LOCUS       NM_022470               8936 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger matrin-type 3 (ZMAT3), transcript variant
            1, mRNA.
ACCESSION   NM_022470
VERSION     NM_022470.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8936)
  AUTHORS   Li,Q., Xiao,M., Shi,Y., Hu,J., Bi,T., Wang,C., Yan,L. and Li,X.
  TITLE     eIF5B regulates the expression of PD-L1 in prostate cancer cells by
            interacting with Wig1
  JOURNAL   BMC Cancer 21 (1), 1022 (2021)
   PUBMED   34525951
  REMARK    GeneRIF: eIF5B regulates the expression of PD-L1 in prostate cancer
            cells by interacting with Wig1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8936)
  AUTHORS   Muys,B.R., Anastasakis,D.G., Claypool,D., Pongor,L., Li,X.L.,
            Grammatikakis,I., Liu,M., Wang,X., Prasanth,K.V., Aladjem,M.I.,
            Lal,A. and Hafner,M.
  TITLE     The p53-induced RNA-binding protein ZMAT3 is a splicing regulator
            that inhibits the splicing of oncogenic CD44 variants in colorectal
            carcinoma
  JOURNAL   Genes Dev 35 (1-2), 102-116 (2021)
   PUBMED   33334821
  REMARK    GeneRIF: The p53-induced RNA-binding protein ZMAT3 is a splicing
            regulator that inhibits the splicing of oncogenic CD44 variants in
            colorectal carcinoma.
REFERENCE   3  (bases 1 to 8936)
  AUTHORS   Bieging-Rolett,K.T., Kaiser,A.M., Morgens,D.W., Boutelle,A.M.,
            Seoane,J.A., Van Nostrand,E.L., Zhu,C., Houlihan,S.L., Mello,S.S.,
            Yee,B.A., McClendon,J., Pierce,S.E., Winters,I.P., Wang,M.,
            Connolly,A.J., Lowe,S.W., Curtis,C., Yeo,G.W., Winslow,M.M.,
            Bassik,M.C. and Attardi,L.D.
  TITLE     Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression
            Program
  JOURNAL   Mol Cell 80 (3), 452-469 (2020)
   PUBMED   33157015
  REMARK    GeneRIF: Zmat3 Is a Key Splicing Regulator in the p53 Tumor
            Suppression Program.
REFERENCE   4  (bases 1 to 8936)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8936)
  AUTHORS   Lee,H.C., Jung,S.H., Hwang,H.J., Kang,D., De,S., Dudekula,D.B.,
            Martindale,J.L., Park,B., Park,S.K., Lee,E.K., Lee,J.H., Jeong,S.,
            Han,K., Park,H.J., Ko,Y.G., Gorospe,M. and Lee,J.S.
  TITLE     WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via
            miRNA-dependent and -independent mechanisms
  JOURNAL   Nucleic Acids Res 45 (11), 6894-6910 (2017)
   PUBMED   28472401
  REMARK    GeneRIF: WIG1 governs the miRNA-dependent and the miRNA-independent
            recruitment of AGO2 to lower the stability of and suppress the
            translation of ACOT7 mRNA.
REFERENCE   6  (bases 1 to 8936)
  AUTHORS   Mendez Vidal,C., Prahl,M. and Wiman,K.G.
  TITLE     The p53-induced Wig-1 protein binds double-stranded RNAs with
            structural characteristics of siRNAs and miRNAs
  JOURNAL   FEBS Lett 580 (18), 4401-4408 (2006)
   PUBMED   16844115
  REMARK    GeneRIF: Results demonstrate that human Wig-1 can bind different
            types of double-stranded RNAs (dsRNAs), including dsRNAs resembling
            small interfering RNAs and microRNAs, and indicate that dsRNA
            binding has a role in Wig-1-mediated regulation of cell growth.
REFERENCE   7  (bases 1 to 8936)
  AUTHORS   Higashi,Y., Asanuma,M., Miyazaki,I., Haque,M.E., Fujita,N.,
            Tanaka,K. and Ogawa,N.
