LOCUS       NM_015346               9674 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens zinc finger FYVE-type containing 26 (ZFYVE26), mRNA.
ACCESSION   NM_015346
VERSION     NM_015346.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9674)
  AUTHORS   Saffari,A., Kellner,M., Jordan,C., Rosengarten,H., Mo,A., Zhang,B.,
            Strelko,O., Neuser,S., Davis,M.Y., Yoshikura,N., Futamura,N.,
            Takeuchi,T., Nabatame,S., Ishiura,H., Tsuji,S., Aldeen,H.S.,
            Cali,E., Rocca,C., Houlden,H., Efthymiou,S., Assmann,B., Yoon,G.,
            Trombetta,B.A., Kivisakk,P., Eichler,F., Nan,H., Takiyama,Y.,
            Tessa,A., Santorelli,F.M., Sahin,M., Blackstone,C., Yang,E.,
            Schule,R. and Ebrahimi-Fakhari,D.
  TITLE     The clinical and molecular spectrum of ZFYVE26-associated
            hereditary spastic paraplegia: SPG15
  JOURNAL   Brain 146 (5), 2003-2015 (2023)
   PUBMED   36315648
  REMARK    GeneRIF: The clinical and molecular spectrum of ZFYVE26-associated
            hereditary spastic paraplegia: SPG15.
REFERENCE   2  (bases 1 to 9674)
  AUTHORS   Hsu,S.L., Lu,Y.J., Tsai,Y.S., Chao,H.C., Fuh,J.L., Liao,Y.C. and
            Lee,Y.C.
  TITLE     Investigating ZFYVE26 mutations in a Taiwanese cohort with
            hereditary spastic paraplegia
  JOURNAL   J Formos Med Assoc 121 (1 Pt 1), 126-133 (2022)
   PUBMED   33637369
  REMARK    GeneRIF: Investigating ZFYVE26 mutations in a Taiwanese cohort with
            hereditary spastic paraplegia.
REFERENCE   3  (bases 1 to 9674)
  AUTHORS   Pashaei,M., Davarzani,A., Hajati,R., Zamani,B., Nafissi,S.,
            Larti,F., Nilipour,Y., Rohani,M. and Alavi,A.
  TITLE     Description of clinical features and genetic analysis of one
            ultra-rare (SPG64) and two common forms (SPG5A and SPG15) of
            hereditary spastic paraplegia families
  JOURNAL   J Neurogenet 35 (2), 84-94 (2021)
   PUBMED   33771085
  REMARK    GeneRIF: Description of clinical features and genetic analysis of
            one ultra-rare (SPG64) and two common forms (SPG5A and SPG15) of
            hereditary spastic paraplegia families.
REFERENCE   4  (bases 1 to 9674)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9674)
  AUTHORS   Boukhris,A., Stevanin,G., Feki,I., Denis,E., Elleuch,N.,
            Miladi,M.I., Truchetto,J., Denora,P., Belal,S., Mhiri,C. and
            Brice,A.
  TITLE     Hereditary spastic paraplegia with mental impairment and thin
            corpus callosum in Tunisia: SPG11, SPG15, and further genetic
            heterogeneity
  JOURNAL   Arch Neurol 65 (3), 393-402 (2008)
   PUBMED   18332254
  REMARK    GeneRIF: Autosomal recessive HSP-TCC is a frequent subtype of
            complicated HSP in Tunisia and is clinically and genetically
            heterogeneous. SPG11 and SPG15 are the major loci for this entity.
REFERENCE   6  (bases 1 to 9674)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 9674)
  AUTHORS   Elleuch,N., Bouslam,N., Hanein,S., Lossos,A., Hamri,A., Klebe,S.,
            Meiner,V., Birouk,N., Lerer,I., Grid,D., Bacq,D., Tazir,M.,
            Zelenika,D., Argov,Z., Durr,A., Yahyaoui,M., Benomar,A., Brice,A.
            and Stevanin,G.
