LOCUS       NM_001409033            1440 bp    mRNA    linear   PRI 14-FEB-2025
DEFINITION  Homo sapiens zinc finger GATA like protein 1 (ZGLP1), transcript
            variant 2, mRNA.
ACCESSION   NM_001409033
VERSION     NM_001409033.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1440)
  AUTHORS   Kousathanas,A., Pairo-Castineira,E., Rawlik,K., Stuckey,A.,
            Odhams,C.A., Walker,S., Russell,C.D., Malinauskas,T., Wu,Y.,
            Millar,J., Shen,X., Elliott,K.S., Griffiths,F., Oosthuyzen,W.,
            Morrice,K., Keating,S., Wang,B., Rhodes,D., Klaric,L., Zechner,M.,
            Parkinson,N., Siddiq,A., Goddard,P., Donovan,S., Maslove,D.,
            Nichol,A., Semple,M.G., Zainy,T., Maleady-Crowe,F., Todd,L.,
            Salehi,S., Knight,J., Elgar,G., Chan,G., Arumugam,P., Patch,C.,
            Rendon,A., Bentley,D., Kingsley,C., Kosmicki,J.A., Horowitz,J.E.,
            Baras,A., Abecasis,G.R., Ferreira,M.A.R., Justice,A., Mirshahi,T.,
            Oetjens,M., Rader,D.J., Ritchie,M.D., Verma,A., Fowler,T.A.,
            Shankar-Hari,M., Summers,C., Hinds,C., Horby,P., Ling,L.,
            McAuley,D., Montgomery,H., Openshaw,P.J.M., Elliott,P., Walsh,T.,
            Tenesa,A., Fawkes,A., Murphy,L., Rowan,K., Ponting,C.P., Vitart,V.,
            Wilson,J.F., Yang,J., Bretherick,A.D., Scott,R.H., Hendry,S.C.,
            Moutsianas,L., Law,A., Caulfield,M.J. and Baillie,J.K.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   2  (bases 1 to 1440)
  AUTHORS   Nagaoka,S.I., Nakaki,F., Miyauchi,H., Nosaka,Y., Ohta,H.,
            Yabuta,Y., Kurimoto,K., Hayashi,K., Nakamura,T., Yamamoto,T. and
            Saitou,M.
  TITLE     ZGLP1 is a determinant for the oogenic fate in mice
  JOURNAL   Science 367 (6482) (2020)
   PUBMED   32054698
REFERENCE   3  (bases 1 to 1440)
  AUTHORS   Matikainen,N., Bjornson,E., Soderlund,S., Boren,C., Eliasson,B.,
            Pietilainen,K.H., Bogl,L.H., Hakkarainen,A., Lundbom,N.,
            Rivellese,A., Riccardi,G., Despres,J.P., Almeras,N., Holst,J.J.,
            Deacon,C.F., Boren,J. and Taskinen,M.R.
  TITLE     Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial
            Lipemia in Obese Men
  JOURNAL   PLoS One 11 (1), e0145890 (2016)
   PUBMED   26752550
  REMARK    GeneRIF: There is minor contribution of endogenous GLP-1 and GLP-2
            to postprandial lipemia in obese men.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1440)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 1440)
  AUTHORS   Li,S., Lu,M.M., Zhou,D., Hammes,S.R. and Morrisey,E.E.
  TITLE     GLP-1: a novel zinc finger protein required in somatic cells of the
            gonad for germ cell development
  JOURNAL   Dev Biol 301 (1), 106-116 (2007)
   PUBMED   16982049
  REMARK    GeneRIF: Characterization and functional analysis of the mouse
            GLP-1 ortholog, and comparison to the human protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011511.12.
            
            Summary: ZGLP1 encodes an evolutionary conserved transcriptional
            regulator with GATA-like zinc fingers. In females, it is expressed
            in embryonic germ cells and is essential for oogenic fate
            determination. It acts downstream of bone morphogenetic protein
            (BMP) and is involved in the regulation of genes involved in RNA
            processing, transcription and chromatin modification,
            retrotransposon regulation, meiotic cell cycle, and oocyte
            development. In males it is not required for the germ cell sex
            determination but is required by the spermatogonia for efficiently
            completing the meiotic prophase. [provided by RefSeq, Jul 2022].
