LOCUS       NM_001384317           10074 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc fingers and homeoboxes 3 (ZHX3), transcript
            variant 4, mRNA.
ACCESSION   NM_001384317 XM_024451861
VERSION     NM_001384317.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10074)
  AUTHORS   Igata,T., Tanaka,H., Etoh,K., Hong,S., Tani,N., Koga,T. and
            Nakao,M.
  TITLE     Loss of the transcription repressor ZHX3 induces
            senescence-associated gene expression and mitochondrial-nucleolar
            activation
  JOURNAL   PLoS One 17 (1), e0262488 (2022)
   PUBMED   35085309
  REMARK    GeneRIF: Loss of the transcription repressor ZHX3 induces
            senescence-associated gene expression and mitochondrial-nucleolar
            activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10074)
  AUTHORS   Deng,M., Wei,W., Duan,J., Chen,R., Wang,N., He,L., Peng,Y., Ma,X.,
            Wu,Z., Liu,J., Li,Z., Zhang,Z., Jiang,L., Zhou,F. and Xie,D.
  TITLE     ZHX3 promotes the progression of urothelial carcinoma of the
            bladder via repressing of RGS2 and is a novel substrate of TRIM21
  JOURNAL   Cancer Sci 112 (5), 1758-1771 (2021)
   PUBMED   33440047
  REMARK    GeneRIF: ZHX3 promotes the progression of urothelial carcinoma of
            the bladder via repressing of RGS2 and is a novel substrate of
            TRIM21.
REFERENCE   3  (bases 1 to 10074)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 10074)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 10074)
  AUTHORS   Kwon,R.J., Kim,Y.H., Jeong,D.C., Han,M.E., Kim,J.Y., Liu,L.,
            Jung,J.S. and Oh,S.O.
  TITLE     Expression and prognostic significance of zinc fingers and
            homeoboxes family members in renal cell carcinoma
  JOURNAL   PLoS One 12 (2), e0171036 (2017)
   PUBMED   28152006
  REMARK    GeneRIF: ZHX3 expression in renal cell carcinoma
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10074)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 10074)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 10074)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T. and Miyamoto,K.
  TITLE     The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a
            heterodimer with ZHX3
  JOURNAL   Gene 323, 133-140 (2003)
   PUBMED   14659886
REFERENCE   9  (bases 1 to 10074)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
  REMARK    GeneRIF: dimerizes with both ZHX1 and ZHX3, also interacts with the
            activation domain of the NF-YA
REFERENCE   10 (bases 1 to 10074)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031257.1 and AL022394.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 16, 2020 this sequence version replaced XM_024451861.1.
            
            Summary: This gene encodes a member of the zinc fingers and
            homeoboxes (ZHX) gene family. The encoded protein contains two
            C2H2-type zinc fingers and five homeodomains and forms a dimer with
            itself or with zinc fingers and homeoboxes family member 1. In the
            nucleus, the dimerized protein interacts with the A subunit of the
            ubiquitous transcription factor nuclear factor-Y and may function
            as a transcriptional repressor. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1-10 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2444991.1,
