LOCUS       NM_024645               2471 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger matrin-type 4 (ZMAT4), transcript variant
            1, mRNA.
ACCESSION   NM_024645
VERSION     NM_024645.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2471)
  AUTHORS   Cheong,K.X., Yong,R.Y.Y., Tan,M.M.H., Tey,F.L.K. and Ang,B.C.H.
  TITLE     Association of VIPR2 and ZMAT4 with high myopia
  JOURNAL   Ophthalmic Genet 41 (1), 41-48 (2020)
   PUBMED   32166996
  REMARK    GeneRIF: Association of VIPR2 and ZMAT4 with high myopia.
REFERENCE   3  (bases 1 to 2471)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2471)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 2471)
  AUTHORS   Verhoeven,V.J., Hysi,P.G., Wojciechowski,R., Fan,Q.,
            Guggenheim,J.A., Hohn,R., MacGregor,S., Hewitt,A.W., Nag,A.,
            Cheng,C.Y., Yonova-Doing,E., Zhou,X., Ikram,M.K., Buitendijk,G.H.,
            McMahon,G., Kemp,J.P., Pourcain,B.S., Simpson,C.L., Makela,K.M.,
            Lehtimaki,T., Kahonen,M., Paterson,A.D., Hosseini,S.M., Wong,H.S.,
            Xu,L., Jonas,J.B., Parssinen,O., Wedenoja,J., Yip,S.P., Ho,D.W.,
            Pang,C.P., Chen,L.J., Burdon,K.P., Craig,J.E., Klein,B.E.,
            Klein,R., Haller,T., Metspalu,A., Khor,C.C., Tai,E.S., Aung,T.,
            Vithana,E., Tay,W.T., Barathi,V.A., Chen,P., Li,R., Liao,J.,
            Zheng,Y., Ong,R.T., Doring,A., Evans,D.M., Timpson,N.J.,
            Verkerk,A.J., Meitinger,T., Raitakari,O., Hawthorne,F.,
            Spector,T.D., Karssen,L.C., Pirastu,M., Murgia,F., Ang,W.,
            Mishra,A., Montgomery,G.W., Pennell,C.E., Cumberland,P.M.,
            Cotlarciuc,I., Mitchell,P., Wang,J.J., Schache,M.,
            Janmahasatian,S., Igo,R.P. Jr., Lass,J.H., Chew,E., Iyengar,S.K.,
            Gorgels,T.G., Rudan,I., Hayward,C., Wright,A.F., Polasek,O.,
            Vatavuk,Z., Wilson,J.F., Fleck,B., Zeller,T., Mirshahi,A.,
            Muller,C., Uitterlinden,A.G., Rivadeneira,F., Vingerling,J.R.,
            Hofman,A., Oostra,B.A., Amin,N., Bergen,A.A., Teo,Y.Y., Rahi,J.S.,
            Vitart,V., Williams,C., Baird,P.N., Wong,T.Y., Oexle,K.,
            Pfeiffer,N., Mackey,D.A., Young,T.L., van Duijn,C.M., Saw,S.M.,
            Bailey-Wilson,J.E., Stambolian,D., Klaver,C.C. and Hammond,C.J.
  CONSRTM   Consortium for Refractive Error and Myopia (CREAM); Diabetes
            Control and Complications Trial/Epidemiology of Diabetes
            Interventions and Complications (DCCT/EDIC) Research Group;
            Wellcome Trust Case Control Consortium 2 (WTCCC2); Fuchs' Genetics
            Multi-Center Study Group
  TITLE     Genome-wide meta-analyses of multiancestry cohorts identify
            multiple new susceptibility loci for refractive error and myopia
  JOURNAL   Nat Genet 45 (3), 314-318 (2013)
   PUBMED   23396134
  REMARK    Erratum:[Nat Genet. 2013 Jun;45(2):712. Janmahasathian, Sarayut
            [corrected to Sarayut Janmahasatian]]
REFERENCE   6  (bases 1 to 2471)
  AUTHORS   Wan,J., Gao,Y., Zhao,X., Wu,Q., Fu,X., Shao,Y., Yang,H., Guan,M.,
            Yu,B. and Zhang,W.
  TITLE     The association between the copy-number variations of ZMAT4 and
            hematological malignancy
  JOURNAL   Hematology 16 (1), 20-23 (2011)
   PUBMED   21269563
  REMARK    GeneRIF: Examines the expression of ZMAT4 mRNA in the samples with
            1 or 2 copies of DNA, and observed a weak yet positive correlation
            between the relative expression level and gene dosage.
REFERENCE   7  (bases 1 to 2471)
  AUTHORS   Meigs,J.B., Manning,A.K., Fox,C.S., Florez,J.C., Liu,C.,
            Cupples,L.A. and Dupuis,J.
