LOCUS       NM_033132               4497 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Zic family member 5 (ZIC5), transcript variant 1,
            mRNA.
ACCESSION   NM_033132
VERSION     NM_033132.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4497)
  AUTHORS   Zhong,Y., Yang,S., Wang,X. and Sun,C.
  TITLE     Research progress of ZIC5 for tumor metastasis
  JOURNAL   Biochem Soc Trans 52 (3), 1363-1372 (2024)
   PUBMED   38747731
  REMARK    GeneRIF: Research progress of ZIC5 for tumor metastasis.
            Review article
REFERENCE   2  (bases 1 to 4497)
  AUTHORS   Li,T., Zhang,G., Li,W., Xiao,J., Zhou,Z., Tan,G. and Ai,J.
  TITLE     MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell
            proliferation and cisplatin resistance through ZIC5 down-regulation
            by targeting SOX2
  JOURNAL   Biol Chem 404 (10), 961-975 (2023)
   PUBMED   36752150
  REMARK    GeneRIF: MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell
            proliferation and cisplatin resistance through ZIC5 down-regulation
            by targeting SOX2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4497)
  AUTHORS   Jia,Q., Song,J., Xu,T., Liu,J., Chai,J., Yang,Y., Li,L., Li,M. and
            Yang,X.
  TITLE     ZIC5 promotes aggressiveness and cancer stemness in cervical
            squamous cell carcinoma
  JOURNAL   Pathol Res Pract 241, 154268 (2023)
   PUBMED   36495760
  REMARK    GeneRIF: ZIC5 promotes aggressiveness and cancer stemness in
            cervical squamous cell carcinoma.
REFERENCE   4  (bases 1 to 4497)
  AUTHORS   Xu,S., Li,Y., Zhang,J. and Li,Z.
  TITLE     LINC01116 Regulates the Proliferation and Apoptosis of Nucleus
            Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway
            and Affects the Progression of Intervertebral Disc Degeneration
  JOURNAL   Curr Stem Cell Res Ther 18 (7), 979-992 (2023)
   PUBMED   35927800
  REMARK    GeneRIF: LINC01116 Regulates the Proliferation and Apoptosis of
            Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt
            Pathway and Affects the Progression of Intervertebral Disc
            Degeneration.
REFERENCE   5  (bases 1 to 4497)
  AUTHORS   Han,Z., Jia,J., Lv,Y., Wang,R. and Cao,K.
  TITLE     Transcriptional expression of ZICs as an independent indicator of
            survival in gliomas
  JOURNAL   Sci Rep 11 (1), 17532 (2021)
   PUBMED   34475426
  REMARK    GeneRIF: Transcriptional expression of ZICs as an independent
            indicator of survival in gliomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4497)
  AUTHORS   Aruga,J., Nozaki,Y., Hatayama,M., Odaka,Y.S. and Yokota,N.
  TITLE     Expression of ZIC family genes in meningiomas and other brain
            tumors
  JOURNAL   BMC Cancer 10, 79 (2010)
   PUBMED   20199689
  REMARK    GeneRIF: ZIC1, ZIC2, and ZIC5 may have roles in meningiomas
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4497)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 4497)
  AUTHORS   Grinberg,I. and Millen,K.J.
  TITLE     The ZIC gene family in development and disease
  JOURNAL   Clin Genet 67 (4), 290-296 (2005)
   PUBMED   15733262
  REMARK    Review article
REFERENCE   9  (bases 1 to 4497)
  AUTHORS   Ishiguro,A., Inoue,T., Mikoshiba,K. and Aruga,J.
  TITLE     Molecular properties of Zic4 and Zic5 proteins: functional
            diversity within Zic family
  JOURNAL   Biochem Biophys Res Commun 324 (1), 302-307 (2004)
   PUBMED   15465018
REFERENCE   10 (bases 1 to 4497)
  AUTHORS   Furushima,K., Murata,T., Matsuo,I. and Aizawa,S.