                                           SRR14038194.946320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683867.1/ ENSP00000506788.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AL031257.1         66238-66460         c
            224-317             AL031257.1         17719-17812         c
            318-3327            AL022394.3         97233-100242        c
            3328-10074          AL022394.3         73631-80377         c
FEATURES             Location/Qualifiers
     source          1..10074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q12"
     gene            1..10074
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="zinc fingers and homeoboxes 3"
                     /db_xref="GeneID:23051"
                     /db_xref="HGNC:HGNC:15935"
                     /db_xref="MIM:609598"
     exon            1..223
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..317
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..3327
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..3338
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="isoform a is encoded by transcript variant 4;
                     triple homeobox 1; zinc fingers and homeoboxes protein 3;
                     triple homeobox protein 1; zinc finger and homeodomain
                     protein 3"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 3 isoform a"
                     /protein_id="NP_001371246.1"
                     /db_xref="CCDS:CCDS13315.1"
                     /db_xref="GeneID:23051"
                     /db_xref="HGNC:HGNC:15935"
                     /db_xref="MIM:609598"
                     /translation="MASKRKSTTPCMIPVKTVVLQDASMEAQPAETLPEGPQQDLPPE
                     ASAASSEAAQNPSSTDGSTLANGHRSTLDGYLYSCKYCDFRSHDMTQFVGHMNSEHTD
                     FNKDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSIPESTS
                     TPDLAGEPSAEGADGQAEIIITKTPIMKIMKGKAEAKKIHTLKENVPSQPVGEALPKL
                     STGEMEVREGDHSFINGAVPVSQASASSAKNPHAANGPLIGTVPVLPAGIAQFLSLQQ
                     QPPVHAQHHVHQPLPTAKALPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAEL
                     CYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLN
                     TPLVASAGNVQHLIQAALPGHVVGQPEGTGGGLLVTQPLMANGLQATSSPLPLTVTSV
                     PKQPGVAPINTVCSNTTSAVKVVNAAQSLLTACPSITSQAFLDASIYKNKKSHEQLSA
                     LKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGSRAMIPGDHSSI
                     IIDSVPEVSFSPSSKVPEVTCIPTTATLATHPSAKRQSWHQTPDFTPTKYKERAPEQL
                     RALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKKVNAEETKKAEENASQE
                     EEEAAEDEGGEEDLASELRVSGENGSLEMPSSHILAERKVSPIKINLKNLRVTEANGR
                     NEIPGLGACDPEDDESNKLAEQLPGKVSCKKTAQQRHLLRQLFVQTQWPSNQDYDSIM
                     AQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMT
                     HKMLYEEDLQNLCDKTQMSSQQVKQWFAEKMGEETRAVADTGSEDQGPGTGELTAVHK
                     GMGDTYSEVSENSESWEPRVPEASSEPFDTSSPQAGRQLETD"
     exon            3328..10074
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="hexamer: AATAAA"
     polyA_site      3708
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="major polyA site"
