LOCUS       NM_201599               5536 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger MYM-type containing 3 (ZMYM3), transcript
            variant 1, mRNA.
ACCESSION   NM_201599
VERSION     NM_201599.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5536)
  AUTHORS   Hiatt,S.M., Trajkova,S., Sebastiano,M.R., Partridge,E.C.,
            Abidi,F.E., Anderson,A., Ansar,M., Antonarakis,S.E., Azadi,A.,
            Bachmann-Gagescu,R., Bartuli,A., Benech,C., Berkowitz,J.L.,
            Betti,M.J., Brusco,A., Cannon,A., Caron,G., Chen,Y., Cochran,M.E.,
            Coleman,T.F., Crenshaw,M.M., Cuisset,L., Curry,C.J., Darvish,H.,
            Demirdas,S., Descartes,M., Douglas,J., Dyment,D.A., Elloumi,H.Z.,
            Ermondi,G., Faoucher,M., Farrow,E.G., Felker,S.A., Fisher,H.,
            Hurst,A.C.E., Joset,P., Kelly,M.A., Kmoch,S., Leadem,B.R.,
            Lyons,M.J., Macchiaiolo,M., Magner,M., Mandrile,G., Mattioli,F.,
            McEown,M., Meadows,S.K., Medne,L., Meeks,N.J.L., Montgomery,S.,
            Napier,M.P., Natowicz,M., Newberry,K.M., Niceta,M., Noskova,L.,
            Nowak,C.B., Noyes,A.G., Osmond,M., Prijoles,E.J., Pugh,J.,
            Pullano,V., Quelin,C., Rahimi-Aliabadi,S., Rauch,A., Redon,S.,
            Reymond,A., Schwager,C.R., Sellars,E.A., Scheuerle,A.E.,
            Shukarova-Angelovska,E., Skraban,C., Stolerman,E., Sullivan,B.R.,
            Tartaglia,M., Thiffault,I., Uguen,K., Umana,L.A., van Bever,Y., van
            der Crabben,S.N., van Slegtenhorst,M.A., Waisfisz,Q.,
            Washington,C., Rodan,L.H., Myers,R.M. and Cooper,G.M.
  TITLE     Deleterious, protein-altering variants in the transcriptional
            coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay
            phenotype
  JOURNAL   Am J Hum Genet 110 (2), 215-227 (2023)
   PUBMED   36586412
  REMARK    GeneRIF: Deleterious, protein-altering variants in the
            transcriptional coregulator ZMYM3 in 27 individuals with a
            neurodevelopmental delay phenotype.
REFERENCE   2  (bases 1 to 5536)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5536)
  AUTHORS   Afshar,H., Khamse,S., Alizadeh,F., Delbari,A., Najafipour,R.,
            Bozorgmehr,A., Khazaei,M., Adelirad,F., Alizadeh,A., Kowsari,A. and
            Ohadi,M.
  TITLE     Evolving evidence on a link between the ZMYM3 exceptionally long
            GA-STR and human cognition
  JOURNAL   Sci Rep 10 (1), 19454 (2020)
   PUBMED   33173136
  REMARK    GeneRIF: Evolving evidence on a link between the ZMYM3
            exceptionally long GA-STR and human cognition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5536)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5536)
  AUTHORS   Alizadeh,F., Moharrami,T., Mousavi,N., Yazarlou,F., Bozorgmehr,A.,
            Shahsavand,E., Delbari,A. and Ohadi,M.
  TITLE     Disease-only alleles at the extreme ends of the human ZMYM3
            exceptionally long 5' UTR short tandem repeat in bipolar disorder:
            A pilot study
  JOURNAL   J Affect Disord 251, 86-90 (2019)
   PUBMED   30909162
  REMARK    GeneRIF: The ZMYM3 'exceptionally long' 5' UTR STR findings may
            alter our perspective of disease pathogenesis in psychiatric
            disorders, and set an example in which the low frequency alleles at
            the extreme short and long ends of the human STRs are, at least in
            part, a result of natural selection against these alleles and their
            unambiguous link to major human disorders.
