LOCUS       NM_197968               7429 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger MYM-type containing 2 (ZMYM2), transcript
            variant 2, mRNA.
ACCESSION   NM_197968
VERSION     NM_197968.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7429)
  AUTHORS   Owen,D.J., Aguilar-Martinez,E., Ji,Z., Li,Y. and Sharrocks,A.D.
  TITLE     ZMYM2 controls human transposable element transcription through
            distinct co-regulatory complexes
  JOURNAL   Elife 12, 86669 (2023)
   PUBMED   37934570
  REMARK    GeneRIF: ZMYM2 controls human transposable element transcription
            through distinct co-regulatory complexes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7429)
  AUTHORS   Graham-Paquin,A.L., Saini,D., Sirois,J., Hossain,I., Katz,M.S.,
            Zhuang,Q.K., Kwon,S.Y., Yamanaka,Y., Bourque,G., Bouchard,M. and
            Pastor,W.A.
  TITLE     ZMYM2 is essential for methylation of germline genes and active
            transposons in embryonic development
  JOURNAL   Nucleic Acids Res 51 (14), 7314-7329 (2023)
   PUBMED   37395395
  REMARK    GeneRIF: ZMYM2 is essential for methylation of germline genes and
            active transposons in embryonic development.
REFERENCE   3  (bases 1 to 7429)
  AUTHORS   Zeng,X., Zheng,W., Sheng,Y. and Ma,H.
  TITLE     UBE2B promotes ovarian cancer growth via promoting RAD18 mediated
            ZMYM2 monoubiquitination and stabilization
  JOURNAL   Bioengineered 13 (4), 8000-8012 (2022)
   PUBMED   35313791
  REMARK    GeneRIF: UBE2B promotes ovarian cancer growth via promoting RAD18
            mediated ZMYM2 monoubiquitination and stabilization.
REFERENCE   4  (bases 1 to 7429)
  AUTHORS   Ludtke,T.H., Kleppa,M.J., Rivera-Reyes,R., Qasrawi,F.,
            Connaughton,D.M., Shril,S., Hildebrandt,F. and Kispert,A.
  TITLE     Proteomic analysis identifies ZMYM2 as endogenous binding partner
            of TBX18 protein in 293 and A549 cells
  JOURNAL   Biochem J 479 (1), 91-109 (2022)
   PUBMED   34935912
  REMARK    GeneRIF: Proteomic analysis identifies ZMYM2 as endogenous binding
            partner of TBX18 protein in 293 and A549 cells.
REFERENCE   5  (bases 1 to 7429)
  AUTHORS   Connaughton,D.M., Dai,R., Owen,D.J., Marquez,J., Mann,N.,
            Graham-Paquin,A.L., Nakayama,M., Coyaud,E., Laurent,E.M.N.,
            St-Germain,J.R., Blok,L.S., Vino,A., Klambt,V., Deutsch,K.,
            Wu,C.W., Kolvenbach,C.M., Kause,F., Ottlewski,I., Schneider,R.,
            Kitzler,T.M., Majmundar,A.J., Buerger,F., Onuchic-Whitford,A.C.,
            Youying,M., Kolb,A., Salmanullah,D., Chen,E., van der Ven,A.T.,
            Rao,J., Ityel,H., Seltzsam,S., Rieke,J.M., Chen,J., Vivante,A.,
            Hwang,D.Y., Kohl,S., Dworschak,G.C., Hermle,T., Alders,M.,
            Bartolomaeus,T., Bauer,S.B., Baum,M.A., Brilstra,E.H.,
            Challman,T.D., Zyskind,J., Costin,C.E., Dipple,K.M., Duijkers,F.A.,
            Ferguson,M., Fitzpatrick,D.R., Fick,R., Glass,I.A., Hulick,P.J.,
            Kline,A.D., Krey,I., Kumar,S., Lu,W., Marco,E.J., Wentzensen,I.M.,
            Mefford,H.C., Platzer,K., Povolotskaya,I.S., Savatt,J.M.,
            Shcherbakova,N.V., Senguttuvan,P., Squire,A.E., Stein,D.R.,
            Thiffault,I., Voinova,V.Y., Somers,M.J.G., Ferguson,M.A.,
            Traum,A.Z., Daouk,G.H., Daga,A., Rodig,N.M., Terhal,P.A., van
            Binsbergen,E., Eid,L.A., Tasic,V., Rasouly,H.M., Lim,T.Y.,
            Ahram,D.F., Gharavi,A.G., Reutter,H.M., Rehm,H.L., MacArthur,D.G.,
            Lek,M., Laricchia,K.M., Lifton,R.P., Xu,H., Mane,S.M.,
            Sanna-Cherchi,S., Sharrocks,A.D., Raught,B., Fisher,S.E.,
            Bouchard,M., Khokha,M.K., Shril,S. and Hildebrandt,F.
