LOCUS       NM_001370100            4100 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger MYND-type containing 11 (ZMYND11),
            transcript variant 13, mRNA.
ACCESSION   NM_001370100
VERSION     NM_001370100.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4100)
  AUTHORS   Zhang,Z., Xu,L., Hu,Z., Yang,B. and Xu,J.
  TITLE     MicroRNA-196b promotes cell growth and metastasis of ovarian cancer
            by targeting ZMYND11
  JOURNAL   Minerva Med 113 (4), 707-717 (2022)
   PUBMED   32512976
  REMARK    GeneRIF: MicroRNA-196b promotes cell growth and metastasis of
            ovarian cancer by targeting ZMYND11.
REFERENCE   2  (bases 1 to 4100)
  AUTHORS   Devoucoux,M., Fort,V., Khelifi,G., Xu,J., Alerasool,N., Galloy,M.,
            Wong,N., Bourriquen,G., Fradet-Turcotte,A., Taipale,M., Hope,K.,
            Hussein,S.M.I. and Cote,J.
  TITLE     Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60
            histone acetyltransferase complex to the coding region of active
            genes
  JOURNAL   Cell Rep 39 (11), 110947 (2022)
   PUBMED   35705031
  REMARK    GeneRIF: Oncogenic ZMYND11-MBTD1 fusion protein anchors the
            NuA4/TIP60 histone acetyltransferase complex to the coding region
            of active genes.
REFERENCE   3  (bases 1 to 4100)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 4100)
  AUTHORS   Oates,S., Absoud,M., Goyal,S., Bayley,S., Baulcomb,J., Sims,A.,
            Riddett,A., Allis,K., Brasch-Andersen,C., Balasubramanian,M.,
            Bai,R., Callewaert,B., Huffmeier,U., Le Duc,D., Radtke,M.,
            Korff,C., Kennedy,J., Low,K., Moller,R.S., Nielsen,J.E.K., Popp,B.,
            Quteineh,L., Ronde,G., Schonewolf-Greulich,B., Shillington,A.,
            Taylor,M.R., Todd,E., Torring,P.M., Tumer,Z., Vasileiou,G.,
            Yates,T.M., Zweier,C., Rosch,R., Basson,M.A. and Pal,D.K.
  TITLE     ZMYND11 variants are a novel cause of centrotemporal and
            generalised epilepsies with neurodevelopmental disorder
  JOURNAL   Clin Genet 100 (4), 412-429 (2021)
   PUBMED   34216016
  REMARK    GeneRIF: ZMYND11 variants are a novel cause of centrotemporal and
            generalised epilepsies with neurodevelopmental disorder.
REFERENCE   5  (bases 1 to 4100)
  AUTHORS   Li,J., Galbo,P.M. Jr., Gong,W., Storey,A.J., Tsai,Y.H., Yu,X.,
            Ahn,J.H., Guo,Y., Mackintosh,S.G., Edmondson,R.D., Byrum,S.D.,
            Farrar,J.E., He,S., Cai,L., Jin,J., Tackett,A.J., Zheng,D. and
            Wang,G.G.
  TITLE     ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60
            acetyltransferase complex and a PWWP-mediated chromatin association
            mechanism
  JOURNAL   Nat Commun 12 (1), 1045 (2021)
   PUBMED   33594072
  REMARK    GeneRIF: ZMYND11-MBTD1 induces leukemogenesis through hijacking
            NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin
            association mechanism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4100)
  AUTHORS   Ansieau,S. and Leutz,A.
  TITLE     The conserved Mynd domain of BS69 binds cellular and oncoviral
            proteins through a common PXLXP motif
  JOURNAL   J Biol Chem 277 (7), 4906-4910 (2002)
   PUBMED   11733528
  REMARK    GeneRIF: the C-terminal Mynd domain of BS69 (amino acids 516-561)
            or Mynd domains of the Caenorhabditis elegans proteins Bra-1 and
            Bra-2 bind not only to E1A but also to the Epstein-Barr virus EBNA2
            oncoprotein and the Myc-related cellular protein MGA
REFERENCE   7  (bases 1 to 4100)
  AUTHORS   Lo,K.W., Naisbitt,S., Fan,J.S., Sheng,M. and Zhang,M.
