LOCUS       NM_005095               7366 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger MYM-type containing 4 (ZMYM4), transcript
            variant 1, mRNA.
ACCESSION   NM_005095 XM_375716
VERSION     NM_005095.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7366)
  AUTHORS   Moon,S.W., Son,H.J., Chae,J., Yoo,N.J., An,C.H. and Lee,S.H.
  TITLE     Expression and Mutation Alterations of ZMYM4 Gene in Gastric and
            Colonic Cancers
  JOURNAL   Appl Immunohistochem Mol Morphol 29 (8), 570-575 (2021)
   PUBMED   33938481
  REMARK    GeneRIF: Expression and Mutation Alterations of ZMYM4 Gene in
            Gastric and Colonic Cancers.
REFERENCE   2  (bases 1 to 7366)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7366)
  AUTHORS   Cibis,H., Biyanee,A., Dorner,W., Mootz,H.D. and Klempnauer,K.H.
  TITLE     Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as
            novel B-MYB binding proteins
  JOURNAL   Sci Rep 10 (1), 8390 (2020)
   PUBMED   32439918
  REMARK    GeneRIF: Characterization of the zinc finger proteins ZMYM2 and
            ZMYM4 as novel B-MYB binding proteins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7366)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7366)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   6  (bases 1 to 7366)
  AUTHORS   Shchors,K., Yehiely,F., Kular,R.K., Kotlo,K.U., Brewer,G. and
            Deiss,L.P.
  TITLE     Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated
            region binds AUF1 and heat shock protein 27
  JOURNAL   J Biol Chem 277 (49), 47061-47072 (2002)
   PUBMED   12356764
  REMARK    GeneRIF: regulates apoptosis by altering mRNA turnover and CDIR
            inhibits apoptosis by acting as a competitive inhibitor of AUF1,
            preventing AUF1 from binding to its targets
REFERENCE   7  (bases 1 to 7366)
  AUTHORS   Smedley,D., Hamoudi,R., Lu,Y.J., Cooper,C. and Shipley,J.
  TITLE     Cloning and mapping of members of the MYM family
  JOURNAL   Genomics 60 (2), 244-247 (1999)
   PUBMED   10486218
REFERENCE   8  (bases 1 to 7366)
  AUTHORS   Sohal,J., Chase,A., Goldman,J.M. and Cross,N.C.
  TITLE     Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 306-307 (1999)
   PUBMED   10449923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590434.16, BG499626.1, CD653525.1, BC012093.1, AB007885.1,
            BU683493.1 and AL356362.21.
            
            On May 17, 2019 this sequence version replaced NM_005095.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.48256.1,
                                           SRR1660807.244047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314607.11/ ENSP00000322915.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL590434.16        154258-154515
            259-441             BG499626.1         2-184
            442-1007            CD653525.1         78-643
            1008-5493           BC012093.1         329-4814
            5494-7244           AB007885.1         4356-6106
            7245-7252           BU683493.1         18-25               c
            7253-7366           AL356362.21        80539-80652
FEATURES             Location/Qualifiers
     source          1..7366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..7366
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /note="zinc finger MYM-type containing 4"
                     /db_xref="GeneID:9202"
                     /db_xref="HGNC:HGNC:13055"
                     /db_xref="MIM:613568"
     exon            1..377
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..4985
