LOCUS       NM_001204180            1324 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ZHX1-C8orf76 readthrough (ZHX1-C8orf76), mRNA.
ACCESSION   NM_001204180
VERSION     NM_001204180.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018992.6, BP340117.1 and BC012379.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001204180.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring zinc fingers and homeoboxes 1
            (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The
            read-through transcript encodes a protein that shares sequence
            identity with the downstream gene, but it has a distinct N-terminus
            encoded by exon structure from the upstream gene. [provided by
            RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 11244, 84933
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC018992.6         32786-32787
            3-70                BP340117.1         2-69
            71-1324             BC012379.2         2-1255
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..1324
                     /gene="ZHX1-C8orf76"
                     /note="ZHX1-C8orf76 readthrough"
                     /db_xref="GeneID:100533106"
                     /db_xref="HGNC:HGNC:42975"
     exon            1..70
                     /gene="ZHX1-C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            71..184
                     /gene="ZHX1-C8orf76"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1042
                     /gene="ZHX1-C8orf76"
                     /note="ZHX1-C8orf76 readthrough transcript protein; zinc
                     fingers and homeoboxes protein 1"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 1, isoform
                     2"
                     /protein_id="NP_001191109.1"
                     /db_xref="GeneID:100533106"
                     /db_xref="HGNC:HGNC:42975"
                     /translation="MLRKLWQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQE
                     YSSISEKLSSTNFAMKRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLTTVLY
                     LQLAICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLGPALSAALASSQKQH
                     SFTSSDKTIKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNIQNCMA
                     EKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDKMKGFSFKE
                     DTLLLIAEVSVSLGFM"
     exon            185..280
                     /gene="ZHX1-C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            281..424
                     /gene="ZHX1-C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            425..882
                     /gene="ZHX1-C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1324
                     /gene="ZHX1-C8orf76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX1-C8orf76"
                     /note="hexamer: AATAAA"
     polyA_site      1324
                     /gene="ZHX1-C8orf76"
                     /note="major polyA site"
ORIGIN      
        1 gaaaagtgca gccggtttga aatgcaagat ggcggcggcg tggcgctgag aggcgcggcg
       61 gcccctgcag gagaagacag actgctgctt tggacctgtt ggtaatgatg gcctgagcta
      121 aacatctaac tagaagggat acccttccat ttcaaagaac agaatgctaa ggaagctgtg
      181 gcaatggttt tatgaagaaa cagaaagcag tgatgatgtt gaagtgctga ctctcaagaa
      241 attcaaagga gacctggcct acagacgaca agagtatcag aaagcactgc aggagtattc
      301 cagtatctct gaaaaattgt catcaaccaa ttttgccatg aaaagggatg tccaggaagg
      361 tcaggctcgg tgtctggctc acctgggtag gcatatggag gcgctggaga ttgctgcaaa
      421 cttggaaaat aaagcaacca acacagacca tttaaccacg gtactctacc tccagcttgc
      481 tatttgttca agtttgcaga acttggagaa aacaattttc tgcctgcaga aactgatttc
      541 tttgcatcct tttaatcctt ggaactgggg caaattggca gaggcttacc tgaatctggg
      601 gccagctctt tcagcagcac ttgcgtcatc tcagaaacag cacagtttca cctcaagtga
      661 caaaactatc aaatccttct ttccacactc aggaaaagac tgtcttttgt gttttcctga
      721 aaccttgcct gagagctctt tattttctgt ggaagcgaat agcagtaata gccagaaaaa
      781 tgagaaagct ctgacaaata tccaaaactg tatggcagaa aagagagaaa cagtgttgat
      841 agagactcag ctgaaagcat gtgcctcttt tatacgaacc aggcttctgc ttcagtttac
      901 ccaacctcag caaacatcgt ttgctttgga gaggaactta aggactcagc aggaaattga
      961 agataaaatg aaagggttca gcttcaaaga agacactttg ctgttgatag ctgaggtgag
     1021 tgtatccctc gggtttatgt gaaacgaagc atcatagata ttttccctgg ctctgatagc
     1081 attttttata aagcagggcc aaatttaatc tactgaagga cttgtctccc tcctctgtgt
     1141 gccttttgat cactcagcaa tcaccaaggc ggcctcttga tcggcattcc cctgcagcgt
     1201 gcgggaccgc aggggctgtg tttcatgtac ttgtcagtgc ttgttagcac ctgcctgcct
     1261 gaacatcatc aatgcccaat aattgtttgt ttcagtgctg aataaatgaa tgaatgaatg
     1321 ctta
//
