LOCUS       NM_003412               5260 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens Zic family member 1 (ZIC1), mRNA.
ACCESSION   NM_003412
VERSION     NM_003412.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5260)
  AUTHORS   Thottappillil,N., Gomez-Salazar,M.A., Xu,M., Qin,Q., Xing,X.,
            Xu,J., Broderick,K., Yea,J.H., Archer,M., Ching-Yun Hsu,G.,
            Peault,B. and James,A.W.
  TITLE     ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal
            Progenitor Cells Via a Hedgehog Dependent Mechanism
  JOURNAL   Stem Cells 41 (9), 862-876 (2023)
   PUBMED   37317792
  REMARK    GeneRIF: ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human
            Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism.
REFERENCE   2  (bases 1 to 5260)
  AUTHORS   Hopfner,F., Tietz,A.K., Ruf,V.C., Ross,O.A., Koga,S., Dickson,D.,
            Aguzzi,A., Attems,J., Beach,T., Beller,A., Cheshire,W.P., van
            Deerlin,V., Desplats,P., Deuschl,G., Duyckaerts,C., Ellinghaus,D.,
            Evsyukov,V., Flanagan,M.E., Franke,A., Frosch,M.P., Gearing,M.,
            Gelpi,E., van Gerpen,J.A., Ghetti,B., Glass,J.D., Grinberg,L.T.,
            Halliday,G., Helbig,I., Hollerhage,M., Huitinga,I., Irwin,D.J.,
            Keene,D.C., Kovacs,G.G., Lee,E.B., Levin,J., Marti,M.J.,
            Mackenzie,I., McKeith,I., Mclean,C., Mollenhauer,B., Neumann,M.,
            Newell,K.L., Pantelyat,A., Pendziwiat,M., Peters,A., Molina
            Porcel,L., Rabano,A., Matej,R., Rajput,A., Rajput,A., Reimann,R.,
            Scott,W.K., Seeley,W., Selvackadunco,S., Simuni,T., Stadelmann,C.,
            Svenningsson,P., Thomas,A., Trenkwalder,C., Troakes,C.,
            Trojanowski,J.Q., Uitti,R.J., White,C.L., Wszolek,Z.K., Xie,T.,
            Ximelis,T., Yebenes,J., Muller,U., Schellenberg,G.D., Herms,J.,
            Kuhlenbaumer,G. and Hoglinger,G.
  CONSRTM   Alzheimer's Disease Genetics Consortium
  TITLE     Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple
            System Atrophy
  JOURNAL   Mov Disord 37 (10), 2110-2121 (2022)
   PUBMED   35997131
  REMARK    GeneRIF: Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed
            Multiple System Atrophy.
REFERENCE   3  (bases 1 to 5260)
  AUTHORS   Serth,J., Peters,I., Hill,B., Hubscher,T., Hennenlotter,J.,
            Klintschar,M. and Kuczyk,M.A.
  TITLE     Age-Related DNA Methylation in Normal Kidney Tissue Identifies
            Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1
            Genes
  JOURNAL   Int J Mol Sci 23 (10), 5327 (2022)
   PUBMED   35628134
  REMARK    GeneRIF: Age-Related DNA Methylation in Normal Kidney Tissue
            Identifies Epigenetic Cancer Risk Susceptibility Loci in the
            ANKRD34B and ZIC1 Genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5260)
  AUTHORS   Datta,H.K., Kringen,M.K., Tuck,S.P., Salpingidou,G., Olstad,O.K.,
            Gautvik,K.M., Cockell,S.J., Gautvik,V.T., Prediger,M., Wu,J.J.,
            Birch,M.A. and Reppe,S.
  TITLE     Mechanical-Stress-Related Epigenetic Regulation of ZIC1
            Transcription Factor in the Etiology of Postmenopausal Osteoporosis
  JOURNAL   Int J Mol Sci 23 (6), 2957 (2022)
   PUBMED   35328378
  REMARK    GeneRIF: Mechanical-Stress-Related Epigenetic Regulation of ZIC1
            Transcription Factor in the Etiology of Postmenopausal
            Osteoporosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5260)
  AUTHORS   Han,Z., Jia,J., Lv,Y., Wang,R. and Cao,K.
  TITLE     Transcriptional expression of ZICs as an independent indicator of
            survival in gliomas
  JOURNAL   Sci Rep 11 (1), 17532 (2021)
   PUBMED   34475426
  REMARK    GeneRIF: Transcriptional expression of ZICs as an independent
            indicator of survival in gliomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5260)
  AUTHORS   Bagutti,C., Forro,G., Ferralli,J., Rubin,B. and
            Chiquet-Ehrismann,R.