  TITLE     The 8-kDa dynein light chain binds to its targets via a conserved
            (K/R)XTQT motif
  JOURNAL   J Biol Chem 276 (17), 14059-14066 (2001)
   PUBMED   11148209
REFERENCE   8  (bases 1 to 4100)
  AUTHORS   Masselink,H. and Bernards,R.
  TITLE     The adenovirus E1A binding protein BS69 is a corepressor of
            transcription through recruitment of N-CoR
  JOURNAL   Oncogene 19 (12), 1538-1546 (2000)
   PUBMED   10734313
  REMARK    GeneRIF: The adenovirus E1A binding protein BS69 is a corepressor
            of transcription through recruitment of N-CoR.
REFERENCE   9  (bases 1 to 4100)
  AUTHORS   Kurozumi,K., Nishita,M., Yamaguchi,K., Fujita,T., Ueno,N. and
            Shibuya,H.
  TITLE     BRAM1, a BMP receptor-associated molecule involved in BMP
            signalling
  JOURNAL   Genes Cells 3 (4), 257-264 (1998)
   PUBMED   9663660
REFERENCE   10 (bases 1 to 4100)
  AUTHORS   Hateboer,G., Gennissen,A., Ramos,Y.F., Kerkhoven,R.M.,
            Sonntag-Buck,V., Stunnenberg,H.G. and Bernards,R.
  TITLE     BS69, a novel adenovirus E1A-associated protein that inhibits E1A
            transactivation
  JOURNAL   EMBO J 14 (13), 3159-3169 (1995)
   PUBMED   7621829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL713922.12, AL731539.7,
            AL589988.7 and AL603831.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 26, 2020 this sequence version replaced NM_001370100.4.
            
            Summary: The protein encoded by this gene was first identified by
            its ability to bind the adenovirus E1A protein. The protein
            localizes to the nucleus. It functions as a transcriptional
            repressor, and expression of E1A inhibits this repression.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (13), as well as variants 1,
            10-12, 14, and 15, encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.638277.1,
                                           SRR11853561.3173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381604.9/ ENSP00000371017.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AL713922.12        121395-121499
            106-240             AL731539.7         3529-3663
            241-400             AL589988.7         31430-31589
            401-562             AL589988.7         42736-42897
            563-640             AL589988.7         58379-58456
            641-733             AL589988.7         59126-59218
            734-821             AL589988.7         60979-61066
            822-877             AL589988.7         61597-61652
            878-955             AL589988.7         62434-62511
            956-1074            AL589988.7         63562-63680
            1075-1282           AL589988.7         68307-68514
            1283-1351           AL589988.7         68939-69007
            1352-1624           AL589988.7         69877-70149
            1625-1810           AL589988.7         70444-70629
            1811-4100           AL603831.23        1316-3605
FEATURES             Location/Qualifiers
     source          1..4100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..4100
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="zinc finger MYND-type containing 11"
                     /db_xref="GeneID:10771"
                     /db_xref="HGNC:HGNC:16966"
                     /db_xref="MIM:608668"
     exon            1..105
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            106..240
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1933
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="isoform a is encoded by transcript variant 13; zinc
                     finger MYND domain-containing protein 11; bone
                     morphogenetic protein receptor-associated molecule 1;
                     adenovirus 5 E1A-binding protein"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 11
