LOCUS       NM_001010879            4291 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein interacting with K protein 1
            (ZIK1), transcript variant 1, mRNA.
ACCESSION   NM_001010879 XM_209111
VERSION     NM_001010879.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4291)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092538.1, BC103958.1 and AC003682.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001010879.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.241080.1,
                                           SRR1803614.212101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000597850.2/ ENSP00000472867.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AK092538.1         4-118
            116-2791            BC103958.1         1-2676
            2792-4291           AC003682.1         81103-82602
FEATURES             Location/Qualifiers
     source          1..4291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4291
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /note="zinc finger protein interacting with K protein 1"
                     /db_xref="GeneID:284307"
                     /db_xref="HGNC:HGNC:33104"
     exon            1..245
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1676
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein interacting with ribonucleoprotein K; zinc
                     finger protein 762; zinc finger protein interacting with K
                     protein 1 homolog"
                     /codon_start=1
                     /product="zinc finger protein interacting with
                     ribonucleoprotein K isoform 1"
                     /protein_id="NP_001010879.2"
                     /db_xref="CCDS:CCDS33135.1"
                     /db_xref="GeneID:284307"
                     /db_xref="HGNC:HGNC:33104"
                     /translation="MAAAALRAPTQVTVSPETHMDLTKGCVTFEDIAIYFSQDEWGLL
                     DEAQRLLYLEVMLENFALVASLGCGHGTEDEETPSDQNVSVGVSQSKAGSSTQKTQSC
                     EMCVPVLKDILHLADLPGQKPYLVGECTNHHQHQKHHSAKKSLKRDMDRASYVKCCLF
                     CMSLKPFRKWEVGKDLPAMLRLLRSLVFPGGKKPGTITECGEDIRSQKSHYKSGECGK
                     ASRHKHTPVYHPRVYTGKKLYECSKCGKAFRGKYSLVQHQRVHTGERPWECNECGKFF
                     SQTSHLNDHRRIHTGERPYECSECGKLFRQNSSLVDHQKIHTGARPYECSQCGKSFSQ
                     KATLVKHQRVHTGERPYKCGECGNSFSQSAILNQHRRIHTGAKPYECGQCGKSFSQKA
                     TLIKHQRVHTGERPYKCGDCGKSFSQSSILIQHRRIHTGARPYECGQCGKSFSQKSGL
                     IQHQVVHTGERPYECNKCGNSFSQCSSLIHHQKCHNT"
     exon            246..284
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /inference="alignment:Splign:2.1.0"
     exon            285..411
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /inference="alignment:Splign:2.1.0"
     exon            412..4291
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2207..2212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /note="hexamer: AATAAA"
     polyA_site      2231
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /note="major polyA site"
     regulatory      4273..4278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /note="hexamer: AATAGA"
     polyA_site      4291
                     /gene="ZIK1"
                     /gene_synonym="ZNF762"
                     /note="major polyA site"
ORIGIN      
        1 agtggcggtc atttttgcag cgcttgggtg catccagacc gtcagagctt tgggagcgct
       61 ttgtttggcg acagtcggaa ggcgcgaggg gaggggtcct cccgctgaac agtgggggtt
      121 ctaagggtcg gcggcggcgg ggttgacggc tttgcctagg tccctccgcc cgtagctgtc
      181 gggtcccggc cccgctctgc ccacagactc cgatggctgc ggccgcgctg agggccccga
      241 ctcaggttac tgtgtctcca gaaacacata tggacctcac aaagggctgt gtgacctttg
      301 aggacatcgc catttacttc tcacaggacg agtggggact tcttgatgag gctcagagac
      361 tcctgtacct tgaagtgatg ctggagaact ttgcccttgt agcctcactg ggttgtggcc
      421 atggaacaga ggatgaagag acaccttctg accagaatgt ttctgtagga gtgtcacagt
      481 caaaggcagg ttcatccaca cagaagactc aatcctgtga gatgtgtgtc ccagtcctga
      541 aagatatttt gcatctagct gatctccctg ggcagaaacc atacttggtt ggagaatgta
      601 caaaccatca ccagcaccag aagcatcaca gtgcaaagaa atccttgaag agggacatgg
      661 acagagcctc atatgtgaag tgctgcctat tctgtatgtc attgaagccc tttcgcaaat
      721 gggaggttgg aaaggacctt ccagccatgt tgcggcttct gaggtccctg gtctttcctg
      781 gaggcaagaa acccggcaca attactgaat gtggggagga cattcgcagt caaaaaagtc