  TITLE     Refinement of the SPG15 candidate interval and phenotypic
            heterogeneity in three large Arab families
  JOURNAL   Neurogenetics 8 (4), 307-315 (2007)
   PUBMED   17661097
  REMARK    GeneRIF: phenotypic heterogeneity of SPG15 in which mental
            retardation or cognitive deterioration, but not all other signs of
            Kjellin syndrome, are associated with hereditary spastic paraplegia
            and significantly reduces the SPG15 locus
REFERENCE   8  (bases 1 to 9674)
  AUTHORS   Hughes,C.A., Byrne,P.C., Webb,S., McMonagle,P., Patterson,V.,
            Hutchinson,M. and Parfrey,N.A.
  TITLE     SPG15, a new locus for autosomal recessive complicated HSP on
            chromosome 14q
  JOURNAL   Neurology 56 (9), 1230-1233 (2001)
   PUBMED   11342696
REFERENCE   9  (bases 1 to 9674)
  AUTHORS   Ebrahimi-Fakhari,D., Alecu,J.E. and Blackstone,C.
  TITLE     Spastic Paraplegia 15
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34057829
REFERENCE   10 (bases 1 to 9674)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121595.5 and AL049779.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015346.3.
            
            Summary: This gene encodes a protein which contains a FYVE zinc
            finger binding domain. The presence of this domain is thought to
            target these proteins to membrane lipids through interaction with
            phospholipids in the membrane. Mutations in this gene are
            associated with autosomal recessive spastic paraplegia-15.
            [provided by RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537886.1, AB425197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347230.9/ ENSP00000251119.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AL121595.5         160501-160557
            58-334              AL121595.5         161045-161321
            335-413             AL121595.5         163027-163105
            414-503             AL049779.6         182704-182793       c
            504-1026            AL049779.6         180902-181424       c
            1027-1157           AL049779.6         180049-180179       c
            1158-1322           AL049779.6         178958-179122       c
            1323-1411           AL049779.6         178721-178809       c
            1412-1575           AL049779.6         177605-177768       c
            1576-1779           AL049779.6         175583-175786       c
            1780-2388           AL049779.6         171518-172126       c
            2389-2472           AL049779.6         171176-171259       c
            2473-2541           AL049779.6         167675-167743       c
            2542-2693           AL049779.6         167112-167263       c
            2694-2895           AL049779.6         164076-164277       c
            2896-3159           AL049779.6         162839-163102       c
            3160-3279           AL049779.6         159618-159737       c
            3280-3444           AL049779.6         159362-159526       c
            3445-3663           AL049779.6         158563-158781       c
            3664-3766           AL049779.6         157838-157940       c
            3767-4512           AL049779.6         156284-157029       c
            4513-4709           AL049779.6         154837-155033       c
            4710-4814           AL049779.6         153745-153849       c
            4815-4937           AL049779.6         151630-151752       c
            4938-5114           AL049779.6         151063-151239       c
            5115-5361           AL049779.6         149364-149610       c
            5362-5460           AL049779.6         148520-148618       c
            5461-5624           AL049779.6         145551-145714       c
            5625-5761           AL049779.6         143098-143234       c
            5762-5793           AL049779.6         142021-142052       c
            5794-5930           AL049779.6         141208-141344       c
            5931-6151           AL049779.6         139731-139951       c
            6152-6299           AL049779.6         136176-136323       c
