LOCUS       NM_001394560            3327 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens zinc finger matrin-type 1 (ZMAT1), transcript variant
            5, mRNA.
ACCESSION   NM_001394560 XM_005262214
VERSION     NM_001394560.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3327)
  AUTHORS   Ma,Z., Li,Z., Wang,S., Zhou,Z., Liu,C., Zhuang,H., Zhou,Q.,
            Huang,S., Zhang,C. and Hou,B.
  TITLE     ZMAT1 acts as a tumor suppressor in pancreatic ductal
            adenocarcinoma by inducing SIRT3/p53 signaling pathway
  JOURNAL   J Exp Clin Cancer Res 41 (1), 130 (2022)
   PUBMED   35392973
  REMARK    GeneRIF: ZMAT1 acts as a tumor suppressor in pancreatic ductal
            adenocarcinoma by inducing SIRT3/p53 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3327)
  AUTHORS   Lai,Y., Xu,P., Li,Q., Ren,D., Wang,J., Xu,K. and Gao,W.
  TITLE     Downregulation of long noncoding RNA ZMAT1 transcript variant 2
            predicts a poor prognosis in patients with gastric cancer
  JOURNAL   Int J Clin Exp Pathol 8 (5), 5556-5562 (2015)
   PUBMED   26191264
  REMARK    GeneRIF: Suggest that ZMAT1 transcript variant 2 is a potential
            diagnostic factor in patients with gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3327)
  AUTHORS   Brayer,K.J. and Segal,D.J.
  TITLE     Keep your fingers off my DNA: protein-protein interactions mediated
            by C2H2 zinc finger domains
  JOURNAL   Cell Biochem Biophys 50 (3), 111-131 (2008)
   PUBMED   18253864
  REMARK    Review article
REFERENCE   4  (bases 1 to 3327)
  AUTHORS   Brown,R.S.
  TITLE     Zinc finger proteins: getting a grip on RNA
  JOURNAL   Curr Opin Struct Biol 15 (1), 94-98 (2005)
   PUBMED   15718139
  REMARK    Review article
REFERENCE   5  (bases 1 to 3327)
  AUTHORS   Iuchi,S.
  TITLE     Three classes of C2H2 zinc finger proteins
  JOURNAL   Cell Mol Life Sci 58 (4), 625-635 (2001)
   PUBMED   11361095
  REMARK    Review article
REFERENCE   6  (bases 1 to 3327)
  AUTHORS   Pieler,T. and Bellefroid,E.
  TITLE     Perspectives on zinc finger protein function and evolution--an
            update
  JOURNAL   Mol Biol Rep 20 (1), 1-8 (1994)
   PUBMED   7531280
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z68326.1, Z68868.1, Z69304.1
            and KF459260.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 24, 2021 this sequence version replaced XM_005262214.4.
            
            Summary: This gene encodes a protein containing Cys2-His2
            (C2H2)-type zinc fingers, which are similar to those found in the
            nuclear matrix protein matrin 3. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Jan
            2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.580498.1,
                                           SRR1660805.49643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651725.2/ ENSP00000498446.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               Z68326.1           9628-9938           c
            312-418             Z68868.1           9913-10019          c
            419-520             Z68868.1           3808-3909           c
            521-695             Z68868.1           3557-3731           c
            696-795             Z69304.1           15852-15951         c
            796-1654            Z69304.1           13183-14041         c
            1655-1937           KF459260.1         1-283               c
            1938-3327           Z69304.1           11510-12899         c
FEATURES             Location/Qualifiers