  TITLE     A new murine zinc finger gene, Opr
  JOURNAL   Mech Dev 98 (1-2), 161-164 (2000)
   PUBMED   11044622
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355338.33.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 17, 2020 this sequence version replaced NM_033132.4.
            
            Summary: This gene encodes a member of the ZIC family of C2H2-type
            zinc finger proteins. The encoded protein may act as a
            transcriptional repressor. Studies in mouse and Xenopus support a
            role for this gene in neural crest development. Elevated expression
            of this gene has been observed in various human cancers and may
            contribute to cancer progression. This gene is closely linked to a
            related family member on chromosome 13. [provided by RefSeq, Mar
            2017].
            
            Transcript Variant: This variant (1) encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378304.1, SRR11853562.9086.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000267294.5/
                                                ENSP00000267294.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1641              AL355338.33        30431-32071         c
            1642-4497           AL355338.33        23268-26123         c
FEATURES             Location/Qualifiers
     source          1..4497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.3"
     gene            1..4497
                     /gene="ZIC5"
                     /note="Zic family member 5"
                     /db_xref="GeneID:85416"
                     /db_xref="HGNC:HGNC:20322"
                     /db_xref="MIM:617896"
     exon            1..1641
                     /gene="ZIC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2084
                     /gene="ZIC5"
                     /note="Zic family member 5 (odd-paired homolog,
                     Drosophila); zinc finger protein of the cerebellum 5"
                     /codon_start=1
                     /product="zinc finger protein ZIC 5"
                     /protein_id="NP_149123.3"
                     /db_xref="CCDS:CCDS9494.3"
                     /db_xref="GeneID:85416"
                     /db_xref="HGNC:HGNC:20322"
                     /db_xref="MIM:617896"
                     /translation="MEPPLSKRNPPALRLADLATAQVQPLQNMTGFPALAGPPAHSQL
                     RAAVAHLRLRDLGADPGVATTPLGPEHMAQASTLGLSPPSQAFPAHPEAPAAAARAAA
                     LVAHPGAGSYPCGGGSSGAQPSAPPPPAPPLPPTPSPPPPPPPPPPPALSGYTTTNSG
                     GGGSSGKGHSRDFVLRRDLSATAPAAAMHGAPLGGEQRSGTGSPQHPAPPPHSAGMFI
                     SASGTYAGPDGSGGPALFPALHDTPGAPGGHPHPLNGQMRLGLAAAAAAAAAELYGRA
                     EPPFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAGPGPHLQHHAPPP
                     APPPPPAPAQHPHQHHPHLPGAAGAFLRYMRQPIKQELICKWIDPDELAGLPPPPPPP
                     PPPPPPPPAGGAKPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKA
                     KYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKF
                     ANSSDRKKHSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPGPLGYSS
                     VGTPVGAPLSPVLDPARSHSSTLSPQVTNLNEWYVCQASGAPSHLHTPSSNGTTSETE
                     DEEIYGNPEVVRTIH"
