LOCUS       NM_020972               4114 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens zinc finger FYVE-type containing 28 (ZFYVE28),
            transcript variant 2, mRNA.
ACCESSION   NM_020972 XM_035371
VERSION     NM_020972.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Yu,L., Xu,M., Yan,Y., Huang,S., Yuan,M., Cui,B., Lv,C., Zhang,Y.,
            Wang,H., Jin,X., Hui,R. and Wang,Y.
  TITLE     ZFYVE28 mediates insulin resistance by promoting phosphorylated
            insulin receptor degradation via increasing late endosomes
            production
  JOURNAL   Nat Commun 14 (1), 6833 (2023)
   PUBMED   37884540
  REMARK    GeneRIF: ZFYVE28 mediates insulin resistance by promoting
            phosphorylated insulin receptor degradation via increasing late
            endosomes production.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Zambrano,S., Rodriguez,P.Q., Guo,J., Moller-Hackbarth,K.,
            Schwarz,A. and Patrakka,J.
  TITLE     FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in
            podocytes but is not critical for the function of filtration
            barrier in mice
  JOURNAL   Sci Rep 8 (1), 4712 (2018)
   PUBMED   29549365
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Fanous,A.H., Zhou,B., Aggen,S.H., Bergen,S.E., Amdur,R.L., Duan,J.,
            Sanders,A.R., Shi,J., Mowry,B.J., Olincy,A., Amin,F.,
            Cloninger,C.R., Silverman,J.M., Buccola,N.G., Byerley,W.F.,
            Black,D.W., Freedman,R., Dudbridge,F., Holmans,P.A., Ripke,S.,
            Gejman,P.V., Kendler,K.S. and Levinson,D.F.
  CONSRTM   Schizophrenia Psychiatric Genome-Wide Association Study (GWAS)
            Consortium
  TITLE     Genome-wide association study of clinical dimensions of
            schizophrenia: polygenic effect on disorganized symptoms
  JOURNAL   Am J Psychiatry 169 (12), 1309-1317 (2012)
   PUBMED   23212062
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Mosesson,Y., Chetrit,D., Schley,L., Berghoff,J., Ziv,T.,
            Carvalho,S., Milanezi,F., Admon,A., Schmitt,F., Ehrlich,M. and
            Yarden,Y.
  TITLE     Monoubiquitinylation regulates endosomal localization of Lst2, a
            negative regulator of EGF receptor signaling
  JOURNAL   Dev Cell 16 (5), 687-698 (2009)
   PUBMED   19460345
  REMARK    GeneRIF: Study concludes that endosomal localization of Lst2
            (ZFYVE28), along with an ability to divert incoming EGFR molecules
            to degradation in lysosomes, is regulated by
            ubiquitinylation/deubiquitinylation cycles.
REFERENCE   6  (bases 1 to 4114)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645924.13, BC032605.1, AB046863.1, BC137310.1, AK294874.1 and
            BM128958.1.
            
            On Jun 2, 2019 this sequence version replaced NM_020972.2.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR and uses an upstream start codon, compared to
            variant 1. The resulting isoform (2) has a longer N-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290974.7/ ENSP00000290974.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL645924.13        98046-98047
            3-3                 BC032605.1         12-12
            4-828               AB046863.1         1-825
            829-829             BC137310.1         570-570
            830-2335            AB046863.1         827-2332
            2336-2336           AK294874.1         2295-2295
            2337-4113           AB046863.1         2334-4110
            4114-4114           BM128958.1         17-17               c
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..4114
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /note="zinc finger FYVE-type containing 28"
                     /db_xref="GeneID:57732"
                     /db_xref="HGNC:HGNC:29334"
                     /db_xref="MIM:614176"
     exon            1..361
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2986
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lateral signaling target protein 2 homolog; zinc finger,
