LOCUS       NM_019110               5346 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger with KRAB and SCAN domains 4 (ZKSCAN4),
            transcript variant 1, mRNA.
ACCESSION   NM_019110
VERSION     NM_019110.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5346)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5346)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5346)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 5346)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5346)
  AUTHORS   Liang,Y., Li,Q., Chen,K., Ni,W., Zhan,Z., Ye,F., Li,Y., Fang,Y.,
            Zhang,F., Chen,L. and Ding,Y.
  TITLE     Zinc finger protein 307 functions as a tumor-suppressor and
            inhibits cell proliferation by inducing apoptosis in hepatocellular
            carcinoma
  JOURNAL   Oncol Rep 38 (4), 2229-2236 (2017)
   PUBMED   28765950
  REMARK    GeneRIF: our results indicate that ZNF307 may serve as a tumor
            suppressor and inhibits cell proliferation of hepatocellular
            carcinoma via inducing apoptosis
REFERENCE   6  (bases 1 to 5346)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 5346)
  AUTHORS   Yue,W.H., Wang,H.F., Sun,L.D., Tang,F.L., Liu,Z.H., Zhang,H.X.,
            Li,W.Q., Zhang,Y.L., Zhang,Y., Ma,C.C., Du,B., Wang,L.F., Ren,Y.Q.,
            Yang,Y.F., Hu,X.F., Wang,Y., Deng,W., Tan,L.W., Tan,Y.L., Chen,Q.,
            Xu,G.M., Yang,G.G., Zuo,X.B., Yan,H., Ruan,Y.Y., Lu,T.L., Han,X.,
            Ma,X.H., Wang,Y., Cai,L.W., Jin,C., Zhang,H.Y., Yan,J., Mi,W.F.,
            Yin,X.Y., Ma,W.B., Liu,Q., Kang,L., Sun,W., Pan,C.Y., Shuang,M.,
            Yang,F.D., Wang,C.Y., Yang,J.L., Li,K.Q., Ma,X., Li,L.J., Yu,X.,
            Li,Q.Z., Huang,X., Lv,L.X., Li,T., Zhao,G.P., Huang,W., Zhang,X.J.
            and Zhang,D.
  TITLE     Genome-wide association study identifies a susceptibility locus for
            schizophrenia in Han Chinese at 11p11.2
  JOURNAL   Nat Genet 43 (12), 1228-1231 (2011)
   PUBMED   22037552
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5346)
  AUTHORS   Ecker,K., Lorenz,A., Wolf,F., Ploner,C., Bock,G., Duncan,T.,
            Geley,S. and Helmberg,A.
  TITLE     A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid
            receptor-interacting protein
  JOURNAL   J Mol Endocrinol 42 (2), 105-117 (2009)
   PUBMED   19008334
  REMARK    GeneRIF: The SCAN- and KRAB-domain-containing zinc finger protein
            307 (ZKSCAN4) was co-precipitated with the receptor when both
            proteins were overexpressed in HEK293 cells.
REFERENCE   9  (bases 1 to 5346)
  AUTHORS   Li,J., Wang,Y., Fan,X., Mo,X., Wang,Z., Li,Y., Yin,Z., Deng,Y.,
            Luo,N., Zhu,C., Liu,M., Ma,Q., Ocorr,K., Yuan,W. and Wu,X.