  TITLE     Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic
            Urinary Tract Malformations
  JOURNAL   Am J Hum Genet 107 (4), 727-742 (2020)
   PUBMED   32891193
  REMARK    GeneRIF: Mutations of the Transcriptional Corepressor ZMYM2 Cause
            Syndromic Urinary Tract Malformations.
REFERENCE   6  (bases 1 to 7429)
  AUTHORS   Reiter,A., Sohal,J., Kulkarni,S., Chase,A., Macdonald,D.H.,
            Aguiar,R.C., Goncalves,C., Hernandez,J.M., Jennings,B.A.,
            Goldman,J.M. and Cross,N.C.
  TITLE     Consistent fusion of ZNF198 to the fibroblast growth factor
            receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome
  JOURNAL   Blood 92 (5), 1735-1742 (1998)
   PUBMED   9716603
REFERENCE   7  (bases 1 to 7429)
  AUTHORS   Still,I.H. and Cowell,J.K.
  TITLE     The t(8;13) atypical myeloproliferative disorder: further analysis
            of the ZNF198 gene and lack of evidence for multiple genes
            disrupted on chromosome 13
  JOURNAL   Blood 92 (4), 1456-1458 (1998)
   PUBMED   9694738
REFERENCE   8  (bases 1 to 7429)
  AUTHORS   Popovici,C., Adelaide,J., Ollendorff,V., Chaffanet,M., Guasch,G.,
            Jacrot,M., Leroux,D., Birnbaum,D. and Pebusque,M.J.
  TITLE     Fibroblast growth factor receptor 1 is fused to FIM in stem-cell
            myeloproliferative disorder with t(8;13)
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5712-5717 (1998)
   PUBMED   9576949
REFERENCE   9  (bases 1 to 7429)
  AUTHORS   Smedley,D., Hamoudi,R., Clark,J., Warren,W., Abdul-Rauf,M.,
            Somers,G., Venter,D., Fagan,K., Cooper,C. and Shipley,J.
  TITLE     The t(8;13)(p11;q11-12) rearrangement associated with an atypical
            myeloproliferative disorder fuses the fibroblast growth factor
            receptor 1 gene to a novel gene RAMP
  JOURNAL   Hum Mol Genet 7 (4), 637-642 (1998)
   PUBMED   9499416
REFERENCE   10 (bases 1 to 7429)
  AUTHORS   Xiao,S., Nalabolu,S.R., Aster,J.C., Ma,J., Abruzzo,L., Jaffe,E.S.,
            Stone,R., Weissman,S.M., Hudson,T.J. and Fletcher,J.A.
  TITLE     FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the
            t(8;13) leukaemia/lymphoma syndrome
  JOURNAL   Nat Genet 18 (1), 84-87 (1998)
   PUBMED   9425908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137119.26 and AL138688.27.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 10, 2020 this sequence version replaced NM_197968.3.