  TITLE     The intracellular domain of teneurin-2 has a nuclear function and
            represses zic-1-mediated transcription
  JOURNAL   J Cell Sci 116 (Pt 14), 2957-2966 (2003)
   PUBMED   12783990
  REMARK    GeneRIF: zic-1-mediated transcription is repressed by the
            intracellular domain of teneurin-2
REFERENCE   7  (bases 1 to 5260)
  AUTHORS   Koyabu,Y., Nakata,K., Mizugishi,K., Aruga,J. and Mikoshiba,K.
  TITLE     Physical and functional interactions between Zic and Gli proteins
  JOURNAL   J Biol Chem 276 (10), 6889-6892 (2001)
   PUBMED   11238441
REFERENCE   8  (bases 1 to 5260)
  AUTHORS   Salero,E., Perez-Sen,R., Aruga,J., Gimenez,C. and Zafra,F.
  TITLE     Transcription factors Zic1 and Zic2 bind and transactivate the
            apolipoprotein E gene promoter
  JOURNAL   J Biol Chem 276 (3), 1881-1888 (2001)
   PUBMED   11038359
REFERENCE   9  (bases 1 to 5260)
  AUTHORS   Michiels,E.M., Oussoren,E., Van Groenigen,M., Pauws,E.,
            Bossuyt,P.M., Voute,P.A. and Baas,F.
  TITLE     Genes differentially expressed in medulloblastoma and fetal brain
  JOURNAL   Physiol Genomics 1 (2), 83-91 (1999)
   PUBMED   11015565
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5260)
  AUTHORS   Yokota,N., Aruga,J., Takai,S., Yamada,K., Hamazaki,M., Iwase,T.,
            Sugimura,H. and Mikoshiba,K.
  TITLE     Predominant expression of human zic in cerebellar granule cell
            lineage and medulloblastoma
  JOURNAL   Cancer Res 56 (2), 377-383 (1996)
   PUBMED   8542595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092959.6 and BF920299.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003412.3.
            
            Summary: This gene encodes a member of the ZIC family of C2H2-type
            zinc finger proteins. Members of this family are important during
            development. Aberrant expression of this gene is seen in
            medulloblastoma, a childhood brain tumor. This gene is closely
            linked to the gene encoding zinc finger protein of the cerebellum
            4, a related family member on chromosome 3. This gene encodes a
            transcription factor that can bind and transactivate the
            apolipoprotein E gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.908517.1,
                                           SRR3476690.870081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282928.5/ ENSP00000282928.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC092959.6         109356-109384       c
            30-1524             AC092959.6         107861-109355       c
            1525-1894           BF920299.1         118-487             c
            1895-5260           AC092959.6         102030-105395       c
FEATURES             Location/Qualifiers
     source          1..5260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..5260
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /note="Zic family member 1"
                     /db_xref="GeneID:7545"
                     /db_xref="HGNC:HGNC:12872"
                     /db_xref="MIM:600470"
     exon            1..1730
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /inference="alignment:Splign:2.1.0"
     CDS             749..2092
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /note="Zic family member 1 (odd-paired homolog,
                     Drosophila); Zinc finger protein of the cerebellum 1; zinc
                     finger protein 201"
                     /codon_start=1
                     /product="zinc finger protein ZIC 1"
                     /protein_id="NP_003403.2"
                     /db_xref="CCDS:CCDS3136.1"
                     /db_xref="GeneID:7545"
                     /db_xref="HGNC:HGNC:12872"
                     /db_xref="MIM:600470"
                     /translation="MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGM
                     GAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLF
                     RNRGFGDAAAAASAQHSLFAASAGGFGGPHGHTDAAGHLLFPGLHEQAAGHASPNVVN
                     GQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMR
                     QPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEEC
                     PREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKC
                     EFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQ
                     PSPAASSGYESSTPPTIVSPSTDNPTTSSLSPSSSAVHHTAGHSALSSNFNEWYV"
     exon            1731..1894
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..5260
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3083..3088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /note="hexamer: ATTAAA"
     polyA_site      3102
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /note="major polyA site"
     regulatory      5237..5242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /note="hexamer: AATAAA"
     polyA_site      5260
                     /gene="ZIC1"
                     /gene_synonym="BAIDCS; CRS6; ZIC; ZNF201"
                     /note="major polyA site"
ORIGIN      
        1 aattcattta tctgcaggaa tgattgctgc tatcagtctc gcgctcaccg cccggctgag
       61 gaggtgaaag tttctcccca ggaagataaa ccgcaaaaga caatattgtg catgatttgc
      121 gccttttctt tggctttttc tttctttctt caccccccca cccacttttt tttttttttt
      181 tttcaaaaag cagagaggga aaaacggaga gtgaaggagc gaggaggcga gcgtgagaga
      241 aaggagagag agagaaaaga aagggcgagg ggctagtgga gaagtaagga ggggcgcgct
      301 gcgcgaggcg gagagagggc gaagcagtcg cggcactggc gctcacattc ctctatgcta
      361 caaatccagg aggaagtttt tttttagggg gctgagatgc tccatgcctt tccccgggca
      421 gccttgacgc gcggccctct cggcagagac tgagcggcga gaaagtgcga gccgggccgg
      481 cagaatctgc ctggcgggcg ctggagcctg cgttactcgc ggcccgcagc cgtccggcta
      541 ctttgcgttt ggcccggcca gcgcccgggc gcgccgcgcc attgcctgca ggctaggact
      601 tcgcgaggtg ggtcgactcc ccctccctcc tcctcttctt cctcctcttc ctcctcctct
      661 tgttcctcct cctcctcccg attttccctc ctcggctggc gagggtgggg ggggcggggg
      721 aggccggggc tcgccccgag cagccacgat gctcctggac gccggccccc agtacccagc
      781 gatcggcgtg accacctttg gcgcgtcccg ccaccactcc gcgggcgacg tggccgaacg
      841 agacgtgggc ctgggcatca acccgttcgc cgacggcatg ggcgccttca agctcaaccc
      901 cagttcgcac gagctggctt cggccggcca gacggccttc acgtcgcagg cgccaggcta
      961 cgcggctgct gcggccctgg gccatcacca tcacccgggc cacgtcggct cctattccag
     1021 cgcagccttc aactccacgc gggactttct gttccgcaac cggggttttg gcgacgcggc
     1081 ggcggcagcc agcgcacagc acagcctctt tgctgcatcg gccgggggct tcgggggccc
     1141 acacggccac acggacgccg cgggccacct cctcttcccc gggcttcacg agcaggctgc
     1201 cggccacgcg tcgcctaacg tggtcaacgg gcagatgagg ctcggcttct cgggggacat
     1261 gtacccgcga ccggagcagt acggccaggt gaccagcccg cgttcggagc actatgctgc
     1321 gccgcagctg cacggctacg ggcccatgaa cgtgaacatg gccgcgcatc acggcgccgg
     1381 cgccttcttc cgctacatgc gccaacccat caagcaagag ctcatctgca agtggatcga
     1441 gcccgagcag ctggccaacc ccaaaaagtc gtgcaacaaa actttcagca ccatgcacga
     1501 gctagttacg cacgtcaccg tggagcacgt aggtggcccg gagcagagta atcacatctg
     1561 cttctgggag gagtgtccgc gcgagggcaa gcccttcaaa gccaaataca aactggttaa
     1621 ccacatccgc gtgcacacgg gcgagaagcc ctttccctgc cccttccctg gctgtggcaa
     1681 ggtcttcgcg cgctccgaga atttaaagat ccacaaaagg acgcacacag gggagaagcc
     1741 cttcaagtgc gagtttgagg gctgtgaccg gcgcttcgct aacagcagcg accgcaagaa
     1801 gcacatgcac gtgcacacga gcgacaagcc ctatctttgc aagatgtgcg acaagtccta
     1861 cacgcatccc agttcgctgc gcaaacacat gaaggtccac gaatcctcct cgcagggctc
     1921 gcagccttcg ccggccgcca gctctggcta cgaatcctcc acgcctccca ccatcgtgtc
     1981 tccctccaca gacaacccga ccacaagctc cttatcgccc tcctcctccg cagtccacca
     2041 cacagccggc cacagtgcgc tctcttccaa ttttaacgaa tggtacgttt aaaatcagaa
     2101 acaaaacatc gaacaaaacc ctatttaaga gactgatcac acacgtatac acaacattac