      841 attacaagtc aggtgaatgt gggaaggctt ccaggcacaa acacactcct gtttaccatc
      901 caagagtcta cactggaaaa aagctttatg agtgtagcaa atgtgggaaa gccttccgtg
      961 gcaagtactc acttgttcag caccagagag tccatactgg agaaaggcct tgggagtgca
     1021 atgaatgtgg aaaattcttt agccaaacct cccacctgaa tgatcatcgg agaatccaca
     1081 ccggagaaag gccttatgag tgcagcgaat gtggaaaatt atttagacaa aactccagcc
     1141 ttgttgacca ccagaaaata cacactggag caaggcctta tgagtgtagc cagtgtggga
     1201 aatcctttag ccaaaaagcc acccttgtta aacaccaaag agttcacact ggagaaaggc
     1261 cttataagtg tggtgaatgt gggaattcct ttagtcaaag tgccattctt aatcaacacc
     1321 gaagaattca cactggagca aagccttatg agtgtggcca gtgtgggaaa tcctttagtc
     1381 aaaaagctac cctcattaaa caccagagag ttcacactgg agaaaggcct tataagtgtg
     1441 gtgactgtgg gaaatccttt agtcaaagct ccatccttat tcaacaccgg agaattcata
     1501 ctggagcaag gccttatgag tgtggccagt gtggaaagtc ctttagccaa aagtctggtc
     1561 tcattcaaca ccaagtggtt cacactggag aaaggcctta tgagtgcaac aaatgtggga
     1621 attcctttag ccaatgctcc agcctcatac atcaccaaaa atgtcataac acatagaggc
     1681 ctcatgaatg cagcaaatgt ggaagcgcct tcaactcaag atctatcatc atttagctcc
     1741 tgaaagtcca cacttaagta gagccttaga cctacaggga aagtgctgtc tctgtagtat
     1801 tgtagcagta gagagccttt gtgagggagc catctgcctg aagttgaacc tcattcttcc
     1861 ttgtttctct ggtagaaacc atctaccctc taccaccttg cacagtgggc actggtcact
     1921 cctatgtgct aagacaaggc agacatctgt gtgttctctt aagtctttgg aggaaatctt
     1981 gagcagtcta agcctttaga gaaaattcat tcttttttct gactgatcac agcatacgtg
     2041 tgacccagtt tgggtcagga gggcccagcc ttggttctgc tggacactta tgtgcaagga
     2101 ttcccttcat gtaaattctt ggtctcacat gacacttggt cattcttcca gcctccatgt
     2161 caccacgtgg tgaatggctg cctcacattg ctccagtttg tgcactaata aaagccttat
     2221 atttgaatct acctgtagtc ttggggttct gtttactgtg tggggtggct gggagacaga
     2281 cttcaactct atatgaagga atggatggct tttgtgggcc tctgcaggaa agtaagatga
     2341 cagagtaatt ctaattctgg ttttggtcat acttgctttg ctacctaaaa tctcctagga
     2401 aaaaatgcaa ggttttggtt attctaattt gtggcctgga tccctattct ttctgtgaga
     2461 ctagaggtca tcctgaggag aggccagctg ttatgacaag catgtgtgct tcagggaata
     2521 ggacaatttt attccattgt ttccagagga tgtcatatga tgcccagtgc tgctgagaag
     2581 cttttcatgg ggttctataa ggaggcatgc cctgatatca aacattccat aggccgatgt
     2641 cacgcagaag acaacgcgag tcacatgtga actgtaattg gtacagaaat acctgggtat
     2701 ttctgtactg tgtgtactgt agcaaactag ttggaatgtg cctcttataa aagtacattt
     2761 acaaatcttc ccgtgactgt ggctttgagc agtcatagga cctagaaatc tgtgtatgtc
     2821 caatagctga ggttattttc agcaaaaata attaaagggt tttatttttt aattcttgtt
     2881 ggttttctag gttgttcacc tcaagtgcat tgctgtagag gcagaaaaag gaggataaag
     2941 ataacagaag tcctataggc cagggatgta ttgatagctc ttgtgatttc caccagtgtt
     3001 gctgttgtct caaattgcca cagccttcat tgcttgccaa catttcctgc atggagggac
     3061 tcatggttgc ccttccccag gcctgaagag agagtgcagt caacatgaga ttgctaggca
     3121 ttctggtttc tgaaagttgg gtgatcagat actttattgt gaaacatgtt ttacaaactt
     3181 tcttgatgtg taagtgacat gccatagttt acatccattt atggtgtata atttgaagag
     3241 tttgtcatac aagcctgtga aaccataatc atgatcatga acatattcat gattcacctc
     3301 ttgctgtttt acaatctctg cgtgtacttt ccaggccttc aggagtcctg tcatttactt
     3361 tccctacagg agaatagttt gtgttttcta ggattttatg tgaattgaaa cgtaaaatac
     3421 ttactccatt tttcctgatg atgcacaatt tttttttttt ttttgagatg gagtctcagt
     3481 ctgtcaccag gctggagtgc agtggcatga tcttggctca ctccaacctc ctcctgggtt
     3541 ccagcgattc tcctgcctca gcctcctgag aagctaggac tacaggcatg cactaccacg
     3601 cccaactaat ttttgtattt ttagtagaga tgtggtttta ccatgtttgc caggatggtc
     3661 ttgatctctt gacctcgtga tccgcccgcc tcagcctccc gaagtgctgg gattacaggc
     3721 gtaagccacc acaccagctg atgcacaatt acttttaaga tttatcaata ttgcttatgt
     3781 gaatagttca tttgtattgc tgagaaatag tctgtggata tgtcacaatt tggataaaca
     3841 gttggatgct ttccagtttt gggctgttgc aaataatgct actatgaaca taggcatata
     3901 actcttaata tgcagaaatg ctttatttct cctgtgtcag tagtacagtg tacgtgaatg
     3961 cgtcactttt aaagacaagg ccagactata acctaactgt accatttgca ttctcatcaa
     4021 cagtatgtga accttcttat ttctctacat tcttgccata cttggtatgg ttagtctttt
     4081 taattttagt tgttttaata gctgtataat agcatctgtc tgtgatttta ttgcattttt
     4141 ctggtatttt atggtattga acatttgaac atcttgtatc tagttgccac ctgtatatcc
     4201 tctttggaag aatgtttatt aatgtctttt gcttattttt aaatggatgt tggtgatact
     4261 ttttcattaa taaatagacg tataacaaag a
//
