LOCUS       NM_145102               5083 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens zinc finger with KRAB and SCAN domains 5 (ZKSCAN5),
            transcript variant 2, mRNA.
ACCESSION   NM_145102
VERSION     NM_145102.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5083)
  AUTHORS   Yang,Y., Xie,W., Qiao,X., Yang,J., Yao,D. and Zhu,D.
  TITLE     ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote
            metastasis in pancreatic ductal adenocarcinoma
  JOURNAL   Histol Histopathol 39 (6), 747-760 (2024)
   PUBMED   38018874
  REMARK    GeneRIF: ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to
            promote metastasis in pancreatic ductal adenocarcinoma.
REFERENCE   2  (bases 1 to 5083)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5083)
  AUTHORS   Ding,Y., Zhou,X., Wu,C., Li,Q., Sun,J., Niu,H., Lin,D., Sun,D.,
            Xie,P., Wu,D., Zhao,J. and He,P.
  TITLE     Telomere length, ZNF208 genetic variants and risk of chronic
            obstructive pulmonary disease in the Hainan Li population
  JOURNAL   J Gene Med 20 (12), e3061 (2018)
   PUBMED   30397981
  REMARK    GeneRIF: Shorter telomeres increase chronic obstructive pulmonary
            disease (COPD) risk and the zinc finger protein 95 homolog ZFP95
            (ZNF208) polymorphism affects telomere length in COPD patients.
REFERENCE   4  (bases 1 to 5083)
  AUTHORS   Kim,Y.H., Choe,S.H., Song,B.S., Park,S.J., Kim,M.J., Park,Y.H.,
            Yoon,S.B., Lee,Y., Jin,Y.B., Sim,B.W., Kim,J.S., Jeong,K.J.,
            Kim,S.U., Lee,S.R., Park,Y.I., Huh,J.W. and Chang,K.T.
  TITLE     Macaca specific exon creation event generates a novel ZKSCAN5
            transcript
  JOURNAL   Gene 577 (2), 236-243 (2016)
   PUBMED   26657034
REFERENCE   5  (bases 1 to 5083)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 5083)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   7  (bases 1 to 5083)
  AUTHORS   Zhai,G., Teumer,A., Stolk,L., Perry,J.R., Vandenput,L.,
            Coviello,A.D., Koster,A., Bell,J.T., Bhasin,S., Eriksson,J.,
            Eriksson,A., Ernst,F., Ferrucci,L., Frayling,T.M., Glass,D.,
            Grundberg,E., Haring,R., Hedman,A.K., Hofman,A., Kiel,D.P.,
            Kroemer,H.K., Liu,Y., Lunetta,K.L., Maggio,M., Lorentzon,M.,
            Mangino,M., Melzer,D., Miljkovic,I., Nica,A., Penninx,B.W.,
            Vasan,R.S., Rivadeneira,F., Small,K.S., Soranzo,N.,
            Uitterlinden,A.G., Volzke,H., Wilson,S.G., Xi,L., Zhuang,W.V.,
            Harris,T.B., Murabito,J.M., Ohlsson,C., Murray,A., de Jong,F.H.,
            Spector,T.D. and Wallaschofski,H.
  CONSRTM   MuTHER Consortium
  TITLE     Eight common genetic variants associated with serum DHEAS levels
            suggest a key role in ageing mechanisms
  JOURNAL   PLoS Genet 7 (4), e1002025 (2011)
   PUBMED   21533175
REFERENCE   8  (bases 1 to 5083)
  AUTHORS   Thompson,E.E., Kuttab-Boulos,H., Yang,L., Roe,B.A. and Di Rienzo,A.
  TITLE     Sequence diversity and haplotype structure at the human CYP3A
            cluster
  JOURNAL   Pharmacogenomics J 6 (2), 105-114 (2006)
   PUBMED   16314882
REFERENCE   9  (bases 1 to 5083)
  AUTHORS   Dreyer,S.D., Zheng,Q., Zabel,B., Winterpacht,A. and Lee,B.
  TITLE     Isolation, characterization, and mapping of a zinc finger gene,
            ZFP95, containing both a SCAN box and an alternatively spliced KRAB
            A domain
  JOURNAL   Genomics 62 (1), 119-122 (1999)
   PUBMED   10585779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA580238.1, AF170025.1,
            AB023232.1, CA311067.1 and AC005020.5.
            
            On Jun 2, 2019 this sequence version replaced NM_145102.3.
