LOCUS       NM_020338               7615 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger MIZ-type containing 1 (ZMIZ1), mRNA.
ACCESSION   NM_020338
VERSION     NM_020338.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7615)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7615)
  AUTHORS   Pang,Y., Sun,Y., Wu,Y., Li,J., Qin,P., Guo,S., Zhou,W., Chen,J. and
            Wang,J.
  TITLE     Targeting the ZMIZ1-Notch1 signaling axis for the treatment of
            tongue squamous cell carcinoma
  JOURNAL   Sci Rep 14 (1), 13577 (2024)
   PUBMED   38866828
  REMARK    GeneRIF: Targeting the ZMIZ1-Notch1 signaling axis for the
            treatment of tongue squamous cell carcinoma.
            Erratum:[Sci Rep. 2024 Jul 18;14(1):16609. doi:
            10.1038/s41598-024-67609-2.. PMID: 39025882]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7615)
  AUTHORS   K,C. R, Patel,N.R., Shenoy,A., Scallan,J.P., Chiang,M.Y.,
            Galazo,M.J. and Meadows,S.M.
  TITLE     Zmiz1 is a novel regulator of lymphatic endothelial cell gene
            expression and function
  JOURNAL   PLoS One 19 (5), e0302926 (2024)
   PUBMED   38718095
  REMARK    GeneRIF: Zmiz1 is a novel regulator of lymphatic endothelial cell
            gene expression and function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7615)
  AUTHORS   Li,X., Wu,A., Wang,Y., Li,D. and Wu,M.
  TITLE     Knockdown of circZMIZ1 enhances the anti-tumor activity of CD8+ T
            cells to alleviate hepatocellular carcinoma
  JOURNAL   Funct Integr Genomics 24 (1), 27 (2024)
   PUBMED   38332346
  REMARK    GeneRIF: Knockdown of circZMIZ1 enhances the anti-tumor activity of
            CD8[+] T cells to alleviate hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7615)
  AUTHORS   Dubois,P.C., Trynka,G., Franke,L., Hunt,K.A., Romanos,J.,
            Curtotti,A., Zhernakova,A., Heap,G.A., Adany,R., Aromaa,A.,
            Bardella,M.T., van den Berg,L.H., Bockett,N.A., de la Concha,E.G.,
            Dema,B., Fehrmann,R.S., Fernandez-Arquero,M., Fiatal,S.,
            Grandone,E., Green,P.M., Groen,H.J., Gwilliam,R., Houwen,R.H.,
            Hunt,S.E., Kaukinen,K., Kelleher,D., Korponay-Szabo,I., Kurppa,K.,
            MacMathuna,P., Maki,M., Mazzilli,M.C., McCann,O.T., Mearin,M.L.,
            Mein,C.A., Mirza,M.M., Mistry,V., Mora,B., Morley,K.I.,
            Mulder,C.J., Murray,J.A., Nunez,C., Oosterom,E., Ophoff,R.A.,
            Polanco,I., Peltonen,L., Platteel,M., Rybak,A., Salomaa,V.,
            Schweizer,J.J., Sperandeo,M.P., Tack,G.J., Turner,G., Veldink,J.H.,
            Verbeek,W.H., Weersma,R.K., Wolters,V.M., Urcelay,E., Cukrowska,B.,
            Greco,L., Neuhausen,S.L., McManus,R., Barisani,D., Deloukas,P.,
            Barrett,J.C., Saavalainen,P., Wijmenga,C. and van Heel,D.A.
  TITLE     Multiple common variants for celiac disease influencing immune gene
            expression
  JOURNAL   Nat Genet 42 (4), 295-302 (2010)
   PUBMED   20190752
  REMARK    Erratum:[Nat Genet.2010 May;42(5):465]
REFERENCE   6  (bases 1 to 7615)
  AUTHORS   Soler,G., Radford-Weiss,I., Ben-Abdelali,R., Mahlaoui,N.,
            Ponceau,J.F., Macintyre,E.A., Vekemans,M., Bernard,O.A. and
            Romana,S.P.