                     FYVE domain containing 28; hLst2; zinc finger FYVE
                     domain-containing protein 28; lateral signaling target-2
                     homolog"
                     /codon_start=1
                     /product="lateral signaling target protein 2 homolog
                     isoform 2"
                     /protein_id="NP_066023.2"
                     /db_xref="CCDS:CCDS33942.1"
                     /db_xref="GeneID:57732"
                     /db_xref="HGNC:HGNC:29334"
                     /db_xref="MIM:614176"
                     /translation="MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRK
                     DPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLW
                     FGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREA
                     LRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDD
                     YEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTE
                     EELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELACS
                     MQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRS
                     GSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLP
                     ASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRT
                     GGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVC
                     CGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGR
                     EPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSG
                     SSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQ
                     LQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSE
                     LAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAP
                     LPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL"
     exon            362..502
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..640
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..843
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..933
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1023
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1125
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..2373
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2528
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2645
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2750
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2854
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..4114
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4092..4097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /note="hexamer: CATAAA"
     polyA_site      4114
                     /gene="ZFYVE28"
                     /gene_synonym="lst-2; LST2; LYST2"
                     /note="major polyA site"
ORIGIN      
        1 gtgaccagcg gagcgctggg tgtcagtgag cagcgaggag ccgcgcgccc ccgtgcccgc
       61 gtctgtccgt gcgcccgagc gcccactccc gggtctgagg tctgcccggc gcgccgcttg
      121 cagagcatac tcagggccgc gcacctgccc cgcgcacctg cccgccgccc gctcggcgct
      181 ccgggcttcg ctagccagcc tccctgcgac agcgcggggg ctccggccgt gcctccgcgt
      241 ccgccccgcg cctcagccgg gcccgggcgc agcgctgcgg agggcgaggg ccgcccggag
      301 tccggccagg gccggcgcgg cgatgatgaa caggttccga aagtggctct acaaacccaa
      361 gaggtcggat ccgcagctgc ttgcccggtt ctactatgcc gacgaggagc tgaaccaggt
      421 ggccgcggag ctggacagcc tggatgggcg gaaggacccc cagcggtgca cgctgctggt
      481 cagccagttc cgctcctgtc aggacaatgt gttgaacatc attaaccaga tcatggatga
      541 gtgcatcccc caggaccgcg cccccagaga tttctgcgtc aagttccctg aggagatccg
      601 gcacgacaac ctggccggcc agctgtggtt cggtgccgag tgcctggccg ccggctccat
      661 catcatgaac cgggagctgg agagcatggc catgcgcccg ctggccaagg agctgacgcg
      721 cagcctggag gacgtgcggg gcgccctccg tgaccaggcg ctgcgggacc tgaacaccta
      781 cacagagaag atgagggaag cgctgaggca cttcgacgtc ctgttcgcag agtttgagct
      841 cagctacgtc tcggccatgg tgcctgtgaa gtcccccagg gagtactacg tgcagcagga
      901 ggtcatcgtg ctcttctgcg agacggtgga gagggccctg gacttcgggt acctgactca
