LOCUS       NM_004799               5148 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens zinc finger FYVE-type containing 9 (ZFYVE9),
            transcript variant 3, mRNA.
ACCESSION   NM_004799
VERSION     NM_004799.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5148)
  AUTHORS   Porcu,L., Fichera,M., Nanetti,L., Rulli,E., Giunti,P.,
            Parkinson,M.H., Durr,A., Ewenczyk,C., Boesch,S., Nachbauer,W.,
            Indelicato,E., Klopstock,T., Stendel,C., Rodriguez de Rivera,F.J.,
            Schols,L., Fleszar,Z., Giordano,I., Didszun,C., Castaldo,A.,
            Rai,M., Klockgether,T., Pandolfo,M., Schulz,J.B., Reetz,K. and
            Mariotti,C.
  CONSRTM   EFACTS Study Group
  TITLE     Longitudinal changes of SARA scale in Friedreich ataxia: Strong
            influence of baseline score and age at onset
  JOURNAL   Ann Clin Transl Neurol 10 (11), 2000-2012 (2023)
   PUBMED   37641437
  REMARK    GeneRIF: Longitudinal changes of SARA scale in Friedreich ataxia:
            Strong influence of baseline score and age at onset.
REFERENCE   2  (bases 1 to 5148)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5148)
  AUTHORS   Wojtowicz,S., Lee,S., Chan,E., Ng,E., Campbell,C.I. and Di
            Guglielmo,G.M.
  TITLE     SMURF2 and SMAD7 induce SARA degradation via the proteasome
  JOURNAL   Cell Signal 72, 109627 (2020)
   PUBMED   32283253
  REMARK    GeneRIF: SMURF2 and SMAD7 induce SARA degradation via the
            proteasome.
REFERENCE   4  (bases 1 to 5148)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5148)
  AUTHORS   Tang,W.B., Ling,G.H., Sun,L. and Liu,F.Y.
  TITLE     Smad anchor for receptor activation (SARA) in TGF-beta signaling
  JOURNAL   Front Biosci (Elite Ed) 2 (3), 857-860 (2010)
   PUBMED   20515759
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5148)
  AUTHORS   Panopoulou,E., Gillooly,D.J., Wrana,J.L., Zerial,M., Stenmark,H.,
            Murphy,C. and Fotsis,T.
  TITLE     Early endosomal regulation of Smad-dependent signaling in
            endothelial cells
  JOURNAL   J Biol Chem 277 (20), 18046-18052 (2002)
   PUBMED   11877415
  REMARK    GeneRIF: Expression of a SARA mutant protein lacking the FYVE
            finger inhibits downstream activin A signaling in endothelial
            cells.
REFERENCE   7  (bases 1 to 5148)
  AUTHORS   Souchelnytskyi,S., Ronnstrand,L., Heldin,C.H. and ten Dijke,P.
  TITLE     Phosphorylation of Smad signaling proteins by receptor
            serine/threonine kinases
  JOURNAL   Methods Mol Biol 124, 107-120 (2001)
   PUBMED   11100470
REFERENCE   8  (bases 1 to 5148)
  AUTHORS   Wu,G., Chen,Y.G., Ozdamar,B., Gyuricza,C.A., Chong,P.A.,
            Wrana,J.L., Massague,J. and Shi,Y.
  TITLE     Structural basis of Smad2 recognition by the Smad anchor for
            receptor activation
  JOURNAL   Science 287 (5450), 92-97 (2000)
   PUBMED   10615055
REFERENCE   9  (bases 1 to 5148)
  AUTHORS   Tsukazaki,T., Chiang,T.A., Davison,A.F., Attisano,L. and Wrana,J.L.
  TITLE     SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta
            receptor
  JOURNAL   Cell 95 (6), 779-791 (1998)
   PUBMED   9865696
REFERENCE   10 (bases 1 to 5148)
  AUTHORS   Meckelein,B., Marshall,D.C., Conn,K.J., Pietropaolo,M., Van
            Nostrand,W. and Abraham,C.R.
  TITLE     Identification of a novel serine protease-like molecule in human
            brain
  JOURNAL   Brain Res Mol Brain Res 55 (2), 181-197 (1998)
   PUBMED   9582421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139156.11, DR005493.1,
            AF130419.1 and BC032680.1.
            
            On Aug 13, 2020 this sequence version replaced NM_004799.3.