  TITLE     ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway
  JOURNAL   Biochem Biophys Res Commun 363 (4), 895-900 (2007)
   PUBMED   17910948
  REMARK    GeneRIF: ZNF307 might suppress p53-p21 pathway through activating
            MDM2 and EP300 expression and inducing p53 degradation
REFERENCE   10 (bases 1 to 5346)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY070446.1, AY781778.1 and AL022393.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019110.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.216014.1,
                                           SRR1803615.173787.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377294.3/ ENSP00000366509.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 HY070446.1         28-30
            4-2417              AY781778.1         1-2414
            2418-5346           AL022393.1         7810-10738
FEATURES             Location/Qualifiers
     source          1..5346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..5346
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /note="zinc finger with KRAB and SCAN domains 4"
                     /db_xref="GeneID:387032"
                     /db_xref="HGNC:HGNC:13854"
                     /db_xref="MIM:611643"
     exon            1..712
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1927
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 307; p373c6.1 (novel C2H2 type zinc finger
                     protein); zinc finger protein 427; zinc finger protein
                     with KRAB and SCAN domains 4"
                     /codon_start=1
                     /product="zinc finger protein with KRAB and SCAN domains 4
                     isoform 1"
                     /protein_id="NP_061983.2"
                     /db_xref="CCDS:CCDS4647.1"
                     /db_xref="GeneID:387032"
                     /db_xref="HGNC:HGNC:13854"
                     /db_xref="MIM:611643"
                     /translation="MAREPRKNAALDAQSAEDQTGLLTVKVEKEEASALTAEVRAPCS
                     PARGPERSRQRFRGFRYPEAAGPREALSRLRELCGQWLQPEMHSKEQILELLVLEQFL
                     TILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVPVGDQGQELLCCKMALLT
                     QTQGSQSSQCQPMKALFKHESLGSQPLHDRVLQVPGLAQGGCCREDAMVASRLTPGSQ
                     GLLKMEDVALTLTPGWTQLDSSQVNLYRDEKQENHSSLVSLGGEIQTKSRDLPPVKKL
                     PEKEHGKICHLREDIAQIPTHAEAGEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSG
                     LTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLI
                     KHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRH
                     QRIHGDKNVQNPEHGESWESQGRTESQWENTEAPVSYKCNECERSFTRNRSLIEHQKI
                     HTGEKPYQCDTCGKGFTRTSYLVQHQRSHVGKKTLSQ"
     exon            713..860
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /inference="alignment:Splign:2.1.0"
     exon            861..943
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1067
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..5346
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /note="hexamer: AGTAAA"
     polyA_site      2417
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /note="major polyA site"
     regulatory      4108..4113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /note="hexamer: AATATA"
     polyA_site      4128
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
     regulatory      5315..5320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