                     isoform a"
                     /protein_id="NP_001357029.1"
                     /db_xref="CCDS:CCDS7052.2"
                     /db_xref="GeneID:10771"
                     /db_xref="HGNC:HGNC:16966"
                     /db_xref="MIM:608668"
                     /translation="MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRV
                     HGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEIDWETENHDWY
                     CFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSPWQCPVCRSIKKKNTNKQEMGT
                     YLRFIVSRMKERAIDLNKKGKDNKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKA
                     DAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYP
                     CIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNIHR
                     LHVKRSMGWKKACDELELHQRFLREGRFWKSKNEDRGEEEAESSISSTSNEQLKVTQE
                     PRAKKGRRNQSVEPKKEEPEPETEAVSSSQEIPTMPQPIEKVSVSTQTKKLSASSPRM
                     LHRSTQTTNDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEE
                     KRQAVNKAVANMQGEMDRKCKQVKEKCKEEFVEEIKKLATQHKQLISQTKKKQWCYNC
                     EEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR"
     exon            241..400
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            401..562
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            563..640
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            641..733
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            734..821
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            822..877
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            878..955
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1074
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1282
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1351
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1624
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1810
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..4100
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="hexamer: ATTAAA"
     polyA_site      2998
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="major polyA site"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="hexamer: ATTAAA"
     polyA_site      3853
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
     regulatory      3910..3915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
                     /note="hexamer: ATTAAA"
     polyA_site      3935
                     /gene="ZMYND11"
                     /gene_synonym="BRAM1; BS69; MRD30"
ORIGIN      
        1 gtcgccggct caggcccgag aggcgccggg cggcgggaag gaggcggcac cggaggggag
       61 ggccgggcgc ggcggcggcg gcggtggagg agccggagca taatgctaaa gaagtaaaca
      121 ggtcatggca cgtttaacaa aaagacgaca ggcggataca aaagctatcc agcatctttg
      181 ggcagccatt gagattatac ggaaccagaa gcagattgcc aacattgacc gtattacaaa
      241 gtatatgtct cgagtccacg gtatgcaccc taaagagacc acccgtcagc tgagcttagc
      301 tgtgaaagat ggtcttattg tcgaaactct aacagtgggc tgcaaaggtt caaaagctgg
      361 tattgaacaa gaaggatatt ggttgccagg agatgagatt gactgggaaa cagaaaatca
      421 tgactggtat tgttttgaat gccatttgcc tggagaggtg ttgatatgtg acctgtgttt
      481 tcgtgtgtat cattccaagt gtttgtctga tgagttcagg cttagagaca gcagtagtcc
      541 ctggcagtgc ccagtttgca ggagcattaa gaagaagaat acaaacaaac aggagatggg
      601 cacatacctc agattcattg tctcccgcat gaaggagagg gctatagatc ttaataaaaa
      661 ggggaaggac aataaacacc cgatgtacag gaggctggtg cactcagctg tggacgttcc
      721 caccattcaa gagaaagtga atgaagggaa ataccgaagt tatgaagagt tcaaagctga
      781 tgcccaattg cttctccaca ataccgtgat tttctatgga gcagacagtg agcaagctga
      841 cattgcgagg atgctatata aagacacatg tcatgagctg gatgaactgc agctttgcaa
      901 gaattgcttt tacttgtcaa atgctcgtcc tgacaactgg ttctgttatc cttgtatacc
      961 taatcatgag ctggtttggg ctaaaatgaa aggttttggg ttttggccag ccaaagtcat