  TITLE     The p53-activated gene, PAG608, requires a zinc finger domain for
            nuclear localization and oxidative stress-induced apoptosis
  JOURNAL   J Biol Chem 277 (44), 42224-42232 (2002)
   PUBMED   12196512
REFERENCE   8  (bases 1 to 8936)
  AUTHORS   Varmeh-Ziaie,S., Ichimura,K., Yang,F., Rabbits,P. and Collins,V.P.
  TITLE     Cloning and chromosomal localization of human WIG-1/PAG608 and
            demonstration of amplification with increased expression in primary
            squamous cell carcinoma of the lung
  JOURNAL   Cancer Lett 174 (2), 179-187 (2001)
   PUBMED   11689294
REFERENCE   9  (bases 1 to 8936)
  AUTHORS   Hellborg,F., Qian,W., Mendez-Vidal,C., Asker,C., Kost-Alimova,M.,
            Wilhelm,M., Imreh,S. and Wiman,K.G.
  TITLE     Human wig-1, a p53 target gene that encodes a growth inhibitory
            zinc finger protein
  JOURNAL   Oncogene 20 (39), 5466-5474 (2001)
   PUBMED   11571644
REFERENCE   10 (bases 1 to 8936)
  AUTHORS   Varmeh-Ziaie,S., Okan,I., Wang,Y., Magnusson,K.P., Warthoe,P.,
            Strauss,M. and Wiman,K.G.
  TITLE     Wig-1, a new p53-induced gene encoding a zinc finger protein
  JOURNAL   Oncogene 15 (22), 2699-2704 (1997)
   PUBMED   9400996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA001239.1, BC002896.2 and
            AC117456.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022470.3.
            
            Summary: This gene encodes a protein containing three zinc finger
            domains and a nuclear localization signal. The mRNA and the protein
            of this gene are upregulated by wildtype p53 and overexpression of
            this gene inhibits tumor cell growth, suggesting that this gene may
            have a role in the p53-dependent growth regulatory pathway.
            Alternative splicing of this gene results in two transcript
            variants encoding two isoforms differing in only one amino acid.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            5' UTR and uses an alternate in-frame splice site in the 3' coding
            region, compared to variant 1. The resulting isoform (1) includes
            one extra residue in the C-terminal region, compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.553124.1, BC002896.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311417.7/ ENSP00000311221.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA001239.1         60-72
            14-1256             BC002896.2         1-1243
            1257-8936           AC117456.6         82809-90488
FEATURES             Location/Qualifiers
     source          1..8936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.32"
     gene            1..8936
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /note="zinc finger matrin-type 3"
                     /db_xref="GeneID:64393"
                     /db_xref="HGNC:HGNC:29983"
                     /db_xref="MIM:606452"
     exon            1..215
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..542
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1142
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /note="isoform 1 is encoded by transcript variant 1; p53
                     target zinc finger protein; zinc finger protein WIG1;
