LOCUS       NP_852150                511 aa            linear   PRI 30-APR-2025
DEFINITION  zinc finger CCCH-type with G patch domain-containing protein
            isoform c [Homo sapiens].
ACCESSION   NP_852150
VERSION     NP_852150.2
DBSOURCE    REFSEQ: accession NM_181485.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 511)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (residues 1 to 511)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 511)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 511)
  AUTHORS   Chen,Z., Gui,B., Zhang,Y., Xie,G., Li,W., Liu,S., Xu,B., Wu,C.,
            He,L., Yang,J., Yi,X., Yang,X., Sun,L., Liang,J. and Shang,Y.
  TITLE     Identification of a 35S U4/U6.U5 tri-small nuclear
            ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome
            assembly
  JOURNAL   J Biol Chem 292 (44), 18113-18128 (2017)
   PUBMED   28878014
  REMARK    GeneRIF: Data suggest that ZIP, USP39, Prp24/p100/SART3, and Prp43
            associate to form complex instrumental in spliceosome assembly; ZIP
            regulates pre-mRNA splicing of USP39 independent of RNA binding;
            stable 35S tri-snRNP particles are enriched in Cajal body. (USP39 =
            ubiquitin specific peptidase 39; SART3 = squamous cell carcinoma
            antigen recognised by T cells 3; Prp43 = RNA helicase Prp43)
REFERENCE   5  (residues 1 to 511)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 511)
  AUTHORS   Feng,T. and Zhu,X.
  TITLE     Genome-wide searching of rare genetic variants in WTCCC data
  JOURNAL   Hum Genet 128 (3), 269-280 (2010)
   PUBMED   20549515
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (residues 1 to 511)
  AUTHORS   Yu,W., Li,R., Gui,B. and Shang,Y.
  TITLE     sZIP, an alternative splice variant of ZIP, antagonizes
            transcription repression and growth inhibition by ZIP
  JOURNAL   J Biol Chem 285 (19), 14301-14307 (2010)
   PUBMED   20233718
  REMARK    GeneRIF: sZIP, an alternative splice variant of ZIP, antagonizes
            transcription repression and growth inhibition by ZIP in liver
            neoplasms.
REFERENCE   8  (residues 1 to 511)
  AUTHORS   Amre,D.K., Mack,D.R., Morgan,K., Fujiwara,M., Israel,D.,
            Deslandres,C., Seidman,E.G., Lambrette,P., Costea,I., Krupoves,A.,
            Fegury,H., Dong,J., Grimard,G. and Levy,E.
  TITLE     Investigation of reported associations between the 20q13 and 21q22
            loci and pediatric-onset Crohn's disease in Canadian children
  JOURNAL   Am J Gastroenterol 104 (11), 2824-2828 (2009)
   PUBMED   19623168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (residues 1 to 511)
  AUTHORS   Li,R., Zhang,H., Yu,W., Chen,Y., Gui,B., Liang,J., Wang,Y., Sun,L.,
            Yang,X., Zhang,Y., Shi,L., Li,Y. and Shang,Y.
  TITLE     ZIP: a novel transcription repressor, represses EGFR oncogene and
            suppresses breast carcinogenesis
  JOURNAL   EMBO J 28 (18), 2763-2776 (2009)
   PUBMED   19644445
REFERENCE   10 (residues 1 to 511)
  AUTHORS   Kugathasan,S., Baldassano,R.N., Bradfield,J.P., Sleiman,P.M.,
            Imielinski,M., Guthery,S.L., Cucchiara,S., Kim,C.E.,
            Frackelton,E.C., Annaiah,K., Glessner,J.T., Santa,E., Willson,T.,
            Eckert,A.W., Bonkowski,E., Shaner,J.L., Smith,R.M., Otieno,F.G.,
            Peterson,N., Abrams,D.J., Chiavacci,R.M., Grundmeier,R., Mamula,P.,
            Tomer,G., Piccoli,D.A., Monos,D.S., Annese,V., Denson,L.A.,
            Grant,S.F. and Hakonarson,H.
  TITLE     Loci on 20q13 and 21q22 are associated with pediatric-onset
            inflammatory bowel disease
  JOURNAL   Nat Genet 40 (10), 1211-1215 (2008)
   PUBMED   18758464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA848516.1, BC032612.1, AL121845.20 and BC019338.1.
            
            On Mar 22, 2007 this sequence version replaced NP_852150.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the middle portion of the
            coding region, compared to variant 1. This results in a shorter
            protein (isoform c), compared to isoform a. Variants 3, 4 and 5
            encode the same isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032612.1, SRR11853563.20868.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355969.11/ ENSP00000348242.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     Protein         1..511
                     /product="zinc finger CCCH-type with G patch
                     domain-containing protein isoform c"
                     /note="zinc finger CCCH-type with G patch
                     domain-containing protein; g patch domain-containing
                     protein 6; zinc finger CCCH domain-containing protein 9;
                     zinc finger and G patch domain-containing protein; zinc
                     finger, CCCH-type with G patch domain"
                     /calculated_mol_wt=55369
     Region          178..198
                     /region_name="zf-CCCH_4"
                     /note="CCCH-type zinc finger; pfam18044"
                     /db_xref="CDD:465626"
     Region          214..268
                     /region_name="Tudor_ZGPAT"
                     /note="Tudor domain found in zinc finger CCCH-type with G
                     patch domain-containing protein (ZGPAT) and similar
                     proteins; cd20384"
                     /db_xref="CDD:410455"
     Site            order(228,232,234,250,254,256)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410455"
     Region          313..355
                     /region_name="G-patch"
                     /note="G-patch domain; pfam01585"
                     /db_xref="CDD:396249"
     CDS             1..511
                     /gene="ZGPAT"
                     /gene_synonym="GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9;
                     ZIP"
                     /coded_by="NM_181485.3:109..1644"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS13535.1"
                     /db_xref="GeneID:84619"
                     /db_xref="HGNC:HGNC:15948"
                     /db_xref="MIM:619577"
ORIGIN      
        1 mdeeslesal qtyraqlqqv elalgaglds seqadlrqlq gdlkelielt easlvsvrks
       61 sllaaldeer pgrqedaeyq afreaiteav eapaaargsg setvpkaeag pesaaggqee
      121 eegedeeels gtkvsapyys swgtleyhna mvvgteeaed gsagvrvlyl ypthkslkpc
      181 pfflegkcrf kencrfshgq vvsldelrpf qdpdlsslqa gsaclakhqd glwhaaritd
      241 vdngyytvkf dslllreavv egdgilpplr teatesdsds dgtgdssyar vvgsdavdsg
      301 tcssafagwe vhtrgigsrl ltkmgyefgk glgrhaegrv epihavvlpr gksldqcvet
      361 lqkqtrvgka gtnkpprcrg rgarpggrpa prnvfdflne klqgqapgal eagaapagrr
      421 skdmyhasks akralslrlf qteekiertq rdirsiqeal arnagrhsva saqlqeklag
      481 aqrqlgqlra qeaglqqeqr kadthkkmte f
//
