LOCUS       NM_007129               2963 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens Zic family member 2 (ZIC2), mRNA.
ACCESSION   NM_007129
VERSION     NM_007129.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Hossain,I., Priam,P., Reynoso,S.C., Sahni,S., Zhang,X.X., Cote,L.,
            Doumat,J., Chik,C., Fu,T., Lessard,J.A. and Pastor,W.A.
  TITLE     ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression
            towards human primed pluripotency
  JOURNAL   Nat Commun 15 (1), 8539 (2024)
   PUBMED   39358345
  REMARK    GeneRIF: ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard
            progression towards human primed pluripotency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Chen,H., Lee,L.J., Vincent,K.M., Xu,Z., Liu,J., Zhang,G.,
            Nakevska,Z., Smith,D., Lee,C.H., Postovit,L.M. and Fu,Y.
  TITLE     Transcription factor ZIC2 regulates the tumorigenic phenotypes
            associated with both bulk and cancer stem cells in epithelial
            ovarian cancer
  JOURNAL   Oncogene 43 (22), 1688-1700 (2024)
   PUBMED   38594503
  REMARK    GeneRIF: Transcription factor ZIC2 regulates the tumorigenic
            phenotypes associated with both bulk and cancer stem cells in
            epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Yu,Y., Tan,C., Ding,L., Zhu,Z., Zhang,G. and Long,C.
  TITLE     ZIC2 accelerates growth and stemness in gastric cancer through the
            Wnt/beta-catenin pathway
  JOURNAL   Tissue Cell 85, 102222 (2023)
   PUBMED   37774522
  REMARK    GeneRIF: ZIC2 accelerates growth and stemness in gastric cancer
            through the Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Liu,Q., Yang,T., Zhang,Y., Hu,Z.D., Liu,Y.M., Luo,Y.L., Liu,S.X.,
            Zhang,H. and Zhong,Q.
  TITLE     ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal
            carcinoma by activating the JUNB/MCSF axis
  JOURNAL   Cell Death Dis 14 (7), 455 (2023)
   PUBMED   37479694
  REMARK    GeneRIF: ZIC2 induces pro-tumor macrophage polarization in
            nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2963)
  AUTHORS   Lv,Z., Wang,M., Hou,H., Tang,G., Xu,H., Wang,X., Li,Y., Wang,J. and
            Liu,M.
  TITLE     FOXM1-regulated ZIC2 promotes the malignant phenotype of renal
            clear cell carcinoma by activating UBE2C/mTOR signaling pathway
  JOURNAL   Int J Biol Sci 19 (11), 3293-3306 (2023)
   PUBMED   37496990
  REMARK    GeneRIF: FOXM1-regulated ZIC2 promotes the malignant phenotype of
            renal clear cell carcinoma by activating UBE2C/mTOR signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2963)
  AUTHORS   Koyabu,Y., Nakata,K., Mizugishi,K., Aruga,J. and Mikoshiba,K.
  TITLE     Physical and functional interactions between Zic and Gli proteins
  JOURNAL   J Biol Chem 276 (10), 6889-6892 (2001)
   PUBMED   11238441
REFERENCE   7  (bases 1 to 2963)
  AUTHORS   Salero,E., Perez-Sen,R., Aruga,J., Gimenez,C. and Zafra,F.
  TITLE     Transcription factors Zic1 and Zic2 bind and transactivate the
            apolipoprotein E gene promoter
  JOURNAL   J Biol Chem 276 (3), 1881-1888 (2001)
   PUBMED   11038359
REFERENCE   8  (bases 1 to 2963)
  AUTHORS   Yang,Y., Hwang,C.K., Junn,E., Lee,G. and Mouradian,M.M.
  TITLE     ZIC2 and Sp3 repress Sp1-induced activation of the human D1A
            dopamine receptor gene
  JOURNAL   J Biol Chem 275 (49), 38863-38869 (2000)
   PUBMED   10984499
REFERENCE   9  (bases 1 to 2963)
  AUTHORS   Brown,S.A., Warburton,D., Brown,L.Y., Yu,C.Y., Roeder,E.R.,
            Stengel-Rutkowski,S., Hennekam,R.C. and Muenke,M.
