LOCUS       NM_024071               1383 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens zinc finger FYVE-type containing 21 (ZFYVE21),
            transcript variant 2, mRNA.
ACCESSION   NM_024071
VERSION     NM_024071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Jiang,Q., Song,G., He,L., Li,X., Jiang,B., Wang,Q., Wang,S.,
            Kim,C., Barkestani,M.N., Lopez,R., Fan,M., Wanniarachchi,K.,
            Quaranta,M., Tian,X., Mani,A., Gonzalez,A., Goodwin,J.E.,
            Sessa,W.C., Ishibe,S. and Jane-Wit,D.
  TITLE     ZFYVE21 promotes endothelial nitric oxide signaling and vascular
            barrier function in the kidney during aging
  JOURNAL   Kidney Int 106 (3), 419-432 (2024)
   PUBMED   38797325
  REMARK    GeneRIF: ZFYVE21 promotes endothelial nitric oxide signaling and
            vascular barrier function in the kidney during aging.
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1383)
  AUTHORS   Fang,C., Manes,T.D., Liu,L., Liu,K., Qin,L., Li,G., Tobiasova,Z.,
            Kirkiles-Smith,N.C., Patel,M., Merola,J., Fu,W., Liu,R., Xie,C.,
            Tietjen,G.T., Nigrovic,P.A., Tellides,G., Pober,J.S. and
            Jane-Wit,D.
  TITLE     ZFYVE21 is a complement-induced Rab5 effector that activates
            non-canonical NF-kappaB via phosphoinosotide remodeling of
            endosomes
  JOURNAL   Nat Commun 10 (1), 2247 (2019)
   PUBMED   31113953
  REMARK    GeneRIF: ZFYVE21 is identified as a posttranslationally induced
            Rab5 effector that triggers phosphoinositide remodeling of early
            endosome membranes to mediate non-canonical NF-kappaB signal
            activation and tissue inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1383)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1383)
  AUTHORS   Nagano,M., Hoshino,D., Sakamoto,T., Akizawa,T., Koshikawa,N. and
            Seiki,M.
  TITLE     ZF21 is a new regulator of focal adhesion disassembly and a
            potential member of the spreading initiation center
  JOURNAL   Cell Adh Migr 5 (1), 23-28 (2011)
   PUBMED   20890123
  REMARK    GeneRIF: ZF21 is a new regulator of focal adhesion disassembly and
            a potential member of the spreading initiation center. We
            identified 45 proteins including FA-related proteins and multiple
            RNA binding proteins
REFERENCE   7  (bases 1 to 1383)
  AUTHORS   Figl,A., Scherer,D., Nagore,E., Bermejo,J.L., Botella-Estrada,R.,
            Gast,A., Thirumaran,R.K., Planelles,D., Hemminki,K., Schadendorf,D.
            and Kumar,R.
  TITLE     Single-nucleotide polymorphisms in DNA-repair genes and cutaneous
            melanoma
  JOURNAL   Mutat Res 702 (1), 8-16 (2010)
   PUBMED   20601096
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1383)
  AUTHORS   Nagano,M., Hoshino,D., Sakamoto,T., Kawasaki,N., Koshikawa,N. and
            Seiki,M.
  TITLE     ZF21 protein regulates cell adhesion and motility
  JOURNAL   J Biol Chem 285 (27), 21013-21022 (2010)
   PUBMED   20439989
REFERENCE   9  (bases 1 to 1383)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1383)
  AUTHORS   Bergamaschi,D., Samuels,Y., O'Neil,N.J., Trigiante,G., Crook,T.,
            Hsieh,J.K., O'Connor,D.J., Zhong,S., Campargue,I., Tomlinson,M.L.,
            Kuwabara,P.E. and Lu,X.
  TITLE     iASPP oncoprotein is a key inhibitor of p53 conserved from worm to
            human
  JOURNAL   Nat Genet 33 (2), 162-167 (2003)
   PUBMED   12524540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005999.1 and CA311020.1.
