LOCUS       NM_001370114            3937 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger MYND-type containing 11 (ZMYND11),
            transcript variant 27, mRNA.
ACCESSION   NM_001370114
VERSION     NM_001370114.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3937)
  AUTHORS   Zhang,Z., Xu,L., Hu,Z., Yang,B. and Xu,J.
  TITLE     MicroRNA-196b promotes cell growth and metastasis of ovarian cancer
            by targeting ZMYND11
  JOURNAL   Minerva Med 113 (4), 707-717 (2022)
   PUBMED   32512976
  REMARK    GeneRIF: MicroRNA-196b promotes cell growth and metastasis of
            ovarian cancer by targeting ZMYND11.
REFERENCE   2  (bases 1 to 3937)
  AUTHORS   Devoucoux,M., Fort,V., Khelifi,G., Xu,J., Alerasool,N., Galloy,M.,
            Wong,N., Bourriquen,G., Fradet-Turcotte,A., Taipale,M., Hope,K.,
            Hussein,S.M.I. and Cote,J.
  TITLE     Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60
            histone acetyltransferase complex to the coding region of active
            genes
  JOURNAL   Cell Rep 39 (11), 110947 (2022)
   PUBMED   35705031
  REMARK    GeneRIF: Oncogenic ZMYND11-MBTD1 fusion protein anchors the
            NuA4/TIP60 histone acetyltransferase complex to the coding region
            of active genes.
REFERENCE   3  (bases 1 to 3937)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 3937)
  AUTHORS   Oates,S., Absoud,M., Goyal,S., Bayley,S., Baulcomb,J., Sims,A.,
            Riddett,A., Allis,K., Brasch-Andersen,C., Balasubramanian,M.,
            Bai,R., Callewaert,B., Huffmeier,U., Le Duc,D., Radtke,M.,
            Korff,C., Kennedy,J., Low,K., Moller,R.S., Nielsen,J.E.K., Popp,B.,
            Quteineh,L., Ronde,G., Schonewolf-Greulich,B., Shillington,A.,
            Taylor,M.R., Todd,E., Torring,P.M., Tumer,Z., Vasileiou,G.,
            Yates,T.M., Zweier,C., Rosch,R., Basson,M.A. and Pal,D.K.
  TITLE     ZMYND11 variants are a novel cause of centrotemporal and
            generalised epilepsies with neurodevelopmental disorder
  JOURNAL   Clin Genet 100 (4), 412-429 (2021)
   PUBMED   34216016
  REMARK    GeneRIF: ZMYND11 variants are a novel cause of centrotemporal and
            generalised epilepsies with neurodevelopmental disorder.
REFERENCE   5  (bases 1 to 3937)
  AUTHORS   Li,J., Galbo,P.M. Jr., Gong,W., Storey,A.J., Tsai,Y.H., Yu,X.,
            Ahn,J.H., Guo,Y., Mackintosh,S.G., Edmondson,R.D., Byrum,S.D.,
            Farrar,J.E., He,S., Cai,L., Jin,J., Tackett,A.J., Zheng,D. and
            Wang,G.G.
  TITLE     ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60
            acetyltransferase complex and a PWWP-mediated chromatin association
            mechanism
  JOURNAL   Nat Commun 12 (1), 1045 (2021)
   PUBMED   33594072
  REMARK    GeneRIF: ZMYND11-MBTD1 induces leukemogenesis through hijacking
            NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin
            association mechanism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3937)
  AUTHORS   Ansieau,S. and Leutz,A.
  TITLE     The conserved Mynd domain of BS69 binds cellular and oncoviral
            proteins through a common PXLXP motif
  JOURNAL   J Biol Chem 277 (7), 4906-4910 (2002)
   PUBMED   11733528
  REMARK    GeneRIF: the C-terminal Mynd domain of BS69 (amino acids 516-561)
            or Mynd domains of the Caenorhabditis elegans proteins Bra-1 and
            Bra-2 bind not only to E1A but also to the Epstein-Barr virus EBNA2
            oncoprotein and the Myc-related cellular protein MGA
REFERENCE   7  (bases 1 to 3937)
  AUTHORS   Lo,K.W., Naisbitt,S., Fan,J.S., Sheng,M. and Zhang,M.
