LOCUS       NM_145252                689 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zymogen granule protein 16B (ZG16B), mRNA.
ACCESSION   NM_145252
VERSION     NM_145252.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 689)
  AUTHORS   Ghosh,S., Ahearn,C.P., Isabella,C.R., Marando,V.M., Dodge,G.J.,
            Bartlett,H., McPherson,R.L., Dugan,A.E., Jain,S., Neznanova,L.,
            Tettelin,H., Putnik,R., Grimes,C.L., Ruhl,S., Kiessling,L.L. and
            Imperiali,B.
  TITLE     Human oral lectin ZG16B acts as a cell wall polysaccharide probe to
            decode host-microbe interactions with oral commensals
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2216304120 (2023)
   PUBMED   37216558
  REMARK    GeneRIF: Human oral lectin ZG16B acts as a cell wall polysaccharide
            probe to decode host-microbe interactions with oral commensals.
REFERENCE   2  (bases 1 to 689)
  AUTHORS   Youn,S.E., Jiang,F., Won,H.Y., Hong,D.E., Kang,T.H., Park,Y.Y. and
            Koh,S.S.
  TITLE     PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively
            via the TLR4/MyD88/NF-kappaB Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (19), 11414 (2022)
   PUBMED   36232715
  REMARK    GeneRIF: PAUF Induces Migration of Human Pancreatic Cancer Cells
            Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 689)
  AUTHORS   Yoo,W., Choi,H., Son,Y.H., Lee,J., Jo,S., Jung,D., Kim,Y.J.,
            Koh,S.S., Yang,Y.R., Kwon,E.S., Lee,K.P., Noh,K.H., Kim,K.W.,
            Ko,Y., Jun,E., Kim,S.C. and Kim,S.
  TITLE     Pancreatic cancer induces muscle wasting by promoting the release
            of pancreatic adenocarcinoma upregulated factor
  JOURNAL   Exp Mol Med 53 (3), 432-445 (2021)
   PUBMED   33731895
  REMARK    GeneRIF: Pancreatic cancer induces muscle wasting by promoting the
            release of pancreatic adenocarcinoma upregulated factor.
REFERENCE   4  (bases 1 to 689)
  AUTHORS   Escudero-Paniagua,B., Bartolome,R.A., Rodriguez,S., De Los Rios,V.,
            Pintado,L., Jaen,M., Lafarga,M., Fernandez-Acenero,M.J. and
            Casal,J.I.
  TITLE     PAUF/ZG16B promotes colorectal cancer progression through
            alterations of the mitotic functions and the Wnt/beta-catenin
            pathway
  JOURNAL   Carcinogenesis 41 (2), 203-213 (2020)
   PUBMED   31095674
  REMARK    GeneRIF: PAUF/ZG16B promotes colorectal cancer progression through
            alterations of the mitotic functions and the Wnt/beta-catenin
            pathway.
REFERENCE   5  (bases 1 to 689)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 689)
  AUTHORS   Mullins,J.J., Mullins,L.J., Dunbar,D.R., Brammar,W.J., Gross,K.W.
            and Morley,S.D.
  TITLE     Identification of a human ortholog of the mouse Dcpp gene locus,
            encoding a novel member of the CSP-1/Dcpp salivary protein family
  JOURNAL   Physiol Genomics 28 (1), 129-140 (2006)
   PUBMED   16954406
  REMARK    GeneRIF: Bioinformatic analysis identified a putative human
            CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human
            salivary tissue, that shows 31% amino acid identity and 45% amino
            acid similarity to the mouse Dcpp query sequence.
REFERENCE   7  (bases 1 to 689)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   8  (bases 1 to 689)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 689)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 689)
  AUTHORS   Kuster,B., Mortensen,P., Andersen,J.S. and Mann,M.
  TITLE     Mass spectrometry allows direct identification of proteins in large
            genomes
  JOURNAL   Proteomics 1 (5), 641-650 (2001)
   PUBMED   11678034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005361.1.
            
            On Jul 31, 2020 this sequence version replaced NM_145252.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359021.1, BP334554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000382280.8/
                                                ENSP00000371715.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC005361.1         9381-9406           c
            27-105              AC005361.1         9216-9294           c
            106-208             AC005361.1         8913-9015           c
            209-689             AC005361.1         7433-7913           c
FEATURES             Location/Qualifiers
     source          1..689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..689
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /note="zymogen granule protein 16B"
                     /db_xref="GeneID:124220"
                     /db_xref="HGNC:HGNC:30456"
                     /db_xref="MIM:620477"
     exon            1..26
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /inference="alignment:Splign:2.1.0"
     exon            27..105
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..572
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /note="jacalin-like lectin domain containing 2; pancreatic
                     adenocarcinoma upregulated factor; endocrine and exocrine
                     protein; zymogen granule protein 16 homolog B; pancreatic
                     adenocarcinoma up-regulated factor"
                     /codon_start=1
                     /product="pancreatic adenocarcinoma up-regulated factor
                     precursor"
                     /protein_id="NP_660295.3"
                     /db_xref="CCDS:CCDS10479.3"
                     /db_xref="GeneID:124220"
                     /db_xref="HGNC:HGNC:30456"
                     /db_xref="MIM:620477"
                     /translation="MLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVS
                     VGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMYTS
                     KDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWNYPLEEPTTEPPV
                     NLTYSANSPVGR"
     exon            106..208
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /inference="alignment:Splign:2.1.0"
     exon            209..689
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /inference="alignment:Splign:2.1.0"
     regulatory      672..677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /note="hexamer: AATAAA"
     polyA_site      689
                     /gene="ZG16B"
                     /gene_synonym="EECP; HRPE773; JCLN2; PAUF; PRO1567"
                     /note="major polyA site"
ORIGIN      
        1 caaccagacg cccagtcaca ggcgagagcc ctgggatgca ccggccagag gccatgctgc
       61 tgctgctcac gcttgccctc ctggggggcc ccacctgggc agggaagatg tatggccctg
      121 gaggaggcaa gtatttcagc accactgaag actacgacca tgaaatcaca gggctgcggg
      181 tgtctgtagg tcttctcctg gtgaaaagtg tccaggtgaa acttggagac tcctgggacg
      241 tgaaactggg agccttaggt gggaataccc aggaagtcac cctgcagcca ggcgaataca
      301 tcacaaaagt ctttgtcgcc ttccaagctt tcctccgggg tatggtcatg tacaccagca
      361 aggaccgcta tttctatttt gggaagcttg atggccagat ctcctctgcc taccccagcc
      421 aagaggggca ggtgctggtg ggcatctatg gccagtatca actccttggc atcaagagca
      481 ttggctttga atggaattat ccactagagg agccgaccac tgagccacca gttaatctca
      541 catactcagc aaactcaccc gtgggtcgct agggtggggt atggggccat ccgagctgag
      601 gccatctggg tggtggtggc tgatggtact ggagtaactg agtcgggacg ctgaatctga
      661 atccaccaat aaataaaggt tctgcagaa
//
