LOCUS       NM_031449               5228 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger MIZ-type containing 2 (ZMIZ2), transcript
            variant 1, mRNA.
ACCESSION   NM_031449 XM_371897 XM_374430
VERSION     NM_031449.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5228)
  AUTHORS   Gan,X., Feng,Y., Liu,Y., Lin,X., Yu,X., Rong,X. and Han,Q.
  TITLE     Identification of zinc finger MIZ-type containing 2 as an
            oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1
            deacetylase activity to regulate Wnt and Hippo pathways in
            non-small-cell lung cancer
  JOURNAL   Cell Mol Biol Lett 29 (1), 122 (2024)
   PUBMED   39266996
  REMARK    GeneRIF: Identification of zinc finger MIZ-type containing 2 as an
            oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1
            deacetylase activity to regulate Wnt and Hippo pathways in
            non-small-cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5228)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 5228)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5228)
  AUTHORS   Zhu,Y., Gu,L., Lin,X., Cui,K., Liu,C., Lu,B., Zhou,F., Zhao,Q.,
            Shen,H. and Li,Y.
  TITLE     LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and
            USP7-mediated stabilization of beta-catenin
  JOURNAL   Cell Death Differ 27 (4), 1316-1327 (2020)
   PUBMED   31527801
  REMARK    GeneRIF: LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and
            USP7-mediated stabilization of beta-catenin.
REFERENCE   5  (bases 1 to 5228)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5228)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 5228)
  AUTHORS   Peng,Y., Lee,J., Zhu,C. and Sun,Z.
  TITLE     A novel role for protein inhibitor of activated STAT (PIAS)
            proteins in modulating the activity of Zimp7, a novel PIAS-like
            protein, in androgen receptor-mediated transcription
  JOURNAL   J Biol Chem 285 (15), 11465-11475 (2010)
   PUBMED   20159969
  REMARK    GeneRIF: there is an interaction between Zimp7 and PIAS proteins
            with higher preference for PIAS3, in androgen receptor-mediated
            transcription
REFERENCE   8  (bases 1 to 5228)
  AUTHORS   Li,X., Thyssen,G., Beliakoff,J. and Sun,Z.
  TITLE     The novel PIAS-like protein hZimp10 enhances Smad transcriptional
            activity
  JOURNAL   J Biol Chem 281 (33), 23748-23756 (2006)
   PUBMED   16777850
REFERENCE   9  (bases 1 to 5228)
  AUTHORS   Huang,C.Y., Beliakoff,J., Li,X., Lee,J., Li,X., Sharma,M., Lim,B.
            and Sun,Z.
  TITLE     hZimp7, a novel PIAS-like protein, enhances androgen
            receptor-mediated transcription and interacts with SWI/SNF-like BAF
            complexes
  JOURNAL   Mol Endocrinol 19 (12), 2915-2929 (2005)
   PUBMED   16051670
  REMARK    GeneRIF: hZimp7 modulates androgen receptor and/or other nuclear
            receptor-mediated transcription, possibly through alteration of
            chromatin structure by SWI/SNF-like BAF complexes.
REFERENCE   10 (bases 1 to 5228)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004859.3, AK090415.1, AY426594.1, BI115680.1, AK128359.1 and
            CD367243.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031449.3.
