LOCUS       NM_001288590            3455 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger with KRAB and SCAN domains 7 (ZKSCAN7),
            transcript variant 3, mRNA.
ACCESSION   NM_001288590 XM_005265322
VERSION     NM_001288590.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3455)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3455)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3455)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 3455)
  AUTHORS   Calabro,V., Pengue,G., Bartoli,P.C., Pagliuca,A., Featherstone,T.
            and Lania,L.
  TITLE     Positional cloning of cDNAs from the human chromosome 3p21-22
            region identifies a clustered organization of zinc-finger genes
  JOURNAL   Hum Genet 95 (1), 18-21 (1995)
   PUBMED   7814019
REFERENCE   5  (bases 1 to 3455)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   6  (bases 1 to 3455)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291285.1 and AY280798.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001288590.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 both encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.65756.1,
                                           SRR1660803.169519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426540.6/ ENSP00000395524.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AK291285.1         1-655
            656-3455            AY280798.1         665-3464
FEATURES             Location/Qualifiers
     source          1..3455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3455
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /note="zinc finger with KRAB and SCAN domains 7"
                     /db_xref="GeneID:55888"
                     /db_xref="HGNC:HGNC:12955"
     exon            1..289
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /inference="alignment:Splign:2.1.0"
     exon            290..830
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..2672
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /note="isoform 1 is encoded by transcript variant 3; zinc
                     finger protein 64; zinc finger protein 448; zinc finger
                     protein with KRAB and SCAN domains 7; zinc finger protein
                     167"
                     /codon_start=1
                     /product="zinc finger protein with KRAB and SCAN domains 7
                     isoform 1"
                     /protein_id="NP_001275519.1"
                     /db_xref="CCDS:CCDS2715.1"
                     /db_xref="GeneID:55888"
                     /db_xref="HGNC:HGNC:12955"
                     /translation="MTTAGRGNLGLIPRSTAFQKQEGRLTVKQEPANQTWGQGSSLQK
                     NYPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQF
                     LSILPGELRTWVQLHHPESGEEAVAVVEDFQRHLSGSEEVSAPAQKQEMHFEETTALG
                     TTKESPPTSPLSGGSAPGAHLEPPYDPGTHHLPSGDFAQCTSPVPTLPQVGNSGDQAG
                     ATVLRMVRPQDTVAYEDLSVDYTQKKWKSLTLSQRALQWNMMPENHHSMASLAGENMM
                     KGSELTPKQEFFKGSESSNRTSGGLFGVVPGAAETGDVCEDTFKELEGQTSDEEGSRL
                     ENDFLEITDEDKKKSTKDRYDKYKEVGEHPPLSSSPVEHEGVLKGQKSYRCDECGKAF
                     NRSSHLIGHQRIHTGEKPYECNECGKTFRQTSQLIVHLRTHTGEKPYECSECGKAYRH
                     SSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDHQRTHTGEKPYECNECGEAFIRSK
                     SLARHQVLHTGKKPYKCNECGRAFCSNRNLIDHQRIHTGEKPYECSECGKAFSRSKCL
                     IRHQSLHTGEKPYKCSECGKAFNQNSQLIEHERIHTGEKPFECSECGKAFGLSKCLIR
                     HQRLHTGEKPYKCNECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQ
                     RTHTGEKPYKCNDCGKAFSDSSQLIVHQRVHTGEKPYECSECGKAFSQRSTFNHHQRT
                     HTGEKSSGLAWSVS"
     exon            831..999
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1091
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1218
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..3455
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /note="hexamer: AATAAA"
     polyA_site      3455
                     /gene="ZKSCAN7"
                     /gene_synonym="ZFP; ZNF167; ZNF448; ZNF64; ZSCAN39"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggct cggccattgt ttttggtcta acgggcagta gagtgtccgg cttcggtgcc