  TITLE     Fusion of ZMIZ1 to ABL1 in a B-cell acute lymphoblastic leukaemia
            with a t(9;10)(q34;q22.3) translocation
  JOURNAL   Leukemia 22 (6), 1278-1280 (2008)
   PUBMED   18007576
  REMARK    GeneRIF: Fusion of ZMIZ1 to ABL1 is associated with a B-cell acute
            lymphoblastic leukemia with a t(9;10)(q34;q22.3) translocation
REFERENCE   7  (bases 1 to 7615)
  AUTHORS   Beliakoff,J., Lee,J., Ueno,H., Aiyer,A., Weissman,I.L., Barsh,G.S.,
            Cardiff,R.D. and Sun,Z.
  TITLE     The PIAS-like protein Zimp10 is essential for embryonic viability
            and proper vascular development
  JOURNAL   Mol Cell Biol 28 (1), 282-292 (2008)
   PUBMED   17967885
  REMARK    GeneRIF: provides evidence to demonstrate a crucial role for Zimp10
            in vasculogenesis
REFERENCE   8  (bases 1 to 7615)
  AUTHORS   Lee,J., Beliakoff,J. and Sun,Z.
  TITLE     The novel PIAS-like protein hZimp10 is a transcriptional
            co-activator of the p53 tumor suppressor
  JOURNAL   Nucleic Acids Res 35 (13), 4523-4534 (2007)
   PUBMED   17584785
  REMARK    GeneRIF: Expression of exogenous hZimp10 enhances the
            transcriptional activity of p53 and knockdown of endogenous hZimp10
            reduces the transcriptional activity of p53.
REFERENCE   9  (bases 1 to 7615)
  AUTHORS   Li,X., Thyssen,G., Beliakoff,J. and Sun,Z.
  TITLE     The novel PIAS-like protein hZimp10 enhances Smad transcriptional
            activity
  JOURNAL   J Biol Chem 281 (33), 23748-23756 (2006)
   PUBMED   16777850
  REMARK    GeneRIF: First line of evidence demonstrates a physiological role
            for endogenous Zimp10 in regulating Smad3/4-mediated transcription.
REFERENCE   10 (bases 1 to 7615)
  AUTHORS   Sharma,M., Li,X., Wang,Y., Zarnegar,M., Huang,C.Y., Palvimo,J.J.,
            Lim,B. and Sun,Z.
  TITLE     hZimp10 is an androgen receptor co-activator and forms a complex
            with SUMO-1 at replication foci
  JOURNAL   EMBO J 22 (22), 6101-6114 (2003)
   PUBMED   14609956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356753.16, BC007288.1,
            AL358782.9, AL391665.28, AY235683.1 and AB033050.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020338.3.
            
            Summary: This gene encodes a member of the PIAS (protein inhibitor
            of activated STAT) family of proteins. The encoded protein
            regulates the activity of various transcription factors, including
            the androgen receptor, Smad3/4, and p53. The encoded protein may
            also play a role in sumoylation. A translocation between this locus
            on chromosome 10 and the protein tyrosine kinase ABL1 locus on
            chromosome 9 has been associated with acute lymphoblastic leukemia.