            
            Summary: ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see
            MIM 603566)-like family of proteins that interact with nuclear
            hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM
            313700) and enhances AR-mediated transcription (Huang et al., 2005
            [PubMed 16051670]).[supplied by OMIM, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309315.9/ ENSP00000311778.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC004859.3         9626-9709           c
            85-1430             AK090415.1         1-1346
            1431-2500           AY426594.1         1170-2239
            2501-3970           AK090415.1         2417-3886
            3971-4172           BI115680.1         116-317
            4173-5217           AK128359.1         1971-3015
            5218-5228           CD367243.1         16-26               c
FEATURES             Location/Qualifiers
     source          1..5228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..5228
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /note="zinc finger MIZ-type containing 2"
                     /db_xref="GeneID:83637"
                     /db_xref="HGNC:HGNC:22229"
                     /db_xref="MIM:611196"
     exon            1..145
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            146..257
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2970
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger MIZ domain-containing protein 2; PIAS-like protein
                     Zimp7"
                     /codon_start=1
                     /product="zinc finger MIZ domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_113637.3"
                     /db_xref="CCDS:CCDS43576.1"
                     /db_xref="GeneID:83637"
                     /db_xref="HGNC:HGNC:22229"
                     /db_xref="MIM:611196"
                     /translation="MNSMNPMKPALPPAPHGDGSFAYESVPWQQSATQPAGSLSVVTT
                     VWGVGNATQSQVLGNPMGPAGSPSGSSMMPGVAGGSSALTSPQCLGQQAFAEGGANKG
                     YVQQGVYSRGGYPGAPGFTTGYAGGPGGLGLPSHAARPSTDFTQAAAAAAVAAAAATA
                     TATATATVAALQEKQSQELSQYGAMGAGQSFNSQFLQHGGPRGPSVPAGMNPTGIGGV
                     MGPSGLSPLAMNPTRAAGMTPLYAGQRLPQHGYPGPPQAQPLPRQGVKRTYSEVYPGQ
                     QYLQGGQYAPSTAQFAPSPGQPPAPSPSYPGHRLPLQQGMTQSLSVPGPTGLHYKPTE
                     QFNGQGASFNGGSVSYSQPGLSGPTRSIPGYPSSPLPGNPTPPMTPSSSVPYMSPNQE
                     VKSPFLPDLKPNLNSLHSSPSGSGPCDELRLTFPVRDGVVLEPFRLQHNLAVSNHVFQ
                     LRDSVYKTLIMRPDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHK
                     PLYLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCIT
                     KIKRNFSSGTIPGTPGPNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCRHIQCFDL
                     ESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGILIYIQNSDYEEITIDPTCSWKP
                     VPVKPDMHIKEEPDGPALKRCRTVSPAHVLMPSVMEMIAALGPGAAPFAPLQPPSVPA
                     PSDYPGQGSSFLGPGTFPESFPPTTPSTPTLAEFTPGPPPISYQSDIPSSLLTSEKST
                     ACLPSQMAPAGHLDPTHNPGTPGLHTSNLGAPPGPQLHHSNPPPASRQSLGQASLGPT
                     GELAFSPATGVMGPPSMSGAGEAPEPALDLLPELTNPDELLSYLGPPDLPTNNNDDLL
                     SLFENN"
     exon            258..372
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            373..575
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            576..759
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1020
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1200
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1278
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1447
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1592
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1803