            
            Summary: This gene encodes a double zinc finger motif-containing
            protein that participates in the transforming growth factor-beta
            (TGFB) signalling pathway. The encoded protein interacts directly
            with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor.
            There are multiple pseudogenes for this gene on chromosomes 2, 15,
            and X. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (3) represents the longer
            transcript and encodes the longer isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3877756.1,
                                           SRR14038192.302550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287727.8/ ENSP00000287727.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL139156.11        61328-61337
            11-285              DR005493.1         8-282
            286-454             AF130419.1         1-169
            455-5148            BC032680.1         9-4702
FEATURES             Location/Qualifiers
     source          1..5148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..5148
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /note="zinc finger FYVE-type containing 9"
                     /db_xref="GeneID:9372"
                     /db_xref="HGNC:HGNC:6775"
                     /db_xref="MIM:603755"
     exon            1..315
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            316..421
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            422..527
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..4735
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /note="isoform 3 is encoded by transcript variant 3; MAD,
                     mothers against decapentaplegic homolog interacting
                     protein, receptor activation anchor; smad anchor for
                     receptor activation; MADH-interacting protein; novel
                     serine protease; zinc finger, FYVE domain containing 9;
                     zinc finger FYVE domain-containing protein 9; protein
                     phosphatase 1, regulatory subunit 173"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 9
                     isoform 3"
                     /protein_id="NP_004790.2"
                     /db_xref="CCDS:CCDS563.1"
                     /db_xref="GeneID:9372"
                     /db_xref="HGNC:HGNC:6775"
                     /db_xref="MIM:603755"
                     /translation="MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPS
                     HRLSFNPTLASVNESAVSNESQPQLKVFSLAHSAPLTTEEEDHCANGQDCNLNPEIAT
                     MWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKR
                     TLQNDLQDCNNYNSQSLMDAFSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNR
                     PKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVISSQGTD
                     GCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLR
                     SGLPLLLKPDMPNGSGRNNDCERCSDCLVPNEVRADENEGYEHEETLGTTEFLNMTEH
                     FSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLK
                     GTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEI
                     EESKSECYSNIYEQRGNEATEGSGLLLNSTGDLMKKNYLHNFCSQVPSVLGQSSPKVV
                     ASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNNTKNKNDILGKAKLG
                     ENSATNVCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDSPDNDLRAGQFGISA
                     RKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLL
                     YMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGAL
                     SSPPPTVMVPVGVLKHPGAEVAQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGT
                     LAVSHDPVKPVTTSPLPAETDICLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVK
                     GDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHA
                     VGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVSNLGHSFFSQSFLGSKEH
                     GGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCP
                     LFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNE
                     MMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFV
                     FSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQE
                     HIHIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLEND
                     DQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAG
                     SNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIV"
     exon            528..2635
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2735
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2912
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3082
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3203
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3326
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3482
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3707
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3790
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3895
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4046
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4127
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4290
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4396
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4573
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..5148
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5130..5135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /note="hexamer: AATAAA"
     polyA_site      5148
                     /gene="ZFYVE9"
                     /gene_synonym="MADHIP; NSP; PPP1R173; SARA; SMADIP"
                     /note="major polyA site"
ORIGIN      
        1 acccgacgct ggaggcttcg ctgaggatcc ccgcctgccg cacctcggtc gtcccgccgc
       61 agccttgcgc ccccggcccg gctcggcggc gctcctccgg gatccgcgtg gctgccgcgg
      121 cccgggcgcc gatgcggctg ggcgggtgcc gggccttagc agcagtagca gccgcagctg
      181 cggctaccgc agctcctaca ggagtgggag gtttcgcggc ggcgcctggg gccgcgccgg
      241 tgccctccgg aggaggcttt cggctcaggg acgacccccg tggccatgct gaagcggagg
      301 cggccgctgc tcgaggatca aacagagcat actgaatcag caggactggc tggtggtgca
      361 gcagacatca tgagtaagca ccgagaagtc tgttccttat cacgtgtgta aggggaaaaa
      421 ggtttaaaca agtctcttaa gtggtgtttc ctcaccgatg gagaattact tccaagcaga
      481 agcttacaac ctggacaagg tgttagatga atttgaacaa aacgaagatg aaacagtttc
      541 ttctacttta ttggatacaa agtggaataa gattctagat cccccttctc accggctgtc
      601 atttaaccct actttggcca gtgtgaatga atctgcagtt tctaatgagt cacaaccaca
      661 actgaaagtc ttctccctgg ctcattcagc tcccctgacc acagaggaag aggatcactg
      721 tgctaatgga caggactgta atctaaatcc agagattgcc acaatgtgga ttgatgaaaa
      781 tgctgttgca gaagaccagt taattaagag aaactatagt tgggatgatc aatgcagtgc
      841 tgttgaagtg ggagagaaga aatgtggaaa cctggcttgt ctgccagatg agaagaatgt
      901 tcttgttgta gccgtcatgc ataactgtga taaaaggaca ttacaaaacg atttacagga
      961 ttgtaataat tataatagtc aatcccttat ggatgctttt agctgttcac tggataatga
     1021 aaacagacaa actgatcaat ttagttttag tataaatgag tccactgaaa aagatatgaa
     1081 ttcagagaaa caaatggatc cattgaatag accgaaaaca gaggggagat ctgttaacca
     1141 tctgtgtcct acttcatctg atagtctagc cagtgtctgt tccccttcac aattaaagga
     1201 tgacggaagt ataggtagag acccctccat gtctgcgatt acaagtttaa cggttgattc
     1261 agtaatctca tcccagggaa cagatggatg tcctgctgtt aaaaagcaag agaactatat
     1321 accagatgag gacctcactg gcaaaatcag ctctcctagg acagatctag ggagtccaaa
     1381 ttccttttcc cacatgagtg aggggatttt gatgaaaaaa gagccagcag aggagagcac
     1441 cactgaagaa tccctccggt ctggtttacc tttgcttctc aaaccagaca tgcctaatgg
     1501 gtctggaagg aataatgact gtgaacggtg ttcagattgc cttgtgccta atgaagttag
     1561 ggctgatgaa aatgaaggtt atgaacatga agaaactctt ggcactacag aattccttaa
     1621 tatgacagag catttctctg aatctcagga catgactaat tggaagttga ctaaactaaa
     1681 tgagatgaat gatagccaag taaacgaaga aaaggaaaag tttctacaga ttagtcagcc
     1741 tgaggacact aatggtgata gtggaggaca gtgtgttgga ttggcagatg caggtctaga
     1801 tttaaaagga acttgcatta gtgaaagtga agaatgtgat ttctccactg ttatagacac
     1861 accagcagca aattatctat ctaatggttg tgattcctat ggaatgcaag acccaggtgt
