LOCUS       NM_021260               4380 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger FYVE-type containing 1 (ZFYVE1),
            transcript variant 1, mRNA.
ACCESSION   NM_021260
VERSION     NM_021260.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4380)
  AUTHORS   Ricciardi,S., Guarino,A.M., Giaquinto,L., Polishchuk,E.V.,
            Santoro,M., Di Tullio,G., Wilson,C., Panariello,F., Soares,V.C.,
            Dias,S.S.G., Santos,J.C., Souza,T.M.L., Fusco,G., Viscardi,M.,
            Brandi,S., Bozza,P.T., Polishchuk,R.S., Venditti,R. and De
            Matteis,M.A.
  TITLE     The role of NSP6 in the biogenesis of the SARS-CoV-2 replication
            organelle
  JOURNAL   Nature 606 (7915), 761-768 (2022)
   PUBMED   35551511
REFERENCE   2  (bases 1 to 4380)
  AUTHORS   Kojima,W., Yamano,K., Kosako,H., Imai,K., Kikuchi,R., Tanaka,K. and
            Matsuda,N.
  TITLE     Mammalian BCAS3 and C16orf70 associate with the phagophore assembly
            site in response to selective and non-selective autophagy
  JOURNAL   Autophagy 17 (8), 2011-2036 (2021)
   PUBMED   33499712
REFERENCE   3  (bases 1 to 4380)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4380)
  AUTHORS   Gao,G., Sheng,Y., Yang,H., Chua,B.T. and Xu,L.
  TITLE     DFCP1 associates with lipid droplets
  JOURNAL   Cell Biol Int 43 (12), 1492-1504 (2019)
   PUBMED   31293035
REFERENCE   5  (bases 1 to 4380)
  AUTHORS   Li,D., Zhao,Y.G., Li,D., Zhao,H., Huang,J., Miao,G., Feng,D.,
            Liu,P., Li,D. and Zhang,H.
  TITLE     The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact
            Formation
  JOURNAL   Cell Rep 27 (2), 343-358 (2019)
   PUBMED   30970241
  REMARK    GeneRIF: Study reveals that fusion of DFCP1-labeled nascent
            structures contributes to initial LD growth and that the
            DFCP1-Rab18 complex is involved in tethering the ER-LD contact for
            LD expansion.
REFERENCE   6  (bases 1 to 4380)
  AUTHORS   Orsi,A., Razi,M., Dooley,H.C., Robinson,D., Weston,A.E.,
            Collinson,L.M. and Tooze,S.A.
  TITLE     Dynamic and transient interactions of Atg9 with autophagosomes, but
            not membrane integration, are required for autophagy
  JOURNAL   Mol Biol Cell 23 (10), 1860-1873 (2012)
   PUBMED   22456507
REFERENCE   7  (bases 1 to 4380)
  AUTHORS   Hayashi-Nishino,M., Fujita,N., Noda,T., Yamaguchi,A., Yoshimori,T.
            and Yamamoto,A.
  TITLE     A subdomain of the endoplasmic reticulum forms a cradle for
            autophagosome formation
  JOURNAL   Nat Cell Biol 11 (12), 1433-1437 (2009)
   PUBMED   19898463
REFERENCE   8  (bases 1 to 4380)
  AUTHORS   Ridley,S.H., Ktistakis,N., Davidson,K., Anderson,K.E., Manifava,M.,
            Ellson,C.D., Lipp,P., Bootman,M., Coadwell,J., Nazarian,A.,
            Erdjument-Bromage,H., Tempst,P., Cooper,M.A., Thuring,J.W.,
            Lim,Z.Y., Holmes,A.B., Stephens,L.R. and Hawkins,P.T.
  TITLE     FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct
            functions in the endosomal and Golgi compartments
  JOURNAL   J Cell Sci 114 (Pt 22), 3991-4000 (2001)
   PUBMED   11739631
REFERENCE   9  (bases 1 to 4380)
  AUTHORS   Cheung,P.C., Trinkle-Mulcahy,L., Cohen,P. and Lucocq,J.M.
  TITLE     Characterization of a novel phosphatidylinositol
            3-phosphate-binding protein containing two FYVE fingers in tandem
            that is targeted to the Golgi
  JOURNAL   Biochem J 355 (Pt 1), 113-121 (2001)
   PUBMED   11256955
REFERENCE   10 (bases 1 to 4380)
  AUTHORS   Derubeis,A.R., Young,M.F., Jia,L., Robey,P.G. and Fisher,L.W.
  TITLE     Double FYVE-containing protein 1 (DFCP1): isolation, cloning and
            characterization of a novel FYVE finger protein from a human bone
            marrow cDNA library
  JOURNAL   Gene 255 (2), 195-203 (2000)
   PUBMED   11024279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC053520.1, AB046809.1 and
            HY248287.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021260.3.