     exon            1642..4497
                     /gene="ZIC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3022..3027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIC5"
                     /note="hexamer: AATAAA"
     polyA_site      3049
                     /gene="ZIC5"
                     /note="major polyA site"
     regulatory      4354..4359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIC5"
                     /note="hexamer: AATAAA"
     polyA_site      4378
                     /gene="ZIC5"
                     /note="major polyA site"
     regulatory      4476..4481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIC5"
                     /note="hexamer: AATAGA"
     polyA_site      4497
                     /gene="ZIC5"
                     /note="major polyA site"
ORIGIN      
        1 actctgccaa tcgctggagg atagagtggg aacaggaata agcagagtta agaggccagg
       61 acaaaagaag ttaaagagcg cccaatacat acatgttttt gaaggcgggc agagggaata
      121 aagtcccccc agtgagggtc tatgggcctg attgtgtagt tctgatggag ccccctttga
      181 gcaagaggaa cccgccagcg ctgagattag cggatttggc aacggctcag gtccagccgc
      241 ttcagaatat gacaggcttc ccggcgctgg ccggcccgcc cgcccactcc caactccggg
      301 ccgccgtcgc gcacctccgc ctgcgggacc tgggcgctga ccccggcgtg gccaccactc
      361 cgctcggacc cgagcacatg gcccaggcga gcacgctggg cctcagccct ccctcccagg
      421 cgttcccggc acacccggag gctccggcag ccgccgcccg tgctgcagcc ttggtcgcgc
      481 accccggcgc gggcagctac ccctgcggcg ggggcagcag tggcgcgcag ccctccgcgc
      541 ccccgccccc agcccctcct cttcctccca ccccttcacc ccctccccct cccccgcctc
      601 ctcctcctcc tgccctctcg ggctacacca ccaccaacag tggcggcggc ggcagcagcg
      661 gcaaaggcca cagcagggac ttcgtcctcc ggagggacct ttccgccacg gcccccgcgg
      721 cggccatgca cggggccccg ctcggagggg agcagcggtc cggcaccggc tccccccagc
      781 acccggcccc gcctccccac tcggccggca tgttcatctc cgccagcggc acctacgcgg
      841 gcccggacgg cagcggcggc ccggcgctct tccccgcgct gcacgacacg ccgggggccc
      901 caggcggcca cccgcacccg ctcaacggcc agatgcgcct ggggctggcg gcggcagcgg
      961 cagccgcggc ggctgagctg tacggccgcg ccgaaccgcc cttcgcgccg cgctctgggg
     1021 acgcgcacta cggggcggtt gcggccgcag cggcggccgc cctgcacggc tacggagccg
     1081 tgaacttaaa cctgaacctg gcggctgcgg cggccgcagc agcggccggg cccgggcccc
     1141 acctgcagca ccacgcgccg cccccggcgc cgccgccgcc gccggcgccc gcgcagcacc
     1201 cgcaccagca ccacccccac ctcccagggg cggctggggc cttcctgcgc tacatgcggc
     1261 agccaatcaa gcaggagctc atctgcaagt ggatcgaccc cgacgagctg gccgggctgc
     1321 cgccgccgcc gccgccgccg ccgccgccgc cgccaccgcc cccggccggc ggcgccaagc
     1381 cctgctccaa aactttcggc accatgcacg agctggtgaa tcacgtcacg gtggagcacg
     1441 tgggaggccc cgagcagagc agccacgtct gcttctggga ggactgtccg cgcgagggca
     1501 agcccttcaa ggccaaatac aagctcatca accacatccg cgtgcacacc ggcgagaagc
     1561 cctttccctg ccctttcccc ggctgcggca aggtcttcgc gcgctccgag aacctcaaga
     1621 tccacaagcg tactcataca ggggaaaagc ctttcaaatg tgaatttgat ggctgtgaca
     1681 ggaagtttgc caatagcagt gatcggaaga aacattccca tgtccacacc agtgacaagc
     1741 cctactactg caagattcga ggctgtgaca aatcctacac tcacccaagc tccctgagga
     1801 agcacatgaa gattcactgc aagtccccgc caccttctcc aggacccctt ggttactcat
     1861 cagtggggac tccagtgggc gcccccttgt cccctgtgct ggacccagcc aggagtcact