REFERENCE   6  (bases 1 to 5536)
  AUTHORS   Beever,C., Lai,B.P., Baldry,S.E., Penaherrera,M.S., Jiang,R.,
            Robinson,W.P. and Brown,C.J.
  TITLE     Methylation of ZNF261 as an assay for determining X chromosome
            inactivation patterns
  JOURNAL   Am J Med Genet A 120A (3), 439-441 (2003)
   PUBMED   12838571
REFERENCE   7  (bases 1 to 5536)
  AUTHORS   Hakimi,M.A., Dong,Y., Lane,W.S., Speicher,D.W. and Shiekhattar,R.
  TITLE     A candidate X-linked mental retardation gene is a component of a
            new family of histone deacetylase-containing complexes
  JOURNAL   J Biol Chem 278 (9), 7234-7239 (2003)
   PUBMED   12493763
REFERENCE   8  (bases 1 to 5536)
  AUTHORS   Scheer,M.P., van der Maarel,S., Kubart,S., Schulz,A., Wirth,J.,
            Schweiger,S., Ropers,H. and Nothwang,H.G.
  TITLE     DXS6673E encodes a predominantly nuclear protein, and its mouse
            ortholog DXHXS6673E is alternatively spliced in a developmental-
            and tissue-specific manner
  JOURNAL   Genomics 63 (1), 123-132 (2000)
   PUBMED   10662551
REFERENCE   9  (bases 1 to 5536)
  AUTHORS   Smedley,D., Hamoudi,R., Lu,Y.J., Cooper,C. and Shipley,J.
  TITLE     Cloning and mapping of members of the MYM family
  JOURNAL   Genomics 60 (2), 244-247 (1999)
   PUBMED   10486218
REFERENCE   10 (bases 1 to 5536)
  AUTHORS   van der Maarel,S.M., Scholten,I.H., Huber,I., Philippe,C.,
            Suijkerbuijk,R.F., Gilgenkrantz,S., Kere,J., Cremers,F.P. and
            Ropers,H.H.
  TITLE     Cloning and characterization of DXS6673E, a candidate gene for
            X-linked mental retardation in Xq13.1
  JOURNAL   Hum Mol Genet 5 (7), 887-897 (1996)
   PUBMED   8817323
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA539831.1, AB002383.1 and
            CB305871.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_201599.2.
            
            Summary: This gene is located on the X chromosome and is subject to
            X inactivation. It is highly conserved in vertebrates and most
            abundantly expressed in the brain. The encoded protein is a
            component of histone deacetylase-containing multiprotein complexes
            that function through modifying chromatin structure to keep genes
            silent. A chromosomal translocation (X;13) involving this gene is
            associated with X-linked cognitive disability. Several
            alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002383.1, SRR11853567.32020.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314425.9/ ENSP00000322845.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               DA539831.1         66-609
            545-5535            AB002383.1         501-5491
            5536-5536           CB305871.1         19-19               c
FEATURES             Location/Qualifiers
     source          1..5536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..5536
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /note="zinc finger MYM-type containing 3"
                     /db_xref="GeneID:9203"
                     /db_xref="HGNC:HGNC:13054"
                     /db_xref="MIM:300061"
     exon            1..112
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            113..798
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..4244
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 261; zinc finger MYM-type protein 3; zinc
                     finger, MYM-type 3"
                     /codon_start=1
                     /product="zinc finger MYM-type protein 3 isoform 1"
                     /protein_id="NP_963893.1"