                     WIG-1/PAG608 protein; p53-activated gene 608 protein"
                     /codon_start=1
                     /product="zinc finger matrin-type protein 3 isoform 1"
                     /protein_id="NP_071915.1"
                     /db_xref="CCDS:CCDS3224.1"
                     /db_xref="GeneID:64393"
                     /db_xref="HGNC:HGNC:29983"
                     /db_xref="MIM:606452"
                     /translation="MILLQHAVLPPPKQPSPSPPMSVATRSTGTLQLPPQKPFGQEAS
                     LPLAGEEELSKGGEQDCALEELCKPLYCKLCNVTLNSAQQAQAHYQGKNHGKKLRNYY
                     AANSCPPPARMSNVVEPAATPVVPVPPQMGSFKPGGRVILATENDYCKLCDASFSSPA
                     VAQAHYQGKNHAKRLRLAEAQSNSFSESSELGQRRARKEGNEFKMMPNRRNMYTVQNN
                     SAGPYFNPRSRQRIPRDLAMCVTPSGQFYCSMCNVGAGEEMEFRQHLESKQHKSKVSE
                     QRYRNEMENLGYV"
     exon            543..662
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..829
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..930
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..8936
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6092..6097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /note="hexamer: AATAAA"
     polyA_site      6120
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /note="major polyA site"
     regulatory      8906..8911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /note="hexamer: AATAAA"
     polyA_site      8936
                     /gene="ZMAT3"
                     /gene_synonym="PAG608; WIG-1; WIG1"
                     /note="major polyA site"
ORIGIN      
        1 agtcacttcc tgcagctgtt tccctgtggg tcgggttgga ctgacttttg acagtcagcc
       61 ttcggctgcg gagggggctc ggcggcggcc ggcggagaaa gttgctccga gaagaggctg
      121 ggtcgagctg ggccgagccg ggcgcgcagg gcgggcgtcg cgggcgtccc gggcggacgc
      181 ggcgcggaga ctgccggcgc gtcccggggg ttccgatttg aagaccttgc ttctcatcac
      241 ccactggatt atgccccagg cttccctacc caatgatcct cttgcaacac gccgtgcttc
      301 ctccacctaa gcagccctca ccctcgcctc ctatgtcagt ggccaccagg tctacaggaa
      361 ccttgcagct tccaccacag aagccttttg ggcaggaggc ttccttgcct cttgcagggg
      421 aagaagagtt atcgaaggga ggggagcaag actgtgccct ggaggagcta tgtaagcccc
      481 tgtactgcaa actctgcaat gtcaccttga actctgcaca gcaagcccag gctcattatc
      541 agggtaaaaa tcatggtaag aaactccgaa attactatgc agcaaatagc tgtcctcctc
      601 ctgctagaat gagcaatgtg gtcgagcctg cagctactcc agttgttcca gtccctccgc
      661 agatgggctc ctttaagcca ggaggccgag tgatcctggc cacggagaat gattactgta
      721 agctctgtga tgcctccttc agttccccag ctgtggctca ggctcactat caagggaaga
      781 atcatgccaa gaggctgcgg ctggcggaag ctcagagtaa ctcattctcg gaatcctcag
      841 agctgggtca acggcgggcc aggaaagaag ggaatgagtt taagatgatg cctaacagga
      901 gaaatatgta tacagtacag aataattcag caggtcctta cttcaatccc cgctctcggc
      961 agagaattcc acgtgatctg gccatgtgtg ttactccaag tggccagttt tactgctcaa
     1021 tgtgtaatgt tggagctggc gaagagatgg aattccggca gcatttagag agcaagcaac
     1081 ataagagcaa ggtgtctgaa cagcggtaca ggaatgagat ggagaatctg ggatatgtat
     1141 agtgattatc atattaagat agagcagctt ttcctgcctg ttgtttgcct tttgtcaact
     1201 tgccctgctt tgtggtcttt ttgatatgag tacattcctc tgcttaatgt taatacatgt
