LOCUS       NM_015896               1774 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger MYND-type containing 10 (ZMYND10),
            transcript variant 1, mRNA.
ACCESSION   NM_015896
VERSION     NM_015896.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Wang,Y., Dan,L., Li,Q., Li,L., Zhong,L., Shao,B., Yu,F., He,S.,
            Tian,S., He,J., Xiao,Q., Putti,T.C., He,X., Feng,Y., Lin,Y. and
            Xiang,T.
  TITLE     ZMYND10, an epigenetically regulated tumor suppressor, exerts
            tumor-suppressive functions via miR145-5p/NEDD9 axis in breast
            cancer
  JOURNAL   Clin Epigenetics 11 (1), 184 (2019)
   PUBMED   31801619
  REMARK    GeneRIF: Study identified ZMYND10 as a tumor suppressor, which is
            downregulated in breast cancer due to its promoter
            hypermethylation, and suggested that ZMYND10 suppresses breast
            cancer metastasis by through the miR145-5p/NEDD9 signaling cascade.
            Erratum:[Clin Epigenetics. 2022 Mar 9;14(1):36. doi:
            10.1186/s13148-022-01256-0.. PMID: 35264219]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Cho,K.J., Noh,S.H., Han,S.M., Choi,W.I., Kim,H.Y., Yu,S., Lee,J.S.,
            Rim,J.H., Lee,M.G., Hildebrandt,F. and Gee,H.Y.
  TITLE     ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic
            pre-assembly of dynein arms
  JOURNAL   PLoS Genet 14 (3), e1007316 (2018)
   PUBMED   29601588
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Zhou,J., Huang,Z., Wang,Z., Liu,S., Grandien,A., Ernberg,I., He,Z.
            and Zhang,X.
  TITLE     Tumor suppressor BLU promotes TRAIL-induced apoptosis by
            downregulating NF-kappaB signaling in nasopharyngeal carcinoma
  JOURNAL   Oncotarget 8 (27), 43853-43865 (2017)
   PUBMED   28029652
  REMARK    GeneRIF: BLU suppressed tumor formation by strengthening the
            antitumor immunity.
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Kurkowiak,M., Zietkiewicz,E., Greber,A., Voelkel,K., Wojda,A.,
            Pogorzelski,A. and Witt,M.
  TITLE     ZMYND10--Mutation Analysis in Slavic Patients with Primary Ciliary
            Dyskinesia
  JOURNAL   PLoS One 11 (1), e0148067 (2016)
   PUBMED   26824761
  REMARK    GeneRIF: A novel frameshift mutation (c.367delC) in ZMYND10, unique
            for Slavic primary ciliary dyskinesia population (PCD), was found
            in homozygous state in two unrelated PCD patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Hesson,L., Bieche,I., Krex,D., Criniere,E., Hoang-Xuan,K.,
            Maher,E.R. and Latif,F.
  TITLE     Frequent epigenetic inactivation of RASSF1A and BLU genes located
            within the critical 3p21.3 region in gliomas
  JOURNAL   Oncogene 23 (13), 2408-2419 (2004)
   PUBMED   14743209
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Liu,X.Q., Chen,H.K., Zhang,X.S., Pan,Z.G., Li,A., Feng,Q.S.,
            Long,Q.X., Wang,X.Z. and Zeng,Y.X.
  TITLE     Alterations of BLU, a candidate tumor suppressor gene on chromosome
            3p21.3, in human nasopharyngeal carcinoma
  JOURNAL   Int J Cancer 106 (1), 60-65 (2003)
   PUBMED   12794757
  REMARK    GeneRIF: BLU may be one of the critical tumor suppressor genes on
            chromosome 3p21.3 involved in the development of nasopharyngeal
            carcinoma
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Agathanggelou,A., Dallol,A., Zochbauer-Muller,S., Morrissey,C.,
            Honorio,S., Hesson,L., Martinsson,T., Fong,K.M., Kuo,M.J.,
            Yuen,P.W., Maher,E.R., Minna,J.D. and Latif,F.
  TITLE     Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU
            in human cancers
  JOURNAL   Oncogene 22 (10), 1580-1588 (2003)
   PUBMED   12629521
  REMARK    GeneRIF: These data suggest a significant role for epigenetic
            inactivation of BLU in the pathogenesis of common human cancers and
            that methylation inactivation of BLU occurs independent of RASSF1A
            in SCLC and neuroblastoma tumours.
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Zariwala,M.A., Knowles,M.R. and Leigh,M.W.
  TITLE     Primary Ciliary Dyskinesia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB036846.1, AK315123.1 and
            BC022186.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015896.3.
            
            Summary: This gene encodes a protein containing a MYND-type zinc
            finger domain that likely functions in assembly of the dynein
            motor. Mutations in this gene can cause primary ciliary dyskinesia.