            [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY235683.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968189, SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334512.10/ ENSP00000334474.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL356753.16        99694-99762
            70-565              BC007288.1         1-496
            566-592             AL358782.9         11375-11401
            593-636             AL391665.28        8980-9023
            637-3145            AY235683.1         65-2573
            3146-4853           AB033050.2         2296-4003
            4854-7615           AL391665.28        121154-123915
FEATURES             Location/Qualifiers
     source          1..7615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..7615
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /note="zinc finger MIZ-type containing 1"
                     /db_xref="GeneID:57178"
                     /db_xref="HGNC:HGNC:16493"
                     /db_xref="MIM:607159"
     exon            1..305
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            306..415
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            416..511
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            512..592
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            593..701
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             642..3845
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /note="zinc finger-containing, Miz1, PIAS-like protein on
                     chromosome 10; retinoic acid induced 17"
                     /codon_start=1
                     /product="zinc finger MIZ domain-containing protein 1"
                     /protein_id="NP_065071.1"
                     /db_xref="CCDS:CCDS7357.1"
                     /db_xref="GeneID:57178"
                     /db_xref="HGNC:HGNC:16493"
                     /db_xref="MIM:607159"
                     /translation="MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRA
                     FQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEE
                     LGRLLLLRHQKSRQSDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQP
                     PGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAG
                     QQQQFSAKAGPAQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGIPPHTRPPADF
                     TQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQP
                     GPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPG
                     PRPQSLPIQNIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPAPNPPRPLTSPNYPGQRM
                     PSQPSSGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYP
                     HSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTF
                     PVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNW
                     PASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLV
                     HRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSL
                     KCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQY
                     MWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMP
                     NVMEMIAALGPGPSPYPLPPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDF
                     MHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQS
                     GPPLHHSGAPPPPPSQPPRQPPQAAPSSHPHSDLTFNPSSALEGQAGAQGASDMPEPS
                     LDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN"
     exon            702..815
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            816..921
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1066