            6300-6509           AL049779.6         135707-135916       c
            6510-6728           AL049779.6         134870-135088       c
            6729-6926           AL049779.6         129452-129649       c
            6927-7126           AL049779.6         128555-128754       c
            7127-7268           AL049779.6         127575-127716       c
            7269-7328           AL049779.6         127211-127270       c
            7329-7511           AL049779.6         125848-126030       c
            7512-7556           AL049779.6         124556-124600       c
            7557-9674           AL049779.6         120026-122143       c
FEATURES             Location/Qualifiers
     source          1..9674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..9674
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /note="zinc finger FYVE-type containing 26"
                     /db_xref="GeneID:23503"
                     /db_xref="HGNC:HGNC:20761"
                     /db_xref="MIM:612012"
     exon            1..57
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            58..334
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..7760
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /note="spastizin; zinc finger, FYVE domain containing 26;
                     FYVE domain-containing centrosomal protein"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 26"
                     /protein_id="NP_056161.2"
                     /db_xref="CCDS:CCDS9788.1"
                     /db_xref="GeneID:23503"
                     /db_xref="HGNC:HGNC:20761"
                     /db_xref="MIM:612012"
                     /translation="MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQG
                     DIPKRVEDILQALVVCPNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKL
                     EFLLLSEDLQGDIPENILEELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDL
                     LRQSPQPAQALLELLLEEDDGTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAI
                     YGALRTLRCPAEPLGVELHLLCEELLEACRTEGSPLREERLLSCLLHKASRGLLSLYG
                     HTYAEKVTEKPPRATASGKVSPDHLDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHF
                     LEQILVTALTLLKEEDFPNLGCLLDREFRPLSCLLVLLGWTHCQSLESAKRLLQTLHR
                     TQGPGCDELLRDACDGLWAHLEVLEWCIQQSSNPIPKRDLLYHLHGGDSHSVLYTLHH
                     LTNLPALREEDVLKLLQKVPAKDPQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYAI
                     YALCVNSHQHSQCQDCKDSLSEDLASATEPANDSLSSPGAANLFSTYLARCQQYLCSI
                     PDSLCLELLENIFSLLLITSADLHPEPHLPEDYAEDDDIEGKSPSGLRSPSESPQHIA
                     HPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGPHRHSFLDLKHFTSGISGFLADE
                     FAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRDGLQSRLHRLSKVVSEAQWRH
                     KVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRDRGSNPSLESTSSELSTS
                     TSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTF
                     NLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGS
                     AAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAM
                     AAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQI
                     SKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLD
                     QVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGS
                     RQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQ
                     VPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHAS
                     HCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
                     LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLR
                     GSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVY
                     GRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEIL
                     AYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMN
                     MILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMC
                     LEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHR
                     ASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAE
                     KALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLR
                     ERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLV
                     CSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVV
                     RVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHC
                     CRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILV
                     AAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACL
                     KAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATL
                     RELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREAL
                     LHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKK
                     NYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQET
                     SRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLF
                     GNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEI
                     QQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICC
                     KLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSR
                     K"
     exon            335..413
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            414..503
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            504..1026
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1157
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1322
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1411
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1575
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1779
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2388
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2472
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2541
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2693
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2895
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3159
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3279
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3444
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3663
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3766
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..4512
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4709
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4814
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4937
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            4938..5114
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5115..5361
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5362..5460
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5461..5624
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5625..5761
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5762..5793
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5794..5930
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            5931..6151
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            6152..6299
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            6300..6509
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            6510..6728
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            6729..6926
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            6927..7126
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            7127..7268
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            7269..7328
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            7329..7511
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            7512..7556
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     exon            7557..9674
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7967
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /note="major polyA site"
     regulatory      9654..9659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /note="hexamer: AATAAA"
     polyA_site      9674
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /note="major polyA site"
ORIGIN      
        1 gactcggctc aaacatggct gcgctgagag ctctattgct ttgggcgccg ggagcaggag
       61 gtactccgcg aatgagaaca ttgagaatgt gttcggcata actcatttct ttgtatctcc
      121 ctgcactctg tgctgggaaa atgaatcatc catttggaaa agaggaagct gcttcgcaga
      181 agcagctttt tggatttttc tgcgaatgcc tgcggagggg agaatgggag ctggcacagg
      241 catgtgtacc tcagctacag gagggacaag gggatatccc aaagagggta gaagacatac
      301 ttcaggcatt ggtggtgtgt ccaaatctgc tgagatgtgg gcaggacatc aaccctcaaa
      361 gagtagcctg ggtctggctt cttgtactgg agaaatggtt ggcccgggaa aagaagttac
      421 tcccagttgt tttccggaga aagcttgagt ttcttttatt gtcagaagac ctccaaggtg
      481 acattccaga gaacatcctc gaggagctgt atgagacctt aacacagggt gcagtaggcc
      541 acgtgcctga cggaaatcca aggagggaga gctggactcc tcgtctcagc tccgaagctg
      601 tctctgtgct ctgggatctc ctgaggcagt ctccccagcc agcacaggcc ctgctggagc
      661 tcctgcttga ggaggatgac ggtactggcc tctgtcactg gcctctgcag aatgcactgg
      721 tggacctcat tcgaaaggca ttgcgggctt tgcagggccc tgattcggtg ccccctgggg
      781 tagtcgatgc catctatgga gccctgcgga ctctgcgttg ccccgcagaa ccacttgggg
      841 ttgagttgca tctcctgtgt gaggaactac tagaggcctg caggaccgag gggagtcccc
      901 tgcgggagga gcggctgctc agctgcctgc tgcacaaggc cagccggggc ctgctgtccc
      961 tgtatggcca tacctatgca gagaaggtca cagaaaagcc accgagggct acagcctcgg
     1021 gaaaagtctc accggatcat ctagatcctg agcgggcaat gctagccctg ttctccaatc
     1081 ccaacccagc cgaggcttgg aaagtggcct atttctactg cctgagcaac aacaaacact
     1141 tcctcgagca gattctggta acagcactaa cattgttgaa agaagaagac ttcccaaatc
     1201 ttggctgcct acttgataga gaattcaggc ccctcagttg cctgcttgta ctcctgggct
     1261 ggacacactg ccagagccta gagtcagcca agaggctgct ccagaccctg cacaggaccc
     1321 agggcccagg ctgtgatgag ctcctcaggg atgcctgtga tgggttgtgg gctcacctgg
     1381 aggtcctgga gtggtgcata cagcagagca gcaaccccat accaaagaga gatctgttgt
     1441 atcatttaca cggtggagac agccactcag tgctctacac tctccatcac cttacaaacc
     1501 ttccagccct cagggaggaa gatgttctca agctcttaca gaaagtgcca gccaaggacc
     1561 cccagcaaga gcctgatgca gttgatgctc cagtccctga gcacctgagc cagtgtcaga
     1621 acctgacact ctaccagggc ttctgtgcca tgaagtatgc catctatgcc ctctgtgtaa
     1681 actcacacca gcactcccag tgccaggact gcaaagacag cctctctgag gacctggcct
     1741 cagctacaga gccagcgaat gactctctct cctccccagg tgctgcaaat ctcttctcaa
     1801 cttacctggc caggtgtcaa cagtatctgt gcagtattcc tgactctctg tgcctggagc
     1861 ttctggaaaa catcttctca ttgcttctca tcacctctgc tgatcttcac ccagagcctc
     1921 acttgcctga ggactatgct gaggatgatg acattgaggg gaagagcccc tcaggtttga
     1981 ggtccccatc agagagccct cagcacatag cacatcctga aaggaagtca gaacggggtt
     2041 ccctgggagt cccaaagacc cttgcttata caatgccaag ccatgtgaag gcagagccaa
     2101 aagacagtta cccagggcct cataggcaca gctttttgga cttaaaacac tttactagtg
     2161 gtatcagtgg atttctggct gatgaatttg caataggggc cttcctcagg cttctccaag
     2221 agcaactgga tgagatcagt agccgcagcc ctcctgagaa gccaaagcaa gaaagtcaga
     2281 gctgctcagg aagcagagat ggactgcaga gccgcctgca tcgactttcc aaggttgtct
     2341 ctgaggccca gtggagacac aaggtggtga caagcaacca tcgttcagag gagcaacctt
     2401 cccgaagata ccagcctgcc acacgtcacc ccagtctccg ccggggtcgt cggacaagaa
     2461 ggagccaggc agatggccga gacagaggtt caaacccatc cctggaaagt acaagtagtg
     2521 agctgagcac aagtacgtca gagggaagtc tgagtgccat gtctggccgg aatgagctgc
     2581 acagtagatt gcacccccat cctcaaagtt cactcatccc catgatgttc tccccacctg
     2641 agtcactgct ggcatcctgc atccttcgcg ggaacttcgc agaagcccat caggtgctgt
     2701 tcacgttcaa cctgaagtcc tcacccagtt caggggaact gatgttcatg gagcgctacc
     2761 aggaagtgat ccaagaactg gcccaagtag agcacaagat tgaaaaccag aactcagatg
     2821 cgggtagcag caccattcgg agaactggca gtggccgctc aactctacag gccattggca
     2881 gcgctgcagc agcaggaatg gtgttttact ctatctctga cgtgactgac aagctgctca
     2941 acacctctgg agaccccatc cccatgctcc aggaggactt ttggataagc acggctctag
     3001 tggagcccac tgctcccctg agagaggttc tggaagacct cagtccccct gccatggctg
     3061 catttgacct agcttgctct cagtgccagc tctggaaaac ctgcaagcag cttttggaga
     3121 cagccgaacg gcgtttgaat agtagccttg aaaggcgggg tcgacggata gaccacgtac
