LOCUS       NP_009060                532 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein ZIC 2 [Homo sapiens].
ACCESSION   NP_009060
VERSION     NP_009060.2
DBSOURCE    REFSEQ: accession NM_007129.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 532)
  AUTHORS   Hossain,I., Priam,P., Reynoso,S.C., Sahni,S., Zhang,X.X., Cote,L.,
            Doumat,J., Chik,C., Fu,T., Lessard,J.A. and Pastor,W.A.
  TITLE     ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression
            towards human primed pluripotency
  JOURNAL   Nat Commun 15 (1), 8539 (2024)
   PUBMED   39358345
  REMARK    GeneRIF: ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard
            progression towards human primed pluripotency.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 532)
  AUTHORS   Chen,H., Lee,L.J., Vincent,K.M., Xu,Z., Liu,J., Zhang,G.,
            Nakevska,Z., Smith,D., Lee,C.H., Postovit,L.M. and Fu,Y.
  TITLE     Transcription factor ZIC2 regulates the tumorigenic phenotypes
            associated with both bulk and cancer stem cells in epithelial
            ovarian cancer
  JOURNAL   Oncogene 43 (22), 1688-1700 (2024)
   PUBMED   38594503
  REMARK    GeneRIF: Transcription factor ZIC2 regulates the tumorigenic
            phenotypes associated with both bulk and cancer stem cells in
            epithelial ovarian cancer.
REFERENCE   3  (residues 1 to 532)
  AUTHORS   Yu,Y., Tan,C., Ding,L., Zhu,Z., Zhang,G. and Long,C.
  TITLE     ZIC2 accelerates growth and stemness in gastric cancer through the
            Wnt/beta-catenin pathway
  JOURNAL   Tissue Cell 85, 102222 (2023)
   PUBMED   37774522
  REMARK    GeneRIF: ZIC2 accelerates growth and stemness in gastric cancer
            through the Wnt/beta-catenin pathway.
REFERENCE   4  (residues 1 to 532)
  AUTHORS   Liu,Q., Yang,T., Zhang,Y., Hu,Z.D., Liu,Y.M., Luo,Y.L., Liu,S.X.,
            Zhang,H. and Zhong,Q.
  TITLE     ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal
            carcinoma by activating the JUNB/MCSF axis
  JOURNAL   Cell Death Dis 14 (7), 455 (2023)
   PUBMED   37479694
  REMARK    GeneRIF: ZIC2 induces pro-tumor macrophage polarization in
            nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 532)
  AUTHORS   Lv,Z., Wang,M., Hou,H., Tang,G., Xu,H., Wang,X., Li,Y., Wang,J. and
            Liu,M.
  TITLE     FOXM1-regulated ZIC2 promotes the malignant phenotype of renal
            clear cell carcinoma by activating UBE2C/mTOR signaling pathway
  JOURNAL   Int J Biol Sci 19 (11), 3293-3306 (2023)
   PUBMED   37496990
  REMARK    GeneRIF: FOXM1-regulated ZIC2 promotes the malignant phenotype of
            renal clear cell carcinoma by activating UBE2C/mTOR signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 532)
  AUTHORS   Koyabu,Y., Nakata,K., Mizugishi,K., Aruga,J. and Mikoshiba,K.
  TITLE     Physical and functional interactions between Zic and Gli proteins
  JOURNAL   J Biol Chem 276 (10), 6889-6892 (2001)
   PUBMED   11238441
REFERENCE   7  (residues 1 to 532)
  AUTHORS   Salero,E., Perez-Sen,R., Aruga,J., Gimenez,C. and Zafra,F.
  TITLE     Transcription factors Zic1 and Zic2 bind and transactivate the
            apolipoprotein E gene promoter
  JOURNAL   J Biol Chem 276 (3), 1881-1888 (2001)
   PUBMED   11038359
REFERENCE   8  (residues 1 to 532)
  AUTHORS   Yang,Y., Hwang,C.K., Junn,E., Lee,G. and Mouradian,M.M.