            
            Summary: This gene encodes a zinc finger protein of the Kruppel
            family. The protein contains a SCAN box and a KRAB A domain and may
            be involved in transcriptional regulation. A similar protein in
            mouse is differentially expressed in spermatogenesis. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.269554.1,
                                           SRR1803611.267480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326775.10/ ENSP00000322872.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA580238.1         13-23
            12-3357             AF170025.1         4-3349
            3358-3644           AB023232.1         3438-3724
            3645-4205           CA311067.1         18-578              c
            4206-5083           AC005020.5         161109-161986       c
FEATURES             Location/Qualifiers
     source          1..5083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..5083
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="zinc finger with KRAB and SCAN domains 5"
                     /db_xref="GeneID:23660"
                     /db_xref="HGNC:HGNC:12867"
                     /db_xref="MIM:611272"
     exon            1..72
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     exon            73..526
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2632
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger protein homologous to Zfp95 in mouse; zinc finger
                     protein with KRAB and SCAN domains 5; zinc finger protein
                     95 homolog"
                     /codon_start=1
                     /product="zinc finger protein with KRAB and SCAN domains 5
                     isoform a"
                     /protein_id="NP_659570.1"
                     /db_xref="CCDS:CCDS5667.1"
                     /db_xref="GeneID:23660"
                     /db_xref="HGNC:HGNC:12867"
                     /db_xref="MIM:611272"
                     /translation="MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPP
                     TFETFYQRFRHFQYHEASGPREALSQLRVLCCEWLRPELHTKEQILELLVLEQFLTIL
                     PEEFQPWVREHHPESGEEAVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESC
                     SPHPLTVDTQPEQAPQKPRLLEENALPVLQVPSLPLKDSQELTASLLSTGSQKLVKIE
                     EVADVAVSFILEEWGHLDQSQKSLYRDDRKENYGSITSMGYESRDNMELIVKQISDDS
                     ESHWVAPEHTERSVPQDPDFAEVSDLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDI
                     SPKQSTHGERGHRCSDCGKFFLQASNFIQHRRIHTGEKPFKCGECGKSYNQRVHLTQH
                     QRVHTGEKPYKCQVCGKAFRVSSHLVQHHSVHSGERPYGCNECGKNFGRHSHLIEHLK
                     RHFREKSQRCSDKRSKNTKLSVKKKISEYSEADMELSGKTQRNVSQVQDFGEGCEFQG
                     KLDRKQGIPMKEILGQPSSKRMNYSEVPYVHKKSSTGERPHKCNECGKSFIQSAHLIQ
                     HQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHTGEKPYTCPLCGKAFRVRSHLVQHQ
                     SVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKSHQCRECGEIFFQYVSLIEHQVL
                     HMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCDICGKAFGYSSDLIQHYRTHT
                     AEKPYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGRGFTLKSHLNQHQRIHTGE
                     KPFQCKECGMNFSWSCSLFKHLRSHERTDPINTLSVEGSLL"
     exon            527..665
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     exon            666..748
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     exon            749..884
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1490
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..5083