     3181 tcctaaatgc tgatggcatt cgaggttttc cagttgttct tcagcaaatc agtaagagtc
     3241 tcaattatct gcttatgtca gccagtcaaa ccaaatcaga gagtgtggaa gaaaagggag
     3301 gaggccctcc acggtgcagc atcactgaac tgcttcagat gtgctggccc agcctaagcg
     3361 aggactgtgt tgccagccac accaccctct cccagcagct agatcaggtc cttcagtcac
     3421 tgagagaggc actagagctg ccagagccca ggactcctcc actgtcttcc ctggtggagc
     3481 aggcagccca gaaagctcca gaggcagagg cccaccctgt gcagatccag actcagctcc
     3541 tccagaagaa cctgggcaaa cagaccccat caggcagcag gcagatggac tacttgggca
     3601 ccttcttcag ttactgcagc acccttgctg cagttctcct tcaaagtttg agctctgagc
     3661 ctgatcatgt ggaggtcaag gtaggaaatc cctttgttct gctgcaacag agctcttccc
     3721 aactggtgtc acatctcctg tttgagagac aagttccccc agagagactg gcagcccttc
     3781 tggcccaaga gaatctcagc ctaagtgtgc cacaggtcat cgtcagctgc tgctgtgagc
     3841 cccttgctct ttgctcatcc cggcaaagcc agcagacctc ctccctcctg actcgtctgg
     3901 gtactctggc ccagctacac gcctctcact gcctggatga cctcccactt tctacaccga
     3961 gctccccgag gacaactgag aaccctacat tggaaagaaa gccctactcc tccccaaggg
     4021 actcatcact cccagccctc acctcctctg ccttggcctt tcttaagtca cgctcaaagc
     4081 tcctagctac ggtggcctgc ctgggggctt ccccgaggtt aaaggtcagc aaacccagct
     4141 tgtcatggaa ggaacttcgt ggccgcaggg aggtgcctct ggctgcagag caggtagccc
     4201 gggagtgtga gcgccttctg gaacaattcc ctctgtttga ggccttcctc ctggctgcct
     4261 gggagcccct gcgagggtct ttgcagcagg ggcagagtct ggcagtgaat ctctgtggtt
     4321 gggccagtct ttctaccgtt ctcctgggcc tacattctcc cattgcccta gatgtactga
     4381 gtgaggcttt tgaggaatcc ttggtggcca gagattggtc ccgggccctt cagctcactg
     4441 aagtgtacgg gcgagatgtg gacgatttga gcagcataaa ggatgcagtc ctgagctgtg
     4501 ctgtggcatg tgacaaagaa ggttggcaat acctgtttcc cgtgaaggat gcatctctga
     4561 gaagtcggct ggccctacag tttgtggaca ggtggcccct ggagtcatgc ctggagattc
     4621 tggcctactg catttcagac acggctgtcc aagaaggact aaagtgtgag ctacagagga
     4681 agctggcgga gctgcaggtg tatcagaaga ttctgggttt gcagtctccc ccagtgtggt
     4741 gtgactggca gaccttgagg agctgttgtg ttgaggaccc atcaactgtc atgaacatga
     4801 ttctagaagc acaggagtat gaactgtgtg aagagtgggg ctgcctgtac cccattccaa
     4861 gagaacattt aatcagcctt catcaaaagc atcttctcca ccttctagaa agaagagatc
     4921 atgacaaggc tctgcaactc ctgcgaagaa tccctgaccc caccatgtgc cttgaagtga
     4981 cagagcaatc cctcgaccag cacactagct tggccacttc tcacttcttg gccaactacc
     5041 tcaccaccca cttctatgga caactgactg ctgtccgaca ccgtgaaatc caggcgctgt
     5101 atgtgggatc caagattctg ctgaccctgc ctgagcagca ccgggccagc tattcccact
     5161 tgtcctctaa ccccctgttc atgctggagc agctgcttat gaacatgaag gtggattggg
     5221 ccactgtggc tgtgcagact ctccagcagc tgctggttgg acaggagatt ggcttcacta
     5281 tggacgaggt ggactcactg ctttccagat acgcagagaa agccctggac tttccatacc
     5341 ctcagaggga gaaacgatca gattctgtga ttcacctcca agaaattgtc caccaggctg
     5401 cagatcccga gaccctccct agatcaccat cagcagagtt ctctcctgct gctcctcctg
     5461 gtatctccag tatacattcc cctagtctaa gggaaaggag tttcccacca acccagccct
     5521 cacaggaatt tgtgccccca gcgacacccc ctgccaggca ccagtgggta ccggatgaga
     5581 ctgagagtat ctgcatggtc tgctgcaggg agcacttcac catgtttaac aggcgtcatc
     5641 attgtcgccg ctgtggccgg ctagtgtgca gctcctgctc cactaagaaa atggtggttg
     5701 aaggctgcag agagaaccct gctcgtgtgt gtgatcagtg ctatagttac tgcaacaaag
     5761 atgtaccaga ggagccttca gaaaaaccag aagctctaga cagctccaag aatgaaagcc
     5821 ctccatactc gtttgtggtg agagtcccca aagcagatga ggtggaatgg attttggatc
     5881 tcaaagagga ggaaaatgag ctggtgcgga gtgaatttta ctatgagcag gcccccagcg
     5941 cctccttgtg cattgccatc ctgaatctgc accgggacag cattgcctgt ggtcaccagc
     6001 tgattgagca ctgctgcagg ctctccaagg gcctcaccaa cccagaggtg gatgccgggc
     6061 tgctcacgga catcatgaag cagctgctgt tcagcgccaa gatgatgttc gtcaaagccg
     6121 gccagagcca agacttggct ctttgtgaca gctacatcag caaggtagat gtgctgaata
     6181 ttttagttgc tgctgcctat cgccacgtgc catctttgga tcagatcttg cagccagctg
     6241 cagtaaccag gctaaggaac cagcttttgg aagccgagta ctaccaactg ggcgttgagg
     6301 tctccacaaa gactgggctt gataccaccg gggcgtggca tgcttggggc atggcctgcc
     6361 tcaaagccgg gaacctcact gctgcacggg agaagttcag tcgctgtctg aagcccccat