                     /note="hexamer: AATAAA"
     polyA_site      5346
                     /gene="ZKSCAN4"
                     /gene_synonym="P1P373C6; ZNF307; ZNF427; ZSCAN36"
ORIGIN      
        1 agcctcaact tccctcctat gtctggagag tgatcacttt cactcccaaa gacatccttt
       61 ggtgatactt actgtgggat tcagagtggg gtgcagagga cgaccctgca aaggcacgga
      121 ctataagaga gatctgtgca gctgcgcctc agggggtgtc ctgggcccct gggcatgaca
      181 ggagggggac cacttgcagt tctactggaa aatttaccac ccttccagaa tcctctgaag
      241 atatacaggt cgcaactaga gtgagacccg agtactgcct tgggtcagaa tggctagaga
      301 accgagaaaa aacgcagccc tggacgccca gtctgcagaa gaccagacgg ggctcctgac
      361 cgtgaaggtg gagaaggagg aagcctccgc cttgacggcg gaggtgagag caccctgcag
      421 ccctgctcgg ggccccgaac gctcccgcca gcgcttccga ggcttccgct acccggaggc
      481 tgcgggcccc cgcgaggcgt tgagccggct ccgagaactc tgcggacaat ggctgcagcc
      541 tgagatgcac agcaaggagc agatcctgga gctgctggtg ctggagcagt tcctgaccat
      601 cctgccgggg aatctgcaga gctgggtgcg ggagcagcat ccagagagcg gggaggaggt
      661 ggtggtgcta ttggagtatt tggagaggca gctggatgag ccggcgccgc aggttcccgt
      721 tggtgaccag gggcaagaac tgctctgttg caagatggca ctattgacac aaactcaagg
      781 gtctcaaagt agccagtgcc agccaatgaa ggctctgttc aagcatgaat ctctgggatc
      841 ccagccctta cacgatagag ttctccaggt tcctgggctt gcccagggag ggtgctgcag
      901 agaagatgca atggtagctt ccaggctcac tccagggtcc cagggtttgc tgaaaatgga
      961 agatgtggcc ctgaccctca ctcctgggtg gacacagctg gattcatctc aggtgaacct
     1021 ctacagagat gaaaagcagg agaaccatag cagcctggtc tcccttggtg gtgaaataca
     1081 gactaagagc agggacttgc ctccagtcaa gaagcttcca gaaaaggagc atgggaagat
     1141 atgccacctg agggaagaca ttgcccagat tcctacacat gcagaagctg gtgaacagga
     1201 gggcaggtta caaagaaagc agaaaaatgc catagggagt aggcgacatt attgccatga
     1261 atgtggaaag agttttgctc aaagttcagg cctgactaaa cacaggagaa tccacactgg
     1321 tgagaaaccc tatgaatgtg aagactgtgg aaagaccttc attgggagct ctgcccttgt
     1381 cattcatcag agagtccaca ctggtgagaa gccatatgag tgtgaagaat gtggtaaggt
     1441 cttcagtcac agctcaaacc ttatcaaaca ccagagaacc cacactgggg agaagcccta
     1501 tgagtgtgat gactgtggga agaccttcag ccagagctgc agcctccttg aacatcacaa
     1561 aattcatact ggggagaagc cataccagtg caatatgtgt ggcaaagcct ttaggcggaa
     1621 ttcacatctc ctgagacatc agaggattca tggtgataaa aatgttcaga atcctgagca
     1681 cggggagtcc tgggaaagtc agggtaggac ggaaagccag tgggaaaata ctgaggctcc
     1741 cgtgtcttat aaatgtaatg agtgtgagag aagtttcaca cggaatagaa gtcttattga
     1801 acatcagaaa atccacactg gtgagaaacc ctatcagtgt gacacatgtg gaaaaggttt
     1861 cactcgaact tcataccttg ttcaacatca gagaagccat gtagggaaaa aaactctttc
     1921 acagtgaccc atggtattca tgccaacatt ggtgctcatt tgtcactgaa ctgaagccac
     1981 cctggagccc ttaatggtta cagaaattgt ggaccagggc tttatttacc actatacatc
     2041 atcgggtatt agaaaatgta gtctggctga gacgatgagt tatcttctac attctagaaa
     2101 gtgattggaa gaagtcattt gataagaggc catgggagag tggtctggaa gttgtaggac
     2161 ctaaaatagt ttgttctcac ccagtgtatt taaatggcct tctggacttg ttaattgccc
     2221 tcagccagca ctttaggaca tctggttgga tggctctgat gtggggggct gctgctctga
     2281 ccattcattt tgcctctaat gaatctttca caaattggtc agatccatga ggtcttttac
     2341 tcttctttgt gccttgtatg ataggtgcta ataaacattt attaaatgta ccagtaaaat
     2401 ggcctttgta ccaaaaattt gatgttgtct atatttctga gaaatttcta acttatgcca
     2461 tttgaattta tgtattattc tctgaggttc tagattctgg gccaatctag tgtatttgtt
     2521 gccacgtaca tactgttttc agaattgggg tgggggaatc catatttctc taccatgata
