LOCUS       NM_001387356            2276 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger imprinted 2 (ZIM2), transcript variant 13,
            mRNA.
ACCESSION   NM_001387356
VERSION     NM_001387356.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Kim,J., Bergmann,A., Lucas,S., Stone,R. and Stubbs,L.
  TITLE     Lineage-specific imprinting and evolution of the zinc-finger gene
            ZIM2
  JOURNAL   Genomics 84 (1), 47-58 (2004)
   PUBMED   15203203
  REMARK    GeneRIF: ZIM2 gene, like the co-transcribed PEG3 gene, is imprinted
            in human, with preferential expression from the paternal allele.
            The imprinting status of ZIM2 is not conserved among mammals.
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Kim,J., Bergmann,A. and Stubbs,L.
  TITLE     Exon sharing of a novel human zinc-finger gene, ZIM2, and
            paternally expressed gene 3 (PEG3)
  JOURNAL   Genomics 64 (1), 114-118 (2000)
   PUBMED   10708526
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006115.1.
            
            Summary: In human, ZIM2 and PEG3 (GeneID:5178) are two distinct
            genes that share a set of 5' exons and have a common promoter, and
            both genes are paternally expressed. Alternative splicing events
            connect the shared exons either with the remaining 4 exons unique
            to ZIM2, or with the remaining 2 exons unique to PEG3. This is in
            contrast to mouse and cow, where ZIM2 and PEG3 genes do not share
            exons in common, and the imprinting status of ZIM2 is also not
            conserved amongst mammals. Additional 5' alternatively spliced
            transcripts encoding the same protein have been found for the human
            ZIM2 gene. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (13), as well as variants 7 and 8,
            encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 15203203
            MANE Ensembl match     :: ENST00000629319.3/ ENSP00000486502.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC006115.1         163393-163537       c
            146-232             AC006115.1         158829-158915       c
            233-308             AC006115.1         149199-149274       c
            309-474             AC006115.1         147073-147238       c
            475-564             AC006115.1         146401-146490       c
            565-648             AC006115.1         145564-145647       c
            649-752             AC006115.1         144462-144565       c
            753-855             AC006115.1         141411-141513       c
            856-948             AC006115.1         140557-140649       c
            949-1028            AC006115.1         112683-112762       c
            1029-1197           AC006115.1         104764-104932       c
            1198-1293           AC006115.1         102188-102283       c
            1294-2276           AC006115.1         97358-98340         c
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2276
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /note="zinc finger imprinted 2"
                     /db_xref="GeneID:23619"
                     /db_xref="HGNC:HGNC:12875"
     exon            1..145
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            146..232
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            233..308
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            309..474
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     CDS             459..2135
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /note="isoform a is encoded by transcript variant 13; zinc
                     finger protein 656"
                     /codon_start=1
                     /product="zinc finger imprinted 2 isoform a"
                     /protein_id="NP_001374285.1"
                     /db_xref="CCDS:CCDS92697.1"
                     /db_xref="GeneID:23619"
                     /db_xref="HGNC:HGNC:12875"
                     /translation="MYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSGDRDWDRRG
                     RSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAES
                     YQNVVDLAEDRKPHNTIQDNMENYRKLLSLGVQLAEDDGHSHMTQGHSSRSKRSAYPS
                     TSRGFLAQDSVPAEKRNTEMLDNLPSAGSQFPDFKHLGTFLVFEELVTFEDVLVDFSP
                     EELSSLSAAQRNLYREVMLENYRNLVSLGHQFSKPDIISRLEEEESYAMETDSRHTVI
                     CQGESHDDPLEPHQGNQEKLLTPITMNDPKTLTPERSYGSDEFERSSNLSKQSKDPLG
                     KDPQEGTAPGICTSPQSASQENKHNRCEFCKRTFSTQVALRRHERIHTGKKPYECKQC
                     AEAFYLMPHLNRHQKTHSGRKTSGCNEGRKPSVQCANLCERVRIHSQEDYFECFQCGK
                     AFLQNVHLLQHLKAHEAARVLPPGLSHSKTYLIRYQRKHDYVGERACQCCDCGRVFSR
                     NSYLIQHYRTHTQERPYQCQLCGKCFGRPSYLTQHYQLHSQEKTVECDHC"
     exon            475..564
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            565..648
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            649..752
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            753..855
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            856..948
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1028
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1197
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1293
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..2276
                     /gene="ZIM2"
                     /gene_synonym="ZNF656"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaagtct gggcagctgc gggaggagag gtttgggagg cgcgggagat gtccaccctg
       61 ggctggtggc gccgccgggc gccgggcgcc atgagggtgc gctaggcggc tgttcgtgcc
      121 cgaggctgcg cagcactgag gtgagctttg ccttcttgat cttccgtcct tcttggagac
      181 gactggcgag aggaagaggg actaggtcca aacgctaggt ggctgggtcc agatacctgt
      241 gttttgactc tgttcctgtg gatagctgct tggtctgaag ttccagaaag gatcctgttc
      301 ccagacagcc ggagacccgc accaaggagg agatcatcga gctcttggtc cttgagcagt
      361 acctgaccat catccctgaa aagctcaagc cttgggtgcg agcaaaaaag ccggagaact
      421 gtgagaagct cgtcactctg ctggagaatt acaaggagat gtaccaacca gaagacgaca
      481 acaacagtga cgtgaccagc gacgacgaca tgacccggaa cagaagagag tcctcaccac
      541 ctcactcagt ccattctttc agtggtgacc gggactggga ccggaggggc agaagcagag
      601 acatggagcc acgagaccgc tggtcccaca ccaggaaccc aagaagcagg atgcctccgc
      661 gggatctttc ccttcctgtg gtggcgaaaa caagctttga aatggacaga gaggacgaca
      721 gggactccag ggcttatgag tcccgatctc aggatgctga atcataccaa aatgtggtgg
      781 acctcgctga ggacaggaaa cctcacaaca caatccagga caacatggaa aactacagga
      841 agctgctctc cctcggagtg cagcttgctg aagacgatgg ccactcccac atgacgcagg
      901 gccactcatc aagatccaag agaagtgcct acccaagcac cagtcgaggt ttccttgctc
      961 aggactctgt ccctgcagaa aagaggaaca cagagatgtt agacaatctg ccatctgctg
     1021 ggtcccagtt cccggacttc aaacacttag gaacatttct ggtgtttgag gagttggtga
     1081 ccttcgagga tgtgcttgtg gacttcagcc cagaggaact tagttccctt agtgctgctc
     1141 agagaaacct ctacagggag gtgatgctgg agaattaccg gaacctggtc tccctggggc
     1201 accagttctc taaacctgac attatctcac gcctggaaga ggaggaatca tatgcaatgg
     1261 agacagacag cagacataca gtgatttgtc aaggagagtc tcatgatgat ccattggaac
     1321 cacaccaggg caaccaagag aaacttttga ctcctataac aatgaatgac cccaagaccc
     1381 tcactccgga aagaagctat ggcagtgatg aatttgagag aagctctaat cttagtaaac
     1441 aatcaaagga tcctctagga aaggatcccc aggaaggcac tgctcctgga atatgtacga
     1501 gtccccagtc agcatcccaa gagaacaaac acaacagatg tgaattttgc aaacgaacct
     1561 ttagtacgca agtagccctt aggagacacg aacggatcca tactgggaag aaaccctatg
     1621 aatgtaaaca gtgtgctgaa gccttctatc tcatgccaca cctcaacaga catcagaaga
     1681 cccattctgg taggaagact tctggctgca atgaaggtag aaagccttcc gtccagtgtg
     1741 cgaatctctg tgaacgtgta agaattcaca gtcaggagga ctactttgaa tgttttcagt
     1801 gcggcaaagc ttttctccag aatgtgcatc ttcttcaaca tctcaaagcc catgaggcag
     1861 caagagtcct tcctcctggg ttgtcccaca gcaagacata cttaattcgt tatcagcgga
     1921 aacatgacta cgttggagag agagcctgcc agtgttgtga ctgtggcaga gtcttcagtc
     1981 ggaattcata tctcattcag cattatagaa ctcacactca agagaggcct taccagtgtc
     2041 agctatgtgg gaaatgtttc ggccgaccct catacctcac tcaacattat caactccatt
     2101 ctcaagagaa aactgttgag tgcgatcact gttgagaaac ctttagtcac agcacacact
     2161 tttctcaaca ttattggctt cctcctagag tgttgtgagt gtgagaaggc ctttcactag
     2221 ccccaccttg ttaacaactt gaacattcat caaagtgtgg taaaaaaaaa aaaaaa
//