     2161 tgaaagaacc ctgcgaatca aaacaacccc cacacagacc ccgcaatcct tttttaaaaa
     2221 atctgccaat agacccagga cgagtaagag aggaagcatc aaccttttaa aaatttcctt
     2281 tcgctttcat tatttttctt tttttggcaa aggcttggta cccaaggtgc ggtagggggt
     2341 cgagggggag gaggccacct gaccaaatgc cgccaacccc gagggccagt ttcttgtcga
     2401 attggtacgg gctctctggg gcttcggctt ctttttttct ttgttttctt gtaaatacag
     2461 aattattagc ttaaaactgt actgttgaat tctgtaaata gttatatctc ggttggagcg
     2521 ggtgggtggg attgtggcgt tgtggtcttt gcattggggg aggggggagg gaccggatgg
     2581 gcggggggag ggggaggggg aggggtgggc ggccgaaagc caactgtttg tactgaatgg
     2641 caagaatgtt ctagtaaatg tgtaccaaaa tgtgaattac tttgtacgat tacagtctcc
     2701 acgtcgacct aacccaatat tattggtatt aatgtgcttt ttttgtataa agtgcaaaca
     2761 tttcgtccca aagtctaagt actttagtgc agtaaaatgt tgtttcatgt cctgtcaaga
     2821 attcgtatag tacgagcctg gatctgcgtg tcaaactgtt ccatttgttt atgtaaagtg
     2881 atattaaaaa agatataaac tataactgtc cgttactttt ggcaaaagat acaaccacat
     2941 aatgtatata attcctagtt tccatattta tccgcatgta aagggccggt ttatccatgt
     3001 tacagctctt caatatttat ggctagaaga actcgtatgt acactttagt ttccagaact
     3061 gtttggtaac ctttcgtacc ttattaaaga ttcttaaatc tccgtgattg tggtaggaat
     3121 ttcttcttca cccaccagca acctgctgcc tcttctgcca gtcttaaagg gtctccagaa
     3181 aagctctcca gtctcccttg ccttcccttt ctgtcactgc aggtcgtata aacgtgataa
     3241 atgaatgcta ccctgctggc tctccgagag agtgtaatta gtatttatat caaaatttat
     3301 gaaacaaatt ttcggccgca gtataattta aatgaccttt gcagatgtag aataacaacc
     3361 ataaaaataa caggaataga ttgcacaggc gacatcaata ttaatgtaga cgaattgtca
     3421 gaagctcagg ggctcgctct gcaacattgc aaatgaactt gcagccgagg gttccgctgc
     3481 cccctagatt aaattccccg ggctgaaact gagttgcaga tttacaatat catattttaa
     3541 attgctgtct tcaattaaac catttatgac cataactaat tttcaggatg tcgatgcatg
     3601 cttttccagg ccttccttct ttgtacaaaa gtaaatgtcc ataaagcgtt tcacttatat
     3661 tcttcaaaca tgatgctaat ttaaattaat tacttcctat gatatgttat tattcctatg
     3721 attttgccac tgttattagt tctctcaaaa atacatctag ggaagaggat tattttaagt
     3781 aatttgatta tctttctatc tcttttattt atttctcatt tacttaagaa attcgttcca
     3841 ttggttggca ttgatacagt aaatttgtaa atgaggagac aatataaaaa atctaaatta
     3901 cttgtgctta atgactgtag cagaatgcct tttctctaaa tcagattgtc tttcttgcag
     3961 tttagtttga tagatttgca agctatgctg cttccatgaa gttagctgcg ctggtaggaa
     4021 cgcaggcttc tttgtctctg gttgtagctt gcatgatcgc cccattaggc agacaacgta
     4081 gccggagatc acaaatcagg cccttggctg tagttgctag tgtgtggagg tgcagagcag
     4141 gtggcagaaa ctgacctcac tgggcaaggg tggccatgga cctgattctt taatgcactc
     4201 tatgtgttca ggaagccaca ggccatattt gactctgaga aagaaaacaa gaggaaaaac
     4261 cccacaaagt ataacaaccc cttaagatac atctatttta aagtgaaatt aatttttcag
     4321 tttataccat tggccaatta caagataaaa atgttcaatt tctttaagaa tcctttgttg
     4381 acttgtcttt tcatctcttg ctatttatat ttgtcactgt ttcaacaaag tcttatttgc
     4441 tgaggaagga ctttgctgca cttactgtac cacatcaaac actggggagg gtggtgttta
     4501 actttttaaa aaatgttatt ctgattataa caataatatt ggcttttttc atgaaaagag
     4561 cgccaccttg caaggtttag tgagatttat ggaagttgaa tacctaagca ggaattgctg
     4621 ctagctccaa aaatttgcga agcaaaagct agccccaatt ggtttggaag tttgaaactg
     4681 attaacagat ttgcatttga agtgactcca gacattaggt ccagacatta gttaaaaata
     4741 gaaagaggaa taaagacatc tcttctctct agaaaagata acaccacaat taataatcct
     4801 tcccactttc attgagatca gcttgtctga taacctgata tgagtgtgat aatgataaac
     4861 atgataatag tggtactttt gtaattttgc tggtgcattt aagaagatag taaatgatga
     4921 gttcatcttt tcttcgaaca ttcctattcc tagatgtagt ttacctcaaa ttgggaatta
     4981 taactgtcta atttttgttg tgtacctgat gccccttttg ctttaatacc acagtgtaac
     5041 aattaaatat cacactatga catatgattt aagtaggata ttttaaagat aaattttagg
     5101 ggtaaatgtt tacttcaaaa tgactccata tttcaaatat ctgtttagac tgtgaaggcc
     5161 aaataatttt taagaaaaca tttgaagagt agtgtgtttg catttgtgaa taatcttact
     5221 cacagcaagt aaacgtaata aaagccaaca tttaagccaa
//
