LOCUS       NM_024493               4687 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens zinc finger with KRAB and SCAN domains 3 (ZKSCAN3),
            transcript variant 2, mRNA.
ACCESSION   NM_024493
VERSION     NM_024493.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4687)
  AUTHORS   Nonoyama,K., Matsuo,Y., Sugita,S., Eguchi,Y., Denda,Y., Murase,H.,
            Kato,T., Imafuji,H., Saito,K., Morimoto,M., Ogawa,R., Takahashi,H.,
            Mitsui,A., Kimura,M. and Takiguchi,S.
  TITLE     Expression of ZKSCAN3 protein suppresses proliferation, migration,
            and invasion of pancreatic cancer through autophagy
  JOURNAL   Cancer Sci 115 (6), 1964-1978 (2024)
   PUBMED   38671550
  REMARK    GeneRIF: Expression of ZKSCAN3 protein suppresses proliferation,
            migration, and invasion of pancreatic cancer through autophagy.
REFERENCE   2  (bases 1 to 4687)
  AUTHORS   Li,X.M., Wen,J.H., Feng,Z.S., Wu,Y.S., Li,D.Y., Liang,S., Wu,D.,
            Wu,H.L., Li,S.M., Ye,Z.N., Yang,C., Sun,L., Tang,J.X. and Liu,H.F.
  TITLE     Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and
            Senescence
  JOURNAL   Int J Mol Sci 24 (9), 7786 (2023)
   PUBMED   37175493
  REMARK    GeneRIF: Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal
            Biogenesis and Senescence.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4687)
  AUTHORS   Yang,Z., Lemacon,D.S., Li,S., Cheruiyot,A., Kong,L., Tan,K.,
            Cheng,C., Turkay,E., He,D. and You,Z.
  TITLE     Context-dependent pro- and anti-resection roles of ZKSCAN3 in the
            regulation of fork processing during replication stress
  JOURNAL   J Biol Chem 298 (8), 102215 (2022)
   PUBMED   35779634
  REMARK    GeneRIF: Context-dependent pro- and anti-resection roles of ZKSCAN3
            in the regulation of fork processing during replication stress.
REFERENCE   4  (bases 1 to 4687)
  AUTHORS   Zhang,X., Bai,Y., Huang,L., Liu,S., Mo,Y., Cheng,W., Wang,G.,
            Cao,Z., Chen,X., Cui,H., Qi,L., Ma,L., Liu,M., Guan,X.Y. and
            Ma,N.F.
  TITLE     CHD1L augments autophagy-mediated migration of hepatocellular
            carcinoma through targeting ZKSCAN3
  JOURNAL   Cell Death Dis 12 (10), 950 (2021)
   PUBMED   34654797
  REMARK    GeneRIF: CHD1L augments autophagy-mediated migration of
            hepatocellular carcinoma through targeting ZKSCAN3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4687)
  AUTHORS   Pan,H.Y. and Valapala,M.
  TITLE     Role of the Transcriptional Repressor Zinc Finger with KRAB and
            SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial Cells
  JOURNAL   Cells 10 (10), 2504 (2021)
   PUBMED   34685484
  REMARK    GeneRIF: Role of the Transcriptional Repressor Zinc Finger with
            KRAB and SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial
            Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4687)
  AUTHORS   Yang,L., Zhang,L., Wu,Q. and Boyd,D.D.
  TITLE     Unbiased screening for transcriptional targets of ZKSCAN3
            identifies integrin beta 4 and vascular endothelial growth factor
            as downstream targets
  JOURNAL   J Biol Chem 283 (50), 35295-35304 (2008)
   PUBMED   18940803
  REMARK    GeneRIF: ZKSCAN3 regulates the expression of several genes favoring
            tumor progression including integrin beta 4 and VEGF
REFERENCE   7  (bases 1 to 4687)
  AUTHORS   Yang,L., Hamilton,S.R., Sood,A., Kuwai,T., Ellis,L., Sanguino,A.,
            Lopez-Berestein,G. and Boyd,D.D.
  TITLE     The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of
            colorectal cancer progression
  JOURNAL   Cancer Res 68 (11), 4321-4330 (2008)
   PUBMED   18519692
  REMARK    GeneRIF: ZKSCAN3 adds to an expanding set of encoded products
            contributing to the progression of colorectal cancer
REFERENCE   8  (bases 1 to 4687)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   9  (bases 1 to 4687)
  AUTHORS   Wang,H., Yang,L., Jamaluddin,M.S. and Boyd,D.D.
