LOCUS       NM_006298               7419 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger with KRAB and SCAN domains 8 (ZKSCAN8),
            transcript variant 2, mRNA.
ACCESSION   NM_006298
VERSION     NM_006298.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7419)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 7419)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7419)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 7419)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   5  (bases 1 to 7419)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 7419)
  AUTHORS   Williams,A.J., Blacklow,S.C. and Collins,T.
  TITLE     The zinc finger-associated SCAN box is a conserved oligomerization
            domain
  JOURNAL   Mol Cell Biol 19 (12), 8526-8535 (1999)
   PUBMED   10567577
REFERENCE   7  (bases 1 to 7419)
  AUTHORS   Lee,P.L., Gelbart,T., West,C., Adams,M., Blackstone,R. and
            Beutler,E.
  TITLE     Three genes encoding zinc finger proteins on human chromosome
            6p21.3: members of a new subclass of the Kruppel gene family
            containing the conserved SCAN box domain
  JOURNAL   Genomics 43 (2), 191-201 (1997)
   PUBMED   9244436
REFERENCE   8  (bases 1 to 7419)
  AUTHORS   Beutler,E., Gelbart,T., West,C., Kuhl,W. and Lee,P.
  TITLE     A strategy for cloning the hereditary hemochromatosis gene
  JOURNAL   Blood Cells Mol Dis 21 (3), 207-216 (1995)
   PUBMED   8673473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL358933.15, AB208793.1, BC130032.1 and BM664529.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006298.3.
            
            Transcript Variant: This variant (2) lacks an internal exon in the
            5' UTR, compared to variant 1. Both variants 1 and 2 encode the
            same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.180801.1,
                                           SRR1660807.129098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330236.7/ ENSP00000332750.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL358933.15        30483-30509
            28-656              AB208793.1         1-629
            657-2033            BC130032.1         620-1996
            2034-6814           AL358933.15        42675-47455
            6815-7419           BM664529.1         30-634              c
FEATURES             Location/Qualifiers
     source          1..7419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..7419
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /note="zinc finger with KRAB and SCAN domains 8"
                     /db_xref="GeneID:7745"
                     /db_xref="HGNC:HGNC:12983"
                     /db_xref="MIM:602240"
     exon            1..147
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /inference="alignment:Splign:2.1.0"
     exon            148..656
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1976
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein with KRAB and SCAN domains 8; zinc finger
                     protein 192"
                     /codon_start=1
                     /product="zinc finger protein with KRAB and SCAN domains 8
                     isoform 1"
                     /protein_id="NP_006289.2"
                     /db_xref="CCDS:CCDS4645.1"
                     /db_xref="GeneID:7745"
                     /db_xref="HGNC:HGNC:12983"
                     /db_xref="MIM:602240"
                     /translation="MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHESNP
                     LGQEVFRLRFRQLRYQETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTI
                     LPEELQTLVKEHQLENGEEVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASA
                     PEPPNTQLQSEATQHKSPVPQESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQT
                     LEKIEDMAVSLIREEWLLDPSQKDLCRDNRPENFRNMFSLGGETRSENRELASKQVIS
                     TGIQPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQS
                     SGLVRHWRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHNKVKRYHCKECGKAFSQNTG
                     LILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLI
                     GHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEH
                     QRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQR
                     IHSGEKSESISV"
     exon            657..798
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /inference="alignment:Splign:2.1.0"
     exon            799..890
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1014
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..7419
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7400..7405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /note="hexamer: AATAAA"
     polyA_site      7419
                     /gene="ZKSCAN8"
                     /gene_synonym="LD5-1; ZNF192; ZSCAN40"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgcctc cgcagattta gaagttagtg gccggagggg cctggtccga gtacagcttt
       61 catcgccttt actccccgac cttccttcga gtctgtttat ccgttgcagc ctcccttccc
      121 cacgacgggg cgcctctgca actcacaaag tacccttaga aagaggccct cagaagagtc
      181 ttctcttaag aagataaaga aggtagtgga aacgaacttc ctgagctttt caggctctaa
      241 tggctgaaga atcaagaaag ccttcagccc catccccacc agaccagact cctgaagagg
      301 atcttgtaat cgtcaaggta gaggaggatc atggttggga ccaggaatct agtctgcatg
      361 aaagtaaccc tcttggccaa gaagtgttcc gcctgcgctt caggcagtta cgctaccagg
      421 agacactagg accccgagaa gctctgatcc aactacgggc cctttgccat cagtggctga
      481 ggccagattt gaacaccaag gaacagatcc tggagctgct ggtgctggag cagttcttga
      541 ccatcctacc tgaggagctc cagacactgg ttaaggaaca tcagctagag aacggagagg
      601 aggtggtgac cctattagag gatttggaaa ggcagattga tatactagga cgaccagtct
      661 cagctcgcgt acatggacat agggtactct gggaggaggt agtacattca gcatctgcac
      721 cagagcctcc aaatactcag ctccaatctg aggcaaccca acataaatct ccagtgcccc
      781 aagagtcaca agagagagcc atgtctactt cccagagtcc tactcgttcc cagaaaggaa
      841 gttctggaga ccaggaaatg acagctacac ttctcacagc agggttccag actttggaga
      901 agattgaaga catggctgtg tcccttattc gagaggagtg gcttcttgat ccatcacaga
      961 aggatctgtg tagagataac aggccagaaa atttcagaaa catgttctcc ctgggtggtg
     1021 agaccaggag tgagaacagg gaattagctt caaaacaggt aatatctact ggaatccagc
     1081 cacatggaga gacagctgcc aaatgcaacg gggatgttat caggggtctt gagcatgaag
     1141 aagcccgaga ccttctgggc agattagaga ggcagcgggg aaatcccaca caagagagac
     1201 gacataaatg tgatgaatgt gggaaaagct ttgctcagag ctcaggcctt gttcgccact
     1261 ggagaatcca cactggggag aaaccctatc agtgtaatgt gtgtggtaaa gccttcagtt
     1321 acaggtcagc ccttctttca catcaggata tccacaacaa agtaaaacgc tatcactgta
     1381 aggagtgtgg caaagccttc agtcagaaca caggcctgat tctgcaccag agaatccaca
     1441 ctggggagaa gccatatcag tgcaatcagt gtgggaaggc tttcagtcag agtgcgggcc
     1501 ttattctgca ccagagaatc cacagtggag agagacccta tgaatgtaat gagtgtggga
     1561 aagctttcag tcatagctca cacctcattg gacatcagag aatccacact ggggagaagc
     1621 cctatgagtg tgatgagtgt gggaaaacct tcaggcggag ctcacatctt attggtcatc
     1681 agaggagcca cactggggag aaaccctaca aatgcaatga gtgtgggagg gccttcagtc
     1741 agaagtcagg ccttattgaa catcagagaa tccacactgg agaaagaccc tataaatgta