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR990792.1, SRR1660809.273398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000707000.1/ ENSP00000516709.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AC011511.12        123992-124458       c
            468-833             AC011511.12        122828-123193       c
            834-940             AC011511.12        120489-120595       c
            941-1034            AC011511.12        120033-120126       c
            1035-1440           AC011511.12        119446-119851       c
FEATURES             Location/Qualifiers
     source          1..1440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1440
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /note="zinc finger GATA like protein 1"
                     /db_xref="GeneID:100125288"
                     /db_xref="HGNC:HGNC:37245"
                     /db_xref="MIM:611639"
     exon            1..467
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1152
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /note="isoform 2 is encoded by transcript variant 2; GATA
                     zinc finger domain containing 3; GATA-type zinc finger
                     protein 1; GATA-like protein 1"
                     /codon_start=1
                     /product="GATA-type zinc finger protein 1 isoform 2"
                     /protein_id="NP_001395962.1"
                     /db_xref="GeneID:100125288"
                     /db_xref="HGNC:HGNC:37245"
                     /db_xref="MIM:611639"
                     /translation="MEAEPIPDSSMPAKLLAPPCLNLERLGGSPSQEKPRTPGCCRIS
                     ERSLWPACQESVTALCFLQETVERLGQSPAQDTPVLGPCWDPMALGTQGRLLLDRDSK
                     DTQTRISQKGRRLQPPGTPSAPPQRRPRKQLNPCRGTERVDPGFEGVTLKFQIKPDSS
                     LQIIPTYSLPCSSRSQESPADAVGGPAAHPGGTEAHSAGSEALEPRRCASCRTQRTPL
                     WRDAEDGTPLCNACGIRYKKYGTRCSSCWLVPRKNVQPKRLCGRCGVSLDPIQEG"
     exon            468..833
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..940
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1034
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1440
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1416..1421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="ZGLP1"
                     /gene_synonym="GATAD3; GLP-1; GLP1"
                     /note="major polyA site"
ORIGIN      
        1 ctaagatgcc gctggggatc caaggcagag gcctgggagc ccccatttcc gagggggagg
       61 gctagcgtgg aaggccccgc cccggcagct gcggagggat ttggtggggt ccaggccgcc
      121 cttgccacgc aggggtgcgc ggatgacctg aaaaaagcca gaaagaggaa aggtgccgcc
      181 gaggctggtc gctctcagct ggggctcatc gcatcctcta ccaagagcgc tcccaccaca
      241 caggtcccgc ccctcccagg tgggtttcat cgggtgggcc cagcgggaca gggccgggtg
      301 aaattaggga gggggctggg ctggggcgca atggaggccg agccaatccc ggactcctca
      361 atgccagcaa agcttctggc gccgccctgt ctgaacctgg agcggctggg aggatccccc
      421 tcccaggaga agccgaggac cccaggatgc tgcagaatca gtgagaggtc cctctggcct
      481 gcatgccagg agtcggtcac cgccctgtgc ttcctccaag agacagtgga gaggctgggt
      541 cagtcccctg cccaggacac cccggtcctg gggccttgct gggacccgat ggctctgggg
      601 actcagggcc gcctgctgct ggacagggat tccaaggaca cacagaccag gatcagccaa
      661 aagggccgcc gtctgcagcc cccggggact ccctcggccc caccccagag aaggccccgg
      721 aaacagctga acccctgccg gggcaccgag agagtggacc ctgggttcga gggggtgact
      781 ctgaagtttc agataaagcc ggactccagc ctgcagatca tccccacgta cagcctgccc
      841 tgcagtagcc gttctcagga atcccctgca gatgctgttg ggggccctgc agcccaccca
      901 ggaggcaccg aggcccactc agcaggcagc gaggccctgg agccccggcg ctgtgcttcc
      961 tgtcggaccc agaggacccc gctctggaga gacgctgaag atgggacccc tctctgcaac
     1021 gcctgtggga tcaggtacaa gaaatacggc actcgctgct ccagctgctg gctggtgccc
     1081 aggaaaaatg tccagcccaa gaggctatgt ggcagatgtg gagtgtccct ggaccccatt
     1141 caggaaggtt aaacccagct tcaccctgct gagctgctgc ttctgcctcc gtttcaccag
     1201 tgggagaatg ggcagaagca gctctcctag gaggattggg gaaagagccg gcctgcctcc
     1261 tctctgccat ctccagattc aaggatcccg ggggaagacc caggcctcag gtggcagagc
     1321 ctgctagggg tcaccagccc cttctccagt cagccttggc cgaggccccc tcaggagacg
     1381 ctctcaggaa ggatgagcat tgttacagca gggacaataa agtacagaga tatgccgaga
//