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     death inhibiting RNA; zinc finger protein 262; zinc finger
                     MYM-type protein 4; zinc finger, MYM-type 4"
                     /codon_start=1
                     /product="zinc finger MYM-type protein 4 isoform 1"
                     /protein_id="NP_005086.2"
                     /db_xref="CCDS:CCDS389.1"
                     /db_xref="GeneID:9202"
                     /db_xref="HGNC:HGNC:13055"
                     /db_xref="MIM:613568"
                     /translation="MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHN
                     LTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKDNLV
                     SSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRE
                     NSKETFSGKEKNRDLTYEREKRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTP
                     ETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKIKDEP
                     DNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPA
                     TAVRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSC
                     SKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
                     AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQ
                     SKKFCSSSCITAYKQKSAKITPCALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYR
                     VKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSS
                     VVPLSQGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSV
                     VKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCKIEKIVKE
                     TVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFC
                     CEECMSKYTVLFYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDP
                     PSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQGAVPT
                     VTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTED
                     TPSQPQIIVVPVPVPVFVPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTES
                     IEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKDQGS
                     TYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDS
                     FDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIVAVEPRSLIQGAFQGCSVSGMT
                     LKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEP
                     GCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFE
                     NGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQLGAYSPIV
                     LLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEP
                     DKLTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQ
                     PERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD"
     exon            378..423
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            424..945
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1007
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1178
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1263
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1519
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1694
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1907
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2058
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2174
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2450
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2601
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2774
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2925
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3066
