LOCUS       NM_001385875            3026 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens zinc finger FYVE-type containing 27 (ZFYVE27),
            transcript variant 9, mRNA.
ACCESSION   NM_001385875 XM_005269504
VERSION     NM_001385875.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Petrova,V., Pearson,C.S., Ching,J., Tribble,J.R., Solano,A.G.,
            Yang,Y., Love,F.M., Watt,R.J., Osborne,A., Reid,E., Williams,P.A.,
            Martin,K.R., Geller,H.M., Eva,R. and Fawcett,J.W.
  TITLE     Protrudin functions from the endoplasmic reticulum to support axon
            regeneration in the adult CNS
  JOURNAL   Nat Commun 11 (1), 5614 (2020)
   PUBMED   33154382
  REMARK    GeneRIF: Protrudin functions from the endoplasmic reticulum to
            support axon regeneration in the adult CNS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Shirane,M., Wada,M., Morita,K., Hayashi,N., Kunimatsu,R.,
            Matsumoto,Y., Matsuzaki,F., Nakatsumi,H., Ohta,K., Tamura,Y. and
            Nakayama,K.I.
  TITLE     Protrudin and PDZD8 contribute to neuronal integrity by promoting
            lipid extraction required for endosome maturation
  JOURNAL   Nat Commun 11 (1), 4576 (2020)
   PUBMED   32917905
  REMARK    GeneRIF: Protrudin and PDZD8 contribute to neuronal integrity by
            promoting lipid extraction required for endosome maturation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Martignoni,M., Riano,E. and Rugarli,E.I.
  TITLE     The role of ZFYVE27/protrudin in hereditary spastic paraplegia
  JOURNAL   Am J Hum Genet 83 (1), 127-8 (2008)
   PUBMED   18606302
  REMARK    GeneRIF: The role of ZFYVE27/protrudin in hereditary spastic
            paraplegia is reported.
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Shirane,M., Ogawa,M., Motoyama,J. and Nakayama,K.I.
  TITLE     Regulation of apoptosis and neurite extension by FKBP38 is required
            for neural tube formation in the mouse
  JOURNAL   Genes Cells 13 (6), 635-651 (2008)
   PUBMED   18459960
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Shirane,M. and Nakayama,K.I.
  TITLE     Protrudin induces neurite formation by directional membrane
            trafficking
  JOURNAL   Science 314 (5800), 818-821 (2006)
   PUBMED   17082457
  REMARK    GeneRIF: protrudin regulates Rab11-dependent membrane recycling to
            promote the directional membrane trafficking required for neurite
            formation [protrudin]
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Mannan,A.U., Krawen,P., Sauter,S.M., Boehm,J., Chronowska,A.,
            Paulus,W., Neesen,J. and Engel,W.
  TITLE     ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in
            hereditary spastic paraplegia
  JOURNAL   Am J Hum Genet 79 (2), 351-357 (2006)
   PUBMED   16826525
  REMARK    GeneRIF: Mutation affects neuronal intracellular trafficking in the
            corticospinal tract, which is consistent with the pathology of
            hereditary spastic paraplegia.
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358938.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 30, 2020 this sequence version replaced XM_005269504.3.
            
            Summary: This gene encodes a protein with several transmembrane
            domains, a Rab11-binding domain and a lipid-binding FYVE finger
            domain. The encoded protein appears to promote neurite formation. A
            mutation in this gene has been reported to be associated with
            hereditary spastic paraplegia, however the pathogenicity of the
            mutation, which may simply represent a polymorphism, is unclear.