     1261 aacccacagt ggtaccatga gatgtcaaaa cctgggggcc cgggggcggg gcggggggag
     1321 gtgggtgtga agaacgtgct tcttaggtca taacgctttt gcagggtcaa tggtgttgag
     1381 ccgctcatag catgtgacct acctacccca tcagaaataa ctttttatct tgctcaagtt
     1441 ctggtcaact agtagcctga cggcttagaa ctttgactat ttaaaagttt cattttcttt
     1501 tgcaatttta gttttatgta ctgttaaaga attgtactga attcttttta gatcacagta
     1561 aaaataggtt ggcagagatt tcagtttccc agggcttaac cagaaccgcc acctcaatgc
     1621 attgtcagta gaatacatta ttagaaactg ttaaggtctt tcccgggaca tttttttctg
     1681 ccattttctt ttgcaattgt agttttatgt actgttaaag aattgtattg aattcttttt
     1741 agatcaaagt aaaaataggt cagcagagat ttcagtttcc cagggcttaa ccagaaccgc
     1801 cacctcaatg cattgtcagt aggatacatt attagaaact gttagggtct ttcccaggac
     1861 attttttttt ctgtatcatg tctccccatc attgaagcgc aaattttctt gaattcaaat
     1921 actcccaatg agcttgtata cttccaaaca gctaaacttg atttccagtt gtggatttca
     1981 cacatataat tgccgccttc ttccctcctc ttttttcccc cctagttgaa tcagcttgtc
     2041 taacaagccc attttcatgc cccagctgtg ctgtgggttt tccaagcctc atatttgaat
     2101 attcaatgag tttaagatgg atatgatttc aaaaaatagg gccgggcgcg gtggctcacg
     2161 cctgtaatcc cagcactttg ggaggccgaa gcaggcggat cacgaggtca ggaggtcgag
     2221 atcatcctgg ctaacacagt gaaaccccat ctctactaaa aatacaaaac attagccggg
     2281 cgtggtggtg ggtgcctgta gtcccagcta ctctggaggc tgaggcagga gaatggcgtg
     2341 aacccgggag gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggtg
     2401 acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaaaaaaata tatatatata
     2461 tagatatatt ttccagcagt ttttaggaaa caaaggtgtg tttgattttc caatttagag
     2521 ttacttcatt gatagtaaca tgcgcttata tcatgatcta aaccataagt tcagattgct
     2581 tgatattttg ttttgccaga cttttttgat aatctgattc ttacggttta cttacatttt
     2641 cctctgtctt gccagtctgg tggccatcct gaaaaatatc accacctgct gttttataca
     2701 cagaggaatt ttttaaaaag caaataaagt ttcactatct tcgtttccag tagaaatata
     2761 cacgaactat ggttttattc tttgtaattc ggctttcttg aagatactaa caagtatatg
     2821 atagatcact ttggcatctg ataattatat cagtattatt atttttgttt ttttgcgttt
     2881 aaaataagaa gttgtatgaa cccaggaggt ggaggttgca gtcagccaag aatcgtgcca
     2941 ctgcactcca gtctgggcga cagagcaata ctccgtctcc aaaaaaaaaa aaaaagaagc
     3001 tataatatat atctagatta actaatggag tgctctgtga atattcatta actacatttt
     3061 atctatttac tatattttat atgggtaaga ccagtggtca tccgtatttc ttttgaaagc
     3121 ccacttgatc aggaagttta tattttaagc agtatgtttg cacaatggtc agttcacatt
     3181 tgattgcttg tattactaat tagaggtaaa acttctattt tttcttgata attctgtagg
     3241 caaaaaaaat tggggaaggc aaattacaat cattcttctt ctgtaatact ttgggacaat
     3301 ttttaaacaa ctcagaccca tgtttaaaaa cgagttttgt gtgattaacc cttgtatagt
     3361 atccagttac tgtcttctct tgaagtggtg gttctttgag aagtagaatt attttgtaac
     3421 ttttcttctc ccagaaacag aagaatcaaa tactattctg ttaggattct atctagacct
     3481 gtgactctta gtataataac ccttttatta ttattattat tattattttt tcagtaatct
     3541 ataaagtaga gttgcttagt tttgagcaat ttagggcttt tcttattggc cagtaggtta
     3601 ttcattttgc tgctaaatat aattttttgg ttaattttaa cattatagtg ctggccgctt
     3661 ggttctatga ttacctaaaa atctagtttt tttcctccat aggtagatgt gtgtgtatgc
     3721 atacccccac acacacacgt acatatatgt tgtcatagag aggtatttca acccttattt
     3781 caaataacag tagaagatac gaacatgaat ttatattttg taaaaatgtc attcatccac