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3104
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3249
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3368
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3537
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3591
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3771
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3866
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..4038
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4134
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4286
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4398
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4647
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4777
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     exon            4778..7366
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5467..5472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /note="hexamer: AATAAA"
     polyA_site      5493
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /note="major polyA site"
     regulatory      6740..6745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /note="hexamer: AATAAA"
     polyA_site      6762
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
     regulatory      7228..7233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
                     /note="hexamer: AATAAA"
     polyA_site      7252
                     /gene="ZMYM4"
                     /gene_synonym="CDIR; MYM; ZNF198L3; ZNF262"
ORIGIN      
        1 gatttggtga tccctttaag aaaccgcagg cggaggaatt tctctgagag aaaataatcc
       61 tactcacggg gccccttgga ggccattaac cccccgagtc ccggccccca ccccgtcccc
      121 gggcaggccc tcccgcccac gcgcggaccc gtgggatctc agaagctgcg gcccggcgcg
      181 cggcatccgc cccctcccca ctctcggcgc aaggcccggc cgggtccggg gaagctgccg
      241 cgaggcggcc gtgcctgcag tgtgggcggg ggccgggggg ccgagaggta ccgccgccac
      301 cgcgcgggga gccgcagcgg ttccgagcgg ggcccaacat ggcggagaga gaggtggagt
      361 ccggcccccg aaagaggttt gaacaaaaaa gtggtgcagt ttttgatgaa attgtagaga
      421 actgtggtgg tatcatggat acagaaatgt ctgaagatat agaccacaac ttaactccta
      481 cccttgacag catgtcttat ggaatgccga atcaaacagg atctgaaaat tcattgctgg
      541 atgaagatga ttattttttg aactctgggg atcttgcagg aattccagtc gttggtagtg
      601 acaatgagga tgaacaggat tttagttcaa aggacaatct tgtttcttca attcatactg
      661 atgatagctt ggaagtagag agaagagtca cacagcatga atcagacaat gaaaatgaaa
      721 tacaaattca aaataagtta aaaaaagact ttcctaaaca atttgatcag gtttctgtct
      781 ttaaatcaat acggaaagat tttagtctag taagagaaaa cagcaaagag acattttctg
      841 gaaaggagaa aaatagagac ctaacttatg aacgtgaaaa acggttggat aaaccccata
      901 aagatttgga ttcaaggttg aaaagcagtt tttttgataa agcagctaat caagttgaag
      961 aaacattaca tacccattta ccacaaaccc cagaaacaaa ctttagggat tccagctacc
     1021 catttgccaa taaagaatcc attggttcgg aactggggaa ttcctttgca tcaaatatta
     1081 gaattaaaga agaacctttg gatgatgagt atgacaaagc aatggcacca cagcagggac
     1141 tactagacaa aataaaagat gaacctgaca atgctcaaga gtatagtcat ggccaacagc
     1201 aaaaaactca agagggggaa ctgaaaatta gtgctgtgtt ttcagtcagt ggcagccctc
     1261 ttgctccaca gttgactact ggctttcagc cctcactggc gtcatctggc atgaataaaa
     1321 tgcttccttc agttccagcc acagctgttc gagtttcctg ttctggttgt aaaaaaatcc
     1381 tccagaaggg gcaaactgct tatcagagga aagggtctac tcagctattc tgctccacac
     1441 tgtgcctcac tggatataca gttccacctg cccgcccacc gcctcctctc accaagaaaa
     1501 cttgttcaag ttgctcaaaa gacattttaa atccaaagga tgtgatcagt gcccagtttg
     1561 aaaacaccac cactagtaaa gatttttgca gtcagtcatg tttgtcaaca tatgaactga