     regulatory      6394..6399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="hexamer: GATAAA"
     polyA_site      6415
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="major polyA site"
     regulatory      10057..10062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="hexamer: AATAAA"
     polyA_site      10074
                     /gene="ZHX3"
                     /gene_synonym="TIX1"
                     /note="major polyA site"
ORIGIN      
        1 gagcagagcc gagcgcctcc gagagcggcc gagcccagcc gagcggcccg gagtcggttg
       61 gtgcagctgc gtccccgccg ctcagcagtc cgcggctccg gcgtcgccgc cgccgccgcc
      121 tctgcggggc ctgcgccggc cgcccgcccg gccgcgggga gggaggcccg cagcgcggga
      181 agagcggccc ggtcgcgggc gccgccaccg ccgccgctgc caggactgaa atgcaactgc
      241 agaagcaaca tgtgaccttt tagagatgct tgtgggactg cataaagtga agagggaaac
      301 tggaaaaaaa caatgaaatt gaatagggaa aacctgcttt ctgcaaacaa ctgaaaaagc
      361 tgcatttaga aactgtttct ttggccctca tcgagaagct ggaacttgta ttgttaggcc
      421 ccttatggga caagctctca actgctgatc acccagtgat tgtcaccatg gccagcaaga
      481 ggaaatccac cacaccatgc atgatcccag tgaagactgt ggtgttgcaa gatgccagca
      541 tggaggccca gcccgctgag accttgcctg aaggacccca gcaggatctg cccccagaag
      601 catctgctgc cagcagtgag gcagcacaga accccagcag tactgatggc tctacactgg
      661 ccaatgggca tcggagcact ttagatggct atttatattc ctgtaaatac tgcgatttca
      721 gatcccatga catgacccaa tttgtgggac atatgaactc agagcacaca gactttaata
      781 aagacccaac ctttgtatgc agtgggtgca gttttctggc aaaaacccct gaggggcttt
      841 ccttgcacaa tgccacatgt cactccgggg aagccagctt tgtgtggaac gtggccaagc
      901 cagacaatca tgtggttgtg gagcagagca tccctgagag caccagcact cctgacctag
      961 cgggtgagcc cagtgctgaa ggggctgatg gacaggcaga aatcatcatt accaaaactc
     1021 caatcatgaa gataatgaaa ggcaaagctg aagccaaaaa aattcataca ctcaaggaga
     1081 atgtccctag ccagcctgtg ggtgaggcct taccaaagct gtcgactgga gaaatggagg
     1141 tgagagaggg ggaccattcc ttcatcaatg gggcagttcc agtcagccag gcatctgcca
     1201 gctctgcaaa aaacccccat gccgccaacg ggcccctgat aggaacagtg ccagttttgc
     1261 cagctggcat agcacagttc ctctccctcc agcagcagcc cccagtgcat gcccaacacc
     1321 atgtccacca gccactgccc acggccaagg cccttcccaa agtgatgatc cccctgagca
     1381 gcattccaac gtacaatgca gccatggact ctaacagctt cctgaagaac tccttccaca
     1441 agttccccta ccccaccaaa gccgagctct gctatttgac tgtggtgacc aagtatccag
     1501 aagaacagct caagatctgg ttcacagccc aaaggctgaa gcaggggatc agctggtccc
     1561 ctgaggagat tgaggatgcc cggaaaaaga tgttcaatac agtcatccag tctgtgcctc
     1621 agcccacaat tacggttcta aataccccac tcgtcgccag tgctggcaat gtccagcatc
     1681 tcatccaggc cgctcttcca ggtcacgttg tggggcagcc agagggtaca ggagggggac
     1741 ttctggtcac tcagccattg atggccaatg ggttgcaagc aacaagttcc cctctccccc
     1801 tcacggtgac atccgtcccc aagcagccag gtgtggcacc cattaacact gtgtgttcaa
     1861 atacaacgtc agctgtgaag gtggtcaatg cggcccagtc gctcctcacg gcctgcccca
     1921 gcataacctc ccaagccttc cttgatgcta gcatctacaa aaataagaaa tctcatgaac
     1981 agctgtcagc tctgaaaggg agcttctgtc ggaaccagtt cccagggcag agcgaagttg
     2041 aacatctcac aaaagtgacg ggcctcagta ccagagaggt gcggaaatgg ttcagtgatc
     2101 gtagatacca ctgccggaac ttgaagggct ccagagcgat gatacctgga gatcacagtt
     2161 ccatcatcat tgactctgtg ccagaggtgt ccttctcccc atcgtccaag gtccctgagg