     1921 ccagcactct gtcccctcag gtgaccaacc tcaatgagtg gtacgtttgc caggccagtg
     1981 gggcccccag ccacctccac accccttcca gcaacggaac cacctctgag actgaagatg
     2041 aggaaattta cgggaaccct gaagttgtgc ggacgataca ttagaattta ttattaataa
     2101 taataagtga aataataagt gggagtcctt ggaccacatc ctaacctgag acaatgccga
     2161 gcctgagaca aacccgtgac tcagacttgc caccgggtct aattagccct atttattcag
     2221 tatgaaaccc tatggtgttt gtacatttaa ttaatttaat taagatattt gggctttttt
     2281 tttttttttt cttaaaaaac aaacaaaaaa caaccaagct ggacttgtac attgcaggag
     2341 gatggggctg ggggcaaatt gtaccaagga aaatgaatgg agagattagt taatggcgat
     2401 acacactgcc gatgcaatat atatatatat atatatatac atatatatat atattatttt
     2461 ttttaaaagg gggagaaaaa gagcattaag tcagaactta acacagcacc aaggccctct
     2521 gcatttccca gagtgcctct caaatgcctt tgacaccata ccatgggctg cttttgagcc
     2581 tccttgttgg accctaattc tgccaaggcc tcttgattgt aaaccacaca cctgctgcat
     2641 tgccaacaga tcctgttccg tacctgtgtc caaaaacatt tgtaaaaacc ctttgagttt
     2701 aatatttgta atttttaatt tccactcttt tattactgat cttagcttaa tacaatattt
     2761 ttatacagga ttatttcttc agtatcctac tgtgtgattt taaaaaaaga tgcagcaacc
     2821 ttaatatatc tccatatctt gtgctactgt gattgttcaa gcaaaagtgg agagaagaaa
     2881 agctgctgca aaagacaact gtgaaactgt gatattttat aaaatagaag aaattcaagt
     2941 gctttctttt tcctatatgt tttttttttt ttatctgaat tctcagatac tgcctcctaa
     3001 ctgtgtccaa acttcttgtg taataaagag attctgtttt cgatcctaag ttctttggga
     3061 tgccaacatt cacagtcaag tcttgaggag gtgtgatgat ggcatcatgc ctattttttt
     3121 ggaaagctgt tgtttttaaa acaggccaac acctctttta tactgttgta tcagcctttt
     3181 aaaaagtcta tttttcaatg cctgaaactg cattttaatg cattttcttc cacctgagca
     3241 ctgagcacac caaactggaa tccatttgaa aatgacagtg tgtgaagtgt atgatttaca
     3301 ttaaaagagg ggagggagtt gccatacata ttaaaaattt ttaaaaggtt tatagttacc
     3361 accaaacact gatgaatgtg tgacctttgc cagagctgtc aagctaggat aaaaaaggtc
     3421 aaggacctag gacaataact cttagtcgat ttattttcgg ttggtacaac acatctcctg
     3481 tgcaaaatgt agtccatcag aaacatccta cagatacact aaagagcact aatttatcct
     3541 tagagacccc gaagacaccc cctccccagg gtttgtagaa atttgttttg tgtgctgtga
     3601 gtggttgatg tagtcttgtc attgttaata acttgtatgt gaacactatt atttgtacag
     3661 ttgaattaat ttattttcag acatcatcct tttttttttt ctttcctgga agagttcaaa
     3721 gcacaccaaa gaattatatt atacattttg gtgaaagatt gtcatttatg atccatggtt
     3781 tatttaaaaa aaaaaggaaa gaaaatggaa aaatatattt ttaagcttac ttgaatgaac
     3841 aacgtaatgt gaaaaccaag actcttcctg catgtctttt ttgcattgtg ttgataagat
     3901 tatatatagt ttatagatat attatattac tagtacagtg catggtgctg tcacttggaa
     3961 agcctttcaa tgttgtcttc agattgttgt gatgaatatg aaacatgcag accctccttt
     4021 ataaagaaaa agaccttaaa acttgaatat gagataattt tacattttaa aagtttattt
     4081 gattttcata ttattcactt tcaaagccct ttcaaataga aaaggtatga acttttgggg
     4141 ggataattta tgtatcgtaa acttattaga acaaaatatt cctgatgtat aatgagttgt
     4201 tttatttata caactttttc aatggtagtt tgcactattc tttattatgc tacaggttta
     4261 tttattatga aacaaaggaa tatgtatttt atgtatttta ccatgcatag gttaactctt
     4321 tgccacagat ttattggttc ttgatacacc taaaataaaa aaaaatgtgt acctccaata
     4381 gagagcaagc aagaatgatt atgaagtaac aaatttaata aaggtattct tgttattatt
     4441 gcttatgttt tacataatgg catatctctc atacaaatag aacaggttgc taatgga
//