  TITLE     The 8-kDa dynein light chain binds to its targets via a conserved
            (K/R)XTQT motif
  JOURNAL   J Biol Chem 276 (17), 14059-14066 (2001)
   PUBMED   11148209
REFERENCE   8  (bases 1 to 3937)
  AUTHORS   Masselink,H. and Bernards,R.
  TITLE     The adenovirus E1A binding protein BS69 is a corepressor of
            transcription through recruitment of N-CoR
  JOURNAL   Oncogene 19 (12), 1538-1546 (2000)
   PUBMED   10734313
  REMARK    GeneRIF: The adenovirus E1A binding protein BS69 is a corepressor
            of transcription through recruitment of N-CoR.
REFERENCE   9  (bases 1 to 3937)
  AUTHORS   Kurozumi,K., Nishita,M., Yamaguchi,K., Fujita,T., Ueno,N. and
            Shibuya,H.
  TITLE     BRAM1, a BMP receptor-associated molecule involved in BMP
            signalling
  JOURNAL   Genes Cells 3 (4), 257-264 (1998)
   PUBMED   9663660
REFERENCE   10 (bases 1 to 3937)
  AUTHORS   Hateboer,G., Gennissen,A., Ramos,Y.F., Kerkhoven,R.M.,
            Sonntag-Buck,V., Stunnenberg,H.G. and Bernards,R.
  TITLE     BS69, a novel adenovirus E1A-associated protein that inhibits E1A
            transactivation
  JOURNAL   EMBO J 14 (13), 3159-3169 (1995)
   PUBMED   7621829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL713922.12, AL731539.7,
            AL589988.7 and AL603831.23.
            
            On Dec 2, 2019 this sequence version replaced NM_001370114.1.
            
            Summary: The protein encoded by this gene was first identified by
            its ability to bind the adenovirus E1A protein. The protein
            localizes to the nucleus. It functions as a transcriptional
            repressor, and expression of E1A inhibits this repression.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (27), as well as variant 6,
            encodes isoform i.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1199624.1,
                                           SRR14038192.3459305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL713922.12        121205-121242
            39-173              AL731539.7         3529-3663
            174-333             AL589988.7         31430-31589
            334-495             AL589988.7         42736-42897
            496-573             AL589988.7         58379-58456
            574-661             AL589988.7         60979-61066
            662-717             AL589988.7         61597-61652
            718-795             AL589988.7         62434-62511
            796-914             AL589988.7         63562-63680
            915-1122            AL589988.7         68307-68514
            1123-1191           AL589988.7         68939-69007
            1192-1464           AL589988.7         69877-70149
            1465-1650           AL589988.7         70444-70629
            1651-3937           AL603831.23        1316-3602
FEATURES             Location/Qualifiers
     source          1..3937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..3937
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="zinc finger MYND-type containing 11"
                     /db_xref="GeneID:10771"
                     /db_xref="HGNC:HGNC:16966"
                     /db_xref="MIM:608668"
     exon            1..38
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            39..173
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1773
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="isoform i is encoded by transcript variant 27; zinc
                     finger MYND domain-containing protein 11; bone
                     morphogenetic protein receptor-associated molecule 1;
                     adenovirus 5 E1A-binding protein"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 11
