LOCUS       NM_014943               4361 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens zinc fingers and homeoboxes 2 (ZHX2), transcript
            variant 2, mRNA.
ACCESSION   NM_014943
VERSION     NM_014943.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4361)
  AUTHORS   Xiao,B., Li,Y., Yang,Y., Chen,C., Gong,S., Li,H., Yao,Q. and
            Wang,L.
  TITLE     METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor
            Property of Renal Cell Carcinoma
  JOURNAL   Kidney Blood Press Res 49 (1), 787-798 (2024)
   PUBMED   39159608
  REMARK    GeneRIF: METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2
            Promotes Tumor Property of Renal Cell Carcinoma.
REFERENCE   2  (bases 1 to 4361)
  AUTHORS   Creasy,K.T., Ren,H., Jiang,J., Peterson,M.L. and Spear,B.T.
  TITLE     Elongation of very long chain fatty acids-3 (Elovl3) is activated
            by ZHX2 and is a regulator of cell cycle progression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (6), G582-G592 (2023)
   PUBMED   37847682
  REMARK    GeneRIF: Elongation of very long chain fatty acids-3 (Elovl3) is
            activated by ZHX2 and is a regulator of cell cycle progression.
REFERENCE   3  (bases 1 to 4361)
  AUTHORS   Tan,S., Wang,Z., Li,N., Guo,X., Zhang,Y., Ma,H., Peng,X., Zhao,Y.,
            Li,C., Gao,L., Li,T., Liang,X. and Ma,C.
  TITLE     Transcription factor Zhx2 is a checkpoint that programs macrophage
            polarization and antitumor response
  JOURNAL   Cell Death Differ 30 (9), 2104-2119 (2023)
   PUBMED   37582865
  REMARK    GeneRIF: Transcription factor Zhx2 is a checkpoint that programs
            macrophage polarization and antitumor response.
REFERENCE   4  (bases 1 to 4361)
  AUTHORS   Ding,R., Shi,H., Guo,Y., Zeng,W. and Fan,J.
  TITLE     Zinc fingers and homeoboxes 2 inhibition could suppress the
            proliferation of ovarian cancer cells by apoptosis pathway
  JOURNAL   Clin Transl Oncol 25 (7), 2116-2126 (2023)
   PUBMED   36746874
  REMARK    GeneRIF: Zinc fingers and homeoboxes 2 inhibition could suppress
            the proliferation of ovarian cancer cells by apoptosis pathway.
REFERENCE   5  (bases 1 to 4361)
  AUTHORS   Xie,H., Zhou,J., Liu,X., Xu,Y., Hepperla,A.J., Simon,J.M., Wang,T.,
            Yao,H., Liao,C., Baldwin,A.S., Gong,K. and Zhang,Q.
  TITLE     USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (36), e2119854119 (2022)
   PUBMED   36037364
  REMARK    GeneRIF: USP13 promotes deubiquitination of ZHX2 and tumorigenesis
            in kidney cancer.
REFERENCE   6  (bases 1 to 4361)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   7  (bases 1 to 4361)
  AUTHORS   de Andrade,T.G., Peterson,K.R., Cunha,A.F., Moreira,L.S.,
            Fattori,A., Saad,S.T. and Costa,F.F.
  TITLE     Identification of novel candidate genes for globin regulation in
            erythroid cells containing large deletions of the human beta-globin
            gene cluster
  JOURNAL   Blood Cells Mol Dis 37 (2), 82-90 (2006)
   PUBMED   16952470
  REMARK    GeneRIF: ZHX2, a transcriptional repressor, may participate in
            globin gene regulation.
REFERENCE   8  (bases 1 to 4361)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 4361)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T. and Miyamoto,K.
  TITLE     The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a
            heterodimer with ZHX3
  JOURNAL   Gene 323, 133-140 (2003)
   PUBMED   14659886
REFERENCE   10 (bases 1 to 4361)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T., Yazawa,T., Yoshino,M.,
            Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX
            family, functions as a transcriptional repressor
  JOURNAL   Biochem J 373 (Pt 3), 747-757 (2003)
   PUBMED   12741956
  REMARK    GeneRIF: identification as a transcriptional repressor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY099683.1, BM148156.1,
            BC042145.1 and AC104316.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014943.4.