  TITLE     The Kruppel-like KLF4 transcription factor, a novel regulator of
            urokinase receptor expression, drives synthesis of this binding
            site in colonic crypt luminal surface epithelial cells
  JOURNAL   J Biol Chem 279 (21), 22674-22683 (2004)
   PUBMED   15031282
REFERENCE   10 (bases 1 to 4687)
  AUTHORS   Petroni,D., Bartolini,E., Chiaramonte,R., Ottolenghi,S. and Comi,P.
  TITLE     Computer sequence analysis of human highly conserved zinc finger
            modules
  JOURNAL   DNA Seq 9 (3), 163-169 (1998)
   PUBMED   10520746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA440043.1, BC006118.1, AL021997.1 and AL358785.10.
            
            On Nov 23, 2018 this sequence version replaced NM_024493.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.54547.1,
                                           SRR1803611.56846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252211.7/ ENSP00000252211.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               DA440043.1         34-549
            517-747             BC006118.1         482-712
            748-782             AL021997.1         726-760             c
            783-1819            BC006118.1         748-1784
            1820-4687           AL358785.10        2329-5196
FEATURES             Location/Qualifiers
     source          1..4687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..4687
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /note="zinc finger with KRAB and SCAN domains 3"
                     /db_xref="GeneID:80317"
                     /db_xref="HGNC:HGNC:13853"
                     /db_xref="MIM:612791"
     exon            1..121
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /inference="alignment:Splign:2.1.0"
     exon            122..585
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1800
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 306; zinc finger protein zfp47; zinc finger
                     protein 309; zinc finger protein with KRAB and SCAN
                     domains 3; zinc finger protein 47 homolog; zinc finger and
                     SCAN domain-containing protein 13"
                     /codon_start=1
                     /product="zinc finger protein with KRAB and SCAN domains 3
                     isoform 1"
                     /protein_id="NP_077819.2"
                     /db_xref="CCDS:CCDS4650.1"
                     /db_xref="GeneID:80317"
                     /db_xref="HGNC:HGNC:13853"
                     /db_xref="MIM:612791"
                     /translation="MARELSESTALDAQSTEDQMELLVIKVEEEEAGFPSSPDLGSEG
                     SRERFRGFRYPEAAGPREALSRLRELCRQWLQPEMHSKEQILELLVLEQFLTILPGNL
                     QSWVREQHPESGEEVVVLLEYLERQLDEPAPQVSGVDQGQELLCCKMALLTPAPGSQS
                     SQFQLMKALLKHESVGSQPLQDRVLQVPVLAHGGCCREDKVVASRLTPESQGLLKVED
                     VALTLTPEWTQQDSSQGNLCRDEKQENHGSLVSLGDEKQTKSRDLPPAEELPEKEHGK
                     ISCHLREDIAQIPTCAEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQSSGLSKHRR
                     IHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTH
                     TGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLRHQRIHTG
                     DKNVQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPY
                     QCNACGKGFTRISYLVQHQRSHVGKNILSQ"
     exon            586..733