     1801 aagaatgtgg gaaagctttc aatgggaaca ctggtctcat tcaacacctg agaattcaca
     1861 caggggagaa gccctaccaa tgtaatgagt gtgggaaagc ctttattcag aggtcaagtc
     1921 tcattcgaca tcagagaatc cacagtggtg aaaaatctga atccataagc gtttaggaac
     1981 aacatcagtt agagtttgag cattattcag cattagggaa accacacact ggtgagaggt
     2041 ctttcagtgt actaaaaggc agaaaggtca tcacaacttt agtgtcagaa tctatagtgg
     2101 tggcaaagtt aggatagctc tttagtaatt tgggcccagt gccttggtga aggttgatta
     2161 gcttgactgt ctttgaaagt atctgatgga gctcctgatg acctaatgta tcctttagaa
     2221 atttaaaata gcattagagc aagttgcttg tcatggcttg aagagcttaa ctttgtcttt
     2281 tgggtgagta gctataggtt tgagagaggc tggctactcc tagttcctgt gcttcttccc
     2341 atctcctgtg atccccctct cccatttatt cccttgaagg tgcccttgta ttcctaatct
     2401 gatctaagaa gctgctgtag agtcagaagt agcttctgtg tgaaacttat atttgtatgt
     2461 agctttctag gaaaatttta cagacactta aagtatttat gcttaagtgt gcattttttt
     2521 attctaatat tccttctagt cagtggaaat ttgtattccc atacaaactc agaatgctat
     2581 atttttaaca gcactccagc atttttcttc atgtatcacc ttcactgact ccattgagtc
     2641 attgagcatc tgtacatatc cttcaccacc cccagtccca gcacctgtgt cagtaaagaa
     2701 agtggacaca ttagtaatgg ttatgggagt aatacagaga aagaggtgag tggagactca
     2761 gcccagctgc tcttgagctt ggatagttat acattttggt gacttctgac tctccttcca
     2821 cctccccact gtacactgtg gtacagatag ttggcactat cctagttatg gcatcaggta
     2881 ggagaaggag acgaagatgc tttaggaaga taaaaacctt acaaagaatg tatactcatc
     2941 ttttttggcc cattacaata ctgctttctc aggttcttaa cagcctgtgc aaactccctg
     3001 actagatggt ctgtcactcc tatcattacc ttgcacccat ctctttagat ggcctcagca
     3061 cctcactcgt tattctccat ctgtttcttg ccattagttt atatgacttt aatatccaca
     3121 gtggtaatct aataccttac ctcacaggtt ttcattcttt tgaactctgg tgcactccat
     3181 ctgtaatcca tgtctataat ctaccaacaa agatgtactc ttaaactcag tatcaccagg
     3241 cactatattt catctttgag gcttttgtta taccaaggaa tactatataa agtaatgaga
     3301 ctggtttaaa gtaacatgcc agaacttacg catccaatgt gggttgtcac ttgttattcc
     3361 caagtactat tattccatac tactatattc ttccaaatat ttggaacact cttagaattc
     3421 ccatttaata aaccatatga gaaaaccctc tattactctt acactttagt tttaccattt
     3481 gagtagccac ttattcacca gagttggaat tgagaaattt tgggctttcc aaaattaacc
     3541 tttaaactta aaattgatta cattgagcct attcagaaaa aaaattatat aggttctgat
     3601 gaaagcttca taatttcacc ctgtgactat cctgaaaaga aataataatc attttatgat
     3661 tgatgggcca aaaaaagcaa tcaaagtctt acgtcataga ggaccacctt ttggatcata
     3721 aattctttcc ctataacatt ccttctctgc ctctctatgg cccactttga ccactaacaa
     3781 catcagaatt atctacatca atttcattga gccattggtg aatgaagaca cccatcactt
     3841 gtcatgttgg tttccaacag tcctttcgat tatcctttat tttcttatcc tcccttctct
     3901 tgtttctttt atttataagt taccattcct agtttctttg tacttgaaat tttaagaaac
     3961 cagaaacaag taaatctggt tgtatctaga tctttgctct gtgtttcagt tgtgccttac
     4021 cctctgtaag atactgattc ttcctggggc cagtattacc ttgtatgcaa atattacata
     4081 tgatgggtgc attgtcagag ggaaaatata tgtgtatgta cacatgtgta tgtacacaca
     4141 cacacacacc tgccatacac tttagaagaa cgcttctctt ctattccaat aaaaagtcct
     4201 tttagcaatg caacatatta acaaaattgg gtgcattcag ggtggtatgg ccatagacca
     4261 gagcaacaca ttgaaatgta tacagatgta ctagctaaag tctctttatg tgtcagtatt
     4321 aagagtaata tgtagccaga ttacttaaat ctcagaatta ctaagcatgt ggcataaatt
     4381 tggagaaaat aatatgacta gaaaaattag tgttatattg ggtgtgagaa aagactgtgt
     4441 cttgaaagaa ttatcaaagc tgatacagca catatacaga attagccaaa tggtataaga
     4501 caatagaaaa aggctgtgga ttctttgagg acatcactag aaatcattct ttgtctcaag
     4561 ttcacactct tagcatagaa tattattgac taggctgtat gacattttga gctcttaact