            [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1062424.1,
                                           SRR1660805.14357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684270.1/ ENSP00000506975.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL358938.8         10708-10901
            195-392             AL358938.8         12057-12254
            393-463             AL358938.8         16674-16744
            464-650             AL358938.8         18309-18495
            651-746             AL358938.8         21849-21944
            747-859             AL358938.8         23054-23166
            860-999             AL358938.8         23911-24050
            1000-1071           AL358938.8         24971-25042
            1072-1092           AL358938.8         26437-26457
            1093-1237           AL358938.8         26618-26762
            1238-1284           AL358938.8         30845-30891
            1285-1366           AL358938.8         31222-31303
            1367-3026           AL358938.8         32816-34475
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..3026
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /note="zinc finger FYVE-type containing 27"
                     /db_xref="GeneID:118813"
                     /db_xref="HGNC:HGNC:26559"
                     /db_xref="MIM:610243"
     exon            1..194
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            195..392
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1431
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /note="isoform 2 is encoded by transcript variant 9; zinc
                     finger FYVE domain containing 27; spastic paraplegia 33
                     protein"
                     /codon_start=1
                     /product="protrudin isoform 2"
                     /protein_id="NP_001372804.1"
                     /db_xref="CCDS:CCDS31263.1"
                     /db_xref="GeneID:118813"
                     /db_xref="HGNC:HGNC:26559"
                     /db_xref="MIM:610243"
                     /translation="MQTSEREGSGPELSPSVMPEAPLESPPFPTKSPAFDLFNLVLSY
                     KRLEIYLEPLKDAGDGVRYLLRWQMPLCSLLTCLGLNVLFLTLNEGAWYSVGALMISV
                     PALLGYLQEVCRARLPDSELMRRKYHSVRQEDLQRGRLSRPEAVAEVKSFLIQLEAFL
                     SRLCCTCEAAYRVLHWENPVVSSQFYGALLGTVCMLYLLPLCWVLTLLNSTLFLGNVE
                     FFRVVSEYRASLQQRMNPKQEEHAFESPPPPDVGGKDGLMDSTPALTPTEDLTPGSVE
                     EAEEAEPDEEFKDAIEETHLVVLEDDEGAPCPAEDELALQDNGFLSKNEVLRSKVSRL
                     TERLRKRYPTNNFGNCTGCSATFSVLKKRRSCSNCGNSFCSRCCSFKVPKSSMGATAP
                     EAQRETVFVCASCNQTLSK"
     exon            393..463
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            464..650
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            651..746
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            747..859
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            860..999
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1071
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1092
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1237
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1284
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1366
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..3026
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3006..3011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /note="hexamer: AATAAA"
     polyA_site      3026
                     /gene="ZFYVE27"
                     /gene_synonym="PROTRUDIN; SPG33"
                     /note="major polyA site"
ORIGIN      
        1 gattcgcgtc ccggaagcgg cggtggcggc cgcggcgtag gcggaggaga ttttcggacc