                     isoform i"
                     /protein_id="NP_001357043.1"
                     /db_xref="CCDS:CCDS91196.1"
                     /db_xref="GeneID:10771"
                     /db_xref="HGNC:HGNC:16966"
                     /db_xref="MIM:608668"
                     /translation="MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRV
                     HGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEIDWETENHDWY
                     CFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSPWQCPVCRSIKKKNTNKQEMGT
                     YLRFIVSRMKERKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTC
                     HELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVD
                     VRFFGHHHQRAWIPSENIQDITVNIHRLHVKRSMGWKKACDELELHQRFLREGRFWKS
                     KNEDRGEEEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKEEPEPETEAVSSSQE
                     IPTMPQPIEKVSVSTQTKKLSASSPRMLHRSTQTTNDGVCQSMCHDKYTKIFNDFKDR
                     MKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVANMQGEMDRKCKQVKEKCKEEF
                     VEEIKKLATQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRT
                     CRRKR"
     exon            174..333
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            334..495
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            496..573
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            574..661
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            662..717
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            718..795
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            796..914
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1122
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1191
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1464
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1650
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..3937
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="hexamer: ATTAAA"
     polyA_site      2838
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="major polyA site"
     regulatory      3675..3680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="hexamer: ATTAAA"
     polyA_site      3693
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
     regulatory      3750..3755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="hexamer: ATTAAA"
     polyA_site      3775
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
ORIGIN      
        1 gcctccctcg ctcaggcgcg accgcggcgt tctctgagct aaagaagtaa acaggtcatg
       61 gcacgtttaa caaaaagacg acaggcggat acaaaagcta tccagcatct ttgggcagcc
      121 attgagatta tacggaacca gaagcagatt gccaacattg accgtattac aaagtatatg
      181 tctcgagtcc acggtatgca ccctaaagag accacccgtc agctgagctt agctgtgaaa
      241 gatggtctta ttgtcgaaac tctaacagtg ggctgcaaag gttcaaaagc tggtattgaa
      301 caagaaggat attggttgcc aggagatgag attgactggg aaacagaaaa tcatgactgg
      361 tattgttttg aatgccattt gcctggagag gtgttgatat gtgacctgtg ttttcgtgtg
      421 tatcattcca agtgtttgtc tgatgagttc aggcttagag acagcagtag tccctggcag
      481 tgcccagttt gcaggagcat taagaagaag aatacaaaca aacaggagat gggcacatac
      541 ctcagattca ttgtctcccg catgaaggag aggaaagtga atgaagggaa ataccgaagt
      601 tatgaagagt tcaaagctga tgcccaattg cttctccaca ataccgtgat tttctatgga
      661 gcagacagtg agcaagctga cattgcgagg atgctatata aagacacatg tcatgagctg
      721 gatgaactgc agctttgcaa gaattgcttt tacttgtcaa atgctcgtcc tgacaactgg
      781 ttctgttatc cttgtatacc taatcatgag ctggtttggg ctaaaatgaa aggttttggg
      841 ttttggccag ccaaagtcat gcagaaagaa gacaatcaag tcgacgttcg cttctttggc
      901 caccaccacc agagggcctg gattccttct gaaaacattc aagatatcac agtcaacatt