  TITLE     ZIC2 and Sp3 repress Sp1-induced activation of the human D1A
            dopamine receptor gene
  JOURNAL   J Biol Chem 275 (49), 38863-38869 (2000)
   PUBMED   10984499
REFERENCE   9  (residues 1 to 532)
  AUTHORS   Brown,S.A., Warburton,D., Brown,L.Y., Yu,C.Y., Roeder,E.R.,
            Stengel-Rutkowski,S., Hennekam,R.C. and Muenke,M.
  TITLE     Holoprosencephaly due to mutations in ZIC2, a homologue of
            Drosophila odd-paired
  JOURNAL   Nat Genet 20 (2), 180-183 (1998)
   PUBMED   9771712
REFERENCE   10 (residues 1 to 532)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Laure Lemmens. The reference sequence was
            derived from AL355338.33, AF193855.1 and AA491603.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 29, 2002 this sequence version replaced NP_009060.1.
            
            Summary: This gene encodes a member of the ZIC family of C2H2-type
            zinc finger proteins. This protein functions as a transcriptional
            repressor and may regulate tissue specific expression of dopamine
            receptor D1. Expansion of an alanine repeat in the C-terminus of
            the encoded protein and other mutations in this gene cause
            holoprosencephaly type 5. Holoprosencephaly is the most common
            structural anomaly of the human brain. A polyhistidine tract
            polymorphism in this gene may be associated with increased risk of
            neural tube defects. This gene is closely linked to a gene encoding
            zinc finger protein of the cerebellum 5, a related family member on
            chromosome 13. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF193855.1, AF104902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376335.8/ ENSP00000365514.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.3"
     Protein         1..532
                     /product="zinc finger protein ZIC 2"
                     /note="Zic family member 2 (odd-paired homolog,
                     Drosophila); Zinc finger protein of the cerebellum 2"
                     /calculated_mol_wt=54875
     Region          100..255
                     /region_name="Necessary for interaction with MDFIC and
                     transcriptional activation or repression.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O95409.2)"
     Site            191
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62520; propagated from
                     UniProtKB/Swiss-Prot (O95409.2)"
     Site            199
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62520; propagated from
                     UniProtKB/Swiss-Prot (O95409.2)"
     Region          250..295
                     /region_name="zf_ZIC"
                     /note="Zic proteins zinc finger domain; pfam18366"
                     /db_xref="CDD:436441"
     Region          307..327
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(312,314,316,318..319,322..323,326,342,344,348..349,
                     352..353,356,372,374,376,378..379,382..383,386)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <329..413
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          335..357
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          365..387
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          395..415
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          406..452
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O95409.2)"
     Region          475..532
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O95409.2)"
     CDS             1..532
                     /gene="ZIC2"
                     /gene_synonym="HPE5"
                     /coded_by="NM_007129.5:282..1880"
                     /db_xref="CCDS:CCDS9495.1"
                     /db_xref="GeneID:7546"
                     /db_xref="HGNC:HGNC:12873"
                     /db_xref="MIM:603073"
ORIGIN      
        1 mlldagpqfp aigvgsfarh hhhsaaaaaa aaaemqdrel slaaaqngfv dsaaahmgaf
       61 klnpgahels pgqssaftsq gpgaypgsaa aaaaaaalgp haahvgsysg ppfnstrdfl
      121 frsrgfgdsa pgggqhglfg pgagglhhah sdaqghllfp glpeqhgphg sqnvlngqmr
      181 lglpgevfgr seqyrqvasp rtdpysaaql hnqygpmnmn mgmnmaaaaa hhhhhhhhhp
      241 gaffrymrqq cikqelickw idpeqlsnpk kscnktfstm helvthvsve hvggpeqsnh
      301 vcfweecpre gkpfkakykl vnhirvhtge kpfpcpfpgc gkvfarsenl kihkrthtge
      361 kpfqcefegc drrfanssdr kkhmhvhtsd kpylckmcdk sythpsslrk hmkvhesspq
      421 gsesspaass gyesstppgl vspsaepqss snlspaaaaa aaaaaaaaaa vsavhrgggs
      481 gsggagggsg ggsgsggggg gaggggggss gggsgtaggh sglssnfnew yv
//