            
            Summary: The protein encoded by this gene is a zinc finger protein
            that may act as a transcription factor. The encoded protein may be
            part of a BHC histone deacetylase complex. Translocation of this
            gene with the fibroblast growth factor receptor-1 gene (FGFR1)
            results in a fusion gene, which may be a cause of stem cell
            leukemia lymphoma syndrome (SCLL). Several transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Jul 2010].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036372.1, SRR14038192.2599831.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610343.5/ ENSP00000479904.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL137119.26        26655-26769
            116-184             AL137119.26        27886-27954
            185-1041            AL137119.26        60991-61847
            1042-1327           AL137119.26        70778-71063
            1328-1493           AL137119.26        73002-73167
            1494-1706           AL137119.26        74302-74514
            1707-1778           AL137119.26        87475-87546
            1779-1929           AL137119.26        94540-94690
            1930-2045           AL137119.26        95131-95246
            2046-2162           AL137119.26        99247-99363
            2163-2313           AL137119.26        102182-102332
            2314-2486           AL137119.26        104665-104837
            2487-2652           AL137119.26        119361-119526
            2653-2687           AL137119.26        120205-120239
            2688-2817           AL137119.26        126503-126632
            2818-2933           AL137119.26        127375-127490
            2934-3105           AL137119.26        128981-129152
            3106-3231           AL137119.26        130774-130899
            3232-3326           AL137119.26        132379-132473
            3327-3495           AL137119.26        134779-134947
            3496-3647           AL137119.26        135167-135318
            3648-3762           AL138688.27        7550-7664
            3763-4014           AL138688.27        8315-8566
            4015-4135           AL138688.27        9190-9310
            4136-7429           AL138688.27        11356-14649
FEATURES             Location/Qualifiers
     source          1..7429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..7429
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="zinc finger MYM-type containing 2"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
     exon            1..115
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            116..184
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            185..1041
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..4328
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 198; rearranged in an atypical
                     myeloproliferative disorder; fused in myeloproliferative
                     disorders protein; zinc finger, MYM-type 2"
                     /codon_start=1
                     /product="zinc finger MYM-type protein 2 isoform 1"
                     /protein_id="NP_932072.1"
                     /db_xref="CCDS:CCDS45016.1"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
                     /translation="MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVS
                     RSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNEELQGNDSKITPS
                     SKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSF
                     SRSKVNAGMGNSGITTEPDSEIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVT
                     SLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGES
                     ATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANC
                     KKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVD
                     SSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSD
                     HCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQVGSH
                     PSFLKEVRDHMQDSFLMQPEKYGKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTAC
                     MNSHKTKYAKSQSLGIICHFCKRNSLPQYQATMPDGKLYNFCNSSCVAKFQALSMQSS