                     /db_xref="CCDS:CCDS14409.1"
                     /db_xref="GeneID:9203"
                     /db_xref="HGNC:HGNC:13054"
                     /db_xref="MIM:300061"
                     /translation="MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRG
                     WAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGT
                     LAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEE
                     ETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAH
                     PSLPGDGLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPND
                     EDFVPFRPRRSPRMSLRSSVSQRAGRSAVGTKMTCAHCRTPLQKGQTAYQRKGLPQLF
                     CSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQ
                     QQRPIPQSGDPADATRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANKGLKTNC
                     CDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNF
                     EMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTV
                     YQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFK
                     RLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYC
                     SQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIR
                     HFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPESKPQTPSQTKVENSNTVRTPEE
                     NGNLGKIPVKTRSAPTAPTPPPPPPPATPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQ
                     TEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVE
                     TIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFG
                     PARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQD
                     LPRTMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKGD
                     ELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYL
                     LENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYS
                     PFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAPVR
                     QRKGRDTGPGKRKREDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYL
                     QPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD"
     exon            799..842
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            843..909
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1204
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1382
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1601
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1752
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1868
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1955
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2106
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2279
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2445
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2543
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2703
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2816
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2991
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3138
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3242
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3411
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3563
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3678
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3933
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4051
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     exon            4052..5536
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5517..5522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /note="hexamer: AATAAA"
