LOCUS       NM_007222               4899 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc fingers and homeoboxes 1 (ZHX1), transcript
            variant 2, mRNA.
ACCESSION   NM_007222
VERSION     NM_007222.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4899)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4899)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4899)
  AUTHORS   Kwon,R.J., Han,M.E., Kim,Y.J., Kim,Y.H., Kim,J.Y., Liu,L., Heo,W.
            and Oh,S.O.
  TITLE     Roles of zinc-fingers and homeoboxes 1 during the proliferation,
            migration, and invasion of glioblastoma cells
  JOURNAL   Tumour Biol 39 (3), 1010428317694575 (2017)
   PUBMED   28351300
  REMARK    GeneRIF: together, this study demonstrates that ZHX1 plays crucial
            roles in the progression of glioblastoma, and its findings suggest
            that ZHX1 be viewed as a potential prognostic maker and therapeutic
            target of glioblastoma.
REFERENCE   4  (bases 1 to 4899)
  AUTHORS   Kwon,R.J., Kim,Y.H., Jeong,D.C., Han,M.E., Kim,J.Y., Liu,L.,
            Jung,J.S. and Oh,S.O.
  TITLE     Expression and prognostic significance of zinc fingers and
            homeoboxes family members in renal cell carcinoma
  JOURNAL   PLoS One 12 (2), e0171036 (2017)
   PUBMED   28152006
  REMARK    GeneRIF: ZHX1 expression is correlated with renal cell carcinoma
            progression and poor survival.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4899)
  AUTHORS   Wienk,H., Lammers,I., Hotze,A., Wu,J., Wechselberger,R.W.,
            Owens,R., Stammers,D.K., Stuart,D., Kaptein,R. and Folkers,G.E.
  TITLE     The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc
            finger structure with a C-terminal extension
  JOURNAL   Biochemistry 48 (21), 4431-4439 (2009)
   PUBMED   19348505
  REMARK    GeneRIF: structure of the tandem zinc-finger region of human ZHX1
REFERENCE   6  (bases 1 to 4899)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
  REMARK    GeneRIF: a search of ZHX1-interacting proteins using a yeast
            two-hybrid system
REFERENCE   7  (bases 1 to 4899)
  AUTHORS   Yamada,K., Kawata,H., Matsuura,K., Shou,Z., Hirano,S., Mizutani,T.,
            Yazawa,T., Yoshino,M., Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Functional analysis and the molecular dissection of zinc-fingers
            and homeoboxes 1 (ZHX1)
  JOURNAL   Biochem Biophys Res Commun 297 (2), 368-374 (2002)
   PUBMED   12237128
  REMARK    GeneRIF: This study characterized features of ZHX-1 involved in
            nuclear localization, dimerization, and transcriptional activity,
            and mapped these domains.
REFERENCE   8  (bases 1 to 4899)
  AUTHORS   Hirano,S., Yamada,K., Kawata,H., Shou,Z., Mizutani,T., Yazawa,T.,
            Kajitani,T., Sekiguchi,T., Yoshino,M., Shigematsu,Y., Mayumi,M. and
            Miyamoto,K.
  TITLE     Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear
            factor-YA-interacting nuclear protein, forms a homodimer
  JOURNAL   Gene 290 (1-2), 107-114 (2002)
   PUBMED   12062805
REFERENCE   9  (bases 1 to 4899)
  AUTHORS   Yamada,K., Osawa,H. and Granner,D.K.
  TITLE     Identification of proteins that interact with NF-YA
  JOURNAL   FEBS Lett 460 (1), 41-45 (1999)
   PUBMED   10571058
REFERENCE   10 (bases 1 to 4899)
  AUTHORS   Yamada,K., Printz,R.L., Osawa,H. and Granner,D.K.
  TITLE     Human ZHX1: cloning, chromosomal location, and interaction with
            transcription factor NF-Y
  JOURNAL   Biochem Biophys Res Commun 261 (3), 614-621 (1999)
   PUBMED   10441475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA238313.1, AF195766.1,
            CA776642.1, BC040481.1 and AK025236.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007222.4.