     3841 tttgttttcc attggaaata gttttataag aagggttccc cttgctctct ccacttaaca
     3901 atttcattat atacgtagaa aaagcagccg acttaagggc ttgatgtttt ttcaggcctt
     3961 gtggattcag gtttccagtt tcccagtgcc cttaatggat gttatgaatg cataagcaca
     4021 ttttctttta aagaaagaag ttagatttat agtgttattt cttacttgct atatttcttt
     4081 gcactaaaaa agagctatgt gtttgtttta taggacactt tagtaccgta ttgcctacaa
     4141 taactcagtt tgctccttaa attccaaact ctgggaagtt gataaataac ttccatgatc
     4201 acttgtaaaa gttacatgca catctgaaaa aaaatcacaa atctctatga cagtaggtta
     4261 tgttttgagc ttgttacctt gcagtattct tctctgttcc ataggtgaaa acaaagggtg
     4321 acagaggtta tcaggcagga aatgcctaaa tagatacatc tctgcatggt acaatttctc
     4381 atattcatgt attccataaa cagtgttttt tctctgttta agcagactgt tgtttcttct
     4441 gagtcagtga tatgtgatct tcgttggttt cattttgtga agctcagtct gtctctgtaa
     4501 catactttag gatttgcacc ttgtgctccc caggaattat gttagtgtcc ttttctatgc
     4561 tgtcttcaag gatggacaga ggcctaaacc acaacaacaa caaaaattag aaaaaaaaat
     4621 acttagattt cggtaatcat ccataggaac tcatagcatc agtctctttt ctctgtgaat
     4681 aatatctttg tgtaagttgt cataaaaaat caacgttaga agatgacaat tagaattctt
     4741 cttaggtatt gagggtaaga agttgtaaag aaagaaaatt cgtgtttcaa ctaaaagatt
     4801 ggattgcata tacctttgaa gtggttttgt aaaaaaagtt cagttactaa actgagtgtg
     4861 ccctgtaatc cttttgagtg cactgaagat gctttgaaaa tactttgttg gtcttcacat
     4921 tgtgcatcat gtcctgcaac ttgtaaatat gtgcatgttg tttatgtttg tctgcctgtc
     4981 tcttattgca ctaaattctg caaggtgaat aattttttta taccatttat ttggaaaaag
     5041 ttcctcctcc aactcttctt cactgacctt ttaattagtt ggtaaactta gaaaaccagg
     5101 taggattttt gaagccctga gtttaaaaga agaatcgtgg ctatttgaca tcatccttac
     5161 attcccctga cttaaaaagc taacaagaag cacgagatct tccacctcat tttagaaagc
     5221 ttttctacag aactatatgc ttgcttatag ctacctatct acagtttgaa cagggagaaa
     5281 gggagatatg tatgtctggt tacatcttcc ttcactcttg aattggctgg gacagcaagc
     5341 aacaacagtt tgaggtccag tgacctacgt aaaatgagtg tcgtttgtgt caggggacac
     5401 atgtaactgt gcaacatggt attttctaca gggagggcta ggaagggtgg ttttggaacc
     5461 taacctactt tgtgtcttca ttgtcagaac taaggttgga aatgcccttt aaagaacttg
     5521 gtgaggcata tgctaggaca atagagctgc tttagaaaga aattgagaca tgttttgtca
     5581 ggacagataa aagtttaatg caggcttttg aacagatgtt ttaaaacaaa tttgacctta
     5641 ccaactattt ttttcttcta gccaaatcat tgtacaggag tttcatatat gataaaaagt
     5701 gttttgttat tgtttttgct ttcttggcag gggagaaccc ctaccattgt gagcagttac
     5761 tgtcactctg gctgaatgga caaatagctg tgtaaatagc ttctcataaa acgcttctac
     5821 tgatagctgt ttgacttttt cttcccgtta tgaatgggag gaacatttgt aaacttcctt
     5881 tctgggtagc taccaaaaaa cgtactggct tatggtccca tgtgaccttg tctccgttaa
     5941 gcccagaatc tgagtgcctt tagcaagtgt tagcatttca cagagagaag agagacagaa
     6001 ttattgctat taatcaccat tcataaatag gagcttggaa taacaaaggt ctgtgtgaat
     6061 tctgttctac gtcttttttt tccctttttt aaataaatgt caatttgata tcaagtaaaa
     6121 ctattgtcat tattgatcag aaaccataca ttctgaaaat gaatccagtt ttcccaagct
     6181 ggcagaagtc agagatcatt tttcaccttg atctgtgttg cgtttgtact tagtgaatgg
     6241 cagtgtggtt gattggaaga gcttgacact gatgtttgga aaaattcttt attctagtgg
     6301 tcattttcaa acttgtcttc tgtagagagg ggaaaaatta tgtatttgca gctaaagcga