     4621 gtgaatggca ttcattaagc tcctttatcc tatagattct atctttatgt tcatctgaaa
     4681 tgaactattc atcagtactt tctcctccca tcctaagctt ctcattttag gaactgacat
     4741 gataaggtgg ttctttcata actctaatgc catccaacat agccctggga gaggcatgtt
     4801 aggtttcaga gattttctcc atggagcaag gtgcagtgct agaatatggt ggttgattcc
     4861 caaacagagc agttaacttt actcttggtt ctgagtctcc aaataataat agccgacgtt
     4921 tattgagcac ttactatgtg cccaaccctg ttatgccttt ctcaggctca tgataaatgt
     4981 attagtctgt tctcatgctg ctattaaaga catacctgac actgggtaat ttataaagga
     5041 aagaggttta atggactcag ttccacatgg ctggggacgc ctcacaatca tggtggaagg
     5101 caaggaggag caaatcatgt cttatacatg gatggcagca ggcaaagaga gaacttgtgc
     5161 aggggaactc tttataaaac cgtccgatct tgtgagactt attcactatc acaagaacag
     5221 cacaggaaag ttctgccccc gtgattcaat tacctcccac ttggtcccac ccacgacacg
     5281 tgggaattgt gggagctaca attcaagatg agatttggat gggacacagc caaaccatat
     5341 caataggtat tattttatcc cccattttat aaatgaggaa acggaggctt agttgagtga
     5401 gctgaccaat atcacccagc cagtatgtga taaaactgat tctgacccac acagtttgat
     5461 tctagagcct gttctgacta ctgtgctaag gtgtgtataa tgaacatggt aattctaacc
     5521 agctttttaa aaatatgtag cgcttgtcat gagaggtact ggggaaaaga atgtgcagta
     5581 gagtgcaaat acattacaat tactggaaaa ttggtggaaa atgctttttg gggttacaat
     5641 tatatcattt ttaagtgttg atgctttgta gtactacaaa gctaaattgt gcaaacaaaa
     5701 catatttaac agagtaattg ggaggataaa gcaataataa attcaaatat atttttctcc
     5761 aaactgccaa agggaaagta gaattgtgga gggaaatgaa atatccatgt accaggccag
     5821 gcagatggtc agttaggatg acaatagtaa gttcatctac agcataaaat gtgaaatgct
     5881 ttcatcctca ttgcccattt ccaactacca ttctgtttct cctctattgt tcatggtttt
     5941 tcaaacatat ctttgatttt tcaacccccc tttttcatta atctgttctt aaaacttctt
     6001 tttactggct ttcatactta gcattccagt gaaatgttct tagactcacc agtggacaaa
     6061 taataaggcc tttttttatt attatttctt gtcttttttg atctaattta tattttatat
     6121 tgttgaattc tccctccttt ggcttgtggg atcctttttc tctaatatct gtctttcttt
     6181 ttttagttga tctttccacc cactcccctt tctcctcttc tccactgaga ataatctccc
     6241 tgtcttttat tcacttcatt ttctatactc ctatttatcc attttgattg tttataccta
     6301 ctatttgtat tcgaatgact tcatttttcc caccctgtgg gtcagtttgt gacttttgga
     6361 attttccaca ggtacctgta caacttgata tttgaaaaca ggattcatca ccatatatcc
     6421 ccagcccccg ttttcttttt aaacaggcct cattgcgtaa ttcctttgcc ctgaaaagtg
     6481 tcaccacctt tatattttta ccccagcctt ggagttatct ttttctgctc tccattctcc
     6541 atgtccaaaa acttgctgtc agtccagttt ttaatcagtt ttctccttga ggcttgatct
     6601 cccatttctc tcatcccatt atagcttttc atgtagatct gaggcccagg ttactgtaat
     6661 tctttttttt ccaatttcct tgctcccagg atccccatct tgtataaagt ttctaaggtg
     6721 ctcctcctca aactccattt ttacaatatc cgtattgtaa aattttcatt ttcagtaaca
     6781 cccagtagat aatttttcaa agacgatcct cctcaaacac ccatttttac aatatctcta
     6841 ttgtaaaatt tcattttcac taagtaacac ccagtagata attcctatgg agcagtggtg
     6901 ttccaaattc tccattacct ctatgcctaa tattcatcag ccttcattac tctctagcat
     6961 attcaccttg attcaacaga ttcaaacttc ctacagcctt ctactgatgt cttacaagct
     7021 cttgcctctg tgcctttctc atgctattct ttttgcttag attgctcttt ggtcccagct
     7081 catgttcatc actcccttca aagcctttct tcctttatat cttctgactg agctctccct
     7141 gattgacatc acctcatgcg atgacctccc tcattctgtg ctgcctcagc acttatcttt
     7201 tgagtttgta ctgtggtcca tgtacttact aatatgttgc tttgtaatta ttttctagca
     7261 ctctgtgtta cagtttcata tttgtattta tttccaaaat taaattgtaa gctccttgag
     7321 ggcaggaata ataactttta catttgtatc tctgcacccc cgagtgccta gtatagtgct
     7381 gagcacatag taggcgttta ataaatgctt gttgaagta
//