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1181
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1399
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1598
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1871
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2054
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2132
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2307
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2449
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2660
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2766
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2927
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..2995
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3064
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3309
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3476
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3737
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..7615
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7596..7601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /note="hexamer: AATAAA"
     polyA_site      7615
                     /gene="ZMIZ1"
                     /gene_synonym="MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10"
                     /note="major polyA site"
ORIGIN      
        1 acttactcac cccctaacgc cgagttcctt ttcactgtct gtggacatta aaaaagcgag
       61 cggcggcggc gggcgccggg gagagcgggc ggccgggcgg caggcgggcg agcagcgatc
      121 gggcggccga gcgagcgagc aacgccggcg cagcgcggtg accccagccc cagccggcgc
      181 ggagcaggag ccggagccga gcggatctcg gcgccctcgc tgcgctcctc ccggcccgag
      241 cctgccctac ccggcggtgg cggcggcgcg tcctccagcg gcggcagcgg cgctcgcagc
      301 gcccggactc acggcagctg tgttctgatt tcgtactact gctggggctg ccacctcctc
      361 ctccagacgc tctcagcaga cttgagtcct ggtccttctg cagaggcctg agcaggagga
      421 agaggaggag gcccgttggc gtcggaccaa tgctgcaagg ggtgtgagga gaggagccgc
      481 tgtttttcac tgagctgcca taccccgaaa gcaggatgga gctggagtga ggtggagggg
      541 ccgcaagctg ctgaccggcg tgtggaacac tggtggtttg cagatcactg aggctggaca
      601 acgttcatgg ctctcgggta gaacctagtg aaacggccag aatgaattct atggacaggc
      661 acatccagca gaccaatgac cgactgcagt gcatcaagca gcacttacag aatcctgcca
      721 acttccacaa tgccgccacg gagctgctgg actggtgcgg agacccacgg gccttccagc
      781 ggcccttcga gcagagcctg atgggctgtt tgacggtggt cagtcgggtg gcagcccagc
      841 aaggctttga cctggacctc ggctacagac tgctggctgt gtgtgctgca aaccgagaca
      901 agttcacccc gaagtctgcc gccttgttgt cctcctggtg cgaagagctc ggccgcctgc
      961 tgctgctccg acatcagaag agccgccaga gcgatccccc tgggaaactc cccatgcagc
     1021 cccctctcag ctccatgagc tccatgaaac ccactctgtc gcacagtgat gggtcgttcc
     1081 cctatgactc tgtcccttgg cagcagaaca ccaaccagcc tcccggctcc ctttccgtgg
     1141 tcaccacggt ttggggagta accaacacat cccagagcca ggtccttggg aaccctatgg
     1201 ccaatgccaa caaccccatg aatccaggcg gcaaccccat ggcgtcgggc atgaccacca
     1261 gcaacccagg cctcaactcc ccacagtttg cggggcagca gcagcagttc tcagccaagg
     1321 ctggccccgc tcagccctac atccagcaga gcatgtatgg ccggcccaac taccccggca
     1381 gcgggggctt tggggccagt taccctgggg gtcctaacgc ccccgcaggc atgggcatcc
     1441 ctccgcacac caggccgcct gctgacttca ctcagcccgc ggcagccgct gcagcagcgg
     1501 cagtggcagc agcagcagcc acagctacag ccacagccac ggccactgtg gcagccctgc
     1561 aggagacaca gaacaaggat ataaaccagt atggaccgat gggtcccacc caggcgtata
     1621 acagccaatt catgaaccag cccgggccgc gggggcctgc ctccatgggg ggcagcatga
     1681 accccgcgag catggcggct ggcatgacgc cctcggggat gagcggccct cccatgggca
     1741 tgaaccagcc ccggccgccc ggcatcagcc cctttggcac acacgggcag cggatgcccc