     2221 taacctgcat tccgacaaca gccacactag caacccaccc ttctgccaaa cgacaatctt
     2281 ggcaccagac tcctgacttc acaccaacca aatacaagga gagagcccct gagcagctca
     2341 gagccctgga gagcagtttt gcacaaaacc ctcttcctct tgatgaggaa ctggaccgcc
     2401 tgagaagtga aaccaaaatg acccgacgag aaattgatag ctggttttca gagagacgga
     2461 aaaaagtgaa tgctgaggag accaagaagg ctgaggagaa tgcctctcag gaggaagagg
     2521 aggctgctga ggatgagggt ggagaagagg atttggccag tgagctaagg gtctctggtg
     2581 aaaatggctc tctggaaatg cccagcagcc atatcttggc agagcgcaaa gtcagcccca
     2641 ttaaaatcaa cctgaagaac ctgagggtca ctgaagccaa tggcaggaac gagattccag
     2701 ggctgggtgc ctgtgaccct gaggatgatg agtcaaacaa actggcagag cagctcccag
     2761 gcaaagtgag ctgcaaaaag actgcccagc agcggcactt gctgcggcag ctctttgtcc
     2821 agacacagtg gccaagcaac caggactatg actccatcat ggcccagacg ggtctgccac
     2881 ggccagaggt ggtgcgctgg tttggagata gcaggtacgc actgaagaac ggccaactca
     2941 aatggtacga agactataag cgaggcaact tcccaccagg gctactggtc attgcccctg
     3001 gcaaccggga gctcctgcag gactattaca tgacacacaa gatgctgtat gaagaggacc
     3061 tgcagaacct ctgtgacaag acccagatga gctcccagca ggtcaagcag tggtttgctg
     3121 agaaaatggg ggaggagacc agagccgtgg cagacacagg cagtgaggac cagggccctg
     3181 gtactggtga gctcacagca gttcacaaag ggatgggtga cacctattca gaggtgtctg
     3241 agaacagtga gtcgtgggag ccccgtgtcc ctgaggccag ctcagagccc tttgacacat
     3301 cgagtcccca ggctggacgt cagctcgaaa cagactgaat ttgatctgat taatgtgaag
     3361 gactggccag tctgggaaac cgcctgccac gtggaagagc caaacccgac tctctgctgc
     3421 cacatgccgt tcccatgccc ggctgctggg cacctgggag agcttccaga atcctcgcag
     3481 acagcccaga gcctgccgct accctcggcc tgcccaccac caagcaagca gcaagcaaga
     3541 tggggttctc atcagttctt cctcccacaa tgtaggacct ttcctttacc ttccaatgga
     3601 taaaatagtt cagagttcat agtcatattc atagacacag aatcaagctt ttaacatata
     3661 catccacctc tatatgttaa ataaaacatc agattatcaa cactgtcatt acgtagaaac
     3721 tttggttagc caagcagtgc attgtcagtt acgtcatctc taaaaatgac ctgtgtctgt
     3781 tctctgggga ttgctgggtc acaggtgccc ctcaccttcc acagtcaggc agggaagtta
     3841 taggcacaaa gctacgtctg gaaccccttt gtgccccctt tgtgttcctc aaggaagcag
     3901 tacctttgaa gagatctctg ctgcattaag tgatgaccgg ctacgtttca tgtcaggctt
     3961 gctttgcctt gtgggctact cagtgcagaa cctgctgtaa ccctcagttc aaaaaatgga
     4021 ctggcaatgt gattagcgtt ggatgcttta ccattctctt tagttgttac cgtaattctg
     4081 ctttttcatg ggagtttgaa tcatggacca taacttttca gttatcagat caactaaaga
     4141 aacatttgtt gttaagccta atgtgctgac ctatgtgcct gcattttttt tttaatctag
     4201 acatgtttgg agtgagagaa agatggaaaa aagacatggg gtagggacgt aagtggaaat
     4261 ctatagccac agcctgaagc tttgaccact gcggttttca gagccctttc tccacactca
     4321 tttcagagcc tcctatggtt tgggaaggaa taacacactg gcccattagt aagggtgaag
     4381 gctggaggga tttgttgact tcttggaatt atcagaggta gggtggtctt tagcacaaag
     4441 acttgcatgc agagatccct ggcagaacac ccagagtgcc cgtggctccc accccagggt
     4501 ctggccggtg tgctggatgc atgcccaagg gtgctgggca tcactggtcc ttgtgaggat
     4561 gcttttaaag ttttatattt atgtccccaa acttggaaac aagaactcta ctttagccta
     4621 accctcatgt ccttttttga attgagaaaa ttacaggaaa tggtgccttt gaaaattaga
     4681 aaacttgctt acagagctgt tctaaatggt aaatcctcaa tttccccaag accggttgct
     4741 ctgagagtag ctggtaaaga ggggcgaact aaagacctgt ccacctgtag ctccgctcat
     4801 ttcttagaaa ccacctgctt cccagagtgc caagccacaa gtaccaggct tcgtgggcac