            
            Summary: The members of the zinc fingers and homeoboxes gene family
            are nuclear homodimeric transcriptional repressors that interact
            with the A subunit of nuclear factor-Y (NF-YA) and contain two
            C2H2-type zinc fingers and five homeobox DNA-binding domains. This
            gene encodes member 2 of this gene family. In addition to forming
            homodimers, this protein heterodimerizes with member 1 of the zinc
            fingers and homeoboxes family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042145.1, SRR1660805.89009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314393.6/ ENSP00000314709.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 HY099683.1         2-8
            8-58                BM148156.1         5-55
            59-196              BM148156.1         57-194
            197-3318            BC042145.1         102-3223
            3319-3319           AC104316.3         95711-95711
            3320-3583           BC042145.1         3225-3488
            3584-3584           AC104316.3         95976-95976
            3585-4232           BC042145.1         3490-4137
            4233-4260           AC104316.3         96625-96652
            4261-4361           BC042145.1         4166-4266
FEATURES             Location/Qualifiers
     source          1..4361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..4361
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="zinc fingers and homeoboxes 2"
                     /db_xref="GeneID:22882"
                     /db_xref="HGNC:HGNC:18513"
                     /db_xref="MIM:609185"
     exon            1..292
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     exon            293..355
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     exon            356..3092
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..3088
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     fingers and homeoboxes protein 2; transcription factor
                     ZHX2; AFP regulator 1; regulator of AFP; alpha-fetoprotein
                     regulator 1; zinc finger and homeodomain protein 2"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 2 isoform 1"
                     /protein_id="NP_055758.1"
                     /db_xref="CCDS:CCDS6336.1"
                     /db_xref="GeneID:22882"
                     /db_xref="HGNC:HGNC:18513"
                     /db_xref="MIM:609185"
                     /translation="MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAK
                     DSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHP
                     NVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTN
                     HVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARL
                     VTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNAT
                     MINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMF
                     NGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSP
                     ITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQ
                     IAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAK
                     DQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVET
                     KLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTS
                     SLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCL
                     LKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEE
                     DLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTV
                     GEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA"
     exon            3093..4361
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4333..4338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="hexamer: AATAAA"
     regulatory      4345..4350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="hexamer: ACTAAA"
     polyA_site      4358
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
     polyA_site      4361
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="major polyA site"
ORIGIN      
        1 atgtgggttt tggcgtagat tccccactga tcgaggcatt ttttttccct ttttttttcc
       61 tttttttttt tcttttaaaa attttggcca tcgttctccg tacgggggct ttttctgtct
      121 gtctgtctgg ctggcaggct ggctttcccc ctctttccca cggagcccga gccgggcgcc
      181 cggtggggag tggggagtgg gtggggggag ccagcagagt tccattttgg aacgcccgtg
      241 ccgcgtctcc gcgttcccag cccgggtccc cgcgttcaca gccccagcgc aggtctggat
      301 gtaccgactg cttttggaat aaaaagattc ccaggatgtg agcaacacgg gaccgatatg
      361 atgcttcctg gtgtgtttag tggttggtgc cattccaatt ttctgtgctg aaatcattct
      421 gaaaactcaa acagtagact tcagcacaca aggaaagcca aagccatttg agggggaata
      481 aagccaaaag cctttcacct tattcgttcc aagaatctca ccgccccctc cttatccccc