            
            Summary: The FYVE domain mediates the recruitment of proteins
            involved in membrane trafficking and cell signaling to
            phosphatidylinositol 3-phosphate-containing membranes. This protein
            contains two zinc-binding FYVE domains in tandem and is reported to
            localize to the Golgi apparatus. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053520.1, SRR1660805.194284.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556143.6/ ENSP00000450742.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3733              BC053520.1         35-3767
            3734-4379           AB046809.1         3665-4310
            4380-4380           HY248287.1         46-46               c
FEATURES             Location/Qualifiers
     source          1..4380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..4380
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /note="zinc finger FYVE-type containing 1"
                     /db_xref="GeneID:53349"
                     /db_xref="HGNC:HGNC:13180"
                     /db_xref="MIM:605471"
     exon            1..181
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..1098
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..2949
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tandem FYVE fingers-1 protein; zinc finger protein,
                     subfamily 2A, member 1; double FYVE-containing protein 1;
                     zinc finger FYVE domain-containing protein 1;
                     phosphoinositide-binding protein SR3; protein phosphatase
                     1, regulatory subunit 172; zinc finger, FYVE domain
                     containing 1"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_067083.1"
                     /db_xref="CCDS:CCDS9811.1"
                     /db_xref="GeneID:53349"
                     /db_xref="HGNC:HGNC:13180"
                     /db_xref="MIM:605471"
                     /translation="MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLR
                     CEEELHRQERLRNHERIRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLE
                     CQKRTHSGGNKRRHPVTVYNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEI
                     QVTNEEDFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCT
                     VGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDL
                     FKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSE
                     VPEKLIQDRFRKLGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRH
                     PGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKKSMNHGKEG
                     VPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYV
                     IECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNF
                     MAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACG
                     EGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVG
                     EAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRAC
                     GQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL"
     exon            1099..1603
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1818
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1925
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2034
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2132
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2250
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2421
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2602
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2716
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..4380
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4361..4366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /note="hexamer: CATAAA"
     polyA_site      4380
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /note="major polyA site"
ORIGIN      
        1 actccgatca gctgatccca actgacaaca ggagaggagg aagcccggga ggcaacgaag
       61 gaggagggtg gcggagatgg agatgaggat ggatctgccg gtgtcctgag gaatagcctc
      121 tgcccccact ggcgccctgc ggccccccga cgccgccttg ctgcggccga gcttctcagt
      181 ggtatcccct gaaatactga cttcaggtcg aattatattg aaaagctcct gaccactttc
      241 tttcattacc aaaactttgt agctgatgtc caaccgatga acccaccacc gtgaacccat
      301 cagacctctc tcagatagcc ataaaagacc cttccaagtc aattttgacc acatctttgc
      361 ttgcacttta tggaggatga aaccatcaaa ccaaatcaac gttgctgcta atacaagagt
      421 cttagaggca gcaaattaaa aatttgaaca tttgtttgtg aagaactata acaggacatg
      481 aaaggtgttc ttttttaaag tgttcagaac cctgtggaag tttcgtgcag tcttcagact
      541 caaatcttcg tcttcacccc cggggcaagc tcagtgacta ttatatggtg ggtgtgtttc
      601 cttaccagcg tgagtatgag tgcccagact tccccagcag agaagggcct gaatccgggg