     1921 ttcttttgtt ccaaagactt taccctccaa agaagattca gtaacagaag aaaaagaaat
     1981 agaggaaagc aagtcagaat gctactcaaa tatttatgaa cagagaggaa atgaggccac
     2041 agaagggagt ggactacttt taaacagcac tggtgaccta atgaagaaaa attatttaca
     2101 taatttctgt agtcaagttc catcagtgct tgggcaatct tcccccaagg tagtagcaag
     2161 cctgccatct atcagtgttc cttttggtgg tgcaagaccc aagcaacctt ctaatcttaa
     2221 acttcaaatt ccaaagccat tatcagacca tttacaaaat gactttcctg caaacagtgg
     2281 aaataatact aaaaataaaa atgatattct tgggaaagca aaattagggg aaaactcagc
     2341 aaccaatgta tgcagtccat ctttgggaaa catctctaat gtcgatacaa atggggaaca
     2401 tttagaaagt tatgaggctg agatctccac tagaccatgc cttgcattag ctccagatag
     2461 cccagataat gatctcagag ctggtcagtt tggaatttct gccagaaagc cattcaccac
     2521 tctgggtgag gtggctccag tatgggtacc ggattctcag gctccaaatt gcatgaaatg
     2581 tgaagccagg tttacattca ccaaaaggag gcatcactgc agagcatgtg ggaaggtttt
     2641 ctgtgcttcc tgctgtagcc tgaaatgtaa actgttatac atggacagaa aggaagctag
     2701 agtgtgtgta atctgccatt cagtgctaat gaatgctcaa gcctgggaga acatgatgag
     2761 tgcctcaagc cagagcccta accctaacaa tcctgctgaa tactgttcta ctatccctcc
     2821 cttgcagcaa gctcaggcct caggagctct gagctctcca cctcccactg tgatggtacc
     2881 tgtgggagtt ttaaagcacc ctggagcaga agtggctcag cccagagagc agaggcgagt
     2941 ttggtttgct gatgggatct tgcccaatgg agaagttgct gatgcagcca aattaacaat
     3001 gaatggaact tcctctgcag gaaccctggc tgtgtcacac gacccagtca agccagtaac
     3061 taccagtcct ctaccagcag agacggatat ttgtctattc tctgggagta taactcaggt
     3121 tggaagtcct gttggaagtg caatgaatct tattcctgaa gatggccttc ctcccattct
     3181 catctccact ggtgtaaaag gagactatgc tgtggaagag aaaccatcac agatttcagt
     3241 aatgcagcag ttggaggatg gtggccctga cccacttgta tttgttttaa atgcaaattt
     3301 gttgtcaatg gttaaaattg taaattatgt gaacaggaag tgctggtgtt tcacaaccaa
     3361 gggaatgcat gcagtgggtc agtctgagat agtcattctt ctacagtgtt taccggatga
     3421 aaagtgtttg ccaaaggata tctttaatca ctttgtgcag ctttatcggg atgctctggc
     3481 agggaatgtg gtgagcaact tgggacattc cttcttcagt caaagtttcc ttggcagtaa
     3541 agaacatggt ggattcttat atgtgacatc tacctaccag tcactgcaag acctagtact
     3601 cccaacccca ccttacttgt ttgggattct tatccagaaa tgggaaactc cttgggctaa
     3661 agtatttcct atccgtctga tgttgagact tggagctgaa tatcgacttt atccatgccc
     3721 actattcagt gtcagatttc ggaagccatt gtttggagag acggggcata ccatcatgaa
     3781 tcttcttgca gacttcagaa attaccagta taccttgcca gtagttcaag gtttggtggt
     3841 tgatatggaa gttcggaaaa ctagcatcaa aattcccagc aacagataca atgagatgat
     3901 gaaagccatg aacaagtcca atgagcatgt cctggcagga ggtgcctgct tcaatgaaaa
     3961 ggcagactct catcttgtgt gtgtacagaa tgatgatgga aactatcaga cccaggctat
     4021 cagtattcac aatcagccca gaaaagtgac tggtgccagt ttctttgtgt tcagtggcgc
     4081 tctgaaatcc tcttctggat accttgccaa gtccagtatt gtggaagatg gtgttatggt
     4141 ccagattact gcagagaaca tggattcctt gaggcaggca ctgcgagaga tgaaggactt
     4201 caccatcacc tgtgggaagg cggacgcgga ggaaccccag gagcacatcc acatccagtg
     4261 ggtggatgat gacaagaacg ttagcaaggg tgtcgtaagt cctatagatg ggaagtccat
     4321 ggagactata acaaatgtga agatattcca tggatcagaa tataaagcaa atggaaaagt
     4381 aatcagatgg acagaggtgt ttttcctaga aaacgatgac cagcacaatt gcctcagtga
     4441 tcctgcagat cacagtagat tgactgagca tgttgccaaa gctttttgcc ttgctctctg
     4501 tcctcacctg aaacttctga aggaagatgg aatgaccaaa ctgggactac gtgtgacact
     4561 tgactcagat caggttggct atcaagcagg gagcaatggc cagccccttc cctcgcagta
     4621 catgaatgat ctggacagcg ccttggtgcc ggtgatccat ggaggggcct gccagcttag
     4681 tgagggcccc gttgtcatgg aactcatctt ttatattctg gaaaacatcg tataaacaga
     4741 gaagacttca tttttttctg ttcagacttg ttgcaacagc agtcataccc aaatcatttg
     4801 cactttaaaa ctggaagatt aagcttttgt taacactatt aatggggtgg ggaatagggt
     4861 gggagtgggg gtttgggaga cgggtgggaa agggtggttg gggggaccga tgttccataa
     4921 ttctaagtct tctatgcatt gtccaccaag aagatctggg cagcttctgt tcctgcacaa
     4981 cagttatgct atccttgcag ctaatcccct tctgttactg tttagacaag aattccgctc
     5041 ctctctcaag atttacttat ggtcatgtgc tcagaaatgc tcaaatgggt acaaccatca
     5101 ccaagggtgg gatgggaggg cagaggggaa ataaaatata aagcatca
//