     source          1..3327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3327
                     /gene="ZMAT1"
                     /note="zinc finger matrin-type 1"
                     /db_xref="GeneID:84460"
                     /db_xref="HGNC:HGNC:29377"
                     /db_xref="MIM:301007"
     exon            1..311
                     /gene="ZMAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2107
                     /gene="ZMAT1"
                     /note="isoform 5 is encoded by transcript variant 5; zinc
                     finger matrin-type protein 1"
                     /codon_start=1
                     /product="zinc finger matrin-type protein 1 isoform 5"
                     /protein_id="NP_001381489.1"
                     /db_xref="CCDS:CCDS94643.1"
                     /db_xref="GeneID:84460"
                     /db_xref="HGNC:HGNC:29377"
                     /db_xref="MIM:301007"
                     /translation="MAAAPSTVTPLAAESSPQEATVSAASSSSYTACAAAAAAAAAAA
                     VIVPASSATSAPACPPAGGCGDGGGGGFGGSTMAAAGRGGSSFKVDTRPCLREDAIWN
                     EQEKAELFTDKFCQVCGVMLQFESQRISHYEGEKHAQNVSFYFQMHGEQNEVPGKKMK
                     MHVENFQVHRYEGVDKNKFCDLCNMMFSSPLIAQSHYVGKVHAKKLKQLMEEHDQASP
                     SGFQPEMAFSMRTYVCHICSIAFTSLDMFRSHMQGSEHQIKESIVINLVKNSRKTQDS
                     YQNECADYINVQKARGLEAKTCFRKMEESSLETRRYREVVDSRPRHRMFEQRLPFETF
                     RTYAAPYNISQAMEKQLPHSKKTYDSFQDELEDYIKVQKARGLDPKTCFRKMRENSVD
                     THGYREMVDSGPRSRMCEQRFSHEASQTYQRPYHISPVESQLPQWLPTHSKRTYDSFQ
                     DELEDYIKVQKARGLEPKTCFRKIGDSSVETHRNREMVDVRPRHRMLEQKLPCETFQT
                     YSGPYSISQVVENQLPHCLPAHDSKQRLDSISYCQLTRDCFPEKPVPLSLNQQENNSG
                     SYSVESEVYKHLSSENNTADHQAGHKRKHQKRKRHLEEGKERPEKEQSKHKRKKSYED
                     TDLDKDKSIRQRKREEDRVKVSSGKLKHRKKKKSHDVPSEKEERKHRKEKKKSVEERT
                     EEEMLWDESILGF"
     exon            312..418
                     /gene="ZMAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..520
                     /gene="ZMAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..695
                     /gene="ZMAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..795
                     /gene="ZMAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..3327
                     /gene="ZMAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3225..3230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT1"
                     /note="hexamer: AATAAA"
     polyA_site      3254
                     /gene="ZMAT1"
                     /note="major polyA site"
     regulatory      3307..3312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZMAT1"
                     /note="hexamer: ATTAAA"
     polyA_site      3327
                     /gene="ZMAT1"
                     /note="major polyA site"
ORIGIN      
        1 gtccgcgcgc ctcgctgcga tggcggcggc gccgagcaca gtcaccccgc tggcggcgga
       61 gtcttcccct caggaagcta ccgtctctgc cgcctcctcc tcctcctaca ccgcctgcgc
      121 ggcagcggcg gcggcggcgg cggcggcggc agtaattgtt cctgcctcct ccgccacctc
      181 cgcccctgcc tgcccgcctg ccggtggctg tggcgacggc ggcggcggcg gctttggcgg
      241 ctccactatg gcggcggcgg ggaggggggg cagtagtttt aaagtagaca cccgcccttg
      301 cctcagagaa gacgccattt ggaatgaaca ggaaaaggct gaacttttta cagataagtt
      361 ttgtcaagta tgtggagtga tgctacagtt tgaatcacaa agaatttcac attatgaggg
      421 tgaaaaacat gctcaaaatg ttagttttta ttttcaaatg catggggaac aaaatgaagt
      481 gcctggtaag aaaatgaaga tgcatgttga gaattttcag gtgcataggt atgaaggagt