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1909
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2067
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2135
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2204
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2449
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2619
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2862
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..5228
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4017..4022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /note="hexamer: ATTAAA"
     polyA_site      4041
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /note="major polyA site"
     regulatory      5210..5215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /note="hexamer: TATAAA"
     polyA_site      5228
                     /gene="ZMIZ2"
                     /gene_synonym="hZIMP7; NET27; TRAFIP20; ZIMP7"
                     /note="major polyA site"
ORIGIN      
        1 attgtgccct cggagcgggc ggcggcgcga tggcgcgggt ggcggcggcc ccggggcggc
       61 gggcggcgcg gagggcgggc tgagcgcatg gagcggcgcg ggccgggggc cgccacggcg
      121 aggggccggg ccaggccggg cggagccaga gcagctgagt tccagataaa aactgtcaga
      181 cccggcctgt aggctgctcc attgccaatg aactccatga accccatgaa acctgccctg
      241 ccccctgcgc cacacggtga tggttcattc gcatatgagt ctgtgccttg gcaacaaagc
      301 gccactcagc cggctggatc gctgtctgtg gtcactactg tgtggggagt tggcaacgcg
      361 acacagagcc aggttttggg gaaccccatg ggccctgcag ggagtccctc tggcagctcc
      421 atgatgcctg gtgtggcagg gggcagctcc gccttgacct ccccacagtg cctgggacag
      481 caggcgtttg ctgaaggcgg cgccaacaag ggctacgtgc agcaaggcgt gtacagccgc
      541 gggggctacc ctggggcccc cggcttcacc accgggtatg caggcggccc ggggggcctg
      601 ggcctcccct cacatgctgc aagaccctcc actgacttca cgcaagcggc agctgctgca
      661 gctgtggctg ctgcggcagc cactgccacc gccacagcca cagccaccgt ggctgctctc
      721 caggagaagc agagccagga gctgagccag tatggagcga tgggggccgg acagtctttt
      781 aacagccagt ttctgcagca tggaggtccc cgggggccta gtgtccccgc tggcatgaac
      841 cctactggca taggaggggt aatgggcccc tctggcctct cccccttggc tatgaacccc
      901 acccgggcag caggaatgac acccttgtat gcagggcagc gtctgcccca acatgggtat
      961 cctgggcctc cccaggccca gccactgccc cgacaggggg tcaagagaac ctactctgag
     1021 gtgtatccag ggcagcagta tctgcaagga ggccagtatg cacccagcac cgcccagttt
     1081 gcgcccagcc ctgggcagcc ccctgccccc tccccttcct accctgggca caggctgccc
     1141 ctgcagcagg gcatgaccca gtccctgtcc gtgcctggcc ccacgggact gcattataag
     1201 cccacagagc agttcaacgg gcagggcgcc agcttcaacg ggggcagcgt cagctacagc
     1261 caacctggcc tgagtgggcc tacccgttcc atcccgggct atcccagttc cccactgcca
     1321 gggaacccca cgccacccat gaccccaagc agcagcgtcc cttacatgtc accaaaccaa
     1381 gaggtcaagt ctcccttctt gcctgatctc aagcccaacc tcaactcctt gcactcatcg
     1441 ccctctggaa gcgggccttg tgacgagttg cggctgacct tccctgtgcg cgatggggtg
     1501 gtcctggagc ccttccgcct gcagcacaac ctggctgtaa gcaaccatgt cttccagctg
     1561 cgagactcag tctacaagac cctgataatg aggcctgacc tggagctgca attcaagtgc
     1621 taccaccacg aggaccggca gatgaacacc aactggccag cctcggtgca ggtcagcgtc
     1681 aatgccacgc cgctcaccat cgagcgtggc gacaacaaga cctcgcacaa gccactctac
     1741 ctgaagcatg tgtgccagcc aggccgcaac accatccaga tcaccgtcac cgcctgctgc
     1801 tgctcccacc tcttcgtgct gcagctagtg caccgcccat ccgtccgctc ggtgctgcag
     1861 ggcctcctca aaaagcgcct cctgcctgct gagcactgca tcaccaagat aaagcggaac
     1921 ttcagcagcg gcaccatccc tggcacccct gggcccaacg gagaggacgg ggtggagcag
     1981 acagctatca aggtgtccct gaagtgcccc atcaccttcc gcaggatcca gctccctgcc
     2041 cgaggtcatg actgtcgcca catacagtgc tttgacctgg agtcgtacct gcagctcaac
     2101 tgtgagcggg ggacttggag gtgtcctgtg tgcaacaaga cagctttgct ggagggcctg
     2161 gaggtggacc agtacatgct gggcatcctg atttacattc agaactctga ctatgaggag