      961 ggacatgatt gatgactacg agccggccct catgttcagc atccccaggc tggccatcgt
     1021 gtgtggcctc gtggtctatg cggacggacc tctgaacttg gaccgcaagg tggaagacat
     1081 gtccgagctg ttccggccct tccacacgtt gctgcggaaa ataagggatt tgctgcagac
     1141 gctgacggag gaggagctgc acacgctgga acggaacctc tgcatttccc aagacgtgga
     1201 gttccccatc cgcgcagacg tgcagggacc cgctgccctg gcgcctgccc tctctgcccc
     1261 tctcccccct gaggggccac tctcagctaa ggccaaagac ccggatgcag agctggcctg
     1321 ctccatgcag tacgacgacc aggagctgga gcagctcagc cgcatggtcc acagggcggg
     1381 ggacgagatg tcctctttgc tttcaccgcc cattgcctgc cagtccccag ctcacaggcc
     1441 aggagcggag ggcagcccag gcggggaggc ctctccaggt agaccgcgcc tgcggtcagg
     1501 cagtgacgag gaggagcgcg tgttcttcat ggatgacgtg gaggggacgg cagaagccct
     1561 ggccaggccc gagtccccag ctggcccatt tgggtgggca ggcagtacct gggccgaccc
     1621 ccaggagaaa gggcagggtg ggccaggcgg agcggcgggg atcagcttgc ccgcctcgga
     1681 aaaggaggag gacttgagca acaacaatct cgaggccgag ggcacagatg gggccagcct
     1741 cgcgggcacc agctcctgca gctgcctgga ctcgcggctg cacctggacg gctgggaggt
     1801 gggtgcggat gacgcagaga cggctgagat gatcgcccac cggacagggg gcatgaagct
     1861 ctcagccacg gtcatcttca accccaaatc gcccacttcc ctggactctg cggtcgccac
     1921 ccaggaggcc gcctcggagc ccgtggccga ggggatggat ggcggccccc acaagcttag
     1981 cactggggcc accaactgcc ttctgcattc ctgcgtgtgc tgtgggagct gcggggacag
     2041 cagggaggac gtggtggagc gtctgcggga gaagtgcagc ccgggaggcg tcattggtgc
     2101 ctcgtacgct gccggcttag ccaaggccag cgacagggcc cctgagagac aggaggaggc
     2161 gcccccaccc tcagaagatg cctccaacgg gcgggagccc aaagccccca cttccgacaa
     2221 gtgcctgcct cacacctcag gttcccaggt ggacacagcg agtgggctgc aaggagaggc
     2281 tggggttgca ggtcagcagg agccagaggc cagagagctg catgctggga gcccctcggc
     2341 tcacgaggcg cctcaggccc tgtcgggctc cagcagctcc acagctgggt cctgctcctc
     2401 agacaagatg gggccagagg cggccccagc agccacgcat gctgccccac aggccacaag
     2461 agagaagatc cggtccaggt tccacggcag ccacgacctc atccaccgcc tgttcgtctg
     2521 catttcaggt gtggctgacc agctgcagac gaactatgcc agtgacctga gaagtattct
     2581 taaaacactg tttgaggtca tggccaccaa gcctgaaaca gacgacaagg aaaagttaag
     2641 gaaggtcacc cagactctgc ggagtgcggc cttggaggac tgtgcactgt gccaggagac
     2701 cctgtcatcc tctgaactgg cagccaagac ccgcgatggg gactttgaag accccccgga
     2761 gtgggtgcca gacgaggcct gtggcttctg cacggcgtgc aaagcaccct tcaccgtcat
     2821 ccgccggaag caccactgcc gcagctgtgg gaagatcttc tgctcgcgct gctcctcgca
     2881 ctcagcaccg ctgccccgct acgggcaggt gaagccggtc cgagtgtgca cccactgcta
     2941 catgttccat gtcacgccct tctacagcga caaggccggc ctgtgacgtg gtgccagggg
     3001 cagccccaac ccacccgggc caggaacccc caggaaggtg gggccacgct gcaggcaggt
     3061 ctcactgcgt ctcatgaggc cgctgccgct gctgcagggg cacccagacc tccagagcat
     3121 ccagagcctc tgtcctgccc acgctagcct ccctgcaggg accccgggcc ggctgcaggg
     3181 gccaacaaga ggtcagcttt gcccagcagg ggacccggag gagcctggtg gctgcctcag
     3241 ggcagggtgc ctggcggaga aggcctgggc cctcccactg gtccctcgga gatctgctgg
     3301 ggctatggga atcggggcgg gtgatggagg tggacaagag tggggccact ctgcgcctct
     3361 gctgttgcgg tgaatctgga agccggagca agggccactc cacaggctct ttggcacagc
     3421 agggctccct atgtgcctcc caaacgtcaa atgcaggcta cccattctcc ccatcagctg
     3481 cccacctcgt tccccagccc tcacccctca cccctcacca tccttcctca ggacttggct
     3541 aaacaacatg catctcattt cttcttggag tggggagatg cgggaagctg acccagtggt
     3601 cctctaggca ggcagggtgc tcctggtgtc tgcccaccac tgtccccttg ctgatggcat
     3661 gggggtccga ccaggcactg acaccgcagg cagaggttgc tcggggcctt gggtcgggtt
     3721 taccaatcag ccaggacgcc cggggccacc agctcagcta ccacttcccc ttccctctgc
     3781 accctctgga accctggccc aattcctcag accccagagt ggcctgggac ccaagctgcc
     3841 gcagctgagt ggccccagcg gacacctcct caggcttaaa tctcaggctt cacattgcaa
     3901 tgacgattgc agttttattt ttggagatga cacacctact gcttcttttc taggataaat
     3961 ctaattactg tttactggtg gagtacatat gcatagaaac ggcttctgtc ggggggagag
     4021 tatataatgg aggaaatatt atgtattgag attatattta ttttctaaat gctgtaattt
     4081 gaagccattt ccataaatct atttaaggat tgca
//