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /inference="alignment:Splign:2.1.0"
     exon            734..816
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /inference="alignment:Splign:2.1.0"
     exon            817..940
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /inference="alignment:Splign:2.1.0"
     exon            941..4687
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /note="hexamer: AATAAA"
     polyA_site      2262
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /note="major polyA site"
     regulatory      4666..4671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /note="hexamer: AATAAA"
     polyA_site      4687
                     /gene="ZKSCAN3"
                     /gene_synonym="dJ874C20.1; dJ874C20.1.; ZF47; zfp-47;
                     ZFP306; Zfp47; ZNF306; ZNF309; ZSCAN13; ZSCAN35"
                     /note="major polyA site"
ORIGIN      
        1 gctagtttca agcactttgt gagtatgggg tgaatcggcg tcggccttcc actgtggggt
       61 taaatctcat cccgcggctc tcctcctgtc ggtcctgcag ttcttttgtc cccgggtaga
      121 gggatcttct gcagaaatag cgctggaagc tagagtgagg cctgagtact gccttggcct
      181 aggatggcta gagaattaag tgaaagcaca gccctggatg cccagtctac agaagaccag
      241 atggagcttc tggtcataaa ggtggaggaa gaagaagccg gttttcccag tagcccagat
      301 ctgggttctg agggctcccg cgagcgcttc cgaggcttcc gctacccgga ggctgcaggc
      361 ccccgcgagg cgctgagtcg gctccgagag ctctgccgac agtggctgca gcctgagatg
      421 cacagcaagg agcagatcct ggagctgctg gtgctggagc agttcctgac catcctgccg
      481 gggaatctgc agagctgggt gcgggagcag catccagaga gcggggagga ggtggtggtg
      541 ctattggagt atttggagag gcagctggat gagccggcgc cgcaggtttc aggtgttgac
      601 caggggcaag aactgctctg ttgcaagatg gcactattga caccagcccc agggtcacaa
      661 agtagccaat ttcagctaat gaaggctctg ctcaagcatg aatctgtggg atcccagcct
      721 ttacaagata gagttctcca ggtccccgtg cttgcccatg gaggatgctg cagagaagat
      781 aaagtggtag cttctaggct tactccagag tcccaggggt tgttgaaagt ggaagatgtg
      841 gccctgaccc tcacccctga atggacacag caggattcat ctcaggggaa tctctgtaga
      901 gatgaaaagc aggagaacca tggcagcctg gtctccctgg gtgatgaaaa acagactaag
      961 agcagggact tgcctccagc tgaggagctt ccagaaaagg agcatgggaa gatatcgtgc
     1021 cacctgagag aagacattgc ccagattcct acatgtgcag aagctggtga acaggagggc
     1081 aggctacaaa gaaagcagaa aaatgccaca ggagggaggc ggcacatctg ccatgaatgt
     1141 ggaaagagtt ttgctcaaag ctcaggcctg agtaaacaca ggagaatcca cactggtgag
     1201 aaaccctacg aatgtgaaga gtgtggcaaa gccttcattg ggagctctgc ccttgtcatt
     1261 catcagagag tccacactgg tgagaagcca tatgagtgtg aagaatgtgg taaggccttc
     1321 agtcatagct cagaccttat caagcatcag agaacccaca ctggggagaa gccctatgag
     1381 tgtgatgact gtgggaagac cttcagccag agctgcagcc tccttgaaca tcacagaatc
     1441 cacactgggg agaagccgta tcagtgcagt atgtgtggca aagcctttag gcgaagttca
     1501 catctcctga gacatcagag gatccatact ggggataaaa atgttcagga acctgagcag
     1561 ggagaggcct ggaaaagtag gatggaaagc cagttggaaa atgttgaaac tcccatgtct
     1621 tataaatgta atgagtgtga aagaagtttc actcagaata caggcctcat tgaacatcaa
     1681 aaaatccaca ctggtgagaa accctatcag tgtaatgcgt gtggaaaagg cttcacccga
     1741 atttcatacc ttgttcaaca tcagagaagc catgtaggga aaaacatcct atcacagtga
     1801 cccatgccat acatgccaga gttggtgctc atttgtcact gatctgaagc cactccccct
     1861 ggagtctcaa ctatagaaat tgtgggctgg gctttattta ccactacaca ttatcaggtg
     1921 ttagaaaatg tagactgggt tagacaaatt atcttctaag ttctagaagg ggtttgtaat