     1621 aaaaaaaacc tattgttacc ataaatacaa atagtatttc aaccaaatgc agcatgtgtc
     1681 agaagaatgc tgttattcga catgaagtta attaccagaa tgtggtccat aaactttgca
     1741 gtgatgcctg cttctctaag tttcgttctg ctaacaacct caccatgaac tgttgtgaga
     1801 actgtggggg ttactgttac agtgggtcgg gacaatgcca catgcttcag atagagggac
     1861 agtctaagaa gttttgtagt tcatcgtgta tcacggcata caagcagaaa tcagccaaaa
     1921 ttacaccgtg tgcgctttgc aaatcattga gatcctcagc agaaatgatt gaaaatacca
     1981 atagcttggg gaagacagag cttttctgtt ctgttaattg cttatctgct tacagagtta
     2041 aaatggttac ttctgcaggt gtacaagttc agtgtaacag ttgtaaaacc tcagcaattc
     2101 ctcagtatca cctagccatg tcagatggaa gtatacgcaa cttctgcagc tacagctgtg
     2161 tggtagcttt ccagaattta ttcaacaaac caactggaat gaattcttca gtagtgccct
     2221 tgtctcaggg ccaagtaatt gtaagcatcc ccacaggttc cacagtgtca gccggaggag
     2281 gtagcacatc tgctgtttct cccacctcca tcagtagctc tgctgcagct ggtctccagc
     2341 gtctcgctgc ccagtcccag catgttgggt ttgcacgaag tgttgtgaaa ctcaaatgtc
     2401 aacactgtaa ccgtcttttt gccacaaaac cagaacttct tgactataag ggcaaaatgt
     2461 ttcagttctg tggcaagaat tgttctgatg aatataagaa aataaataat gtaatggcaa
     2521 tgtgtgaata ttgtaaaatt gagaaaattg taaaggagac tgttcggttc tcaggtgctg
     2581 acaagtcatt ctgtagtgaa ggttgcaaat tgctttataa acatgacttg gcaaaacgct
     2641 ggggaaatca ctgtaaaatg tgcagttatt gtttacagac atctcccaaa ttggtacaga
     2701 ataatttagg agggaaagtg gaagagttct gttgtgaaga atgcatgtcc aaatatacag
     2761 ttttgttcta tcagatggcc aaatgtgatg cttgtaagcg acagggtaaa ctcagtgagt
     2821 ccttgaaatg gcgaggggaa atgaaacatt tctgtaacct gctttgtatc ttgatgttct
     2881 gtaatcagca aagtgtatgt gacccgcctt cacaaaataa tgcagcaaat atttccatgg
     2941 ttcaagctgc ttcagcagga cccccatctc tgagaaaaga ttcgactcca gttatagcca
     3001 atgtagtatc attggcaagt gcccctgctg ctcagcctac agtgaattct aacagtgtct
     3061 tacaaggtgc agttccaaca gtaacagcga aaatcatcgg tgatgcaagt actcaaacag
     3121 atgccctgaa actgccacct tcccaacctc caaggctttt gaagaacaaa gctttattat
     3181 gcaaacccat cacacagact aaagccacct cttgcaaacc acatacccaa aacaaagaat
     3241 gccagacaga agacactcca agtcagcccc agattattgt ggtgccagtt cccgtaccag
     3301 tgtttgttcc catacctctt cacctttata ctcaatatgc tccagtccca tttggaattc
     3361 cagttccaat gcctgtccct atgcttattc catcttcaat ggatagtgaa gataaagtca
     3421 cagagagtat tgaagacatt aaagaaaagc ttcccacaca tccatttgaa gctgatctcc
     3481 ttgagatggc agaaatgatt gcagaagatg aagagaagaa gactctatct cagggagagt
     3541 cccaaacttc tgaacacgaa ctctttctag acaccaagat atttgaaaaa gaccaaggaa
     3601 gtacatacag tggtgatctt gaatcagagg cagtatctac tccacatagc tgggaggaag
     3661 agctgaatca ctatgcctta aagtcaaatg ctgtgcaaga ggctgattca gaattgaagc
     3721 agttctcaaa aggggaaact gaacaggacc tggaagcaga ttttccatca gactcctttg
     3781 acccacttaa taaaggacag ggaatccagg cacgttcccg aacaagacga cgacacagag
     3841 atggcttccc ccaacccaga cgaagaggac ggaagaagtc tatagtggct gtggagccca
     3901 ggagtcttat tcaaggagcc tttcaaggct gctcagtgtc cgggatgaca ctgaaataca
     3961 tgtatggggt aaatgcttgg aagaactggg ttcagtggaa aaatgccaag gaagagcagg
     4021 gggatctaaa atgtggaggg gttgaacagg cctcatctag cccacgttct gaccccttag
     4081 gaagtactca agaccatgca ctctctcaag aatcctcaga gccaggctgt agagtccgct
     4141 ctatcaagct gaaggaagac attctgtcct gcacttttgc tgagttgagt ttgggcttat
     4201 gccagtttat ccaagaggtg cggagaccaa atggtgaaaa atatgatcca gacagtatct
     4261 tatacttgtg ccttggaatt caacagtacc tgtttgaaaa tggtagaata gataacattt
     4321 ttactgagcc ctattccaga tttatgattg aacttaccaa actcttgaaa atatgggaac
     4381 ctacaatact tcctaatggt tacatgttct ctcgcattga ggaagagcat ttgtgggagt
     4441 gcaaacagct gggcgcttac tcaccaatcg tccttttaaa caccctcctt ttcttcaata