  TITLE     Holoprosencephaly due to mutations in ZIC2, a homologue of
            Drosophila odd-paired
  JOURNAL   Nat Genet 20 (2), 180-183 (1998)
   PUBMED   9771712
REFERENCE   10 (bases 1 to 2963)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Laure Lemmens. The reference sequence was
            derived from AL355338.33, AF193855.1 and AA491603.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007129.4.
            
            Summary: This gene encodes a member of the ZIC family of C2H2-type
            zinc finger proteins. This protein functions as a transcriptional
            repressor and may regulate tissue specific expression of dopamine
            receptor D1. Expansion of an alanine repeat in the C-terminus of
            the encoded protein and other mutations in this gene cause
            holoprosencephaly type 5. Holoprosencephaly is the most common
            structural anomaly of the human brain. A polyhistidine tract
            polymorphism in this gene may be associated with increased risk of
            neural tube defects. This gene is closely linked to a gene encoding
            zinc finger protein of the cerebellum 5, a related family member on
            chromosome 13. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF193855.1, AF104902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376335.8/ ENSP00000365514.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AL355338.33        42088-42368
            282-2766            AF193855.1         1-2485
            2767-2963           AA491603.1         20-216              c
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.3"
     gene            1..2963
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /note="Zic family member 2"
                     /db_xref="GeneID:7546"
                     /db_xref="HGNC:HGNC:12873"
                     /db_xref="MIM:603073"
     exon            1..1356
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1880
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /note="Zic family member 2 (odd-paired homolog,
                     Drosophila); Zinc finger protein of the cerebellum 2"
                     /codon_start=1
                     /product="zinc finger protein ZIC 2"
                     /protein_id="NP_009060.2"
                     /db_xref="CCDS:CCDS9495.1"
                     /db_xref="GeneID:7546"
                     /db_xref="HGNC:HGNC:12873"
                     /db_xref="MIM:603073"
                     /translation="MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAA
                     AQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHA
                     AHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFP
                     GLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMN
                     MNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKT
                     FSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFP
                     CPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKP
                     YLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSS
                     SNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGG
                     SSGGGSGTAGGHSGLSSNFNEWYV"
     exon            1357..1520
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2963
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /note="hexamer: AATAAA"
     polyA_site      2963
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /note="major polyA site"
ORIGIN      
        1 ggactcttct cctcctccac ctcctcctcc tcctcccgcg ccgccgcctc ctcctcctct