            
            Summary: The members of the zinc fingers and homeoboxes gene family
            are nuclear homodimeric transcriptional repressors that interact
            with the A subunit of nuclear factor-Y (NF-YA) and contain two
            C2H2-type zinc fingers and five homeobox DNA-binding domains. This
            gene encodes member 1 of this gene family. In addition to forming
            homodimers, this protein heterodimerizes with members 2 and 3 of
            the zinc fingers and homeoboxes family. Alternative splicing
            results in multiple transcript variants. Read-through transcription
            also exists between this gene and the downstream chromosome 8 open
            reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040481.1, AF195766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMN03267750
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395571.8/ ENSP00000378938.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA238313.1         202-237
            37-3512             AF195766.1         1-3476
            3513-3971           CA776642.1         136-594
            3972-4892           BC040481.1         3994-4914
            4893-4899           AK025236.1         2584-2590
FEATURES             Location/Qualifiers
     source          1..4899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..4899
                     /gene="ZHX1"
                     /note="zinc fingers and homeoboxes 1"
                     /db_xref="GeneID:11244"
                     /db_xref="HGNC:HGNC:12871"
                     /db_xref="MIM:604764"
     exon            1..70
                     /gene="ZHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..184
                     /gene="ZHX1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..3034
                     /gene="ZHX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..3031
                     /gene="ZHX1"
                     /note="zinc fingers and homeobox 1; zinc finger and
                     homeodomain protein 1"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 1"
                     /protein_id="NP_009153.3"
                     /db_xref="CCDS:CCDS6342.1"
                     /db_xref="GeneID:11244"
                     /db_xref="HGNC:HGNC:12871"
                     /db_xref="MIM:604764"
                     /translation="MASRRKSTTPCMVLASEQDPDLELISDLDEGPPVLTPVENTRAE
                     SISSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSY
                     VCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKE
                     ENAEQAESTEVSSSGISISKTPIMKMMKNKVENKRIAVHHNSVEDVPEEKENEIKPDR
                     EEIVENPSSSASESNTSTSIVNRIHPSTASTVVTPAAVLPGLAQVITAVSAQQNSNLI
                     PKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSA
                     QRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVG
                     QPGLVLTQVAGTNTLPVTAPIALTVAGVPSQNNIQKSQVPAAQPTAETKPATAAVPTS
                     QSVKHETALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEI
                     KKWFSDTRYNQRNSKSNQCLHLNNDSSTTIIIDSSDETTESPTVGTAQPKQSWNPFPD
                     FTPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKSKA
                     LKEEKMEIDESNAGSSKEEAGETSPADESGAPKSGSTGKICKKTPEQLHMLKSAFVRT
                     QWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSANSSSMNGLSSL
                     RKRGRGRPKGRGRGRPRGRPRGSKRINNWDRGPSLIKFKTGTAILKDYYLKHKFLNEQ
                     DLDELVNKSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSD
                     TWEPPRHVKRKLSKSDD"
     exon            3035..4899
                     /gene="ZHX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4588..4593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX1"
                     /note="hexamer: ATTAAA"
     polyA_site      4612
                     /gene="ZHX1"
                     /note="major polyA site"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX1"
                     /note="hexamer: AATAAA"
     polyA_site      4899
                     /gene="ZHX1"
ORIGIN      
        1 gaaaagtgca gccggtttga aatgcaagat ggcggcggcg tggcgctgag aggcgcggcg
       61 gcccctgcag gagaagacag actgctgctt tggacctgtt ggtaatgatg gcctgagcta
      121 aacatctaac tagaagggat acccttccat ttcaaagaac agaatgctaa ggaagctgtg
      181 gcaagtgatt ggagttgtgc ttcaaaaatt tcagaaattc agcagtattt tatctgccaa
      241 caataagctc tttacttgat tgcaccatga gaaagctgct aatgagactt gttgagcaca
      301 aaaatggact tgaagaacca aaagccattg ttttcaaatg aagaacactg aacagtttta
      361 agcctcgatg ctttttaatc accactgagc ttttcctcat aacatcagaa tggcaagcag
      421 gcgaaaatca acaacacctt gcatggtcct tgccagtgaa caagatccag accttgagtt
      481 gatatcagat ttggatgaag gtcctcctgt gcttacacct gtagaaaaca ccagagcaga
      541 gagtatctca agtgatgaag aggttcatga atctgtggat tcagacaatc agcaaaataa
      601 aaaagttgaa ggtggatatg aatgtaaata ttgtactttt caaactccag atctaaatat
      661 gtttactttt catgtggatt cggaacatcc caatgtagtg ctaaattcat cctatgtttg
      721 tgtcgaatgc aattttctta ccaaaaggta tgatgcactt tctgagcata atctgaaata
      781 tcacccagga gaagagaatt ttaagttgac tatggtgaaa cgtaataacc agacaatctt
      841 tgaacaaaca ataaatgatc tgacttttga tggtagtttt gttaaagagg agaatgcaga
      901 gcaagcagaa tctacagaag tttcttcttc gggaatatct atcagtaaaa ctcctatcat
      961 gaaaatgatg aaaaataaag tggaaaataa acggattgca gttcatcata actcagttga
     1021 ggacgttcct gaagagaaag agaatgaaat caaaccagac cgtgaagaaa ttgtagaaaa
     1081 tccaagttct tcagcttctg aatctaatac aagtacttcc attgtaaaca gaatacatcc
     1141 aagtactgcc agcacggtag tgacaccagc agcagttctt cctggattgg cacaggtgat
     1201 aactgctgta tctgctcagc agaattctaa tttgattccc aaagtcttaa tccctgttaa
     1261 tagcattccc acctacaatg ctgcattgga taacaatccc cttttactta acacctacaa
     1321 caagttccct tacccaacaa tgtcagaaat tacagttctt tctgctcaag caaaatatac
     1381 agaggaacag atcaagatat ggttttcagc ccaacgttta aaacatggtg ttagttggac
     1441 tcccgaggaa gtagaggagg caagaaggaa acaattcaat ggaacagtgc atactgtacc
     1501 tcagaccata actgttattc ctacacacat ttccacaggg agtaatggtt taccatctat
     1561 tttacagaca tgccaaatag ttggtcagcc tggtctggtc cttactcaag tggctggaac
     1621 aaacaccttg ccagttacag cacctatagc cttgacagtg gcaggcgttc caagtcaaaa
     1681 taatatacag aaaagtcagg tacctgctgc tcagcctact gcagaaacaa agccagcaac
     1741 agcagcagtt ccaacttctc aaagtgtcaa acatgaaact gcattggtaa accctgattc
     1801 atttggcatt cgggcaaaaa agacaaaaga gcaactggca gaattaaaag ttagctacct
     1861 taaaaatcag tttccccatg attcagaaat tatcagactt atgaaaataa caggcctgac
     1921 gaaaggagag attaaaaaat ggtttagtga cacaaggtac aaccagagaa attcaaagag
     1981 taatcagtgc ttacatctca acaatgattc ctctaccacc attattatag actccagtga
     2041 tgaaaccacg gaatccccaa ctgttggtac tgcacagcct aagcaatcct ggaatccttt
     2101 tcctgacttt actccccaaa agtttaaaga gaaaactgca gagcagcttc gtgtccttca
