and
            DNAH1, and is required for male fertility and flagellum function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057384.1, BC024186.2, BQ441452.1 and AL136858.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032257.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136858.1, SRR1660807.110068.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372565.8/ ENSP00000361646.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               AK057384.1         246-766
            522-970             BC024186.2         756-1204
            971-971             BQ441452.1         505-505
            972-1530            AL136858.1         1024-1582
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1530
                     /gene="ZMYND12"
                     /note="zinc finger MYND-type containing 12"
                     /db_xref="GeneID:84217"
                     /db_xref="HGNC:HGNC:21192"
     exon            1..135
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1123
                     /gene="ZMYND12"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger, MYND domain containing 12; zinc finger MYND
                     domain-containing protein 12"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 12
                     isoform 1"
                     /protein_id="NP_115633.3"
                     /db_xref="CCDS:CCDS467.1"
                     /db_xref="GeneID:84217"
                     /db_xref="HGNC:HGNC:21192"
                     /translation="MNVIYPLAVPKGRRLCCEVCEAPAERVCAACTVTYYCGVVHQKA
                     DWDSIHEKICQLLIPLRTSMPFYNSEEERQHGLQQLQQRQKYLIEFCYTIAQKYLFEG
                     KHEDAVPAALQSLRFRVKLYGLSSVELVPAYLLLAEASLGLGRIVQAEEYLFQAQWTV
                     LKSTDCSNATHSLLHRNLGLLYIAKKNYEEARYHLANDIYFASCAFGTEDIRTSGGYF
                     HLANIFYDLKKLDLADTLYTKVSEIWHAYLNNHYQVLSQAHIQQMDLLGKLFENDTGL
                     DEAQEAEAIRILTSILNIRESTSDKAPQKTIFVLKILVMFYYLMMNSSKAQEYGMRAL
                     SLAKEQQLDVHEQSTIQELLSLISTEDHPIT"
     exon            136..277
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     exon            278..449
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     exon            450..619
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     exon            620..742
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     exon            743..854
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1000
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1530
                     /gene="ZMYND12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND12"
                     /note="hexamer: TATAAA"
     polyA_site      1325
                     /gene="ZMYND12"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND12"
                     /note="hexamer: ATTAAA"
     polyA_site      1443
                     /gene="ZMYND12"
                     /note="major polyA site"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND12"
                     /note="hexamer: AATAAA"
     polyA_site      1530
                     /gene="ZMYND12"
                     /note="major polyA site"
ORIGIN      
        1 agagaccagc actgctggct gcaccatgaa tgtgatctac ccactggcag tccccaaggg
       61 gcgcagactc tgctgtgagg tgtgcgaagc cccagccgag cgggtgtgcg cggcctgcac
      121 agtcacttat tactgtgggg tggtacatca gaaggctgac tgggacagca tccatgagaa
      181 aatatgtcag ctcttgattc cactgcgcac ttccatgccc ttctacaatt cagaggaaga
      241 acggcagcat ggcctgcagc agctgcagca gcggcagaag tatttgattg aattctgcta
      301 caccatagcc cagaaatacc tctttgaagg gaaacacgaa gatgctgtac cagcagcttt
      361 gcagtccctt cgcttccgtg tgaagctgta tggcctgagc tccgtagagc ttgtgcctgc
      421 ttacctgctg ttggccgagg ccagccttgg tctgggccga atcgttcagg ctgaagaata
      481 tctattccaa gcccagtgga cagtcctcaa atcaactgac tgtagtaatg ccacccactc
      541 tttactgcat cggaatctgg gacttctcta tatagctaag aaaaactatg aagaggcccg
      601 ttatcatctg gccaatgata tttattttgc cagttgtgca tttggaacag aggacattag
      661 gacttcagga ggctacttcc acctggctaa tatattctat gaccttaaaa agttggacct
      721 ggcagacaca ttgtacacca aggtctctga gatctggcat gcatatttga acaatcacta
      781 tcaagtcctc tcacaggctc acatccaaca aatggattta ctgggcaaac tatttgagaa
      841 tgacactggc ttggatgaag cccaagaagc agaagccatt cgcatcctga cttcaatctt
      901 gaacattcga gaatctacat ctgacaaagc cccccaaaaa accatctttg ttctgaagat
      961 cctggtcatg ttttactacc tgatgatgaa ttcttcaaag gcacaggaat atggcatgag
     1021 ggccctcagt ctagccaaag aacaacagct tgatgtccat gagcaaagca ccattcaaga
     1081 gttattaagt ctcatttcaa ctgaagacca tcccattact tagtgaccca tgagctctgc
     1141 atcaagggtt attccagggg ctactgaaga tctaatatat tccagccttg cacaactgct
     1201 ttgaggtact gtagactgct gaagtttcca ccctcttccc ctgggattgc acacatagct
     1261 gttatttttt tcttacacag catattaagg gaatataaag ctttaggcat agaaatcact
     1321 aaaaactgtg tttgtcatga cctttgtact tgatttatca tgactttgta tgactgagta
     1381 atatgtagtc agatcactaa tatggtattt gtaattaaac tacaaatagt ttgtcatttc
     1441 ccagaagtct tccaacgatg catgtttcat acacttttgc taaaggaggg gtaaaggagg
     1501 gggtagggaa taaagctata ttggaacaaa
//