      541 tccaaaaata agccattgca cacagacagg cagcatggct agcaaacgaa aatctacaac
      601 tccatgcatg gttcggacat cacaagtagt agaacaagat gtgcccgagg aagtagacag
      661 ggccaaagag aaaggaatcg gcacaccaca gcctgacgtg gccaaggaca gttgggcagc
      721 agaacttgaa aactcttcca aagaaaacga agtgatagag gtgaaatcta tgggggaaag
      781 ccagtccaaa aaactccaag gtggttatga gtgcaaatac tgcccctact ccacgcaaaa
      841 cctgaacgag ttcacggagc atgtcgacat gcagcatccc aacgtgattc tcaaccccct
      901 ctacgtgtgt gcagaatgta acttcacaac caaaaagtac gactccctat ccgaccacaa
      961 ctccaagttc catcccgggg aggccaactt caagctgaag ttaattaaac gcaataatca
     1021 aactgtcttg gaacagtcca tcgaaaccac caaccatgtc gtgtccatca ccaccagtgg
     1081 ccctggaact ggtgacagtg attctgggat ctcggtgagt aaaaccccca tcatgaagcc
     1141 tggaaaacca aaagcggatg ccaagaaggt gcccaagaag cccgaggaga tcacccccga
     1201 gaaccacgtg gaagggaccg cccgcctggt gacagacaca gctgagatcc tctcgagact
     1261 cggcggggtg gagctcctcc aagacacatt aggacacgtc atgccttctg tacagctgcc
     1321 accaaatatc aaccttgtgc ccaaggtccc tgtcccacta aatactacca aatacaactc
     1381 tgccctggat acaaatgcca cgatgatcaa ctctttcaac aagtttcctt acccgaccca
     1441 ggctgagttg tcctggctga cagctgcctc caaacaccca gaggagcaca tcagaatctg
     1501 gtttgccacc cagcgcttaa agcatggcat cagctggtcc ccagaagagg tggaggaggc
     1561 ccggaagaag atgttcaacg gcaccatcca gtcagtaccc ccgaccatca ctgtgctgcc
     1621 cgcccagttg gcccccacaa aggtgacgca gcccatcctc cagacggctc taccgtgcca
     1681 gatcctcggc cagactagcc tggtgctgac tcaggtgacc agcgggtcaa caaccgtctc
     1741 ttgctccccc atcacacttg ccgtggcagg agtcaccaac catggccaga agagaccctt
     1801 ggtgactccc caagctgccc ccgaacccaa gcgtccacac atcgctcagg tgccagagcc
     1861 cccacccaag gtggccaacc ccccgctcac accagccagt gaccgcaaga agacaaagga
     1921 gcagatagca catctcaagg ccagctttct ccagagccag ttccctgacg atgccgaggt
     1981 ttaccggctc atcgaggtga ctggccttgc caggagcgag atcaagaagt ggttcagtga
     2041 ccaccgatat cggtgtcaaa ggggcatcgt ccacatcacc agcgaatccc ttgccaaaga
     2101 ccagttggcc atcgcggcct cccgacacgg tcgcacgtat catgcgtacc cagactttgc
     2161 cccccagaag ttcaaagaga aaacacaggg tcaggttaaa atcttggaag acagcttttt
     2221 gaaaagttct tttcctaccc aagcagaact ggatcggcta agggtggaga ccaagctgag
     2281 caggagagag atcgactcct ggttctcgga gaggcggaag cttcgagaca gcatggaaca
     2341 agctgtcttg gattccatgg ggtctggcaa aaaaggccaa gatgtgggag cccccaatgg
     2401 tgctctgtct cgactcgacc agctctccgg tgcccagtta acaagttctc tgcccagccc
     2461 ttcgccagca attgcaaaaa gtcaagaaca ggttcatctc ctgaggagca cgtttgcaag
     2521 aacccagtgg cctactcccc aggagtacga ccagttagcg gccaagactg gcctggtccg
     2581 aactgagatt gtgcgttggt tcaaggagaa cagatgcttg ctgaaaacgg gaaccgtgaa
     2641 gtggatggag cagtaccagc accagcccat ggcagatgat cacggctacg atgccgtagc
     2701 aaggaaagca acaaaaccca tggccgagag cccaaagaac gggggtgatg tggttccaca
     2761 atattacaag gaccccaaaa agctctgcga agaggacttg gagaagttgg tgaccagggt
     2821 aaaagtaggc agcgagccag caaaagactg tttgccagca aagccctcag aggccacctc
     2881 agaccggtca gagggcagca gccgggacgg ccagggtagc gacgagaacg aggagtcgag
     2941 cgttgtggat tacgtggagg tgacggtcgg ggaggaggat gcgatctcag atagatcaga
     3001 tagctggagt caggctgcgg cagaaggtgt gtcggaactg gctgaatcag actccgactg
     3061 cgtccctgca gaggctggcc aggcctagac agggaagtct gttagaactg ctgtgctgat
     3121 caacgggacg ctccgtcttt gaagaaagaa gagatggtct ctccccagcc atgggccacc
     3181 cttgccagtg actccaagtg gaactactta gctcgcgtgt gcctggaggg tgcgggaagt
     3241 ccagcgactc tcagacgcac ctcccagagg accggtggga attgttcata gtgccaaagt
     3301 cctactactg cgttttcaat gggtccttgt acatagtttg ctcctctgcc ctagccctca
     3361 cctcttgcta tactggaacc gatttgtaca atgtgggaat tttgttacct ttttaatcaa
     3421 gggcaacttc cttttccagc actaccattg taaggttttt ttcaggaggg agggctaacc
     3481 accttgcttt tctcttttct ctttttcttt tttttatttt tgttttatta atttggggaa
     3541 aggggtgtta gcattagtgc catgatatct actggatttt aagtagggag actttatttt
     3601 taaaggtagg ttgaaatttg ggagatttct cggcaggaag ggctgaaatc caggcccctg
     3661 tctcaacttg gagagaggtg acagacggca gatcttccaa atcaaattcc tttccagttc
     3721 ttcccctggc tgcctttttg ggggtccctg ccttagcccc acacaaggct ttctgaactg
     3781 ccaagagggg atctggcttc tcaactgctc ggcctcttgg gccaggctgt gcccagccag
     3841 ccctgggaga actgggtagc aggtggctga cttctttaag cacctttcta aataccagca
     3901 gaagaggctc ccgcctctgt tagcatgatc agtactattg tgacattaaa acaacaacaa
     3961 taagatcttc ctatctggag ggtacagagg tgaatggctt tggttttcat ttctcttctt
     4021 cactgccttt tctcggtgtg gtatttgaca agattttagc tcaaagcctc accatgaatt
     4081 gatttttttt gtttgtgtgt gtgtttgttt tgggacaatt ttagatacct gagtgcactt
     4141 tttcagttag tcctaacttt taaaagaagg aaaaccaaga gacatatctg gtgtacgtgt
     4201 tgcagtatga actctggttg caatccctcc ccgtcccaca ctgcccccca tttgagtaca
     4261 ccgcacaagt caaacgctag gaagtttgaa taaaaccaat ttttctaact tgttgctcat
     4321 ttgttgtaac tcaataaagc aaagactaaa catttttata a
//