  TITLE     Genome-wide association with diabetes-related traits in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S16 (2007)
   PUBMED   17903298
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC048387.16, AK023904.1 and BC019598.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024645.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.202190.1, AK023904.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297737.11/ ENSP00000297737.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC048387.16        95690-95691         c
            3-1637              AK023904.1         1-1635
            1638-1667           BC019598.1         1394-1423
            1668-2471           BC019598.1         1425-2228
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..2471
                     /gene="ZMAT4"
                     /note="zinc finger matrin-type 4"
                     /db_xref="GeneID:79698"
                     /db_xref="HGNC:HGNC:25844"
     exon            1..144
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            145..250
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..838
                     /gene="ZMAT4"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger matrin-type protein 4"
                     /codon_start=1
                     /product="zinc finger matrin-type protein 4 isoform a"
                     /protein_id="NP_078921.1"
                     /db_xref="CCDS:CCDS34885.1"
                     /db_xref="GeneID:79698"
                     /db_xref="HGNC:HGNC:25844"
                     /translation="MKSSDIDQDLFTDSYCKVCSAQLISESQRVAHYESRKHASKVRL
                     YYMLHPRDGGCPAKRLRSENGSDADMVDKNKCCTLCNMSFTSAVVADSHYQGKIHAKR
                     LKLLLGEKTPLKTTATPLSPLKPPRMDTAPVVASPYQRRDSDRYCGLCAAWFNNPLMA
                     QQHYDGKKHKKNAARVALLEQLGTTLDMGELRGLRRNYRCTICSVSLNSIEQYHAHLK
                     GSKHQTNLKNK"
     exon            251..340
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..497
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            498..725
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..822
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            823..2471
                     /gene="ZMAT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT4"
                     /note="hexamer: AGTAAA"
     polyA_site      2471
                     /gene="ZMAT4"
                     /note="major polyA site"
ORIGIN      
        1 acagttggtc cgagctgccg aaaggtctgg tcgcagagac aggaacgtgt aatcctcagc
       61 gtgctccagc ccacagcttc gctctactgc tcggcagggc agctggcctc tgggcaccgg
      121 cggcccctct gcctcgcgga aaagcctgat gaagtcctcc gatattgatc aggatttatt
      181 cacagacagt tactgcaagg tgtgcagtgc acagctgatc tccgaatcgc agcgtgtggc
      241 ccactacgag agtcgaaaac atgcaagcaa agtccgactg tattacatgc ttcaccccag
      301 ggatggaggg tgtcctgcca agaggctccg gtcagaaaat ggaagtgatg ccgacatggt
      361 ggataagaac aagtgctgca cactctgcaa catgtcattc acttcagcgg tggtggccga
      421 ttcccattat caaggcaaaa tccacgccaa gaggttaaaa ctcttgctag gagagaagac
      481 cccattaaag accacagcaa cacccctgag cccacttaag cccccacgga tggacactgc
      541 tccggtggtc gcatctccct atcaaagaag agattcagac agatactgtg ggctctgtgc
      601 agcctggttt aataaccctc tgatggccca gcaacattat gatggcaaga aacacaaaaa
      661 gaatgcggca agagttgctt tgttagaaca actggggaca accctggata tgggggaact
      721 gagaggtctg aggcgcaatt acagatgtac catctgcagt gtctccctaa actcaataga
      781 acagtatcat gcccatctga aaggatctaa acaccagacc aacctgaaga ataagtagtg
      841 aaagcatcaa tcaagacata agaacaaaac attagcattt ctctgccgtg gagaattgct
      901 tatcaaccac cagaggaggc ttctttcttg aacaataaac atttcttata aggattcaca
      961 gattcacata cgactgatct tgatttttgg aaatgaatga ggtttctttt ttctttttcc
     1021 tttttttaat tttggggtaa gttatgatat ttggatggat ttttaaattc tttcctgata
     1081 acatatttag cacatgttct aaattataat cctatagcaa acagttggag cattattcaa
     1141 actgaaagtg gaaaaattta aatttccaat ttattctaga tttcctcaga gcataattat
     1201 tctgttaaat cctcaatgag tgtgatgtaa accacctcta tccagaaata tacattcttt
     1261 tctcatcatg ttggacacag ttgagggtga catgcacaga actggaacag atcactatta
     1321 gtggaaaata ccaaatggac aaataaatac cagtcgtttt ctccgttctc caagcacagg
     1381 agccaggttt accatctgaa caatgaagac gaagggagta aataaaggaa gaattctcat
     1441 cttttttcct gatcattcaa agaacagttt ctcaaggtta agccaagtcc tccttgcaag
     1501 ttgccaaata atagcttagg aaaagaatta gtctgcctgc atgatgatct tcttaggcaa
     1561 aaacgtcttc acagcccttg accttggtga atttttttcc ccaaaagcat ccaaaagaag
     1621 aattataaac cccagaatga gatggaaata aacaagtatt tttttttatg atgtttggcc
     1681 tgaactgtgg gctttaattg ggggatactg atcgtttgga aagaagtgag aaaattctga
     1741 agaaatggcg gccttgggct aggcggggtc ccctatttct tctgtttctc actgaagtcc
     1801 tactgctgag ccaagactca gtcactctgg aaagagcatg accgataaag aaaacagttc
     1861 ctttctgatg gggagcgtct gagtgcagat catgaggctc tttctctagg tttaattctt
     1921 ttccatggtg accggacttg gtgtcttgta gcctggttac gaagtgggac gttgagcttc
     1981 tactgacgat gccctgcatg gaccagctgg gatctggctg gggctgccct gtgtccctaa
     2041 cgaccatagg caatccatct tcttgtgtca gcaatttctg gacacccact gttttccacc
     2101 aagagctgag gtggcaacaa ctcagtgagc aataaacaaa atgacacaga aatgcacagt
     2161 gttgttatga aggagcctgt ttacctgtgt tcaaaatctg gcaccattcc cttgagcagg
     2221 gcccgctcag gagggaccag gtctgccagt ttctgtgcct gcagagagac gaagccccac
     2281 gagccacacc ctactctaca agaggaaagg gggttggatg ggaagaatct attttgctgt
     2341 tttggaaagc acacagccga cctacaaacc tcctgtgatg gtgtttcttc ggatgtgtaa
     2401 aataaggctt tatttgtcaa ttccgctgta aaataagcat tgtccgagta aaaacagcag
     2461 caacaacaaa a
//