     polyA_site      5536
                     /gene="ZMYM3"
                     /gene_synonym="DXS6673E; MYM; XFIM; XLID112; ZNF198L2;
                     ZNF261"
                     /note="major polyA site"
ORIGIN      
        1 aaaggggccg cgacccctgt cccggctgct agggagggag gtagagaagg agcgcggggc
       61 cgtcgctgtc tgcagttcta ggcttgtagc ctttgcacta accctgccgc agtacatatc
      121 cagccatact catggacccc agtgatttcc ccagtccatt tgacccattg accctgccag
      181 agaagcccct ggctggagac ctaccagtag acatggaatt tggagaggat ctactggaat
      241 cccagactgc cccaactcga ggatgggccc cccctggccc ttctccatcc tcgggagccc
      301 tggacctgct tgatacccct gctggcctgg aaaaagaccc tggagtcctg gatggagcca
      361 ctgagttgct ggggctgggg gggctgctct ataaagcccc ctctcccccg gaggtggacc
      421 acggtcctga gggaaccctg gcatgggatg caggagatca gaccctagag cctggaccag
      481 ggggccagac ccctgaggtg gtaccacctg atccaggggc tggggcaaat tcctgttcac
      541 ctgaggggct actagagcct ttggctccag attctccaat aacactgcag tccccacata
      601 ttgaagagga ggagaccacc tccatagcta ctgcaagaag gggctcccct gggcaggagg
      661 aggagcttcc ccaagggcag ccacagagcc caaatgcccc gcctagccct tcagtgggag
      721 agactctggg ggatggaatc aacagttctc agaccaaacc tgggggctct agcccccctg
      781 cacatccttc cttgccagga gatggcctga ctgcgaaggc gagtgagaag ccgcctgaac
      841 ggaagagaag cgagcgcgtt aggagagcag aacctccaaa acctgaggtt gtagattcca
      901 ctgagagcat tccagtgtca gatgaggatt ctgatgccat ggtagatgac cccaatgatg
      961 aggactttgt gccattccgg ccccggcgct ctcctcgcat gtccctacgc tcaagtgtgt
     1021 cacaaagggc cgggcgctct gcagtgggca ccaagatgac ttgtgcacat tgccggacac
     1081 cactgcagaa ggggcagact gcctatcagc gcaaggggct gcctcagctc ttctgctcgt
     1141 catcctgcct caccactttc tccaagaagc cctcgggcaa aaagacctgt accttctgca
     1201 agaaggagat ctggaacacc aaggactcgg ttgtggcgca gactggttct ggaggctcct
     1261 tccatgagtt ctgcacatcc gtctgtctct ccctgtatga ggcccagcag cagcgcccga
     1321 tcccccagtc tggggatccc gccgacgcta ctcgctgcag catatgccag aagactggag
     1381 aggtcctgca cgaggtcagc aatggcagcg tggtacaccg gctctgcagc gattcttgct
     1441 tctccaaatt ccgggccaac aagggactga aaaccaactg ttgtgaccag tgtggggctt
     1501 acatctacac caagaccggg agtcctggcc ctgagctcct cttccacgag ggccaacaaa
     1561 agcggttctg caacacaacc tgcttggggg cgtacaagaa gaaaaacaca cgtgtgtacc
     1621 catgtgtctg gtgcaagacc ctgtgtaaga actttgagat gctatcacat gtggatcgta
     1681 atggcaagac cagcttgttc tgttccctgt gctgtaccac ttcttacaaa gtgaagcagg
     1741 cagggctcac tggccctccc cgaccctgca gcttctgccg ccgcagcctc tctgacccct
     1801 gttactacaa caaggttgac cgcacagtct accagttctg cagccccagc tgctggacca
     1861 agttccagcg cacaagccct gaggggggca ttcacctgag ctgtcactac tgtcacagcc
     1921 tcttcagtgg caagcctgag gtcttggact ggcaggacca agtgttccag ttctgctgcc
     1981 gtgattgctg tgaggacttc aagcggcttc ggggtgtggt gtcccagtgt gagcactgtc
     2041 ggcaggagaa actcttgcat gagaaactcc gattcagcgg agtggagaaa agcttctgca
     2101 gcgaaggctg tgtgctgctg tacaaacagg acttcactaa gaagctgggc ttgtgctgta
     2161 tcacttgtac ttactgctcc cagacctgcc agcgcggagt caccgagcaa ctggatggca
     2221 gcacctggga cttctgcagt gaggactgta agagcaagta cctgctgtgg tactgcaagg
     2281 ctgcccggtg ccatgcgtgt aagcgccagg ggaagctgct ggagaccatc cactggcgtg
     2341 ggcagatccg tcatttctgc aaccagcagt gtcttctgcg tttctatagc cagcagaacc
     2401 aacccaacct ggatacccag agtgggcccg agagcctcct gaacagtcag tctcctgagt
     2461 caaaacccca gacaccctct caaaccaaag tggagaacag caacacagtg aggaccccag
     2521 aggaaaatgg gaatttgggc aagatccctg tgaagacccg atcagctccc actgctccca
     2581 cccctccacc cccaccaccc ccagcaacac cccgcaaaaa caaggctgcc atgtgtaagc
     2641 cactgatgca gaatcggggc gtctcctgca aggtggagat gaagtccaaa ggaagtcaaa