      961 catcggctgc acgtgaagcg cagtatgggt tggaaaaagg cctgtgatga gctggagctg
     1021 catcagcgtt tcctacgaga agggagattt tggaaatcta agaatgagga ccgaggtgag
     1081 gaagaggcag aatccagtat ctcctccacc agtaatgagc agctaaaggt cactcaagaa
     1141 ccaagagcaa agaaaggacg acgtaatcaa agtgtggagc ccaaaaagga agaaccagag
     1201 cctgaaacag aagcagtaag ttctagccag gaaataccca cgatgcctca gcccatcgaa
     1261 aaagtctccg tgtcaactca gacaaagaag ttaagtgcct cttcaccaag aatgctgcat
     1321 cggagcaccc agaccacaaa cgacggcgtg tgtcagagca tgtgccatga caaatacacc
     1381 aagatcttca atgacttcaa agaccggatg aagtcggacc acaagcggga gacagagcgt
     1441 gttgtccgag aagctctgga gaagctgcgt tctgaaatgg aagaagaaaa gagacaagct
     1501 gtaaataaag ctgtagccaa catgcagggt gagatggaca gaaaatgtaa gcaagtaaag
     1561 gaaaagtgta aggaagaatt tgtagaagaa atcaagaagc tggcaacaca gcacaagcaa
     1621 ctgatttctc agaccaagaa gaagcagtgg tgctacaact gtgaggagga ggccatgtac
     1681 cactgctgct ggaacacatc ctactgctcc atcaagtgcc agcaggagca ctggcacgcg
     1741 gagcacaagc gcacctgccg ccggaaaaga tgaagctggc ccttcccgga gtcaccccga
     1801 tgattactct tttcagacac agcggttttt gtttccaaga agccaaaatt gtttagaatt
     1861 tgcttcccat tttgcaccag cctttaaaca cttttcgtga agaaattttg cacagtagtt
     1921 taaatctttt gttaatgctc ctccgaagtt tttcaggggg taaaagtaac atcagtggag
     1981 ggtattattt taaataaatt ttaattgaga atttgttgca ttttcagcaa attttaaaac
     2041 atttttaggt tttacagaga ttttaacctt taaacaacag atctttaaaa aacaggtgaa
     2101 tacaagtgag tttaacaaag aaacatttag aatagatctg aatgtaagaa ctacagaact
     2161 gtttcagaaa taaaacatac taccttgatg tgacattttt ttcttaacct tgttgagctg
     2221 gttttgttca gcttaattta ctgttcaaag gcattatctg ttggtcacac cagtgggtat
     2281 atgattgaat ttagggaaca gggttgacac agcagggcta gtcctgcata ttttttctta
     2341 aatatttccc aattgtgttt ttcattattt cttttcaata tataactttt ataacaaatt
     2401 attagctttg atcttgtagt ttaaaattgc agggaactgg ggtaatcttt tactgagctg
     2461 gatcttagag aaaatgaata tttaaatttt aaagtttgca catttcatct ttgtcctaac
     2521 atgagtgctt gtaacaaaat aaacaacaaa aacaaagcca aaaactacct ttatccatat
     2581 gtgaaattat agatgaggca tacgaatttg tttaatgctt cccttccctt cccacatatc
     2641 atctcactgc ctattatctg gtgtcacctc atgtatcgta agttaatact aaaagaagag
     2701 aaagcactta agtttcacag aagccgttat gtttgtagta atgggtcatt gcctactaat
     2761 gaactccatc actgtacaca gaatgaagaa taatgcatgt taattttctt gtattaaaga
     2821 tgccgtgatt tgtaaaaagt ctgtattttg cggaatgtct ggattaagaa gcattaccaa
     2881 taggaatgga tcgatagttg aataatgatt ttttatacat agatatataa aatacagcca
     2941 ggaaaactta aattactttt cttttaaaat atctcacaat ttatgtggta tttttaaaga
     3001 ctgatcttag accaagtcaa attcccattt atcatttagt tattttttga ggttagagaa
     3061 taatttgtac atatttattt agacctttga tatttattaa agcaattact cacaatggaa
     3121 gtgaaagaat caggagaaaa gccttttaaa aagtattctc caggtttgtc agggtcactc
     3181 taaagataaa aatgtaacta agtcttctgt gaaatatcat ccatctaatc ttgatgctgt
     3241 tgcagatggt ggtgacacaa gttaattgac aaactactgc caaatggtgc acaatatttt
     3301 gtaaaaagta cccagtagcc ccatttcata caatgtacct aaattatgca gtaacttggc
     3361 atcatcgttc cctccttgtt gctgtgtaat tagtcagtgt tgccacagtg tgtggcgctg
     3421 atggagatgt cagaaccgag aacacttaac cttctttgat tgtttttcaa gttttaagac
     3481 ttcgatccac ccctatgaga gcaagtaatt gtggaaatat ttttggtgta aaatcattcc
     3541 agagtatgta atatttaact gatagctgca tgaaagtgag attcgtgtta ctttggcttt
     3601 tctgtctctg ttgacacggt tgcacatttc caagttacta cagcgtgaaa actgtgtgtt
     3661 taaaaaaaaa caaaattaaa aaaagagatt gtggcctggt tttgtaaaag ttttaggtaa
     3721 aattacaatt gattgtttta ggaatcatta ttaaaaattt tctgcaaatc ataaagctat
     3781 atcgaggtgt tgagcttagc cactatgcac attgtaatta ttcattgtgg ctgtccagtt
     3841 ctatgatgca ttctggcatt ttgtaagctg ctctgactag caatatatag attcatttaa
     3901 tgtgttaaca ttggttaata aatgtattta aaaaaaa
//