     4861 agacacctcc tgggctgggc agagtgacag tgctagaaga ccccagagag agggcaaggg
     4921 ctttgggcaa gaagcactgg tggtgtttta gggaccgtcc ttctccccta cccagggaac
     4981 tggacctggc agggcaccgt gctcatgtgg ctccaaggac aagcatggcg gtggcccctt
     5041 ctgccttcca ggagaggtct tgcttttgaa accaaaatca tgttcttcta aagtgtcatc
     5101 ttctgccctc cctgtcccaa tagggaccac atcttatttg tctcaaacag ggacttgtga
     5161 gtacttggca agttttgcag cctatttttg tattcttaat ttggggagta aagatgtttg
     5221 gtctcaaaaa cctttgagga attgccaaga atggcgagtg attgctttcc ttcagagaac
     5281 agacacttgg aatttctcct tttagtgttt atatacgtgc agattaattt atatatatat
     5341 atatacacac acacatatac agtataaata ctcatttgat tctcgtaaaa cgcgcatctg
     5401 gcgtgtgcag ttgagaaact tggtggcaca tgggtgttgg gggagtagcc tgtgttggag
     5461 ggacaccagt gcactaggca gctggggcgg cccaggctga agccatctcc gggtgtctga
     5521 gaaaccaccc agtgcctcac ctccagatcc tgctggcatc acctccagag ccctgcatgc
     5581 actggctgaa gagttggtct gtggagagga ttttcttggt tacttgtatt cacggttaat
     5641 ttacaaccca aacagcaaaa cacagttggt ggacaagttc atgcaggacc tacagtgacc
     5701 cagccatggg cactagctca tctttcaggt ggaaaagtac agtgctgcct gccctggtat
     5761 gtttttctta tagatgttag ccctgcccaa cagccagggc tacactacaa aaggcaagaa
     5821 tgcccatgta aggagcccag cagtctggac agatccttct tcctctgctg ttggatgaga
     5881 gtgagtgagt atgctctgga ccttatcctt gaaagatgat caaaagcgat gatgagggag
     5941 gcagtcatca cgcaggtgct taaagggaca ttgtaggagg tactcaaggg tttgggggca
     6001 aaaccctgaa tccagccagt cgtgcacaga gacacaccca cactagccca gtggcagtgg
     6061 gggatgtggg atggcagcag ccaggtatgt agccctgtca caggacagct cactgtggtt
     6121 ttgcacactg cctaagggtt aaattgtgtt gttgccttca gtagaaggca tttgtgggct
     6181 gcagagttga gagttgggtg aggttagtct ctcctgaaga aaaagcctat aaaaagtggc
     6241 taatcttatc ccttttctct gtatgcagtt ggactcgtca gagatagtaa aatcatcttt
     6301 tagtgttttt ttgttgctga tgtcttgtac ccatttgttt tttacatggg gttgtagatc
     6361 gagttctcaa aggtgaaacc agatgatcat tctgataaag gaaatttaaa tttgatacat
     6421 atgctttgta tattttgatt acttgttttc gtttttgact ataaaggagc ttttttattt
     6481 tgggagggga ggagtgtcat ttttgagaat cttgggttcc tgaaaaagaa cgccctagtt
     6541 ggatggcttg ccagggcctt ggggtttggt agtgattgta caacttaaag ctcctttctc
     6601 ttggctgagt gacaggtggc tgttcaggtg gaccaaagca ccttgacaca aggactccac
     6661 actgtgctct ctagtagcac aaggaggaag ttggacagaa cattgggtag tgccttgcgg
     6721 gctcacacat gtactagtgg tctcatctcc agctagcctt gggaggccgt cccaccagga
     6781 aatctctcta ttccgtagcc tgagatgtgc ccttgtgggt tttatcctgc tcagtcagtg
     6841 gcctaggggc aggtcctgtg ttctctccct ctctctcctg gctctgggac atctgtccct
     6901 ggctgccttt catggaggaa ggacactggc ctttctggtt ggatgctgtg tggatgctct
     6961 ctgcttgagc ctcgtggtct cttgtctctt tttggaccaa tatcctcaga ttggtgcagc
     7021 tttttcagtt cagatatcac accccaagtg gataaaggca acttgcagga gaggagagcc
     7081 agccaagaag aaaattttaa aaccaaacct cgtttaggat tttcctaaag tcatcttctc
     7141 ttttttcttg ctcagagttt acctgggaga tttcaccagt ttgactcacc atttgcagat
     7201 gtgcttttgt attaaattta aattttcaca tatcacatcc attctcaagg tagttatatg
     7261 ctggagaaga aaaatcctct agacacatga aggcccacat agtcaagtct tccagggcaa
     7321 agccagcagc ccacccaggt caggtagcca gcagggctca gttcccctca ctccagacac
     7381 ggaccctcct cttcagggtc tcttgaccca gcttccttct ctccttttac ctgagagcac