       61 tgcgacttcc gaacaaccct ggcaggagga gcggcgttca gccgggggag gcctgaagaa
      121 acgctccggg gcccagtggc tctacccctg ctcctgcccg accctgccgc ctccctcacg
      181 gagccagcgg ccgggatgca gacatcagaa cgtgagggga gtgggccgga gctgagcccc
      241 agcgtgatgc ccgaggctcc cctggagtct ccaccttttc ctaccaagtc cccagcgttt
      301 gaccttttca acttggttct ctcctacaag aggctggaga tctacctgga acccttgaag
      361 gatgcaggtg atggtgttcg atacttgctc aggtggcaga tgcctttgtg ttccttgctg
      421 acctgcctgg gcctcaacgt cttgttcctc actttgaatg agggtgcatg gtactcagta
      481 ggtgccctga tgatttcagt gcccgccctg ctgggctacc ttcaggaggt ttgccgggca
      541 cggctgcctg attccgagct gatgcggagg aagtatcata gcgtgaggca ggaggacctg
      601 cagagaggtc gcctgtctcg tcccgaggcc gtggctgagg tgaagagctt cttgatccag
      661 ctggaggcct tcctgagccg cctgtgctgc acatgtgaag ccgcctaccg cgtgctgcac
      721 tgggagaacc ccgtcgtgtc ctcacagttc tatggggctc ttctgggcac agtctgcatg
      781 ctgtatttgc tgccactctg ctgggttctc acccttttaa acagcacgct ctttctgggg
      841 aatgtggagt tcttccgagt tgtgtctgag tacagggcat ctctgcagca gaggatgaac
      901 ccaaagcagg aagagcatgc ctttgagagt cctccaccac cagatgttgg ggggaaggat
      961 ggtctgatgg acagcacgcc tgccctcaca cccacggagg acctcacacc gggcagcgtg
     1021 gaggaggctg aggaggctga gccagatgaa gagtttaaag atgcgattga ggagacccac
     1081 ttggtggtgc tggaggatga tgagggcgcc ccgtgcccag cagaggatga gctggccctg
     1141 caggacaacg ggttcctgag caagaatgag gtgctgcgca gcaaggtgtc tcggctcacg
     1201 gagcggctcc gcaagcgcta ccccaccaac aacttcggga actgcacggg ctgctcggcc
     1261 accttctcag tgctgaagaa gaggcggagc tgcagtaatt gtggaaacag cttctgctct
     1321 cgatgctgct ccttcaaggt gcccaagtcc tccatggggg ccacagcccc tgaagcccag
     1381 agggagactg tgtttgtgtg tgcctcgtgt aaccagacct tgagcaagtg agaagagagg
     1441 ccagggtcca accaggcacc cgtccttggg accagcagta gaccccccac tctccccacc
     1501 cctggcccac tgtggtgtgt gctgggcaaa tgtggcctga atgctaggta ggcttcccct
     1561 tccttcctca ctctctccag ctggattctg gagctgttct ccatccatga gagtggctgg
     1621 caatggctgc tctcaatccc ttgagggaga agagcccctg gagggcctgg catgtttgtc
     1681 ctgctctgcc tgggactgag cgagtggact tagggctggg caggcagtag ccaccagagg
     1741 gcagcagcga actaggccag gcctgactgg ggtctgaaga tcagggtcag tgtggctgtg
     1801 cctgggaatt ccagacctga ggttgggaaa agaggttttt ctcctgcagg gtactgggcc
     1861 aggccctcag cctcagagag cctgcagaag ggcttgggag tgccacaccc catctctgct
     1921 gattgaatgt ccctccaggc accaggatct catcatttcc ccatcagagg gtgtggccag
     1981 gcctaacaag accatgggtg cttctagaaa cagggttgaa gttcccagat tccctgagag
     2041 gagaatgtgt ataggagggt ttggctgagt ccttcagcgt taagtggagg aaagcttggg
     2101 gaagccccaa tagctggaca gacctcggcc tcccctcgaa gacacctcaa ttcacagact
     2161 ctcagcccac acaatgcccc agtgtcccca gctccgctgg agcagctgca gggcacttgg
     2221 atcacaactt ctgcaccctc tgtccagagt ctagggcagt cctccactgg cccagcactc
     2281 cagtttcctt tccctgcctc ttgtccaatg gagtgggagg ccaggtgagt ggagcagagg
     2341 tcctgaagcc cttgacccct gggggcctgg gtagtgtagg atctcgctgg gctgggtcct
     2401 ggattccagg gctattccct ggaggacagt ctcagttatg ggataaggcc ccctgggggt
     2461 ctccatttct ttccaacagt ttcatgttca ctactggact cttacgggct cagtatctct
     2521 cccttagcca tgagctggct caggcatccc ttcccttccc tggagctgcc ctgcctttct
     2581 caagtattta tttatttatt gcatggttcc tgggaacatg tggcacaagt aatgggatga
     2641 ggaggaattg ggggtggggg tcttctacct aggactcttc cctggagtca tgggctgcct
     2701 gggacccagg acccatgagg gggctgagag gtttctacac tcgaggagca ggggtccaga
     2761 gaggcaggct ggggaggcaa gggacccatc ctaggcccgc tttcttgccg agccaagcag
     2821 cttagctggg gctgtgcagc caggggctta cccaggccag tggaggtgcc acagccctgg
     2881 ggagccagac aggctttggt atcgtatcgc ctctgtgtcc ttttaagaga ggagagttca
     2941 gtaccccgtg ctttctttac actggagagg aactaaaagg atctctgtgt ctatggagaa
     3001 ttgtcaataa aaaggcctca agcttc
//