                     PNGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKKLHCIVTYCE
                     YCQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATK
                     ELDGVVRDFCSEDCCKKFQDWYYKAARCDCCKSQGTLKERVQWRGEMKHFCDQHCLLR
                     FYCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPTPNKEMKNKAVLCKPLT
                     MTKATYCKPHMQTKSCQTDDTWRTEYVPVPIPVPVYIPVPMHMYSQNIPVPTTVPVPV
                     PVPVFLPAPLDSSEKIPAAIEELKSKVSSDALDTELLTMTDMMSEDEGKTETTNINSV
                     IIETDIIGSDLLKNSDPETQSSMPDVPYEPDLDIEIDFPRAAEELDMENEFLLPPVFG
                     EEYEEQPRPRSKKKGAKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWKHWVKTRQL
                     DEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPDSIYYLC
                     LGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGSIFSRVEEDYLWRI
                     KQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACLRY
                     QVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQ
                     RMDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDIYDKDNYELDEDTD"
     exon            1042..1327
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1493
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1706
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1778
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1929
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2045
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2162
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2313
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2486
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2652
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2687
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2817
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2933
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3105
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3231
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3326
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3495
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3647
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3762
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..4014
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4135
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..7429
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4781..4786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="hexamer: AATAAA"
     polyA_site      4799
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="major polyA site"
     regulatory      4985..4990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="hexamer: ATTAAA"
     polyA_site      5010
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
     regulatory      6906..6911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="hexamer: ATTAAA"
     polyA_site      6927
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
     regulatory      7409..7414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /note="hexamer: AATAAA"
     polyA_site      7429
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
ORIGIN      
        1 ctcctcctca ccagcgctaa agccgggact ggaccgagcg gagttgtgcg tgtcgccgaa
       61 ggggggtggg ccgggggagg ggaggttcgt tccgcggagc cccagccaga accgggacca
      121 agaatcgcct tcagccctgt ctggtgcatc cttggcagaa agtgaggagg aaaacacccc
      181 cattgttctt tggcatggac acaagttcag tgggaggatt agaattgact gatcagactc
      241 ctgttttatt agggagtacg gccatggcaa ctagtctcac gaatgtagga aactcattta
      301 gtggtccagc taatccttta gtgtctagat ctaataagtt tcagaactcg tcagtggaag
      361 atgatgatga tgttgttttt atcgaacctg tacaacctcc cccaccttct gtaccagtgg
      421 tagctgatca aagaaccata acatttacat catcaaaaaa tgaagaacta caaggaaatg
      481 attccaaaat tactccttcc tcaaaagagt tggcatctca gaagggaagt gtaagtgaga
      541 caattgtcat tgatgatgaa gaggacatgg aaacaaatca agggcaagag aaaaattcct
      601 ccaattttat tgaacgaaga cctcctgaga ctaaaaacag aaccaatgat gtggatttct
      661 ccacttccag tttttcaaga agtaaggtaa atgcaggaat gggtaatagt ggtatcacca
      721 cagaaccaga ctctgaaatt cagattgcta atgttacaac tttagaaaca ggtgtaagct