     1801 agcagaccta cccgggcccc cggccccagt cccttcctat tcagaacata aagaggccat
     1861 accctggaga gcccaactat ggaaaccagc aatatggacc aaacagccag ttccccaccc
     1921 agccaggcca gtacccagcc cccaaccccc cgaggccact cacctccccc aactacccag
     1981 gacagaggat gcccagccag ccgagctccg ggcagtaccc gccccccacg gtcaacatgg
     2041 ggcagtatta caagccagaa cagtttaatg gacaaaataa cacgttctcg ggaagcagct
     2101 acagtaacta cagccaaggg aatgtcaaca ggcctcccag gccggttcct gtggcaaatt
     2161 acccccactc acctgttcca gggaacccca caccccccat gacccctggg agcagcatcc
     2221 ctccatacct gtcccccagc caagacgtca aaccaccctt cccgcctgac atcaagccaa
     2281 atatgagcgc tctgccacca cccccagcca accacaatga cgagctgcgg ctcacattcc
     2341 ctgtgcggga tggcgtggtg ctggagccct tccgcctgga gcacaacctg gcggtcagca
     2401 accatgtgtt ccacctgcgg cccacggtcc accagacgct gatgtggagg tctgacctgg
     2461 agctgcagtt caagtgctac caccacgagg accggcagat gaacaccaac tggcccgcct
     2521 cggtgcaggt cagcgtgaac gccacgcccc tcaccattga gcgcggcgac aacaagacct
     2581 cccacaagcc cctgcacctg aagcacgtgt gccagccggg ccgcaacacc atccagatca
     2641 ccgtcacggc ctgctgctgc tcccacctct tcgtgctgca gctggtacac cggccctccg
     2701 tccgctctgt gctgcaagga ctcctcaaga agcgcctcct gcccgcagag cactgtatca
     2761 cgaaaatcaa gcggaatttc agcagcgtgg ctgcctcctc gggcaacacg accctcaacg
     2821 gggaggatgg ggtggagcag acggccatca aggtgtctct gaagtgcccc atcacattcc
     2881 ggcgcatcca gctgcctgct cgaggacacg attgcaagca tgtgcagtgc tttgatctgg
     2941 agtcatacct gcagctgaat tgcgagagag ggacctggag gtgtcctgtg tgcaataaaa
     3001 ccgctctgct ggagggcctg gaggtggatc agtacatgtg gggaatcctg aatgccatcc
     3061 aacactccga gtttgaagag gtcaccatcg atcccacgtg cagctggcgg ccggtgccca
     3121 tcaagtcgga cttacacatc aaggacgacc ctgatggcat cccctccaag cggttcaaga
     3181 ccatgagtcc cagccagatg atcatgccca atgtcatgga gatgatcgca gccctgggcc
     3241 ccggcccgtc cccctatccc ctcccgcctc ccccaggggg caccaactcc aacgactaca
     3301 gcagccaagg caacaactac caaggccatg gcaactttga cttcccccac gggaaccctg
     3361 gagggacatc catgaatgac ttcatgcacg ggccccccca gctctcccac cccccggaca
     3421 tgcccaacaa catggccgcc ctcgagaaac ccctcagcca ccccatgcag gaaactatgc
     3481 cacacgctgg cagctctgac cagccccacc cctccataca acaaggtttg cacgtaccac
     3541 accccagcag ccagtcaggg cctccattac atcacagtgg ggctcctcct cctcctcctt
     3601 cccagcctcc ccggcagccg ccacaggccg ctcccagcag ccatccacac agcgacctga
     3661 cctttaaccc ctcctcagcc ttagagggtc aggccggagc gcagggagcg tccgacatgc
     3721 cggagccttc gctggatctc cttcccgaac tcacaaatcc tgacgagctc ctgtcttatc
     3781 tggacccccc cgacctgccg agcaatagta acgatgacct cctgtctcta tttgagaaca
     3841 actgagggcc acccggtcgg ggccatccct ccacactctg catcctaccc cacctaccca
     3901 acacactttt ccacctggga gcctgtgccc tcagaccgcc ccgcaccaga gccacgggct
     3961 gtggggcggg gagccctccc ccgctgcagc cctctcagaa cagaggggta gggagggtgc
     4021 accagtgcac caggaaggct gtgtgggtct ggagcccacg tcccacctcc acacccttgg
     4081 cttgggccca tgcccagcgc aggcctgaag accaccctcc cgagaggaac cagcccggta
     4141 agagggcaca cgctgatgcg gcttcccggt ccctccgcgt gtgccgattc cagatgacct
     4201 tccagtgtcc ccaaggttct tccatcttct agactgtaac cctgcctccc tgcttcctgg
     4261 tccagagcct ccctccagtg actgtggagc ctgagaaggc ccccgggccc cagcatgggc
     4321 cccgagcctt ggaggagcac tggcagttgg tggcagtgag accagcccac ccaccaccac
     4381 ccaccacaga aaagcacaaa cctctgggaa agacaacgtc tctcgggggc caggggtcat
     4441 cggtttgacc cctgacctat aagccaagat accccataaa cacactcaga aagcagagaa
     4501 aaaggacaag agtctgtgtt tgagaggggg tctgccattc ctgcttgggg actggtgggg
     4561 aagagggcca ggacatcttc tgagccagga cgtccctgag gctccacctc caagctcaga
     4621 cagggcccag gcttggggaa cagagagagc aggtgtacac ccaaccaaag tgattgtgcc
     4681 cttggttggg gggcgcgggc atataacctg tcagaagcaa acaggagcgg caacttctaa