      661 ctgatgtgcc aggaaagtta cgcttgcagc gggactgatg aagctatctt tgagtgtgat
      721 gagtgctgca gtctgcagtg tctccgctgc gaggaggagc tccatcggca ggagcgcctg
      781 agaaaccatg agcggataag actcaaacct ggccatgtcc cttactgtga cctctgcaag
      841 ggtctcagtg ggcatttacc aggtgttagg cagagggcaa tagtgaggtg ccagacctgc
      901 aaaattaact tgtgcctgga gtgccagaag aggactcatt ctgggggtaa caaaaggaga
      961 caccctgtta ctgtgtacaa tgtcagtaat ctccaggagt cactggaggc agaagagatg
     1021 gatgaggaga ccaagaggaa gaagatgact gagaaggttg tgagtttcct cctagtagac
     1081 gaaaatgaag aaattcaggt aacaaatgaa gaagacttta ttagaaaatt ggactgcaaa
     1141 cctgatcagc atctgaaagt ggtttccatt tttggaaata ctggtgatgg aaagtctcat
     1201 actctcaacc acactttctt ttatggtcgt gaagtcttta aaacctcccc gacccaggag
     1261 tcctgcactg tgggagtgtg ggcagcctat gacccagttc acaaagtagc agtgatcgat
     1321 acggaagggc tcctgggggc caccgtgaat ctaagccaga gaacacggct gctgcttaag
     1381 gtcctggcca tctcagacct cgtcatctat cgaactcatg cagaccggct gcataacgac
     1441 ctcttcaaat tccttgggga tgcctcagaa gcttatctga agcacttcac caaggagctc
     1501 aaggccacca ctgctcgctg tggcctggat gtccctttat ccacactggg ccctgcagtt
     1561 atcatcttcc atgagaccgt gcacacccag ctactgggct ctgatcatcc ctcagaggtg
     1621 ccagagaagc tcatccagga ccggttccgg aagctgggcc gtttccctga agcctttagt
     1681 tccattcact acaagggaac gaggacttac aaccctccca cggacttttc tgggcttcgg
     1741 cgtgctttgg agcagctact agagaataac accacccgtt ctccccggca cccgggagtc
     1801 atcttcaaag ccctgaaggc actaagtgac cgcttcagcg gtgagatccc cgatgaccag
     1861 atggcgcaca gctccttttt tccagatgag tatttcacct gctcctcctt gtgcctcagc
     1921 tgtggggttg gatgtaagaa aagcatgaat catgggaagg aaggagtgcc tcatgaagcc
     1981 aagagccgct gcagatactc ccaccagtat gacaaccgag tgtatacctg caaggcctgc
     2041 tatgagagag gcgaggaagt cagtgtagtg cccaaaacat ctgcttccac tgactccccc
     2101 tggatgggtc tcgcaaaata tgcctggtct gggtatgtga tcgaatgtcc taactgtggc
     2161 gtggtctatc gtagtcggca gtactggttt ggaaaccaag atcctgtgga tacggtggtg
     2221 cggacagaga ttgtgcatgt gtggcctgga actgatgggt ttctgaagga caacaacaat
     2281 gctgcccagc gcctgttgga cgggatgaac ttcatggctc agtcggtgtc cgagcttagc
     2341 cttggaccca ccaaggctgt gacttcctgg ctgacagacc agatcgcccc tgcctactgg
     2401 aggcccaact cccagattct gagctgcaac aagtgtgcga cgtcctttaa agataacgac
     2461 actaagcatc actgccgagc ctgtggggag ggcttctgtg acagctgttc atcaaagact
     2521 cggccagtgc ctgagcgggg ctggggccct gcgccagtgc gggtctgtga caactgctac
     2581 gaagccagga acgtccagtt agctgttacc gaggcacaag tggacgatga aggtggaacg
     2641 ctcattgctc ggaaggtggg cgaggccgtg cagaacactc tgggagccgt ggtgacagcc
     2701 attgacatac cactaggtct ggtaaaggac gcggccaggc ctgcgtactg ggtgcctgac
     2761 cacgaaatcc tccactgcca caactgccgg aaggagttca gcatcaagct ctccaagcac
     2821 cactgccggg cctgcggaca gggcttctgt gatgagtgct cccatgaccg ccgggctgtt
     2881 ccttctcgtg gctgggacca tcccgtccga gtctgcttca actgcaataa aaagcccggt
     2941 gacctttaac cccagccccc tctccgagtc cttcacaatt ccttaggttc tcagggttag
     3001 aaacagtctt gcgaggtagg ccctcctccc agtcacctgc tgtggtgtgt gtcctctcct
     3061 ctccgcatcc agggccactt tccctcagtg ggggtgagcc tggcggcagg cccgaaggtg
     3121 tggacccctc agggcagggg accttgcaac ttatcgcaaa ggggaatgaa cctgaatccg
     3181 ttgcatttat ttcagttaaa aataatgaat atatatgtgt atatctctct ctcatatata
     3241 catatgaaag gcactcgggg cgtatcgagg ctgctgctgg ctgtgaagac ttcgcacagt
     3301 ctcctccgca cagggtgagg tggcagtggc agcacgtctt cctcatgagc cgagccaggt
     3361 ccatggccac cacgtggctg gccccttcct ctgctgctct tggagccttg gaagcctctc
     3421 ctgtccttgg ctcttccctc catgcctgtc agctgcctgg ggagtgagcc tccctggtcc
     3481 ttcctgcctg aaacagcctg aagggaattc tccctaggtc tcctgggagt cgagtcccaa
     3541 ttcttggctt aagcctgttt tagtcagaga ccacccaact tagcgtgcag gtcaccggag
     3601 tgggtggagg gtcagaggtc gggtcttcgg ccctgagaag tagaaatgca ggggccgtgc
     3661 tgtccctggt cccccaggga acagcaagga aggaactgag ccttctccag cagggcttcc
     3721 tgtcccgatg cttctgtctc cactcggctt tcccaaaagg cggcacccag ctcctcaatc
     3781 gaagcatctg cctcccaccc ctcggccccc tcaagcccac catctgcttc tgagtgtcgc
     3841 actaggattt tcattgctta ttttaaagtg tcttaatcct ttgttcccag acacacaacc
     3901 cctctagctc tcggaggggc gatcatgaga aaccttccag ggaaactgag cacaggatga
     3961 actgttagtt gtttttaaaa gtctatataa atatttcaac agatcgtaaa gaaaaaattt
     4021 atctctttgg tccttgcaag agaagtcaaa ggaacttttg tttctcctca agagcctgga
     4081 catctctgtc tgtcatgact ggaaagggcc cgttgtgctg aaatcctatc atcatggtgg
     4141 atttgatctt cagtggccaa acacgaatta aagtataatt cttaactgaa ctggtgggtg
     4201 ggttgagctt tagggaagta tatggcggtc attcctggtg cgcctatcgg tgtgacatga
     4261 gccctggagt gtgtcgtccc tctcagccct gctcctcctg cctcctgggg tccagtgact
     4321 gggaccctac tctagaactg tgtaccatcc aattcgccat cataaaggaa tcttcctgca
//