            
            On Feb 27, 2020 this sequence version replaced NM_024071.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005999.1, BX248261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311141.7/ ENSP00000310543.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1381              BC005999.1         3-1383
            1382-1383           CA311020.1         22-23               c
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..1383
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /note="zinc finger FYVE-type containing 21"
                     /db_xref="GeneID:79038"
                     /db_xref="HGNC:HGNC:20760"
                     /db_xref="MIM:613504"
     exon            1..170
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..737
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger FYVE domain-containing protein 21; FYVE domain
                     containing 21; HCV p7-transactivated protein 1; zinc
                     finger, FYVE domain containing 21"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 21
                     isoform 2"
                     /protein_id="NP_076976.1"
                     /db_xref="CCDS:CCDS9985.1"
                     /db_xref="GeneID:79038"
                     /db_xref="HGNC:HGNC:20760"
                     /db_xref="MIM:613504"
                     /translation="MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPD
                     KECRRCMQCDAKFDFLTRKHHCRRCGKCFCDRCCSQKVPLRRMCFVDPVRQCAECALV
                     SLKEAEFYDKQLKVLLSGATFLVTFGNSEKPETMTCRLSNNQRYLFLDGDSHYEIEIV
                     HISTVQILTEGFPPGGGNARATGMFLQYTVPGTEGVTQLKLTVVEDVTVGRRQAVAWL
                     VAMHKAAKLLYESRDQ"
     exon            171..221
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     exon            222..390
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     exon            391..466
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     exon            467..558
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     exon            559..701
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     exon            702..1383
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /note="hexamer: ATTAAA"
     polyA_site      1383
                     /gene="ZFYVE21"
                     /gene_synonym="HCVP7TP1; ZF21"
                     /note="major polyA site"
ORIGIN      
        1 ggggccgctg gccgagaggc tgaggcggcg tcatgtcctc cgaggtgtcc gcgcgccgcg
       61 acgccaagaa gctggtgcgc tccccgagcg gcctgcgcat ggtgcccgaa caccgcgcct
      121 tcggaagccc gttcggcctg gaggagccgc agtgggtccc ggacaaggag tgtcggagat
      181 gtatgcagtg tgacgccaag tttgactttc tcaccagaaa gcaccactgt cgccgctgcg
      241 ggaagtgctt ctgcgacagg tgctgcagcc agaaggtgcc gctgcggcgc atgtgctttg
      301 tggaccccgt gcggcagtgc gcggagtgcg ccctcgtgtc cctcaaggag gcggagttct
      361 acgacaagca gctcaaagtg ctcctgagcg gagccacctt cctcgtcacg tttggaaact
      421 cagagaaacc tgaaactatg acttgtcgtc tttccaataa ccagagatac ttgtttctgg
      481 atggagacag ccactatgaa atcgaaattg tacacatttc caccgtgcag atcctcacag
      541 aaggcttccc tcctggagga ggcaacgcac gggccacagg catgttcctg cagtatacag
      601 tgccggggac ggagggtgtg acccagctga agctgacagt ggtggaggac gtgactgtgg
      661 gcaggaggca ggcggtggcg tggctagtgg ccatgcacaa ggctgccaag ctcctctatg
      721 aatctcggga ccagtaactc tacgtggggc tgagcttgga gtacgtgtgg tcaccaggac
      781 tgagtcgctt ggaacagcag agcctgctcc ttgcgtacca cagggattaa tcctgcttgt
      841 gctgggaaat gcaactcact catgtatttg gagaaacagg agtgttcact tatctagtgc
      901 aatatgttca cagtttatta atgctttaaa cagcttcatg ttttagaatt tgtgtattgt
      961 caatacttaa ttgggggtgg gagagactga gctacactac tgctaaacta tttttagcat
     1021 aatatatacc atttttatga gttcgcaggt ctactagaag gttctggccc atcaatattc
     1081 atttcattta attcttccac agaaccagtt tgggcagtag gaactcaggc ttctggtctg
     1141 cagtggagcc tgttcgcctc taatagccag tttacagcac ttgccttagc ctgtttcaca
     1201 gacttgtcca cttaccttgt cactaatttg gggcttctgg gctgtgagtg atcctttgat
     1261 acttcaccaa ggggaacgtg ggggctttgt gttttgtact tttcactcac tatttcactt
     1321 tattaagatg actgtacagc aatttgtata taaagcttat gattaaaaac tattttgaac
     1381 ata
//
