LOCUS       NM_001142684            3283 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger MYM-type containing 5 (ZMYM5), transcript
            variant 3, mRNA.
ACCESSION   NM_001142684
VERSION     NM_001142684.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Lee,S. and Das,H.K.
  TITLE     Transcriptional regulation of the presenilin-1 gene controls
            gamma-secretase activity
  JOURNAL   Front Biosci (Elite Ed) 2 (1), 22-35 (2010)
   PUBMED   20036849
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3283)
  AUTHORS   Pastorcic,M. and Das,H.K.
  TITLE     Analysis of transcriptional modulation of the presenilin 1 gene
            promoter by ZNF237, a candidate binding partner of the Ets
            transcription factor ERM
  JOURNAL   Brain Res 1128 (1), 21-32 (2007)
   PUBMED   17126306
REFERENCE   5  (bases 1 to 3283)
  AUTHORS   Sohal,J., Reiter,A., Goldman,J.M. and Cross,N.C.
  TITLE     Cloning of ZNF237, a novel member of the MYM gene family that maps
            to human chromosome 13q11-->q12
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 24-28 (2000)
   PUBMED   10894931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355001.20, AJ133352.1, BU853478.1 and AL354808.24.
            
            On Nov 22, 2018 this sequence version replaced NM_001142684.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3). There are no
            full-length transcripts representing the exon combination of this
            variant in human; it is predicted based on partial transcript
            alignments, on alignment of the macaque mRNA AB179330.1, and on
            homology support for the encoded protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.469374.1,
                                           SRR3476690.212217.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337963.9/ ENSP00000337034.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL355001.20        31237-31249         c
            14-125              AL355001.20        31125-31236         c
            126-1315            AJ133352.1         1-1190
            1316-1580           BU853478.1         399-663
            1581-3281           AL354808.24        158387-160087       c
            3282-3283           AL354808.24        158385-158386       c
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..3283
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /note="zinc finger MYM-type containing 5"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
     exon            1..200
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     exon            201..268
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     exon            269..770
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2288
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger protein 237; zinc finger protein 198-like 1; zinc
                     finger, MYM-type 5"
                     /codon_start=1
                     /product="zinc finger MYM-type protein 5 isoform 3"
                     /protein_id="NP_001136156.1"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
                     /translation="MEKCSVGGLELTEQTPALLGNMAMATSLMDIGDSFGHPACPLVS
                     RSRNSPVEDDDDDDDVVFIESIQPPSISAPAIADQRNFIFASSKNEKPQGNYSVIPPS
                     SRDLASQKGNISETIVIDDEEDIETNGGAEKKSSCFIEWGLPGTKNKTNDLDFSTSSL
                     SRSKTKTGVRPFNPGRMNVAGDLFQNGEFATHHSPDSWISQSASFPSNQKQPGVDSLS
                     PVALLRKQNFQPTAQQQLTKPAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSF
                     SHKRTQNTRSIICKKDASTKKANVILPVESSKSFQEFYSTSCLSPCENNWNLKKGVFN
                     KSRCTICSKLAEIRHEVSVNNVTHKLCSNHCFNKYRLANGLIMNCCEHCGEYMPSKST
                     GNNILVIGGQQKRFCCQSCINEYKQMMETKSKKLTASENRKRNAFREENEKQLYGSSN
                     TLLKKIEGIPEKKEKTSQLQLSVECGTDTLLIQENVNLPPSSTSTIADTFQEQLEEKN
                     FEDSIVPVVLSADPGTWPRILNIKQRDTLVENVPPQVRNFNFPKDNTGRKFSETYYTR
                     ILPNGEKTTRSWLLYSTSKDSVFCLYCKLFGEGKNQLKNENGCKDWQHLSHILSKHEE
                     SEMHVNNSVKYSKLKSDLKKNKAIDAAEHRLYENEKNDGVLLLYT"
     exon            771..864
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1150
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1316
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1529
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..3283