       61 tcctctccgc gccttcgcta cgcgcccggc cgcccgaggc agatccaggc ggcggcggag
      121 gcggcgggcg caggagagcg gctcccaggg ctgaagtggc cgccaccacc gccgcctgcg
      181 cctggagccc ggtggccgcc ggacgcaccg cgcggatcgg gagcgggagt cgaggcggcg
      241 cggaggcgca gggctcgcag gggcgggcgg gcgcgctggc catgctcctg gacgcgggtc
      301 cgcagttccc ggccatcggg gtgggcagct tcgcgcgcca ccatcaccac tccgccgcgg
      361 cggcggcggc ggctgccgcc gagatgcagg accgtgaact gagcctggcg gcggcgcaga
      421 acggcttcgt tgactccgcc gccgcgcaca tgggagcctt caagctcaac ccgggcgcgc
      481 acgagctgtc cccgggccag agctcggcgt tcacgtcgca gggccccggc gcctaccccg
      541 gctccgctgc ggctgccgct gcggccgcag cgctcgggcc ccacgccgcg cacgttggct
      601 cctactctgg gccgcccttc aactccaccc gggacttcct gttccgcagc cgcggcttcg
      661 gggactcggc gccgggcggc gggcagcacg ggctgttcgg gccgggcgcg ggcggcctgc
      721 accacgcgca ctcggacgcg cagggccacc tcctcttccc gggcctgcca gagcagcacg
      781 ggccgcacgg ctcgcagaat gtgctcaacg ggcagatgcg cctcgggctg cccggcgagg
      841 tgttcgggcg ctcggagcaa taccgccagg tggccagccc gcggaccgac ccctactcgg
      901 cggcgcaact ccacaaccag tacggcccca tgaatatgaa catgggtatg aacatggcag
      961 cagccgcggc ccaccaccac caccaccacc accaccaccc cggtgccttt ttccgctata
     1021 tgcggcagca gtgcatcaag caggagctaa tctgcaagtg gatcgacccc gagcaactga
     1081 gcaatcccaa gaagagctgc aacaaaactt tcagcaccat gcacgagctg gtgacacacg
     1141 tctcggtgga gcacgtcggc ggcccggagc agagcaacca cgtctgcttc tgggaggagt
     1201 gtccgcgcga gggcaagccc ttcaaggcca aatacaaact ggtcaaccac atccgcgtgc
     1261 acacaggcga gaaacccttc ccctgcccct tcccgggctg tggcaaagtc ttcgcgcgct
     1321 ccgagaacct caagatccac aaaaggaccc acacagggga gaagccgttc cagtgtgagt
     1381 ttgagggctg cgaccggcgc ttcgccaaca gcagcgacag gaagaagcac atgcacgtcc
     1441 acacctccga taagccctat ctctgcaaga tgtgcgacaa gtcctacacg caccccagct
     1501 cgctgcggaa gcacatgaag gtccatgagt cctccccgca gggctctgaa tcctccccgg
     1561 ccgccagctc cggctatgag tcgtccacgc ccccggggct ggtgtccccc agcgccgagc
     1621 cccagagcag ctccaacctg tccccagcgg cggcggcagc ggcggcggcg gctgcggcgg
     1681 cggcggccgc ggtgtccgcg gtgcaccggg gcggaggctc gggcagtggc ggcgcgggag
     1741 gcggctcagg cggcggcagc ggcagtggcg ggggcggcgg cggggcgggc ggcgggggcg
     1801 gcggcagctc tggcgggggc agcgggacag ccgggggtca cagcggcctc tcctccaact
     1861 tcaatgaatg gtacgtgtga cgggtcgggg cctctctccc tctccctgtc cccaccccag
     1921 cgcagcagcc ctccccgcag ctagcagcga gggcaccttg tgatcatgtt gttaaaatta
     1981 tgaatctgat ttttatgatg atgaaaattt taccagcaga aggatttttt aaagtttttt
     2041 tttttttttt aataataatc taggcatgaa gagcaaaaat atcccttccg gagtctttga
     2101 agctgaaaat ataaaacaaa taaaaaataa aaaaataaaa acccacaaaa atgttgaacc
     2161 aaacctccct gctaatctcc atgcccacgt tctttcccac cctgttccca gtcttctgac
     2221 aaactgtgta catagcggac tcctcctttc tcctccgagg tggttttaaa ggctttttgg
     2281 tgtatagaag tttgtccatt tgtaaaactc cggattgcgt tcctccccgc cttccgcccc
     2341 ttcccttccc taaagtgatg ggctttctct tttctctttt tagtttaccc ggtttctttt
     2401 taagtaatgt ggaagaaaat ggtttatttt gtattgtggt attgaatatt gtgttccttt
     2461 ttatgaggca acctgattgt aaacttcatg taactataga ctggaaaaaa tgagccgtgc
     2521 caaagtctcc cttctgtttc ttcagcacat tgacccatag cacacacata cacaccacca
     2581 ccaacaacgc ttgtgaatgt atttttctgt tagctgggtt tacatgtgat gttttagtgc
     2641 ttttgcaagt tcaatttgtt agttcctgta tgaaagattg tgggggaaaa ataaacgtcg
     2701 tgccgttagc tttttccgta ataacaccct tccttctgta aatacccgtt accatattta
     2761 tccatttgta attaaattat ggtattaact tgctacagag gaaacaatat ttataaagaa
     2821 tgtttcttaa ctataaatat gtacaattgt gggcataaac tgtttcagat tttttatttg
     2881 aaggttttaa gtggtttgat catttcttgt gatgttttga gagtaatgca tacagaaata
     2941 taataaaatg tgttgaaact gca
//