     1021 gcagaaagaa gacaatcaag tcgacgttcg cttctttggc caccaccacc agagggcctg
     1081 gattccttct gaaaacattc aagatatcac agtcaacatt catcggctgc acgtgaagcg
     1141 cagtatgggt tggaaaaagg cctgtgatga gctggagctg catcagcgtt tcctacgaga
     1201 agggagattt tggaaatcta agaatgagga ccgaggtgag gaagaggcag aatccagtat
     1261 ctcctccacc agtaatgagc agctaaaggt cactcaagaa ccaagagcaa agaaaggacg
     1321 acgtaatcaa agtgtggagc ccaaaaagga agaaccagag cctgaaacag aagcagtaag
     1381 ttctagccag gaaataccca cgatgcctca gcccatcgaa aaagtctccg tgtcaactca
     1441 gacaaagaag ttaagtgcct cttcaccaag aatgctgcat cggagcaccc agaccacaaa
     1501 cgacggcgtg tgtcagagca tgtgccatga caaatacacc aagatcttca atgacttcaa
     1561 agaccggatg aagtcggacc acaagcggga gacagagcgt gttgtccgag aagctctgga
     1621 gaagctgcgt tctgaaatgg aagaagaaaa gagacaagct gtaaataaag ctgtagccaa
     1681 catgcagggt gagatggaca gaaaatgtaa gcaagtaaag gaaaagtgta aggaagaatt
     1741 tgtagaagaa atcaagaagc tggcaacaca gcacaagcaa ctgatttctc agaccaagaa
     1801 gaagcagtgg tgctacaact gtgaggagga ggccatgtac cactgctgct ggaacacatc
     1861 ctactgctcc atcaagtgcc agcaggagca ctggcacgcg gagcacaagc gcacctgccg
     1921 ccggaaaaga tgaagctggc ccttcccgga gtcaccccga tgattactct tttcagacac
     1981 agcggttttt gtttccaaga agccaaaatt gtttagaatt tgcttcccat tttgcaccag
     2041 cctttaaaca cttttcgtga agaaattttg cacagtagtt taaatctttt gttaatgctc
     2101 ctccgaagtt tttcaggggg taaaagtaac atcagtggag ggtattattt taaataaatt
     2161 ttaattgaga atttgttgca ttttcagcaa attttaaaac atttttaggt tttacagaga
     2221 ttttaacctt taaacaacag atctttaaaa aacaggtgaa tacaagtgag tttaacaaag
     2281 aaacatttag aatagatctg aatgtaagaa ctacagaact gtttcagaaa taaaacatac
     2341 taccttgatg tgacattttt ttcttaacct tgttgagctg gttttgttca gcttaattta
     2401 ctgttcaaag gcattatctg ttggtcacac cagtgggtat atgattgaat ttagggaaca
     2461 gggttgacac agcagggcta gtcctgcata ttttttctta aatatttccc aattgtgttt
     2521 ttcattattt cttttcaata tataactttt ataacaaatt attagctttg atcttgtagt
     2581 ttaaaattgc agggaactgg ggtaatcttt tactgagctg gatcttagag aaaatgaata
     2641 tttaaatttt aaagtttgca catttcatct ttgtcctaac atgagtgctt gtaacaaaat
     2701 aaacaacaaa aacaaagcca aaaactacct ttatccatat gtgaaattat agatgaggca
     2761 tacgaatttg tttaatgctt cccttccctt cccacatatc atctcactgc ctattatctg
     2821 gtgtcacctc atgtatcgta agttaatact aaaagaagag aaagcactta agtttcacag
     2881 aagccgttat gtttgtagta atgggtcatt gcctactaat gaactccatc actgtacaca
     2941 gaatgaagaa taatgcatgt taattttctt gtattaaaga tgccgtgatt tgtaaaaagt
     3001 ctgtattttg cggaatgtct ggattaagaa gcattaccaa taggaatgga tcgatagttg
     3061 aataatgatt ttttatacat agatatataa aatacagcca ggaaaactta aattactttt
     3121 cttttaaaat atctcacaat ttatgtggta tttttaaaga ctgatcttag accaagtcaa
     3181 attcccattt atcatttagt tattttttga ggttagagaa taatttgtac atatttattt
     3241 agacctttga tatttattaa agcaattact cacaatggaa gtgaaagaat caggagaaaa
     3301 gccttttaaa aagtattctc caggtttgtc agggtcactc taaagataaa aatgtaacta
     3361 agtcttctgt gaaatatcat ccatctaatc ttgatgctgt tgcagatggt ggtgacacaa
     3421 gttaattgac aaactactgc caaatggtgc acaatatttt gtaaaaagta cccagtagcc
     3481 ccatttcata caatgtacct aaattatgca gtaacttggc atcatcgttc cctccttgtt
     3541 gctgtgtaat tagtcagtgt tgccacagtg tgtggcgctg atggagatgt cagaaccgag
     3601 aacacttaac cttctttgat tgtttttcaa gttttaagac ttcgatccac ccctatgaga
     3661 gcaagtaatt gtggaaatat ttttggtgta aaatcattcc agagtatgta atatttaact
     3721 gatagctgca tgaaagtgag attcgtgtta ctttggcttt tctgtctctg ttgacacggt
     3781 tgcacatttc caagttacta cagcgtgaaa actgtgtgtt taaaaaaaaa caaaattaaa
     3841 aaaagagatt gtggcctggt tttgtaaaag ttttaggtaa aattacaatt gattgtttta
     3901 ggaatcatta ttaaaaattt tctgcaaatc ataaagctat atcgaggtgt tgagcttagc
     3961 cactatgcac attgtaatta ttcattgtgg ctgtccagtt ctatgatgca ttctggcatt
     4021 ttgtaagctg ctctgactag caatatatag attcatttaa tgtgttaaca ttggttaata
     4081 aatgtattta aaaaaaacta
//