      781 ctgtgaatga tggccaatta gaaaatactg acgggcgaga tatgaactta atgattacac
      841 atgtaacatc actgcagaat accaacttgg gagatgtctc taacggactg cagtcaagta
      901 attttggtgt taatatacaa acatacaccc catctttaac ttcacagacc aagactggag
      961 taggaccttt taatcctggt agaatgaatg tggcaggaga cgtttttcag aatggagaat
     1021 ctgcaactca tcataatcct gattcttgga tctcccagtc agcttcattt ccccgtaatc
     1081 agaaacaacc aggggtggac tctttatcac cagtggcctc acttcctaaa cagattttcc
     1141 agccgtctgt ccaacagcag cctactaaac cagttaaagt cacttgtgca aactgcaaaa
     1201 aacctttaca gaagggccag acagcttatc aacgaaaagg atcagctcac ctcttttgtt
     1261 ctaccacctg cctttcttcc ttctcccaca agcctgctcc aaagaaactc tgtgttatgt
     1321 gtaaaaaaga tataactaca atgaaaggaa ccattgttgc tcaagtggat tcaagtgagt
     1381 ccttccagga attctgtagt acatcttgtt tatctctcta tgaagacaaa cagaatccta
     1441 ctaaaggagc tctaaataaa tcaagatgta caatctgtgg taaactaact gagattcgcc
     1501 atgaagtcag ctttaaaaat atgactcata agctgtgcag tgaccactgc tttaatagat
     1561 atagaatggc caatggttta ataatgaatt gctgtgaaca gtgtggagag tacttgccca
     1621 gtaaaggtgc tggaaataat gttctggtga ttgatggtca acagaaaaga ttttgctgtc
     1681 aaagttgtgt cagtgaatac aaacaggtag gtagccatcc aagcttcctg aaggaggttc
     1741 gagatcacat gcaggactct ttcttaatgc agcctgagaa atatggaaaa ctgacaactt
     1801 gtactggttg ccgaacacag tgcaggtttt ttgatatgac tcagtgtata ggtcctaatg
     1861 gatatatgga gccatattgt tcaactgctt gtatgaacag tcacaagaca aaatatgcaa
     1921 aatcacaaag tttgggaatt atttgccatt tttgtaagcg aaactcttta cctcaatacc
     1981 aagccacaat gcctgatgga aaactgtaca acttttgcaa ttccagttgt gtggctaaat
     2041 ttcaggctct aagtatgcag tcatctccaa atggccagtt tgtagcgcca agtgatattc
     2101 agttgaaatg caactactgc aaaaattcct tttgttcaaa accagaaatc ctggaatggg
     2161 agaacaaagt gcatcagttc tgcagcaaaa cttgttcaga tgactataag aagttgcatt
     2221 gcatagttac atattgcgaa tactgtcaag aggagaagac tcttcatgaa acagtaaatt
     2281 tctctggcgt taagagacct ttctgtagtg aaggctgcaa attattatac aaacaggatt
     2341 ttgccagacg tttaggattg agatgtgtta cttgcaacta ttgttctcag ctatgtaaga
     2401 agggagcaac taaagaactc gatggtgttg tgagagattt ctgcagtgaa gattgctgta
     2461 aaaaatttca ggattggtac tacaaggctg caaggtgtga ctgttgtaaa tctcaaggaa
     2521 ctcttaaaga gcgagttcag tggcgtgggg aaatgaaaca tttctgtgat caacattgct
     2581 tactgcgttt ctactgtcaa caaaatgagc ccaacatgac aactcagaaa ggacctgaaa
     2641 acttacatta tgatcagggt tgtcagacat ctcgaaccaa aatgacaggt tcagcaccac
     2701 ccccttctcc aacacctaac aaagagatga agaacaaagc agttctttgc aaacctttaa
     2761 caatgacaaa agctacttac tgtaaacctc acatgcagac caaatcttgt cagacagatg
     2821 atacttggag gacagaatat gttccagtgc ctatccctgt gcctgtgtat atcccagttc
     2881 ctatgcacat gtacagtcag aatattcctg ttcctactac agttcctgtt cctgtgccag
     2941 ttcctgtttt tctgcctgct ccattggaca gcagtgagaa gattcctgca gcaattgagg
     3001 agctaaaaag caaggtttct tcagatgctc ttgatacaga gttgcttaca atgacggata
     3061 tgatgagtga agacgagggg aaaacagaga caaccaacat caacagtgta attattgaaa
     3121 cagatataat tggttcagac cttttgaaga actctgaccc agagacacag tccagcatgc
     3181 ctgatgtacc atatgaacca gatttggata tcgaaataga ttttcccaga gctgctgagg
     3241 agcttgatat ggaaaatgaa tttttattac cacctgtttt tggcgaagaa tatgaggaac
     3301 agcccagacc tcgatctaaa aaaaagggag ccaagagaaa ggctgtatca ggataccagt
     3361 ctcatgatga tagttctgac aattcagaat gcagctttcc tttcaaatat acgtatggcg
     3421 taaatgcatg gaaacactgg gtcaaaacta ggcaacttga tgaagatctt ctggtattag
     3481 atgagttaaa atcttctaaa tcagtaaagt taaaagagga tctactctct cacaccacag
     3541 ctgagcttaa ctatgggtta gctcattttg tcaatgagat ccgacggcca aatggagaga
     3601 attatgcacc tgacagcatc tattaccttt gccttggaat acaggagtat ttgtgtggaa
     3661 gtaatcgaaa agacaacata tttattgatc ctggatacca aacatttgag caagaattga
     3721 ataaaatact gcgaagctgg caaccaagca tacttccaga tgggtcaata ttctctcgag
     3781 ttgaagaaga ctatctctgg aggataaaac aactaggatc acactctcca gtagctcttc
     3841 tgaatacact gttctacttt aacactaagt attttggcct gaaaacagtg gaacaacact
     3901 taagactttc ctttggcact gtgtttaggc attggaaaaa aaatccttta acgatggaaa
     3961 acaaagcgtg tcttcgatac caagtgtctt ccttgtgtgg aacagataat gaagataaaa
     4021 ttactactgg aaaaagaaaa catgaagatg atgagccagt atttgaacaa attgaaaaca
     4081 cagccaatcc ttccagatgt cctgtgaaaa tgtttgaatg ctacttgtct aaaagtccac