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /note="hexamer: AATAAG"
     polyA_site      3283
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /note="major polyA site"
ORIGIN      
        1 gcctcctcac cagcgcgaaa agccgggact ggacctcgcg gagttgtgct tgtcgccgaa
       61 gcggggtggg cttgttcgtt ccgcgcagcc gcagccagaa ccgggtgacg cttatccccg
      121 ctgtctttcc agtccagggc cgctgagagt gggggtggct gggagcagcg cagcctccgg
      181 aggaggaggc ggaggccgag gaccaggaat caccttcaag cctatgtcgt gaggctttgg
      241 cagaaattaa gaaggaaata tctccattgt tcattggcat ggaaaaatgt tcagtgggag
      301 gattagagtt gactgaacag actcctgctt tattagggaa tatggccatg gcaactagtc
      361 tcatggacat aggggattca tttggtcatc cagcttgtcc tttagtcagt agatctagga
      421 actcaccagt ggaagatgat gatgatgatg atgatgttgt gtttattgaa tctatacaac
      481 ctccttcaat ttctgctcca gcaatagctg atcaaagaaa cttcatattt gcatcatcaa
      541 aaaatgaaaa gcctcaagga aattattctg taattcctcc ttcttcaaga gatttggcat
      601 ctcagaaagg aaatataagt gagacaattg ttattgatga tgaagaggac atagaaacaa
      661 atggaggagc agagaaaaag tcttcctgtt ttatcgaatg gggacttcct ggaactaaaa
      721 acaaaaccaa cgatttggat ttctccactt ccagtctttc aagaagtaag accaagactg
      781 gagtaagacc ttttaaccct ggtagaatga atgtggcagg agacttattt cagaatggag
      841 aatttgcaac tcatcatagt cctgattctt ggatctccca gtcagcttca tttcccagta
      901 atcagaaaca gccaggggtg gattctttat caccagtggc cttacttcgt aagcagaatt
      961 tccagcctac agcccaacaa caacttacta aaccagctaa aatcacttgt gcaaattgca
     1021 aaaagccttt acagaaggga cagacagctt atcaacgaaa aggatcagct cacctctttt
     1081 gctctaccac ctgcctttct tccttctctc ataaacgtac tcaaaacaca cgaagcataa
     1141 tatgtaaaaa agatgcatct acaaagaagg ctaatgtcat tcttccagta gaatcaagca
     1201 aatccttcca agaattttat agtacatctt gtttgtctcc ctgtgaaaac aactggaatc
     1261 ttaaaaaagg agtttttaat aagtcaagat gtacaatttg tagtaaatta gcagagattc
     1321 gccatgaagt cagcgtaaat aatgtaacac ataaactgtg cagtaaccat tgctttaata
     1381 agtacagatt ggccaatggt ctaataatga actgctgtga acactgtgga gagtacatgc
     1441 ctagtaagag tactggaaac aacatcctgg tgattggagg tcagcagaag agattttgct
     1501 gccaaagttg tattaacgaa tataaacaga tgatggaaac aaaatcaaaa aaattaacag
     1561 catcagaaaa tagaaaaagg aatgctttta gagaagaaaa tgagaaacaa ttatatggat
     1621 cgtcaaatac acttttgaaa aaaatagagg gaatcccaga aaaaaaggaa aagacttcac
     1681 agctacagct ttcagtagaa tgtggcacgg atacattact gatccaagag aatgtgaatt
     1741 tacctccttc ttccacgtca accatagctg atacatttca agagcaactg gaagagaaaa
     1801 attttgaaga ctccattgta ccagttgtgc tttccgcaga tccaggtacg tggccccgaa
     1861 ttttgaatat taaacaacgg gacactcttg ttgaaaatgt tccgcctcaa gtaagaaatt
     1921 ttaactttcc aaaagataat acagggagga agttttcaga aacttattat acacggattc
     1981 ttccaaatgg tgaaaaaacc actagatcct ggttacttta ttcaacctca aaagattctg
     2041 tgttttgtct atattgcaaa ctctttgggg aaggaaaaaa tcaactgaaa aatgaaaatg
     2101 ggtgcaaaga ttggcaacat ttatcacata ttcttagtaa acatgaagaa agtgaaatgc
     2161 acgtcaacaa tagtgttaag tactcaaaat taaaatctga tctgaaaaaa aataaagcta
     2221 ttgatgctgc agaacacaga ttatatgaaa atgagaaaaa tgatggtgtg ctgttgttgt
     2281 acacgtaata tacctgagtt gttttttggc atgatgatca gaatcttaca ttactcagaa
     2341 aacatctgtc ctgcaatagt cagtactatt gtgttgtaag tctcctctac agagtaactt
     2401 gcagcagttc cttagcaata agtatgatag caaataaata gcaaagaatg tttccattct
     2461 aaatctaaaa ctaattagat tcaatcatca ttaggcaatg acttcattag gcaatgaaga
     2521 ttaacaatag gtaattgtta atcttcaaaa tctatcaatt tacacctatt taaaaattgg
     2581 catttaatga ctgccatttg atgggtttgg ttaatattct gttcttggcc gggcgcaatg
     2641 gctcacgcct gtaatccaag aactttggga ggctcaggcg ggtagatcaa ttgaggtcag
     2701 aagttcaaga ccagcctggc caacgtggca aaacctcgtc tttactaaaa atacaaaaat
     2761 tagccaggtg tggtggcaca cacctgtagt cccagctact caggaggctg aggcaggaga
     2821 atcgcttgaa cccaggaggc agaggttgca gtgagctgag attgcaccac tgcagtccag
     2881 cctgagcaac agagcgagag tcagtctcaa aagaaagaaa aatattatgt tctaattacc
     2941 ttgaaagagg aaagaaaggc ttgaattgat caataccagt ttgaataaga tacttatgtg
     3001 aacaagcatt ctcaacatta ttattaaagt aaaactactc agtttacaga atgggatctg
     3061 aaactacagc tttttgctat taaaccaaat acttgtgatc tactttgttt gagcaaaaca
     3121 gcattatttg ttatgttaat gatggttaat ttccatttta ttggttttat gtttatttta
     3181 atttgtaaat gttttagcat ttattattgt atgtgaacta tatttaccta ttttatgttg
     3241 ataaaaatat aaaaaatatt aaaataagta tatattaagt taa
//