     6421 ttgacctcaa tcagctgaat catggctcaa ggctggtgca ggatgtggtt gagtacctag
     6481 agtccacagt gaggcccttt gtatccttgc aagatgacga ttactttgcc accctgaggg
     6541 aactggaagc tacccttcgg acgcagagcc tttctctggc agtgattcct gaagggaaaa
     6601 tcatgaacaa cacctactac caggaatgcc tcttctacct gcacaactat agcaccaacc
     6661 tggccatcat cagcttctac gtgaggcaca gctgcctgcg ggaagctctt ctgcaccttc
     6721 tcaacaagga gagtcctcca gaagttttta tagaaggcat tttccaacca agctataaaa
     6781 gtgggaagct acacactttg gagaacttgc tagaatccat tgatccaacc ttggagagct
     6841 ggggaaagta cttgattgct gcctgccaac atttacagaa gaagaactac taccacattc
     6901 tgtatgagct gcagcagttt atgaaggacc aagttcgggc cgccatgacc tgtattcggt
     6961 tcttcagtca caaagcaaag tcatatacag aactgggaga gaagctctca tggctactta
     7021 aggccaagga ccacctgaag atctacctcc aagaaacatc ccgcagctct ggaaggaaga
     7081 aaaccacatt cttcagaaag aagatgactg cagctgatgt gtcaaggcac atgaacacac
     7141 ttcagctgca gatggaagtg accaggttct tgcatcggtg cgaaagtgct gggacctctc
     7201 aaatcaccac tttgcctctg ccaaccctgt ttggaaataa ccacatgaaa atggatgttg
     7261 cctgcaaggt catgctggga gggaaaaatg tagaagatgg ttttggaatt gctttccgtg
     7321 ttctgcagga cttccagctg gatgctgcca tgacctactg cagagctgcc cgccagttgg
     7381 tggagaaaga gaagtacagt gagatccagc aactgctcaa atgtgtcagt gagtcaggca
     7441 tggcagccaa aagtgacggg gacaccatcc tcctcaactg cctggaagcg ttcaagagaa
     7501 ttccgcccca ggagctggag ggcctgatcc aggcaataca caatgatgac aacaaggttc
     7561 gggcctacct gatatgttgc aaactgcgtt ctgcctactt gattgctgtg aagcaagaac
     7621 actcacgggc cacagccctt gtccagcagg tgcagcaggc cgccaagagc agcggggatg
     7681 cagtagtgca agacatctgt gcccagtggc ttctgacaag ccacccccgg ggtgcccatg
     7741 gcccaggctc caggaagtga ccttgggcag tggggccagg aacacgtggc ctgagagctg
     7801 ggcaacagca gtgatggcga tgccctccac ctctttcctc cagtggagtg ggacttctct
     7861 ggctctgccc taggttggaa agagttggat tggaccctac ttgccttccc gggcaaggat
     7921 aggacctttc acgcaagtgc catgtttctc taaaattgtg gaatctatgt gtgtttgtct
     7981 ggagatggcc agttctttct acctcagagt gagtgagtga gtatgtgtgc acacacgtgt
     8041 gcatgttcct gtgcgctgat gtttacgccc aagcatttct gaacaaatga aactcttctc
     8101 catttaaaag aggcacttta ctttagactt gccactctga aaaccttccc tgcgttttgg
     8161 ttcttgaccc gggttgtcct gtttgtatag tcccccctct gtggacgtgc tttagtagct
     8221 cctcttacct agagggcttt tacagagaat tagagcaaca ccaaaaggat tgcctctttt
     8281 ccttccttcc cattccaaaa ttcagagatg gctttggggc aagtgctacc tgtggaataa
     8341 acctgttttc caggtgtctc ttctcccaag cacaagaagt cctggagtct ttggaaggta
     8401 gtctgaatag aagggttttc aggtgcaggc atctgaaagc tgtgggtatg tgtataaatg
     8461 atcaggtctg tgaggctaac acgggcaaga gggaaagaaa ggctaaccat ccaaacaggg
     8521 atacagggga ggcggtgggg ggtggtgggg ggagcgggtg ctcacaagca cagagctgcc
     8581 tgttgtgaat gtccctgctg caaagttggt gggtgagaga atgggacttc ctctttgaga
     8641 gtctggggag agaaaaggtg gccaggatcc taggactgaa tgactcgatt ttacctattt
     8701 gagctgcagt cctgtttgcg ctccttgaat tggttaggaa gctgcttcct tttccctcct
     8761 gcttcccttc agtctcttca ggaccacagg atggatatgc agacatgtgg ggtcattggg
     8821 aagggagtgc gcttcttttc tctgtcttag aaaagggagt caagggttgg ctttggaatt
     8881 gggcctctgg acagagtcag aatgagggaa taatgaatag gtcacatctg gttggtggaa
     8941 aactaggtga agtgcttctt taatatgcac tgtcttgtct tcccacgcaa gatgtgacaa
     9001 tgtttgagaa aaggtgtgtc atactcagtg acttcaattt gcaaatgtgg ggcctaaaga
     9061 aagctctgca gctctgaacc tctcactggc cagagctcag cctattggtc ccatccatga
     9121 tgctgagaca aacagaaact ggaagctgaa gtcagtgtct ctggtgctca gaaaccctgt
     9181 ggatttccct ctgaaccaag atttttagta gtaaaataaa caactcatgg acatctgtca
     9241 gatgagaagt tttggtcctg ttagagagga gaaagactgt aatgaaacta ctagacccat
     9301 ttgggctaaa gtttggcttt tccttccttg agtcatagaa cgtatccatc tcccaggaaa
     9361 tgtccttctc tggcgtctgc ttgcccttct gagtctgcct tttttgcact gaacataagc
     9421 actttatact aatgggtcac aaatcttgca gcccttaatt tgggataaga ccagattttc
     9481 ctgacatttt cctctaactc attgaactat caaattatag gcaaccactg actagactga
     9541 tatgagatga ggctaaaagc ctttgaacac cacgctgtag tctccaacag aaaaacacca
     9601 ccaaaacaga tacccatgtt gaggggttga atgttttact acaaacaagc cacaataaag
     9661 tgtctatcaa catg
//