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3043..3048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="hexamer: AGTAAA"
     polyA_site      3065
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="major polyA site"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="hexamer: AATAAA"
     polyA_site      3842
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="major polyA site"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="hexamer: AATAAA"
     polyA_site      4205
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
     regulatory      4470..4475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
                     /note="hexamer: AATAAA"
     polyA_site      4490
                     /gene="ZKSCAN5"
                     /gene_synonym="ZFP-95; ZFP95; ZNF914; ZSCAN37"
ORIGIN      
        1 agctggcccc tgcgactcgc gggtgtgacg ttgaagatgt cggccttctg agccgactgc
       61 ggtggtcaag agtgtaacac agccagcctc gaagacttcc ctctgagttg gaatgataat
      121 gaccgaatcc cgagaagtta tagacttaga ccccccagct gagacttccc aggagcagga
      181 agaccttttc atagtgaagg tggaagaaga agactgcacc tggatgcagg agtacaaccc
      241 gccaacgttt gagacttttt accagcgctt caggcacttc cagtaccatg aggcttcagg
      301 accccgggag gctctcagcc aactccgggt gctctgctgt gagtggctga ggcccgagct
      361 gcacacgaag gagcagatcc tggagctgct ggtgctggag cagttcctga ccatcctgcc
      421 tgaagagttc cagccctggg tgagggaaca tcaccctgaa agtggagaag aggcggtggc
      481 cgtgatagaa aatatacagc gagaacttga ggaacgcaga cagcagattg ttgcctgccc
      541 tgatgtgctt cctcggaaga tggcaacacc tggagcagtg caggagtcct gcagccccca
      601 tcccctgacc gtggacaccc agcctgagca agcgccacag aagcctcgtc tcctggagga
      661 aaatgccctt cctgttctcc aagttccttc ccttcccctg aaggacagcc aggagctgac
      721 agcttcactt ctctcaactg ggtcccagaa gttggtgaaa attgaagagg tggctgatgt
      781 ggctgtatcc ttcatcctgg aggaatgggg gcatttggac cagtcccaga agtcccttta
      841 tagggatgac aggaaggaga actatgggag tattacttcc atgggttatg agtccaggga
      901 caatatggag ctcatagtga agcagatttc tgatgactct gaatcacact gggtggcgcc
      961 agaacacacc gaaaggagcg ttcctcagga tccagacttt gcagaagtca gtgaccttaa
     1021 aggcatggta caaaggtggc aggtcaaccc cactgtgggg aaatcaaggc agaatccttc
     1081 ccagaaaagg gatctggatg caatcacaga catcagccct aagcaaagca cacatggcga
     1141 gagagggcac agatgcagcg attgtggcaa attcttcctc caagcctcaa actttattca
     1201 gcatcggcgc atccacactg gagaaaaacc gtttaagtgc ggagaatgtg ggaagagcta
     1261 caatcagcgg gtgcacctca cccagcacca gcgcgtccac acaggggaga aaccctacaa
     1321 atgtcaggtg tgcggaaagg ctttccgggt gagttcccac ctggttcagc accacagtgt
     1381 ccacagcgga gagaggccct atggctgcaa tgagtgtggg aagaacttcg gtcgccattc
     1441 gcatctgatc gaacacctaa aacgccactt cagggagaaa tcccagagat gcagtgacaa
     1501 aagaagtaag aacacaaaat taagtgttaa gaagaaaatt tcagaatatt cagaagcaga
     1561 catggaacta tctggaaaaa cccaaagaaa tgtttctcaa gttcaagatt ttggagaagg
     1621 ctgtgagttt caaggcaagc tggatagaaa gcagggaatt cccatgaaag agatactagg
     1681 acaaccatct tcaaagagga tgaactacag tgaagtccca tatgtccaca aaaaatcctc
     1741 cactggagag agaccacata aatgtaacga gtgtgggaaa agcttcattc agagtgcaca
     1801 tcttattcaa catcaaagaa tacacactgg ggagaaacca ttcaggtgtg aggaatgtgg
     1861 gaaaagctac aaccaacgcg tgcacctaac tcagcatcag cgcgtccaca caggtgagaa
     1921 gccctacacc tgtcccttat gtgggaaagc cttcagagtg aggtcccacc ttgttcagca
     1981 tcagagcgtg cacagtgggg agagaccctt caagtgtaac gaatgtggga aaggctttgg
     2041 gaggcgttcc cacctggctg gacatcttcg actccactcc cgagagaaat cccatcagtg
     2101 tcgtgaatgt ggggaaatct tttttcagta cgttagccta attgaacatc aggtgctcca
     2161 catgggtcag aaaaatgaaa aaaatggcat ctgtgaggaa gcatatagtt ggaacttgac