     4741 ctttgctcca agccactctc tttttaaaca gcaacaattt aaagctatga agtcacctgg
     4801 agaaaaggaa cgttgctctt ggacagcaag caaaccattt ctctccgtct gttctgtttt
     4861 tctcctagtc cctctcctgc cacctctcca agacttccgt gggacaccca cttccctctg
     4921 tcctagttct ctttgtccaa tcagatggca agggcagtgc gtggaaaggc cggggaggtg
     4981 cagaaaccag agcccagggc aatggtgtct gtccagcccc tccctctgtc cctgtgctcc
     5041 aagctgcccc cggctgcagc ccaggccatg gacatgtgca ccagtatgta cctgcaggca
     5101 tgggggggag gggggcgtgt ttctgggcct gccccagaca ctgcccttgg ctgccagcct
     5161 accctgcctg cactcctcca ccatcacaat ctcacccaaa ctcctgctca ctcaagcaaa
     5221 agcagcctct ggccttccct ccaccgcttt gctccatctg gcttaccact ctccagggcc
     5281 tcctggggag cctgtcctgt gttcactttg tttcaggctg gtctgtgccc cgtgagccac
     5341 atggcctagg gtgatgccag gttgtcccgt cactggggtc ccatctgtaa attctttgcg
     5401 cccttcccgg ctgctgcctg gggccctttc ctgctctccc gtccgctgtg ggtggtcccc
     5461 agctctcctc tgtgggtttt accggaaagg tggccccagc tgttgacttc cagtcactgt
     5521 cccagacggc acaaggtttt ctgtaggaaa gctgccattg ccccggcccc ttttcttcct
     5581 ttgtcccgtt gtcgaggttt tttcaaatag cgtgttgttc agtatgcaaa tcaattattt
     5641 taagaatcgc ttttgtaaat atctttgtga atattttagt atcgtctttg ataatattca
     5701 acattttcat gacctggtta tagcctttgc tggtgttttt aaaatacctg gactcaatga
     5761 caaagaccga gtcttctttt tttttaaaca aaaacaaaaa aagcaaccag ggctatttgt
     5821 acagttgaag gggtgaacag aatgggcggc tgtgctggga gttggaagac cgggcagccc
     5881 gctatttaga gccatccctc agtcagctgg cagggacaag ccaacgccag gtagcatgtg
     5941 gccacccttg cccagtgtct gtggcctggc aagtggccac gccctgtgtc agaccatctg
     6001 ggaattaagc tccagacaga cttacagatg ccttccttag gagttcttgc ttcttgcgtt
     6061 gatactttgc cccagaaagg cctgggattc attctggttc ttatcagggt gtgtccacac
     6121 tctgctcaca ggtggatcca cggctttcca gtgcggagag tcgagatgct ccctgcagcc
     6181 caggccccgg gcacctcctg caaccatctc tgggctcagc acctgaggcg ggtttcctgg
     6241 gtcccctctc cagcaagcct ccaccagcaa gctcggccca gagcttccct tccggctggc
     6301 tctgaaccgt gcgtggtgcc tacagcctgc agtctggaga caagctcttc cggagtgctc
     6361 tgggagccag gccagggtgt gagggaggtg cagaggcatc cggggcggga gcaagcccca
     6421 ggttgtgaca ggtgcaggta gacaacgccc ataaacagag atggtcctga actctggaga
     6481 gatccttccc tgatcctttc ggacgactac ttggagccat aagtaacctc agcaaaaacg
     6541 aggcctctgc aagccacttt tccatgccaa gcatccaccc ggcccacagg catgtttctg
     6601 ccgccactcc gcaagatgga cagggagcca gcaggcaggc gggaagggcc aagtacaggc
     6661 aatcaccccc atcttcttgg tttgaagctt tatccatgta tcatgttccg tgtagccatt
     6721 ttatttttta agaaactgct aatactttct ccctaatgga agccctgatc ccccagagag
     6781 ctacaggtct gctcccgacg ggcctcgggc ctgacccgtc cacacagggc cgtgtcaaca
     6841 gcagcgactc aagggacgtg tgtacatatg taaatgagaa atagagacgt gtcaacagat
     6901 gcattcattt ctcttggaat gtgtattgtt tttattttgc gaaacaaaac aaaacaaaaa
     6961 aaaaagcttg gaactccatc acgtggaaaa actagatcct gttggttata gcatttgtga
     7021 gttctccacg tctgtctctc tcgctcatgt aatatactct gaccctgagt ggaaaggggt
     7081 ttttgttctg tttttatttt acctacatgt actatttagc ttcagtgtac tagtcctgcc
     7141 acctgtgtat ttttagggtg ctatggaaat aatgaaaaga aacggggatt tcagaagaaa
     7201 attgtaacca aattcatact ttgtataatt tttgatatca tgatcacagg tgattcacac
     7261 gtacacacat aaacacaccc accagtgcag cctgaagtaa ctcccacaga aaccatcatc
     7321 gtctttgtac atcgtatgta caatgcaatc atttcatact ttaaactggt caaaaaacta
     7381 attgtgattt ctagtcttgc aaagctgtat gtagttagat gatgtgacaa cctctaatat
     7441 ttatctaata aatatgtatt cagatgaaac ctgtatatta ggtgttcatg tggttatttt
     7501 gtatttaaag atcaaattat ttgactattg ctagacattt ctatactctg ttgtaacact
     7561 gaggtatctc atttgcccat gttaattttt ttctaaataa attgacaaaa acaaa
//