     1981 caaaacatat ttgataggag gctacgggag agttgtctag aagaggtaag acctgaaact
     2041 gtttgttctc tcccactaga attaaatgga tgtttagact ggctacttgc cctaaaccag
     2101 cacttggtga tgtctactgg gtggatggtt gtgatttggg ggctgcttct ctgaccattc
     2161 tttttgactg taatgaatcc tccacagttg gtcagattca taaagtctta tatccccctc
     2221 tgtgcctttt ctgcaggtgc taataaatgt ttattgaatg taccagtgag attaccttca
     2281 tagatctgaa aatctgatgt tatccaggtt tctgaagaac ttctcgccaa ggccatttgt
     2341 gcttgtgtcc aattctctga cctagattgt gactcaatct agtgtgtttc ttaccaagta
     2401 cataggcaga gcagggttac tgtgattgaa agaatccatt ttttttttgg agacgtagtc
     2461 ttgctctgtc gcccaggctg gagtgcagtg gcacaatctt ggctcactgc aacctccacc
     2521 tcctgggttc aagcgattct cctgcctcag cctcctgagt agctgggatt acaggtgtgt
     2581 gccaccatgc ccggctaatt ttttatgttt ttagtagaga cgggatttta ccgtgttagc
     2641 caggatggtc tcgatctcct aacctcatga tcctcctgcc tcagcctacc aaagtgctgg
     2701 gattacaggc atgagccacc atgcccggcc aagaatccat atttctttac cagactagga
     2761 attctattct agtgcaaatg ccttaaaaag cttatcacta aatcattacg aatgtgtgcc
     2821 atccgtggaa ttgctttttt tttttttttt ttgtaaatat gaggtctcac tatgttgccc
     2881 aggctggtct cgaaatcctg ggcaatcctc ctgcctcacc ctctcaagta ctggaattac
     2941 aggcgtgagc caccataccc agcccaaatt tcactcttta atgttttcct gttgctattc
     3001 tttaaggaaa aaactttcct attcagacag tgtgaaaatc agtcatcaag tcagaataaa
     3061 atgatgaata ttctaatgct cagtatctta gttctctcgg gcctaaccaa tgcctcctaa
     3121 aacaatagat actatcctgc cccaccctac cacccaacac acactgtata gtaaactgca
     3181 tcaaaactta ttcctgctaa gttcatactt tctccagctc aatggattca caccaaattt
     3241 tttttttttt ttttagacgg agtcttctct gtcacccagg ctggagtgca gtggcgcgat
     3301 ctcggctcac tgcaagctcc gcctcccagg ttcctgccat tctcctgcct cagcctcccg
     3361 agtagctggg actataggcg tccgcctcca cgccgggcta tttttttttt ttattttata
     3421 ctttaagttc tagggtacat gtgcacaacg tgcaggtttg ttacatatgt atacatgtgc
     3481 catgttggtg tgctgcaccc attaactcgt catttacatt gggtgtatct cctaatgctt
     3541 tccctccccc caccccacaa caggccccag tgtgtgatgt tccccttcct gtgtccaagt
     3601 gttctcctta ttcaattccc acctatgagt gagaatatgc cgtgtttgat tttttgttct
     3661 tggcgatagt ttgctgagaa tgatgagacg aggtttcact gtgttagcca ggatgctctc
     3721 gatctcctga cctcgtgatc cacctgtctc ggcctcccaa aatgctggga ttacaggcgt
     3781 gagccaccgc gcccggccca agtatcactt atggtttcag aacgccatta ttagtgtctg
     3841 actgtcttgg tcttcttata cattgattcc caaatcacgt gtggtaacag catctcaatt
     3901 tttcatgatg acggtttgaa ccattaattt aattcctcag gctatctact tttttgttaa
     3961 acatactgtg tagaccatct tttttttttc ccatcatgat agtcaaaatt ttagtctgtg
     4021 tattcaagtg agaaaatttt tagtcagcat tatacaagta gtatttatta tgtatacatt
     4081 cagtggagtt gtttctacaa aagtatttcg gaatgactat tctgctgcaa acttttgtgt
     4141 aagcgcttca ccttattcct acaataagga gaagtgcact aacaaaatga acaatgcagc
     4201 aagggcttca gtcgcagctc aggtcttatc aaacaccaga gaaccctcaa tgggagaagc
     4261 cttatgagtg tgacaactgt ggaaagacag ttcctttttt gttagtatca cttctactta
     4321 ttgtagaaat atgctttcat tattgcatct actcacattt ctcactcggt ttctggcacc
     4381 agcaatctct tccatattta taatatcagt caaaaactct ggaattcaaa tataacaaga
     4441 cttttctggt cacctttgat agttaatgac ttgggcattg tgatatatta tctcctgctg
     4501 tatgtatttt gtttagtaga aattgaatca ttatccacaa tcctttatag aactatccaa
     4561 gtccctgttt ttatgctagt ttccaaggct tggtccttca aggttttcag ggatctaggg
     4621 gacacaaatc taacaaatcc taatgtatat tatttgtatt atagtaataa accatatggt
     4681 tactttg
//