            This gene is also considered a tumor suppressor gene and is often
            mutated, deleted, or hypermethylated and silenced in cancer cells.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.185210.1,
                                           SRR3476690.752121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231749.8/ ENSP00000231749.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB036846.1         15-21
            8-752               AK315123.1         8-752
            753-1774            BC022186.1         746-1767
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1774
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /note="zinc finger MYND-type containing 10"
                     /db_xref="GeneID:51364"
                     /db_xref="HGNC:HGNC:19412"
                     /db_xref="MIM:607070"
     exon            1..245
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1476
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger MYND domain-containing protein 10; protein BLu;
                     dynein axonemal assembly factor 7; Ciliary dyskinesia,
                     primary, 22; tumor suppressor BLU"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 10
                     isoform 1"
                     /protein_id="NP_056980.2"
                     /db_xref="CCDS:CCDS2825.1"
                     /db_xref="GeneID:51364"
                     /db_xref="HGNC:HGNC:19412"
                     /db_xref="MIM:607070"
                     /translation="MGDLELLLPGEAEVLVRGLRSFPLREMGSEGWNQQHENLEKLNM
                     QAILDATVSQGEPIQELLVTHGKVPTLVEELIAVEMWKQKVFPVFCRVEDFKPQNTFP
                     IYMVVHHEASIINLLETVFFHKEVCESAEDTVLDLVDYCHRKLTLLVAQSGCGGPPEG
                     EGSQDSNPMQELQKQAELMEFEIALKALSVLRYITDCVDSLSLSTLSRMLSTHNLPCL
                     LVELLEHSPWSRREGGKLQQFEGSRWHTVAPSEQQKLSKLDGQVWIALYNLLLSPEAQ
                     ARYCLTSFAKGRLLKLRAFLTDTLLDQLPNLAHLQSFLAHLTLTETQPPKKDLVLEQI
                     PEIWERLERENRGKWQAIAKHQLQHVFSPSEQDLRLQARRWAETYRLDVLEAVAPERP
                     RCAYCSAEASKRCSRCQNEWYCCRECQVKHWEKHGKTCVLAAQGDRAK"
     exon            246..354
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            355..471
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            472..525
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            526..663
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            664..752
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            753..853
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1026
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1152
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1274
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1400
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1774
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1754..1759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /note="hexamer: AGTAAA"
     polyA_site      1774
                     /gene="ZMYND10"
                     /gene_synonym="BLU; CILD22; DNAAF7; FLU"
                     /note="major polyA site"
ORIGIN      
        1 aacccgtttc catggctgcg agaactgacg ctccccaacc gtcccgcaac tgtcctgtcc
       61 cagactttgg caccgtcggg gtccgtcgtc cccgaatgtg acagcatccc caccccggct
      121 gctgcccagg atccgccgga ccccggcctc gatatgggag acctggaact gctgctgccc
      181 ggggaagctg aagtgctggt gcggggtctg cgcagcttcc cgctacgcga gatgggctcc
      241 gaagggtgga accagcagca tgagaacctg gagaagctga acatgcaagc catcctcgat
      301 gccacagtca gccagggcga gcccattcag gagctgctgg tcacccatgg gaaggtccca
      361 acactggtgg aggagctgat cgcagtggag atgtggaagc agaaggtgtt ccctgtgttc
      421 tgcagggtgg aggacttcaa gccccagaac accttcccca tctacatggt ggtgcaccac
      481 gaggcctcca tcatcaacct cttggagaca gtgttcttcc acaaggaggt gtgtgagtca
      541 gcagaagaca ctgtcttgga cttggtagac tattgccacc gcaaactgac cctgctggtg
      601 gcccagagtg gctgtggtgg cccccctgag ggggagggat cccaggacag caaccccatg
      661 caggagctgc agaagcaggc agagctgatg gaatttgaga ttgcactgaa ggccctctca
      721 gtactacgct acatcacaga ctgtgtggac agcctctctc tcagcacctt gagccgtatg
      781 cttagcacac acaacctgcc ctgcctcctg gtggaactgc tggagcatag tccctggagc
      841 cggcgggaag gaggcaagct gcagcagttc gagggcagcc gttggcatac tgtggccccc
      901 tcagagcagc aaaagctgag caagttggac gggcaagtgt ggatcgccct gtacaacctg
      961 ctgctaagcc ctgaggctca ggcgcgctac tgcctcacaa gttttgccaa gggacggcta
     1021 ctcaagcttc gggccttcct cacagacaca ctgctggacc agctgcccaa cctggcccac
     1081 ttgcagagtt tcctggccca tctgacccta actgaaaccc agcctcctaa gaaggacctg
     1141 gtgttggaac agatcccaga aatctgggag cggctggagc gagaaaacag aggcaagtgg
     1201 caggcaattg ccaagcacca gctccagcat gtgttcagcc cctcagagca ggacctgcgg
     1261 ctgcaggcgc gaaggtgggc tgagacctac aggctggatg tgctagaggc agtggctcca
     1321 gagcggcccc gctgtgctta ctgcagtgca gaggcttcta agcgctgctc acgatgccag
     1381 aatgagtggt attgctgcag ggagtgccaa gtcaagcact gggaaaagca tggaaagact
     1441 tgtgtcctgg cagcccaggg tgacagagcc aaatgagggc tgcagttgct gagggccgac
     1501 cacccatgcc aagggaatcc acccagaatg cacccctgaa cctcaagatc acggtccagc
     1561 ctctgccgga gccccagtct ccgcagtgga gagcagagcg ggcggtaaag ctgctgaccg
     1621 atctccctcc tcctcacccc aagtgaaggc tcgagacttc ctgccccacc cagtgggtag
     1681 gccaagtgtg ttgcttcagc aaaccggacc aggagggcca gggccggatg tggggaccct
     1741 cttcctctag cacagtaaag ctggcctcca gaaa
//