     2581 gtagagatga gaagaatgcc ttaaacagct tctttatcat taagacactg tgagattgct
     2641 ccatccatag aactccactg tctggtcaat gttaattatg ttagtttaca ttaattttgc
     2701 tactctttag ggggagtctt tcacattcag gtaaataaaa atcaacttac tgagttagat
     2761 caaaatgatt attatgaatt ttgaacacat tctgtaacac ttaccatctt gtttcttacc
     2821 ttttagttat cttgggccga ccaagtgcta agacgtcatc tgtgtccctc ttccccagtt
     2881 tatagctgac tgtgcatcaa ggcttatgcc agctaagctt aaactttctc caggtccgaa
     2941 gattcataac aaatatttat aattattatt catggtttca aaactgccct gtcagttggg
     3001 gacaggaaga tcaggttaga ggcagcctat gaggatagaa actcacatct gagtggtagg
     3061 agaaaatgta tctgttcagg ctgggtgcca tggcttacac ctgtaatccc agcaatttgg
     3121 gaggctgtgg caggcagatc acatgaagtc agaagtttga gaccagcctg gccaacacgg
     3181 tgaaacccca tctctacaaa aaatacaaaa attagccagg catggtgaca cacgcctgta
     3241 atccctgcta cttgggaggc tgaggtagga gagttgcttg aaactgggag gtggaggttg
     3301 cagtgagccg agatggtgcc actgcagtcc agcctgggtt tcagagtgag actctgtctc
     3361 aaaaagaaaa aaaaaaaaga aaagaaaatg tgtctgttca gaagcacatt gggaatccta
     3421 ggtatctgat gaaaaagatt gtacaatatc caaagtgttg atatgtgatg tcaaggctca
     3481 atgctgtgag ttattcacaa gaaataagaa ttttttgata tcttctgctt tcacccaaat
     3541 cacctgcgat gcttaaagac tgatttcttc cgaagtgctc aagtgcctat taccatcttc
     3601 cagcattgcc agactgtcat gaatggattc tgcttctgat gaaatccctg accatgtttt
     3661 attcagtcac cagcatcgtg ttcttgtcta tcctcaaata ccctttctgg atttctcctc
     3721 tgaaatacca caggctgacc agagacttac aaaaccgtag agctctccct ttattaattc
     3781 cctacaatct tttattgcct tcattatctc cttttcagtc taatttaaaa cttctttaga
     3841 attccaaagt tctgtagact ttctctgctc aatcttttct agccttttca aatttcttta
     3901 aaatcagctt tatttatgtt atttccacaa agctagccat ttccttttct cctttttcac
     3961 ttctcctaaa tatttgctaa atagctctga ttttacacac tcaaactcat tacagacaac
     4021 tctgttaact tttctgtgat atttgtttct gatgttacat gaagagatat atgtgaaagc
     4081 cttttacaaa ccagaaagca ttatacaaat ataacttcct gagattaact aaggaccact
     4141 gtgcctcctt tcactcctgc gcctccaagc ctaaaagtct tctctgtaga ggagggaaat
     4201 attgtagaaa agtacttttc agtgtctgct atgctagaaa agggaagaaa taaagcctct
     4261 atttgtgtgt gtgtgtgtgt gtgtgtatac acacttaggc ttaggtcttt agtacagtca
     4321 ggttggtaag acttgcacac aaataaggca gtgtaatgat aaatgcctta tgagtggtaa
     4381 actgaggctt gtagaaattc agagaaggaa aaggatgctt ccagctgtgc aagctgttat
     4441 tatatggaca gggtgacatg ttagaaagct gaatggactc acaacaactt tgtccaattg
     4501 agtaaataaa gcaaatttta agagataggg acattgtagg ggccttcagt gccagagcaa
     4561 aaagtttaaa ttttattcag taagcactgg ggagccatga tattttataa tcaaaatatt
     4621 atctaggaaa ctttatctgg tgtattatat aatatcaaat aaaatcattt tgcttacagt
     4681 cttttagata ctccactttt ctataaaaca gtggtatgtg tttataaata gctgaattat
     4741 aaaatgagtt tatctgtagc ctattgaaag gatggccaaa aaagttattt tccaatgaaa
     4801 ttagatctag taaagtaaac tacttagttg agatataagc agtatataaa gcacaataaa
     4861 atgccacttt tcatattttc ttaaattgct tttaggaatt ttagtggtga ctagtctgcc
     4921 attctatttc atttctgtaa ctgaagcagc gcagaaatct tctattttct tttttctccc
     4981 tttgcttgaa tagtaaatgg ttatagcact ttttctactt cgatagaatg aatggttata
     5041 atgaaaaaag cttttgatga atggcactct tggatttgtt cttaattttg gcaaagacgt
     5101 atataattct gcaaaagact ttctctgcct cttcctttag tgagagaaaa aaaaaggtag
     5161 gaatgacaac ttaactccta ggattctgag gatctgctta tacaaataag aagtgctaag
     5221 taaaaactct gaaaatgttg ctaactggta gagaaatgga gattaacact ttgttaatgg
     5281 aaacctccaa ataaaggaat tataattgtt taataataaa gactatattt taaaagtgtc
     5341 ctgtaa
//