      541 ggacaaaaac aaattttgtg atctctgcaa catgatgttt agctctccac ttattgctca
      601 gtctcactat gtgggaaagg tccatgctaa aaaactgaag caattaatgg aggaacatga
      661 tcaggcatct ccatcaggat ttcaaccaga gatggcattt agtatgagaa cctatgtttg
      721 ccatatttgt agtattgctt ttacatcttt agatatgttc cggtcccaca tgcaaggaag
      781 tgaacatcaa attaaagaat ccattgttat caatctagtg aagaattcaa ggaagacaca
      841 agactcttac caaaatgagt gtgcagatta catcaatgtg cagaaagcca gaggactaga
      901 ggccaagact tgtttcagaa agatggaaga gagttctttg gaaacccgta gatacagaga
      961 agtggtcgat tccagaccca gacatagaat gtttgaacaa agactcccat ttgagacttt
     1021 ccggacatac gcagcaccat acaatatttc acaagcaatg gaaaagcagt tacctcattc
     1081 aaagaagaca tatgactctt tccaagatga acttgaagat tacatcaaag tacagaaagc
     1141 cagaggacta gatccaaaga cttgtttcag aaagatgaga gagaactctg tggatactca
     1201 tgggtacaga gaaatggttg attctggacc cagatcaaga atgtgtgagc aaagattttc
     1261 acatgaggct tcccagacct accaacgacc ataccatatt tcaccagtgg aaagccagtt
     1321 acctcagtgg ctaccaaccc attcaaagag gacatatgat tctttccaag atgaacttga
     1381 agattacata aaagtgcaga aagccagagg actagagcca aaaacttgtt tcagaaagat
     1441 aggagatagc tctgtagaaa cacacaggaa cagagaaatg gttgatgtca gacccagaca
     1501 tagaatgttg gagcaaaagc tcccatgtga gactttccag acctattcag gaccatatag
     1561 tatttcacaa gtagtggaaa accagttacc tcattgctta ccagctcatg atagcaaaca
     1621 gagactagat tctattagct actgtcaact caccagagac tgtttcccag aaaaaccagt
     1681 acccttgagc cttaatcagc aagaaaataa ctctggctca tacagtgtag aatctgaagt
     1741 ttacaagcac ctctcttcag aaaacaatac tgctgaccat caagcaggtc ataaacggaa
     1801 acatcagaag agaaaacgac acctagaaga aggcaaagaa aggccagaga aagagcagtc
     1861 caagcataaa aggaaaaaga gttatgaaga tacagattta gacaaagaca agagcatcag
     1921 acaaaggaaa agagaggagg atagagtcaa ggtcagttca ggaaagctta agcatcgaaa
     1981 aaagaaaaaa agccatgatg taccctccga gaaagaagaa cgtaagcaca ggaaagagaa
     2041 aaagaaatct gttgaagaaa ggacagaaga ggaaatgctt tgggatgagt ctattcttgg
     2101 attttgaatg tttagttttg tttacccaag gttgaattga aaaaaaaaaa cagtcaatat
     2161 ggatttagaa aaaggaacac ctgatgaaga aaaggagagg tagatacagt cagtgtcact
     2221 tcaggacact taggtttttt ttgtataaaa atttaaattg aattaaaaga aggaaaaaaa
     2281 aagcccaaac ttaacctctg agaaaagaac ataagaactc aaggagaaca taagagaaaa
     2341 ggaaacctgt tacagaaaag acaagaatct gtgttttgga atgagtctat tcttgggtat
     2401 tgaactttta gttttgtttg cccaaggatt aattgaggaa atcagctaag aaaatggact
     2461 ttagacaaaa gcaagaggat cagatgaaga aaaggagagg tagatacagt cagtgtcact
     2521 tcaggaaagc tatttaaaaa aacttgaaat ttaattgaaa gaagaaacaa caacaaaaaa
     2581 gcctaaacct agcctctgaa caacactaac atgagaacac aagaacttaa gagaaaaaga
     2641 aacctactca agaaaagaca gaagagacag tgatttggga tgagtctact ctaggatttt
     2701 caacttttta gttttgttcc ttcaaagttg aaggaaaaaa agtttggttt tataaaattc
     2761 atgttattgt aatttttcta ggtggatggc tactttaatc tctaaaaaag ccaagtgaag
     2821 taaaagtatt cagtatgcct tttcctcaag ttactttcct tcattttctt aaaaaagaaa
     2881 aaaaattatt aaatgtttct cacatatctc acatataatg taatttccct aaatgaagtt
     2941 gtctctactt ctgctcatca aattgctgtg atagtgaatt atttattcat gggagataat
     3001 ttattttaaa ggacagaatt accaagcgtt acaaaatcag ttctttcctt ggttttgtgt
     3061 tagtgttggt ggtattttat tgttgttttt ctgtgtttat gtgtctcagc tttctccaag
     3121 gaatatgtat gaaataactt aaactgattt tttctttgtt aaatctaatt tgcagtgtat
     3181 ttttgcattt tctagttctg aaagtggaaa atgaaacagt ctataataaa cttagatgat
     3241 atatagtttt aaaacggtct caaaaagtac tgatataagg tcagtctata ttctggaaat
     3301 gtttatatta aagtgtttta atttcta
//