     2221 agtgattgaa gacaagaaga ttgagttaca agagcagcct tatcagtgtg atatctgtgg
     2281 aaaagccttt ggttatagct cagacctcat tcagcattac agaactcata cagcagagaa
     2341 gccctatcaa tgtgatatat gtagagaaaa tgttggccag tgttcccaca ccaaacaaca
     2401 tcaaaaaatc tactccagca caaaatccca tcaatgtcat gaatgtggca gaggcttcac
     2461 tctgaagtca catcttaatc aacatcagag aatccatact ggtgagaaac cttttcaatg
     2521 taaagaatgt ggaatgaatt tcagctggag ttgtagcctc tttaaacacc tgagaagcca
     2581 tgagaggaca gatcccataa ataccttaag tgtagagggg tctctgttgt agaatagctc
     2641 ttaattttag agaaaccttc ctggagggaa accatactcc tataatgagc aaagtaacaa
     2701 cttcaagcat ttttccagcg ttaccatcaa actcacaaat aggttgaaat cctttagtta
     2761 taactcagcc tttaggaaca ccggagaacc cacaataata gaaatctttt cgtgttcccc
     2821 attgagaaat gctttagtta gcatcttcat gcttggaaat ctagacaaga agagaatcca
     2881 tggatggaca tggtcgagga attcggaaag cctgcagttg acattcagtc ttcacttgaa
     2941 actcaaaact gacactagga acagcttcat gagttcagta gaagtaagct ttatttgtag
     3001 cttctgcctt gtttgacggc gtatctattc agggaagcgc acagtaaaag aattccttag
     3061 catgatgtct gttttggtac ctcagcaatg aaccttttct agaaattatt attccaacca
     3121 ctagaatacc ctagtcacta ttcccacttt gagcattaac ccctttgaaa agaaatggac
     3181 ttaaagtatc tctgttttgg caaaattcag gttcaggggc tggatggtat gtgtttctgc
     3241 tgccttattc aatccaccac ttctctgtga aacactctac cttgtttttg gtttgattct
     3301 actgatgtca gggtttagcc ggtagaagga gtagttcagt ttgtcaattc aggagaaact
     3361 gtactggtca gtcacatctt acggcgaagg gagagggacc ttaggggagc agagaagaca
     3421 ggcaaagttg tggactgttt gatcttgtat tacccacagg aatgagggca gctaaaccca
     3481 tagaaggagt tggaccaagg cgaattacga gtcctggtcc cagcagtatg tgtgctgact
     3541 tctgggtgcc ccagaaatag acctctcctg tagagtggtg atatacagaa tgagtttcag
     3601 tttgcattgc agctgggatt gaaagtaatc agtcgtgagc aggcaggcag gaggtcctgt
     3661 tagccctgcc ttccaggaag gttggggtgg gagttttgag tgggaaagag gatgacatgt
     3721 gtgagagagt tctgagcctg tttgctaggg agagtgagtg agtgctcttg ggcactgctc
     3781 aggccgtttc tgctgacttg cctggcttac aataaatgcc caataaatat ttgttgacca
     3841 tatgtgttgt acactgtggt gccctgtcca gtcccctcta ccaagctgag acccccatcc
     3901 ccagctgctc tgagtttggg ctgcaagtgc tcacagctct tgttctccag aaactggaga
     3961 attgccctca ggagatgaga gccatctcac ctcacccagg agtcacttcc tctctacacc
     4021 ccaacacctg gttcatttga ttaaagcgga gaaaactcca gggtgctatg actgctctgg
     4081 cacccttgga tcaggccaag ctagactttt tctgagcctt catccgtgct aagctctctc
     4141 ccttctctat cctgtttcat tccctccctc aaaggcgttt cccaaataaa tcacactgtc
     4201 aatcacatgg ttctgaatcc ctgtctcagg ctctgcttta gagaacctga tctaagacat
     4261 ttggtgccac aagtggtcat aggaagctgc tgtgagagtg gattgtggag ttggtcactc
     4321 gccaggaggg agtgaagacc cgcatcactg ttaatagtcc tggcatgtgg tacctgtcca
     4381 gtcactaagt cattcacttg tggggaactg ggatgagata caggtggaaa gcgatctatt
     4441 gacttgtaga ggtttgggac aaacaggaaa ataaagatta tggaattggg tggctcttgc
     4501 tgaaagtcac tgaatccttg aagagaagaa aatgacaggg caaataacca ccaatttaat
     4561 gccaagtgtg tgtcagagga ccttcttggt agctttttaa tttttttata gacagggtct
     4621 tgctctgctg cccaggctag agtgcagtgg tgcaatcaca gctcactgca gccttgacct
     4681 cccgggctca agtggtctag ccacctcagc ctcctgaata gctgggacta caggcacatg
     4741 ccaccatgag tggctaattt ttaaaaaaca tactttagct gggcgcggtg gctcatgcct
     4801 ataaacccag cactttggga ggctgaggcg ggcagatcac gaggtcaaga gatcgaaacc
     4861 atcctggcca accaacatgg tgaaacccgg tctctactta aaatacaaaa attagctggg
     4921 catagtggcg catgcctata gtcccagcta ctccagaggc tgaggcagga gaatcgcttg
     4981 aacccgggag gcagaggttg cagtgagctg agatcacgcc actgcactct agcccagttg
     5041 acagagcgac agtgtctaaa aaaaaaaaaa aaaaaaaaaa aaa
//