     6361 agagactggc acaataatta ttaattgtgt tagttcattt ctatattaaa tgaagcatct
     6421 tcacaaatca ggtttgaagc cattaaaagc aaaattttcc ctagtttaat taatttaaaa
     6481 ttctaaattg cctgactact tagaatctta gaaacgccct gctagactga ttttattata
     6541 gaaatgttaa catgttcctc aacattttct caagaaaatt ttcagacata tatcaaagtt
     6601 gaaaaaactt tgcagtataa ccactgctag attctgccat caacatttga ctatacttgt
     6661 attgccatgt atctgttcat attctctatc cctcttttca tccatcgatc catcagattt
     6721 tttttttaaa gaacattcca aagtaaattt taggcaatac actgccctaa attcttagca
     6781 tgggtgtcat taattaaggt ttagtattcg tttaaatatc tattttgaaa gtggtgtatg
     6841 aagttgataa tctgagccaa ttaacatact tttttttttt tcctcctgtg gacttttgtc
     6901 ttccagtttc tctttttgtg tgtacttagg gtgagggagg acaattcctt tcaaacacaa
     6961 gtttatttta gaattggtca tttttaagtg cttgtcataa attttaaagt ttcaatataa
     7021 tttttctttt ccccacttct gataatgtat ttttgccaaa ctatgcagct tcttcaaaaa
     7081 actgtaaatt actgattggg gtttatgaaa tcagcgaata cctcatttca atctgttgct
     7141 gcttttctcc ctcttgtcac ttctcctttc actactttca gctgctctac cagaaggtag
     7201 aggggagtaa agggtcaaac ccctatataa ttagctgttt taaacaactc taggagagca
     7261 gattaagtag cttagtaagt tgaaactatt aatttttcta aagaatttga tttgaattcc
     7321 ttgagaattg taattatcca cacttcctcc agctataatt agcagaatta aaaatgattg
     7381 tactgtacaa tgagttgttg aaattgtaag ccttagtaac catctttagc tttattgtag
     7441 tcatgtttag aaaaaattat ttttacatat gcctttattt ttatgcccac tttttgtgga
     7501 taagattctt tagataaaat ctaaagaatt ttaagtgact ttctccaggt catgaagatt
     7561 caatgggtag aattgaatca gaattgaaat gttccagatt catattcttg tgtgtgtttg
     7621 ataaaattca tggcttccaa agtaactgaa cacttccttt gggcccttgg agggaaaatc
     7681 catattttta ctaattacac tttttttttt agacatctgg cagttctttg aacttaaaca
     7741 tattctcatg gccatagttc caaattaagc ccgacgcagt tgctaaaaat cttgctgcac
     7801 tgttgaatac taataatgca acatttattg gatgtttttg cattttgatg accttcatga
     7861 ttcatttata agtctttgta agtgcttaag tgaccccctc actagtgaaa ataataaatg
     7921 ttctatatca tttattatta tttgtgtatt ctctacatga tatatttttt taaggaagag
     7981 taactccaca tgtcagaatg agtgatatta tcctagggca aagcgcaaat agggcagttt
     8041 gtttctactc tgcaaatatg gcatgtatag gaacaaaact cttttggagt ggctggtcat
     8101 tgttctgccc tcttttggta cctgagtacc tttctggggt tttgtaaatc gtgtgtcatt
     8161 tgtaagaatt tcacgttaac tctgcgttac ttggtgttca cctgtggtat ccttgactga
     8221 ccataatgat ttagtttggg tatgatgtgt ctgctttgaa atgccttact ggagtatgtc
     8281 agatcctgct ttaaagcatt ccatatatct gctgggacaa taagttgctt ctccttggaa
     8341 atatgctcta gattcagaag caaaaccgat tttgctttca ccattaaggt tgcattttaa
     8401 tgcagttatt gttttaaatt agagaataaa atgtaaaacc aagggaggct ttagaaccct
     8461 ttattgaatg gcatggcaaa cttttaaaac tgcttttgct atttcactag aactatcttt
     8521 gataaaggat atagctaaaa aatgtcagcc caaactgtgt gtaattaggg ttgtttatta
     8581 aaattttctc taaatgtcat acagaggctt aagatctgtg tatgctgttg ggtcggagtg
     8641 ccagtcactg ctttggaagt ctgtgttctg gggctgcaga atgacaaacg tgtcatggga
     8701 ttaaaaccaa tcaactgtga attgtgaaat tgaaactact ctttcggttt tattttcttt
     8761 agcatattga gtatagaaat ctgaaactta tttaaaattt atactgcttt tgttgatggc
     8821 tcattttggc tgtgtatcct cacttatgta ctgatttctg ataaaggctt gacattatta
     8881 taacacgcat tttgtgttcc agtttaataa aacggtttct gagtcttgtc tgaaaa
//
