LOCUS       NM_144723               1544 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger matrin-type 2 (ZMAT2), mRNA.
ACCESSION   NM_144723
VERSION     NM_144723.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Rotwein,P. and Baral,K.
  TITLE     Zmat2 in mammals: conservation and diversification among genes and
            Pseudogenes
  JOURNAL   BMC Genomics 21 (1), 113 (2020)
   PUBMED   32005145
  REMARK    GeneRIF: Zmat2 in mammals: conservation and diversification among
            genes and Pseudogenes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1544)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1544)
  AUTHORS   Tanis,S.E.J., Jansen,P.W.T.C., Zhou,H., van Heeringen,S.J.,
            Vermeulen,M., Kretz,M. and Mulder,K.W.
  TITLE     Splicing and Chromatin Factors Jointly Regulate Epidermal
            Differentiation
  JOURNAL   Cell Rep 25 (5), 1292-1303 (2018)
   PUBMED   30380419
REFERENCE   6  (bases 1 to 1544)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   7  (bases 1 to 1544)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   8  (bases 1 to 1544)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1544)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055683.1, AA071274.1 and AC116353.2.
            
            On May 17, 2019 this sequence version replaced NM_144723.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.414428.1,
                                           SRR7410570.252410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274712.8/ ENSP00000274712.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1333              AK055683.1         1-1333
            1334-1539           AA071274.1         19-224              c
            1540-1544           AC116353.2         162393-162397
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1544
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="zinc finger matrin-type 2"
                     /db_xref="GeneID:153527"
                     /db_xref="HGNC:HGNC:26433"
                     /db_xref="MIM:619930"
     exon            1..32
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..614
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /codon_start=1
                     /product="zinc finger matrin-type protein 2"
                     /protein_id="NP_653324.1"
                     /db_xref="CCDS:CCDS4239.1"
                     /db_xref="GeneID:153527"
                     /db_xref="HGNC:HGNC:26433"
                     /db_xref="MIM:619930"
                     /translation="MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPV
                     KRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGK
                     KHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYK
                     KEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY"
     exon            33..126
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /inference="alignment:Splign:2.1.0"
     exon            127..250
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /inference="alignment:Splign:2.1.0"
     exon            251..324
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /inference="alignment:Splign:2.1.0"
     exon            325..470
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1544
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="hexamer: AAGAAA"
     polyA_site      908
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="major polyA site"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="hexamer: ATTAAA"
     polyA_site      1274
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="major polyA site"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
                     /note="major polyA site"
     polyA_site      1544
                     /gene="ZMAT2"
                     /gene_synonym="Ptg-12; Snu23"
ORIGIN      
        1 acttcgctgt gaagatggcg tcgggcagcg ggacaaaaaa cttggacttt cgccgaaagt
       61 gggacaaaga tgaatatgag aaactcgccg agaagaggct cacggaagag agagaaaaga
      121 aagatggaaa accagtgcag cctgtcaagc gagagctttt acggcatagg gactacaagg
      181 tggacttgga atccaagctt gggaagacaa ttgtcattac caagacaacc cctcaatctg
      241 agatgggagg atattactgc aatgtctgtg actgtgtggt gaaggactcc atcaactttc
      301 tggatcacat taatggaaag aaacatcaga gaaacctggg catgtctatg cgtgtggaac
      361 gttccaccct ggatcaggtg aagaaacgtt ttgaggtcaa caagaagaag atggaagaga
      421 agcagaagga ttatgatttt gaggaaagga tgaaggagct cagagaagag gaggaaaagg
      481 ccaaagcgta caagaaagag aaacagaagg agaagaaaag gagggctgag gaggacttga
      541 catttgagga ggacgatgag atggcagctg tgatgggctt ctctggcttt ggttccacca
      601 agaagagtta ctgaggcttt ctgtgcttgg cctgactttg gcctatgctg gacctaactt
      661 tgcgtgtgtg tgtgtgtagt agggggtcat ttctttttgg gtaatgggaa agttcttaag
      721 agtgtcaatg gggagggata gagggtgggg gctcatggtt tccctctact ttgggagagg
      781 gcacagattg cagaggtaat gctgtggcat attgcttctg cctcagtgta tcactggagt
      841 cacaggaccc tgcccacctg agttcccaat aaagaaaaac ctccccttct gaggctgctt
      901 tcccaaaact ccccctgcat ctttatctct tcatctatcc cacctcttgt ctgaacatcc
      961 cacctttatc ctgtgttctg cctttgtttt aattttaact catgttcatc ctgcaacaga
     1021 agcattctct aggtcccagt ttccagttga ttgcatatcc ttgatcagcc ctttttccca
     1081 tcctgcccta tggttctcta gccacctgtg catgcatgtg tatttctgcc tggttctatg
     1141 gtgtgtggat gtgtgtgcat gaatctgtca tatagagggg gtccgagctg gaatcctaga
     1201 gcattgctgc cctggggcct gatgttcttg gcttcctcag agcatgtaac aggaaattaa
     1261 atgggatgag tgtttggtgt ggtttgtgtc tgatgagttt tttaacattc aggtgtagat
     1321 tgtttcagct tctcatgttt cattttcctg aagatttatg tttttgtcta ccttgtgagc
     1381 aggcttttgg aagaacctgt ttgatgcaaa aaagaaaatg aaaaacaaaa caaaaaatcc
     1441 ccaaaacctt attatgggag cccgtcggtc ttagaagctg tttgacatgt ataataaatg
     1501 gcattgactg ggcctgtttt acatttggtg agaacattcc ataa
//