     4141 agaatcttaa tcagaggatg gatgtttttt atttgcaacc agaatgctct agttctacag
     4201 atagccctgt ctggtatacg tctacttcac tggaccgaaa caccttggaa aatatgcttg
     4261 tacgggttct tctagtaaaa gatatttatg ataaagacaa ttatgaactg gatgaagaca
     4321 cagactaaaa aggaacgttg cagaagcaat cgggataaaa cagcattaga tagtcatgct
     4381 gctagatctt tattatggaa aacatttcaa gtttactcct tctgttttga gttttgtagc
     4441 agtgtaccca cgctgggtat taccatgtaa ataatctgtg agtgaaagtt gccattattc
     4501 tatgtagtgg ttttaggata cttaacaaat acattcaaat tcttttttta ttattattta
     4561 tttgattagg tatgtttgta actttttaca ttacagaata tgaatgagaa tgtgccatgt
     4621 ataatttttt tcttgtagta agaaacatcc atattgcaca actctactgt tgcaaagctt
     4681 ccttggaagg gggctctttt actgggttct taaccagatg gttgtgtatg ggtagcacta
     4741 ctaaaagttt agaacttgca gtgtctttcg gaatttttaa aataaactgt aaactaatag
     4801 gctggggttt ttgttttgtt ttggggtttt gttttgtttg gttttacatt ttagttactg
     4861 aagccttaca aggttatgta gagagatacc atcttctgta ccaaaaatag acaagagaat
     4921 gctgtcaata ttggtgtact gtaatgtgaa tctatgctgg tgaaaacaat tttttgttcc
     4981 ccttattaaa accttagtgt ccttttctca tttgtggctt tctgcatcac ccaatcaata
     5041 aaaaacaaat atatatatgt atatatatgt atgtatgtgt gtgtgtatat atatatatat
     5101 atatatatat ataaatgatt gtaagttgaa aacaagatca tcaagacatt tcctttgtaa
     5161 aaatgtctgg tgaaagtata aaattctgtt ttcttctatg ccagccataa gtatctgaaa
     5221 tcctcttcat ttatagaggt ttgattttta tttctttttt tccctcttaa ggatacagat
     5281 catgctgcaa tgttagctgt gtagtactct aaaacttagc aattttatca gaattcttgt
     5341 gcctgtttac attggataaa attgttttta gaaattccac tcctgaaata gttacagaaa
     5401 gtcaagctat gttaaataag ataggatcac attttataat gaagattacc agtgtagtaa
     5461 ttctgatatt gcaaatgatt gaggaacaaa caaagaaact aatagagaaa gtcagtctca
     5521 gaggaaatcc catttaatgt tagattgttt ggcttttgaa attacttctt atagaagatt
     5581 gcattaaaaa aaaaaacaac tttgtgcttc tgcatagcaa tttatccatt cagacctttt
     5641 cttttagaat aaggaaactt aaaatctact ttctaaagac tgaacaaagt gctagctgca
     5701 aattatcttg aaatcatttg gctcttttct agcatgtgtg taatcatgtt ttcttctgat
     5761 tcctgaatga ccatggtagc attagtgttt agaaattgtt caggggaaaa ttgagctatt
     5821 ttccatagtg gctagcaatt gctacacatc cttagatact cctctctccc ataggataaa
     5881 tgttacagca cacaaaagaa attttctcaa ttctgatttg gaaaatttca caggtgtcat
     5941 tattgtatat ctaagcaata attatctgaa tgttttggca taaaaaatta taatgttcta
     6001 acttgtttta taagttgaat gacttttcag tcccttgatt ttatattgtt gagtgataat
     6061 cagactgata gtagcaaatc tgatcataca ttactaaaat agattgctga ttgtctattt
     6121 aacgaagaca agtgggtaac atttaaaata tataatacaa aaattttctc taacttacct
     6181 ttttccagaa ctacttcttt aagcactttt cctattaatg cctattgttg attaaaaggt
     6241 ggttaattct aaccatcttt tagtcttcaa agtggtgcta tattccatca agagcaataa
     6301 agtttttccc aggtgtcact tattgtatat gttaccaaat accatgaatt tctgccatag
     6361 tactactatc aagcaccttg tcttgctatt tacagtttct tcatttgtat atttttagct
     6421 tttctaagtg gaaatgtcta cataattttg atcttgacat gattgaggat ttagagctct
     6481 tgtctttgtc ttgattgcaa tccaacgata gattaacttg attctcaggg ggaaaagaaa
     6541 aacttatttt atgagaattg tttgttctgt gaaactcact tcacctagaa cacatttcat
     6601 tgattcttgg atcttagttt atgtggtcat agttgactgc tgagaaaagg acaatgaaat
     6661 gatagcaatt tccttttgct tctaggtgat ctctgattat agatagcatc ctgtaaatat
     6721 aactttattg tcttgaaatg tttattgaag atgctatatt tttctgttct gttttctgaa
     6781 gattttgcca tttaaaatga tccagtgaaa aatatttatc cacattgaag aaagtggatt
     6841 tcccatgcaa attgaatctt cattaacaca ttttaaaagg ctttactgta ttaggtaaca
     6901 tagatattaa aggatttttc taggcaagaa gctcaacttt ttttttccat aaaaataatt
     6961 tttgcttaaa tagtaactca tggttttctt ttattaaatg gggttgttgt cagtatgtta
     7021 aacattgaag taggaggagg atgcatattg tactatgcat tcaaatttat cactgttttt
     7081 tctgacagac tttccctttg tcctttctag ttatgacttg ggaatggggt aacttcttta
     7141 tgcatagtat taagggttat agtatgaaga aatcataaaa ttgcaagttt tggtttgcat
     7201 tactctaatg tgggttcatt taatctgaga tcttaaatat cttgcagcct taaatcacta
     7261 caaacatttg catttttatt atgccagtta tttccaaaat gtattgttat acatgtcact
     7321 tatgttttta agctaatatt gactgtagga taatctcctt gttcccctca aaatagtcat
     7381 gaaagtgtac atgaaaatat ttttaaagaa taaatttctt taaattaca
//