     2161 ggcaagtttt ctcaacagct ctgtacttac agatgaagaa ttaaataggt taagggcaca
     2221 aaccaaactt accagaagag aaatcgatgc ttggtttaca gagaagaaga aatcaaaagc
     2281 tttaaaggaa gagaaaatgg aaatagatga aagtaatgca ggtagttcca aagaagaagc
     2341 tggagaaact tctcctgcag atgaatctgg tgcacctaag tcagggagta caggcaagat
     2401 atgtaaaaaa acacctgagc agctgcacat gcttaagagt gcatttgtcc ggacacagtg
     2461 gccatcacca gaagagtatg acaagttggc caaagaaagc gggcttgcta gaacagacat
     2521 agttagttgg tttggggaca cccgttatgc ttggaagaat ggaaacttga aatggtacta
     2581 ctactatcag agcgccaatt caagtagtat gaatggtctg tcttccctta ggaaaagagg
     2641 gagagggaga cccaaaggac ggggaagagg aagaccgcgt gggcggccta gaggaagcaa
     2701 aagaattaac aactgggaca ggggaccatc actcataaaa tttaaaactg gaactgcaat
     2761 acttaaggat tattacctga agcacaagtt tcttaatgag caagaccttg atgaacttgt
     2821 taacaaatca catatgggct atgagcaggt cagagagtgg tttgcagaaa gacagagaag
     2881 atcagaatta ggtatagaat tatttgagga aaatgaggag gaagatgaag ttattgatga
     2941 ccaggaagag gatgaagaag aaacagatga tagtgacact tgggaacctc cacgacatgt
     3001 gaaacggaag ctgtctaaat cagatgactg aaatctgcct aaaacgttga aggagaatca
     3061 attcttcaac tcaagatgtc tgatttactg tgaatttgcc caatctttga tgacattgaa
     3121 aacgttttgg ggcatacaca ctcaaaaagc aggatccaat acccaaaaga aatggaactt
     3181 aatgttgtgc caaagttaaa ctactgcagt tggtggaagt tctgcaatgt aaatagaaca
     3241 ctaattaaaa aacaacttgt aaaaatgcaa tttaaatttt aatacagtac atttttcttc
     3301 taatatgatg gagacattct gaatcttaga ctttctgagg gggtttaatg accactagag
     3361 cttgtcctca tattcagtcc agtttaatac tgtatgtcta gtaagatggg ctatatattg
     3421 cctctattct ttgagatgtg attaagctta gaactttgac caaaaatttt acagtaaaaa
     3481 ttgttagaaa tgggtaaaaa aaaaaaaaaa aaaaaaaccc tgatttatta ctatgtctta
     3541 tttatcagac cctgcactaa gattaaaagt tgtgcatggg cttatacaat ttcaaatgta
     3601 aaaacagcct atttatatat gttgaaacaa taagatttta tggtttcact ggcccttaat
     3661 aattggatcc ttcattaaac acatccatga ataccactgt ttctactgtt acttgttcca
     3721 ttagaagctg atttgctttt tattaaactg caggaaatta attctgaaga aggaaaagaa
     3781 actgacatgg taatttggat agggtgaagc tttgaaataa atactgcacc aaaaatgtga
     3841 aaaagaatca cgtagtaaat gtatacttag tgttttctta caatcgtgga aatcagaaat
     3901 gtttatacag gtgtcagatc agaattttta agagttatct ttcagtgaaa ttttataaca
     3961 gtttcagtga atagagaaaa aattctgaac tgatcataat gagttaaaag ttagcttttc
     4021 acttatgaat catgggagtg ttaactgtta actcttgccg tatcaggaga ctgaaagttc
     4081 atactaattt acaaactttg taaagactgg tgctgttcat tcatattggg aagaaccctt
     4141 tcttttgtga ccataggacc atttttcaaa atgcgctttc ttcgtagaag aaatgttcag
     4201 tttaattagc tttggatttt aacatgtttt tctgaatgac cagatgtagg cttagccagt
     4261 ttattttctc taatttaatg gataataaat attaagctct tggttaaatg tttttcagcc
     4321 attgaaaatg ttatgaaaaa gccttgaata tgcatgctgc tttcattttt ataaactttt
     4381 tattttttaa ctatagcttt attagtaatt ccaaaatgct gcaatgtagc tgatttcctc
     4441 actcagacag ctggctttgt gggtggcttt tttcatacta ctgttaactt ttttaaaaaa
     4501 gaagcaatgt aaagaccgta atgcactaag cttttttttt ttcttttaca cgtttaaaaa
     4561 cttcttaaag cactctgtaa tataatgatt aaattgctcc cttttataaa cattgctaat
     4621 gtggtctgag ttttgtttga caataatttt aatgttctca aaatttgaaa tgtcaagtat
     4681 tagaaatgaa gcctttgaat atagttgttt cccttgcaat atgttaactc tgtgtagctg
     4741 tatataacta ttaatttccc tcatctcttt tataggcctg ataaaactct tctctgacgt
     4801 ttgctagctt ttaaatatat ttatttgaca gagcaaaaga accctcttct ggttgattgt
     4861 gaccttgaat acaaaataaa agtagtgatt agtagttta
//