     2701 cagaagagtg gaagccacag gtgatcgtgc tgcccatccc agtgcccatc ttcgtgccag
     2761 tgcctatgca tctgtactgc cagaaagtcc cggtgccttt ctcgatgcct atcccggtgc
     2821 ctgtgcccat gttcttgccc actaccttgg agagcacaga caagattgta gagaccattg
     2881 aggagctgaa ggtgaagatc ccttccaacc ccttggaggc cgacatcctg gctatggcag
     2941 aaatgattgc agaggctgag gagttagaca aggcctcatc tgacctttgt gatcttgtga
     3001 gcaaccagag tgcagaggga ctcctggaag actgtgacct gtttgggcct gctcgagatg
     3061 atgtcctggc catggcagtc aagatggcca atgtcttgga tgagcctggg caagacttgg
     3121 aggcagactt ccctaagaat cctctggaca ttaatcccag tgtagacttc ctctttgatt
     3181 gtggcctggt agggcctgag gatgtgtcta ctgaacaaga ccttccccga accatgagga
     3241 agggtcaaaa gcggctggtg ctttccgaaa gctgctcccg ggactccatg agcagtcagc
     3301 ctagttgtac cgggctcaac tattcatatg gtgtcaatgc ttggaagtgc tgggtgcagt
     3361 caaaatatgc caatggagaa accagcaagg gtgatgagct gcgctttggc cccaaaccca
     3421 tgcgtatcaa agaggatatt ctcgcctgct cagctgctga gctcaactac ggtctggccc
     3481 agtttgtgag agaaatcact cggcccaatg gtgaacgata tgaacctgac agtatctact
     3541 atttgtgtct tggcatccag cagtacttgc tggaaaataa ccggatggtg aacattttca
     3601 cggaccttta ctacctgact tttgttcaag aactcaacaa gtctctgagt acctggcagc
     3661 ccacactcct ccccaacaat acggtgttct ctcgagtgga ggaggagcac ctctgggagt
     3721 gtaagcaact gggggtctac tcgccctttg tcctcctcaa caccctcatg ttcttcaaca
     3781 ctaagttttt tgggctgcag acagctgagg aacacatgca actctccttc accaatgtgg
     3841 tgcggcagtc ccgcaagtgt accacccctc ggggcaccac caaggtggtg agcatccgct
     3901 actatgcccc agtccgccag aggaaagggc gagacacggg tcctggaaaa cggaagagag
     3961 aagatgaagc ccctatctta gagcagcgtg agaaccgcat gaatcccctc cgctgccctg
     4021 tcaagttcta tgaattctat ctctcaaaat gtcctgaaag cctccggact cgcaacgatg
     4081 tgttctacct gcaacctgaa cggtcctgca tcgccgagtc acctctctgg tattctgtga
     4141 tccccatgga ccgcagcatg ttggagagca tgctcaatcg catcctggct gtgcgcgaga
     4201 tttatgagga actgggtcgt cctggggagg aagacctgga ctgagctcgt gtgccatcca
     4261 tatccatctt tcacatcaat gtctgtcctg tggccatgtc cctcagggtg acaggcccag
     4321 gaaccaatgc tactcattct gaagggccct gactgctcct ttccgctcac ccattccctg
     4381 ccttctctag gaaccctggc ttttatcttc ttccgtacca cttgacaacc atggggccct
     4441 ggtcttctgt actcaggggc tggtctccca gtgatgggca aaagccagct tgcccgtttt
     4501 ctttatgctt cagagtaaac ccctccttct gggtccagac tctgggtgga gtgttaatag
     4561 ctctggtgat cctgttggct ttgggtttcc tgacccatcc cgcataggta gagcctcttg
     4621 ttcctaggca tgacctaggg aaaaacccag ctgccttctc tgccctgtgc ccactccctt
     4681 ctctactctt ccccagcacc atgccaaaag gtcttatctg aaaggtaaga aataaacaat
     4741 gaaagcgatg aggggaccat ttacataaaa cacagagctt agacactctt cccctcctat
     4801 gaaataattg gttgttggca ccatctcacc accgcatatc cctcaccccc tcggcaagca
     4861 ccaatccttg gtgctgccgt ttttaaaatc ttccaaatgc ctttttttcc tcagaggcag
     4921 agaatgacta agtacgggga gcagactcct gttgtgcaga ctcctgtccc cttggtttct
     4981 gtgtttgtct ctctgccatc ttaggttgcc atgagccatg gtgtcaacat gcttagcccc
     5041 ctctgtaact gcctcccttt agttcaatgg acagacctcc caaggcaaaa actaccttct
     5101 gacttgggtt gaggctgggt tcccctctat tgttccccta tcataagagc taggccaagc
     5161 ctatgggacc ttgagtcatg caggatggga tctgtggtca aaggacaggc gaggagctgt
     5221 gggcgcaggg cctgccgcca ctgcctacat cttctctctt ccccatcttg cattggaggt
     5281 cccagaaaac aattagcttc tggcaaaggg ggtacccact tctttccctg ttgactttgc
     5341 tgtttcccag gctccttttt gtgtttttat aactgtcacc agttagccac tgtttaaatt
     5401 gtatatattg ttctgaggcg cctggcctgt cccttcagtg agccatgccc acccttgtgt
     5461 tgtagtgaga agctgttgtc acgactaacc ttctgtctct gaaattgttt gtttcaaata
     5521 aagagttaaa attgtc
//