     7441 agacctctct cagccagcct gcccagacca cggggggcta ctcccatgta gtttggggag
     7501 cacttgatct cagaaaagct ccattgtctg agcaaatggg cagttgtgga gctcaagcct
     7561 ttctcctgtg ctcaagtccc ttccccaagc aaggcttcaa cctcatctac ccaccatgta
     7621 gttttctctg gccatttaag tggggcggca gggacatggt tgggccatgc cacaccaggg
     7681 ctggtgaggc aaccagtttt gattttgaca gagtggctgg aggaaaagtg gcaatcaagg
     7741 tgctgcttgg tttgctctga gtgcaaatgg aaccaacagg tttctgctgc aatctgtgtg
     7801 ttcccagtgc caggtcacac caggaggggt ggggcagggc taaccaagtg gtctctgaac
     7861 tcaccgagcg tctgcacttg gttgtgaagt taatgggagt acagagagcg tctggccttg
     7921 gagaggggtt gagagcctcc tttttggttc ttcattcctg agctcttgcc tgcccacaaa
     7981 tctgacctct ttgaatgggg acgcagtcct tcaacagaga agtttctatg gcaaagaagt
     8041 ttctatttag ctctagatcc agcagagtca tccattctaa ctgccctgaa gtctagagca
     8101 ggggagggaa cccagaggct ggggatgaga ctaggcagac cctggttacc atatggacaa
     8161 ggacagggga aagcaccccc ttcctcaatt tctgaaagtt ctatctttgg gttcgcagga
     8221 ctttgaggat gataaagaac atataggtac tagcttgttg ttgctggtcc aaagcttcca
     8281 cagccctgag aatttggctt tcgtggctgc tctggcagct gagcgaaggg aggaaggcag
     8341 ccgctctggt ggggactcta ggcaccttcc ctgctgtcca cttggatagg cggtgagccc
     8401 cagggtactg agaggagcct gagcatttac ctgccattag tgcctcttcc ttcaggagac
     8461 tggcttgaaa cgtgtgttca tgtgcgcgtg cacacacaca catgagcacc tgtatgtgtt
     8521 aatgaatagt ttttcttggt taatgctttt taacttctgt tcctttccgt aagtggatga
     8581 ttcaaaatta acgtgacttg gctgggcgca gtggctcaca cctgtaatcc cagcactttg
     8641 ggaggccaag ggaggcggat cacctgaggt caggagttcg agaccagcct gatcggcatg
     8701 gtgaaacccc gtttctacta aaaatacaaa aattagccgg gcgtggtggt gcgcgcctgt
     8761 aatcccagct actcaggagg ctgaggaagg agaatcactt gaacccggga ggtggaggtt
     8821 gcagtgagct gagatcgtgc cactgcactc cagcctgggc gacagagcga aactccgtct
     8881 caaaaaaaaa aaaaaaactt aatgtgactg gagttaaaag tgaaatgtca ggttgtttag
     8941 tcactgaata gagagctaca agtgcttggt ctttcccaag aatcaaacct gagtagaaat
     9001 acatttaaaa gaaaaatcta catggtacct atgaatcctg taatttgttt agggagatct
     9061 tgtcactcat ccctggttcc tgcccatact gtttggtctc gttcttgcag tttgcttgga
     9121 acagggccag agccccacat gagattgtca gcaggagtga ggagcgccag tccctactcc
     9181 tcagcaggga cccagcacag caatccggtt gttctcggtt agactgggtc ggggccaggg
     9241 gagaagcagt cacccctgtg tagagggttc ccgctgtgct tctgagcagt tgctttgttc
     9301 agaagtgtta ggagggtcag attgtgccat aattgttatt aaagagaaaa cacgcccacc
     9361 ttcctttctc ccctgctggc cattgttcat tgagttttac tgagggcagc ctttgtggaa
     9421 gtcagggagg ttgccaaagg cctgtagatg cctcctgaca aggtcttgat tcctggtttt
     9481 ctagcaccca tttgcatttt ggtcttcagc acaaagcctt gttccctgtg gccggacttc
     9541 tgggcaataa gactggggag tgactgttga gcagtctgct gtcaggagag atggctgaaa
     9601 aggtgatcat cttggtgcta aacaagtaag aggcaactgc cctgtttttg tttgttttga
     9661 ggcacaatga aactttagcc aaactctgca agagggtccc atctcctgcc atggccaggt
     9721 gtgagagacc aaaccgagaa aacagcatac tctatcactt aagccttggg tagaatggga
     9781 attctttacc ctgggtaaac gttttaacaa aaaaatggaa cttaacttcg gtttggactg
     9841 tggtcgtgct gaggcaggag tggggttgcc ctcttggggc tgaatctcca ggcctcacga
     9901 ggtcccctgt ggggatgctg ctatttctaa gatgcaaatt gcacatttcc tagattttgt
     9961 atctgtggat ttggataagg gaggggaaca cggacaaatt gcttgtacaa tttgaaatgg
    10021 gcctcaatgg tacttcaaac cttttgatta ttcctaaata aaaacataaa tata
//