     4501 ccaaatactt ccaactaaag aatgttactg agcacttgaa gctttccttt gcccatgtga
     4561 tgagacggac caggactctg aagtacagta ccaagatgac atatctgagg ttcttcccac
     4621 ctttacagaa gcaggagtca gaaccagata aactgactgt tggcaagagg aaacgaaatg
     4681 aagatgatga ggttccagtg ggggtggaga tggcagagaa tactgacaat ccactaagat
     4741 gcccagtccg actttatgag ttttacctgt caaaatgttc tgaaagtgtg aagcaaagga
     4801 atgatgtgtt ttaccttcaa cctgagcgct cctgtgtccc gaatagcccc atgtggtact
     4861 ccacattccc gatagaccct ggaaccctgg acaccatgtt aacacgtatt ctcatggtga
     4921 gggaggtaca tgaagaactt gccaaagcca aatctgaaga ctctgatgtt gaattatcag
     4981 attaaaacgg aagtgaggtt cttattttca tacatattgg tatgcaccaa actgtgaatg
     5041 catccagctg ttggaaaatg atgtataagt ctaagtcctc ttgacttgac cataagatca
     5101 tggaaaacag atgacttgtg aaccccacag tgtggatgtg caaatgaaaa ttgaaggaaa
     5161 gaatatgaac tgagaaatgt tctttggcag tgatatagtt cttagacatc ttcagaatga
     5221 ctaatttctc cgagtggtgc ataatcttat tttgtttggg agtaacaaat cgtggaatat
     5281 ttttaaggaa aactgttgta taaaacttta ccatagtaac cttagacctt agagaggtag
     5341 ctttggagtg aaactttggc tgcaataggc tactttggca agccctccgt aaaagtcaga
     5401 ggagagatca gtacagagct aagagtgaca tcaaatgagg actgtgggac ccagatttga
     5461 agacccaata aaaatactca actttttaaa aaagatagtg aagtggtctt gattgatttt
     5521 gattttcact gccaagccaa tcatgtgaag gacagaagct tttgccatgg gcccctcaca
     5581 tcagggaaaa tgaccttcac tgctgttaac agtaatgtgt ccctttcatt ttctggatca
     5641 agccttctca gcggtgggtc tggatgtggg taaactaagg taaaggggat gatattccac
     5701 aaactaatta tgcacacaga aaatctgtgg agcctatcag accccaagtg tcttgaaatg
     5761 tttgtagaaa cccactaaaa tgccccttct ctgggtgtgg gcccttattg cagctgtctc
     5821 acagcctgag ctgtggtaca gagaaatggg ggttctcctt ttattttcat tttttttccc
     5881 caatggcagc ttttctcccg ttgttttacc ttcctatttc ccaaacagtt cctcttattt
     5941 tgtcttttgc accagtttct ggaggccctt gtcatttcaa aaaggatagt ctcttttctt
     6001 actctggcaa acctgtgagt gattccacaa agatacagta ttacttagct atctgaatta
     6061 tgatagaaaa ggtcctagtt aggttcctat ataaagcatt tggaagatga ccttgttgcc
     6121 cttgaaactt gaaaataggg attctggggt gaggatacaa agacattgtc ttgcatatcc
     6181 ataagcaggt cttagagcat tattccaaac tctagctgtt tcagtagttc tatgaggatt
     6241 gcaagtcata ggtgtgtgtg gcatatcagt ccatctccct catctccatt ctcagtttct
     6301 tccccacaaa atttggaatc aaagctttta tgacgtttgc caattgcaga acttcttcag
     6361 ctaaggttaa tttgacgcta tgataaaact gagagatgtc aaaaagcctc ttagaaattt
     6421 taatcttgaa agacttttca gggtatctca ttttttaggt gggggtggca ggtgtatttc
     6481 ttttttaaca aataaaaggc atttaagtaa aactaaaatg aaaaaagtag gccttctgac
     6541 attgtgtact tggtggttct gtccctctgc ctgtaacaaa tctcattttt gttaccaaga
     6601 actgtatgaa agaagtaaat ccaccccgat tctgtatgat taattccatc tgtgtttgtc
     6661 atttctgact ggaaaacttc ttactccata ccttgttcga tatggaggac aaataattgg
     6721 attgtctgat aagtctgcca ataaactatc cagaaatagc aagtgtaata gtccccacta
     6781 tacgaatttt atggtttgta taaacactaa cattttcccc ttctgtagtt gtatgaaaaa
     6841 acaaatattg ttagcatagt agataaattg ttatgaaata ccagaaaaaa aaatctgtat
     6901 cttttactga gaacacccaa tacccagata aatgactgta tcaggatttc atttgcatgt
     6961 tagtccacag agttgcccag aaccctaaat ttattcataa gagaaaatat tgattaatta
     7021 ttggtcattc ctcataagtg tagctgttga tgtgtgcgtc tgattattgc ttttttaatt
     7081 ttatgaaaat tgtgtaaaat tacatttttt ttccagggga gaaaaaaaca tcaaacaaaa
     7141 acatctaaat catccttttt gttctttttc agtttttaac cacttttagg ttttcccctt
     7201 acagaaacca cagaaatatt cccttagaat aaaatagtat atttgtattt gatgggtgag
     7261 ttcttcttct ttacgtctta aaagaatttg aaatctcttt ttctgattga ccttattggt
     7321 atgacccagc aattagtaaa attacaaaga aagagagcag tttccg
//