     2221 atcaccatcg accccacgtg cagctggaag ccagtgcccg tgaagcctga catgcacatc
     2281 aaggaggagc cggatgggcc agcactgaag cgctgccgca ccgtgagccc cgcccacgtg
     2341 ctcatgccca gcgtgatgga gatgatcgcc gccctgggcc ccggcgctgc cccctttgcc
     2401 cccctgcagc ccccctcagt ccctgccccc agcgactacc ctggccaggg ttccagcttc
     2461 ctggggcctg gaactttccc tgagtccttc ccacccacca cgcccagcac cccaaccctt
     2521 gctgagttca ccccgggacc accccccatc tcctaccagt ctgacattcc cagcagcctc
     2581 ctgacttcag agaagtctac cgcctgcctc ccaagccaga tggcaccagc aggtcacctg
     2641 gaccccactc acaatcctgg gacaccagga ctacacacct ccaaccttgg ggcccctcca
     2701 ggtccccagc tgcaccattc aaaccctccc ccagcgtccc ggcagtcctt gggccaagcg
     2761 agcttaggac ctacgggtga actggccttc agtcctgcca caggcgtgat ggggcccccc
     2821 agcatgtctg gagccgggga ggccccagaa ccagctctgg acctgctccc ggaactgacc
     2881 aaccctgatg agctactgtc ctacttgggc ccacccgacc tccctacgaa caacaatgac
     2941 gacctgcttt ctctgtttga gaacaactga tcctgtgttt accccaagcc cggcggggac
     3001 acgctcacag atgtcaccac agccctgccc ttcatgccca gccccatggg acacccggtg
     3061 gtctttccca aacctccccc aaaacacacc tggagccaga gccttctgcc gccagccctg
     3121 cccctgaatt ggaagcagcc ctgtgctcga tgggaggggc tcccaggccg gcagcccttg
     3181 ccacctccct ctgccaagcc tgctgctgca gaacggtttt tgctgaggtg cccctgccca
     3241 gccctgtcca gccttgtcca cacacacatc tcacgcccct ggtctcacag cctcacacct
     3301 tgtccttcca cccctgcctg cccccaccca gcctgcttct tgtccagcat tgatccttct
     3361 gtttcaacaa ctcctccact gggcagagct gggcatctgg cagggctggc tctgtcccct
     3421 gggcctttgg ctccagtggc ccctgtgccc agcagtccag ctcttggaac ctcgctgaat
     3481 ggcagcctct tgggggcctg gagctctggc agcccagccg tgtgtggtgt caggttcctc
     3541 tccccacccc agcttcaagc agaggcctcg gggtggggga gctacaaagc acaacaatgt
     3601 acatagtgta gaaacactaa cagctgggag aggggagcca gctgtccagc cagcatgttc
     3661 ctgttgtaca gcccggtctc cctgcgcgct ctgctccttc ccatgtgcag acagatcagg
     3721 gaggaacctc caatgggtgg gggacagtga gcttcggcct ggccgaggtg ggtgggtggg
     3781 ctctcagatt cagctctgtg taaagattct ctagcgggct gcgctcccaa gttccccttc
     3841 tctgtgaaag tgaagaatta gtacagctgt gttttttaaa gccacctctc tgtctccacc
     3901 ccatgggccc acacccaggt gggggaggag gaagccactg catctgttgg ctcagggccc
     3961 cagcctgtgc gagcagggcg cctgggctgt tgtgtctcct gtctgtgccg atctctatta
     4021 aaggactccc tcttggtggg cctggccgag tccctccttt gtgctcccag ggactatttt
     4081 ctcctcgtaa gccagcgacc tgcctaaagc ttgggctgtg cctgcaaagc ttgtgcagga
     4141 cctgggggcc aggtcgacct tcaagtggct tttggggccc caggttgagc tctggatgtt
     4201 tcaagccaag gctcggctat tcccgcccca tagtaaattt ccttttccct ggaattttcc
     4261 aagttggctt cagctgaaga gctgttttgt gaagcatccc aggcttgccc aggagagaca
     4321 tttgccacta tgtcacctta tctgggcttg ccctggggca ctgagacagt tgtttggcag
     4381 ccccagccca gccaggggct catccttctc agctcttgtc cctgggaggc ctctgcttgt
     4441 cacttcccag agattgcaga ggtgtgtcct gcctaccatc tgcctgtcca gcttggtggg
     4501 ggtccgggtc accatttcct ccagtcctgg gccccatcct tgagggcctt cccagccagc
     4561 cagcaggaga ggcaagaact gggggaacac aggaacctag gggaggaggg gagcgctggg
     4621 catcctcagg ctggcggcca aggcctgccc ctggaggcac tagaggaggg catctgtctg
     4681 tgggagccca gaggctgcag ggaggaggag gagggaggta tctggtgtga gcgttgcccc
     4741 tgcgacattt gggaccacac aggtgggctt ccttattccc tgacaaagcc tctgtttcca
     4801 gctcttccgc cctctctgga tgagggaaca gaagtggagg aaacaaaaga agcagcagca
     4861 cgcacagtcc tgtcgctggg tgcggagaca gcctggcaaa gtcccactca gccatggcct
     4921 gatgcaggcc ccaggccctc ctttcttggg tgtcaaatga ctgtgtcctg gacatctgat
     4981 gcaccacctg ccctgcctgt tgcaaacgtg atgctcccgg atggagtgga gaaactagga
     5041 gactgggaca agcaaaaggc tgcaaacaac ccagaagccc atcctcagaa gactggagaa
     5101 atgattgagg aatgcatggg caccgtggcc ctgtgctcca tcacaaacac ctctcagaaa
     5161 caacgtggga tgaaaaagca agacagttca tacagtatga tgccattttt ataaagctca
     5221 aaaccaaa
//