       61 gagtgccacc gcgagtgggc cgagacgcgg agggaggcgc ggccggagct cgggtcgccg
      121 acgctggcca ggaccgcgct tcttcccggc ggcaggcggc gcggtccccg tgactctcag
      181 aagccgcccg atgtagagcc gcttctttgt ctcatacccc tgaccattcg tgcgtggcac
      241 ggagccgggt atctgcgggt acagcgatga acagggcaga cgtggccagg ccacactacc
      301 atcacccctt tctccaaccc tgaaaaacag ttcctgagac ctgaactatt gaccatcatt
      361 ttaatcggac caactgcagc tgtaacaagc ttctctttgg ggtcacaatg accactgcag
      421 gcaggggaaa tttaggcctc atccccagga gcactgcttt ccagaagcaa gaggggcgcc
      481 tgactgtgaa gcaggagcca gcaaaccaga cctgggggca gggcagcagt ctccagaaga
      541 actatcctcc tgtctgcgaa atcttccggc tacacttcag gcaattgtgt taccacgaga
      601 tgtctgggcc gcaggaagca ttgagccggc ttcgggagct ctgccgctgg tggctcatgc
      661 cagaggtgca caccaaggag cagatcctgg agctgctggt gcttgagcag ttcctgagca
      721 tcctccctgg ggagctccgg acctgggtgc agctgcatca ccctgagagt ggtgaggagg
      781 ctgtggctgt ggtggaggat ttccagagac acctcagtgg atcagaggag gtttcagccc
      841 cagcacagaa acaggaaatg cattttgagg agacaacagc tctgggtaca acaaaggaat
      901 ctcctcctac ctcacccctc agtgggggct cagcccctgg agcccacctg gagcctcctt
      961 atgacccagg gacacaccac ctccccagtg gggacttcgc tcaatgtact tctccagttc
     1021 ctacccttcc tcaagtgggg aactcaggag accaagcagg ggcaactgta cttcggatgg
     1081 tcaggcccca ggatactgtg gcatatgagg acctatctgt agactacact cagaagaaat
     1141 ggaaaagtct cacactcagt cagagagccc tgcagtggaa catgatgcca gaaaatcacc
     1201 atagcatggc ctccttggca ggtgagaaca tgatgaaggg ttcagagttg actccaaagc
     1261 aggaattttt taaaggatca gagtcatcta acaggacatc agggggactc tttggggtgg
     1321 ttcctggggc agcagagact ggagatgttt gtgaagatac tttcaaggag ttagaaggac
     1381 aaacctcaga tgaagaaggg agcagactag aaaatgattt cttggaaata acagatgaag
     1441 ataagaaaaa atccacaaaa gacagatatg acaaatataa ggaagttggg gaacatccac
     1501 ctctgtcttc cagtcctgtt gaacatgaag gagttttaaa gggacagaaa tcctatcgat
     1561 gtgatgaatg tggcaaagct ttcaatcgga gttctcacct tattggccat cagagaatcc
     1621 acactggaga gaaaccctat gagtgtaatg agtgtgggaa gaccttcagg caaacctccc
     1681 agctcattgt tcatctcaga acccacacag gggaaaaacc ctatgaatgc agtgagtgtg
     1741 gaaaggccta taggcacagc tcccatctca ttcaacacca gagactccat aatggggaga
     1801 aaccctataa atgtaatgaa tgtgcaaaag cctttactca gagttcccga ctcactgacc
     1861 accagagaac ccatactggg gagaaacctt atgaatgcaa tgagtgtgga gaggcattca
     1921 ttcgaagcaa aagtcttgct cgacatcagg tcctgcacac tggtaagaaa ccttacaaat
     1981 gcaatgagtg tgggagagca ttctgttcca atagaaatct cattgaccat cagagaatcc
     2041 acactgggga gaagccttat gagtgtagtg aatgtggcaa agccttcagt cggagtaaat
     2101 gtcttattcg acatcagagc ctccatactg gggaaaagcc atacaaatgt agtgaatgtg
     2161 ggaaagcctt caatcagaac tctcaactca ttgagcatga gcgaattcat actggagaaa
     2221 aaccttttga atgtagcgag tgtggtaagg catttggtct gagtaaatgt cttattcggc
     2281 accagagact tcacacgggt gaaaagccct ataaatgcaa tgagtgtgga aaatccttca
     2341 atcaaaactc acaccttatt atacaccaga gaattcacac tggtgagaaa ccctatgaat
     2401 gtaatgagtg tgggaaggta ttcagttata gctccagcct tatggtacat cagagaaccc
     2461 atactgggga aaaaccctat aaatgcaatg attgtgggaa agcttttagt gacagctcac
     2521 agcttattgt acaccagaga gtccacaccg gagagaaacc ttatgaatgt agtgaatgtg
     2581 ggaaagcctt tagtcagcgt tccactttta atcaccacca gcgaactcac actggagaga
     2641 agtcctcagg tctggcttgg tcagtttctt aaggtatggt tctctgagac agagagcaac
     2701 gacctttgag ttaagctgtc tttataagca ggatgctcat agtggtttcc cggagccagt
     2761 agtcacggtg gaccattccc tacttgcttt tccttggatc actaaggtgg gagagtagga
     2821 gtaacttatt ccagttctta cccattatta ggaaggtaag gactacacat gtcattgaat
     2881 tgtaggtttc cttttttttt ctttactttt aaattttaac ttttaaaatc tatttcattt
     2941 cttagttatg catctcataa tcagactcca tgctttttaa agacagagat aatatcttct
     3001 ctattctatt ctacttcctc catttcacca tttatacaaa gtcattcaaa aaggctgatt
     3061 catgccttcc tgcctcttgg ctatggccct ccccatctac tctttaaact ttaatctata
     3121 acttttcatc agttttgttc cctatctaga aaacattttc ttctgtttgc taatctttgt
     3181 ccctcacaat ttttgaaatc catctcatca ctgaaatact ttcttcttca agtacttttt
     3241 tatttttctt caacttctct tgatttgacc tcagtgcttt gaattcactg gtgctacaat
     3301 atgtaactgt ggttaattgc cttgtaaatt ttgcgtgtct gtatactttt ataccaactt
     3361 attgtaggct ctttgaggtc aggtatgtat ttctttccca tatagatagt attttgtaca
     3421 taccagttgt taaataaata atttttaaaa tctca
//
